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Select item 101758291.

The resurgence of the Adora2b receptor as an immunotherapeutic target in pancreatic cancer

Lincoln N. Strickland, Erika Y. Faraoni, Wei Ruan, Xiaoyi Yuan, Holger K. Eltzschig, Jennifer M. Bailey-Lundberg

Front Immunol. 2023; 14: 1163585. Published online 2023 Apr 28. doi: 10.3389/fimmu.2023.1163585

PMCID:: PMC10175829

Abstract Article PDF–11M

Select item 100718192.

CD73-Dependent Adenosine Signaling through Adora2b Drives Immunosuppression in Ductal Pancreatic Cancer

Erika Y. Faraoni, Kanchan Singh, Vidhi Chandra, Olivereen Le Roux, Yulin Dai, Ismet Sahin, Baylee J. O'Brien, Lincoln N. Strickland, Le Li, Emily Vucic, Amanda N. Warner, Melissa Pruski, Trent Clark, George Van Buren, Nirav C. Thosani, John S. Bynon, Curtis J. Wray, Dafna Bar-Sagi, Kyle L. Poulsen, Lana A. Vornik, Michelle I. Savage, Shizuko Sei, Altaf Mohammed, Zhongming Zhao, Powel H. Brown, Tingting Mills, Holger K. Eltzschig, Florencia McAllister, Jennifer M. Bailey-Lundberg

Cancer Res. 2023 Apr 4; 83(7): 1111–1127. Published online 2023 Jan 31. doi: 10.1158/0008-5472.CAN-22-2553

PMCID:: PMC10071819

Abstract Article PDF–23M

Select item 91007693.

Adenosine Receptor A2B Negatively Regulates Cell Migration in Ovarian Carcinoma Cells

Anaí del Rocío Campos-Contreras, Adriana González-Gallardo, Mauricio Díaz-Muñoz, Francisco G. Vázquez-Cuevas

Int J Mol Sci. 2022 May; 23(9): 4585. Published online 2022 Apr 21. doi: 10.3390/ijms23094585

PMCID:: PMC9100769

Abstract Article PDF–7.8M

Select item 81974794.

Adenosine and Cordycepin Accelerate Tissue Remodeling Process through Adenosine Receptor Mediated Wnt/β-Catenin Pathway Stimulation by Regulating GSK3b Activity

Jaeyoon Kim, Jae Young Shin, Yun-Ho Choi, So Young Lee, Mu Hyun Jin, Chang Deok Kim, Nae-Gyu Kang, Sanghwa Lee

Int J Mol Sci. 2021 Jun; 22(11): 5571. Published online 2021 May 25. doi: 10.3390/ijms22115571

PMCID:: PMC8197479

Abstract Article PDF–46M

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 75298536.

Tumor-derived exosomes promote angiogenesis via adenosine A_2B receptor signalling

Nils Ludwig, Saigopalakrishna S. Yerneni, Juliana H. Azambuja, Delbert G. Gillespie, Elizabeth V. Menshikova, Edwin K. Jackson, Theresa. L. Whiteside

Angiogenesis. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Angiogenesis. 2020 Nov; 23(4): 599–610. Published online 2020 May 18. doi: 10.1007/s10456-020-09728-8

PMCID:: PMC7529853

Abstract Article PDF–781K

Select item 74375167.

Adenosine/A2B receptor signaling ameliorates the effects of ageing and counteracts obesity

Thorsten Gnad, Gemma Navarro, Minna Lahesmaa, Laia Reverte-Salisa, Francesca Copperi, Arnau Cordomi, Jennifer Naumann, Aileen Hochhäuser, Saskia Haufs-Brusberg, Daniela Wenzel, Frank Suhr, Naja Zenius Jespersen, Camilla Scheele, Volodymyr Tsvilovskyy, Christian Brinkmann, Joern Rittweger, Christian Dani, Mathias Kranz, Winnie Deuther-Conrad, Holger K. Eltzschig, Tarja Niemi, Markku Taittonen, Peter Brust, Pirjo Nuutila, Leonardo Pardo, Bernd K. Fleischmann, Matthias Blüher, Rafael Franco, Wilhelm Bloch, Kirsi A. Virtanen, Alexander Pfeifer

Cell Metab. Author manuscript; available in PMC 2021 Jul 7.

Published in final edited form as: Cell Metab. 2020 Jul 7; 32(1): 56–70.e7. Published online 2020 Jun 25