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Select item 102404221.

PKA mediates modality-specific modulation of the mechanically gated ion channel PIEZO2

Irina Schaefer, Clement Verkest, Lucas Vespermann, Thomas Mair, Hannah Voß, Nadja Zeitzschel, Stefan G. Lechner

J Biol Chem. 2023 Jun; 299(6): 104782. Published online 2023 May 4. doi: 10.1016/j.jbc.2023.104782

PMCID:: PMC10240422

Abstract Article PDF–7.8M

Select item 102374222.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 99954963.

A screen for MeCP2-TBL1 interaction inhibitors using a luminescence-based assay

Beatrice Alexander-Howden, Li Zhang, Almer M. van der Sloot, Sylvain Tollis, Daniel J. St-Cyr, Frank Sicheri, Adrian P. Bird, Mike Tyers, Matthew J. Lyst

Sci Rep. 2023; 13: 3868. Published online 2023 Mar 8. doi: 10.1038/s41598-023-29915-z

PMCID:: PMC9995496

Abstract Article PDF–2.4M

Select item 99387954.

The SpACE-CCM: A facile and versatile cell culture medium-based biosensor for detection of SARS-CoV-2 spike-ACE2 interaction

Youngwook Ham, Nam-Chul Cho, Daeyong Kim, Jung-Hee Kim, Min Ju Jo, Min Seon Jeong, Bo-Yeong Pak, Sanghyeok Lee, Mi-Kyung Lee, Seung-Wook Chi, Tae-Don Kim, Nak Cheol Jeong, Sungchan Cho

Biosens Bioelectron. 2023 May 1; 227: 115169. Published online 2023 Feb 19. doi: 10.1016/j.bios.2023.115169

PMCID:: PMC9938795

Abstract Article PDF–6.0M

Select item 98231315.

Flotillin-2 regulates epidermal growth factor receptor activation, degradation by Cbl-mediated ubiquitination, and cancer growth

David J. Wisniewski, Mariya S. Liyasova, Soumya Korrapati, Xu Zhang, Shashikala Ratnayake, Qingrong Chen, Samuel F. Gilbert, Alexis Catalano, Donna Voeller, Daoud Meerzaman, Udayan Guha, Natalie Porat-Shliom, Christina M. Annunziata, Stanley Lipkowitz

J Biol Chem. 2023 Jan; 299(1): 102766. Published online 2022 Dec 5. doi: 10.1016/j.jbc.2022.102766

PMCID:: PMC9823131

Abstract Article PDF–2.5M

Select item 97696986.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 97498517.

Defective synaptic plasticity in a model of Coffin–Lowry syndrome is rescued by simultaneously targeting PKA and MAPK pathways

Rong-Yu Liu, Yili Zhang, Paul Smolen, Leonard J. Cleary, John H. Byrne

Learn Mem. 2022 Dec; 29(12): 435–446. Published online 2022 Dec. doi: 10.1101/lm.053625.122

PMCID:: PMC9749851

Abstract Article PDF–3.8M

Select item 95236458.

SARS-CoV-2 Nsp6 damages Drosophila heart and mouse cardiomyocytes through MGA/MAX complex-mediated increased glycolysis

Jun-yi Zhu, Guanglei Wang, Xiaohu Huang, Hangnoh Lee, Jin-Gu Lee, Penghua Yang, Joyce van de Leemput, Weiliang Huang, Maureen A. Kane, Peixin Yang, Zhe Han

Commun Biol. 2022; 5: 1039. Published online 2022 Sep 30. doi: 10.1038/s42003-022-03986-6

PMCID:: PMC9523645

Abstract Article PDF–3.9M

Select item 92792859.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 917141110.

Physical and functional interactome atlas of human receptor tyrosine kinases

Kari Salokas, Xiaonan Liu, Tiina Öhman, Iftekhar Chowdhury, Lisa Gawriyski, Salla Keskitalo, Markku Varjosalo

EMBO Rep. 2022 Jun; 23(6): e54041. Published online 2022 Apr 5. doi: 10.15252/embr.202154041

PMCID:: PMC9171411

Abstract Article PDF–1.9M

Select item 911973611.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 903609212.

Tumor suppressor BAP1 nuclear import is governed by transportin-1

Tzu-Jing Yang, Tian-Neng Li, Rih-Sheng Huang, Max Yu-Chen Pan, Shu-Yu Lin, Steven Lin, Kuen-Phon Wu, Lily Hui-Ching Wang, Shang-Te Danny Hsu

J Cell Biol. 2022 Jun 6; 221(6): e202201094. Published online 2022 Apr 21. doi: 10.1083/jcb.202201094

PMCID:: PMC9036092

Abstract Article PDF–4.0M

Select item 897683813.

The RBPJ/DAPK3/UBE3A signaling axis induces PBRM1 degradation to modulate the sensitivity of renal cell carcinoma to CDK4/6 inhibitors

Wentao Liu, Bin Zhang, Dan Zhang, Feng Guo, Kun Ye, Liang Zhu, Xin Jin

Cell Death Dis. 2022 Apr; 13(4): 295. Published online 2022 Apr 2. doi: 10.1038/s41419-022-04760-6

PMCID:: PMC8976838

Abstract Article PDF–5.8M

Select item 893369914.

Turnover of the mTOR inhibitor, DEPTOR, and downstream AKT phosphorylation in multiple myeloma cells, is dependent on ERK1-mediated phosphorylation

Mario Vega, Yu Chen, Yijiang Shi, Joseph Gera, Alan Lichtenstein

J Biol Chem. 2022 Apr; 298(4): 101750. Published online 2022 Feb 23. doi: 10.1016/j.jbc.2022.101750

PMCID:: PMC8933699

Abstract Article PDF–1.6M

Select item 889702215.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 884650516.

DNAJB1-PRKACA in HEK293T cells induces LINC00473 overexpression that depends on PKA signaling

Stephanie S. Kim, Ina Kycia, Michael Karski, Rosanna K. Ma, Evan A. Bordt, Julian Kwan, Anju Karki, Elle Winter, Ranan G. Aktas, Yuxuan Wu, Andrew Emili, Daniel E. Bauer, Praveen Sethupathy, Khashayar Vakili

PLoS One. 2022; 17(2): e0263829. Published online 2022 Feb 15. doi: 10.1371/journal.pone.0263829

PMCID:: PMC8846505

Abstract Article PDF–2.4M

Select item 855105917.

Genotype-specific cortisol production associated with Cushing’s syndrome adenoma with PRKACA mutations

Ryuta Baba, Kenji Oki, Celso E. Gomez-Sanchez, Yu Otagaki, Kiyotaka Itcho, Kazuhiro Kobuke, Takaya Kodama, Gaku Nagano, Haruya Ohno, Masayasu Yoneda, Noboru Hattori

Mol Cell Endocrinol. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Mol Cell Endocrinol. 2021 Dec 1; 538: 111456. Published online 2021 Sep 11. doi: 10.1016/j.mce.2021.111456

PMCID:: PMC8551059

Abstract Article PDF–851K

Select item 840943518.

Is disrupted nucleotide-substrate cooperativity a common trait for Cushing’s syndrome driving mutations of protein kinase A?

Caitlin Walker, Yingjie Wang, Cristina Olivieri, V.S. Manu, Jiali Gao, David A. Bernlohr, Davide Calebiro, Susan S. Taylor, Gianluigi Veglia

J Mol Biol. Author manuscript; available in PMC 2022 Sep 3.

Published in final edited form as: J Mol Biol. 2021 Sep 3; 433(18): 167123. Published online 2021 Jul 3. doi: 10.1016/j.jmb.2021.167123

PMCID:: PMC8409435

Abstract Article PDF–2.0M

Select item 831602019.

Cyclic AMP-Dependent Protein Kinase Exhibits Antagonistic Effects on the Replication Efficiency of Different Human Papillomavirus Types

Elina Lototskaja, Olga Sahharov, Marko Piirsoo, Martin Kala, Mart Ustav, Alla Piirsoo

J Virol. 2021 Jul; 95(13): e00251-21. Prepublished online 2021 Apr 14. Published online 2021 Jun 10. doi: 10.1128/JVI.00251-21

PMCID:: PMC8316020

Abstract Article PDF–1.9M

Select item 822489520.

PKA and AKIP1 interact to mediate cAMP-driven COX-2 expression: A potentially pivotal interaction in preterm and term labour

Angela Yulia, Natasha Singh, Alice J. Varley, Kaiyu Lei, Danijela Markovic, Suren R. Sooranna, Mark R. Johnson

PLoS One. 2021; 16(6): e0252720. Published online 2021 Jun 24. doi: 10.1371/journal.pone.0252720

PMCID:: PMC8224895

Abstract Article PDF–2.6M

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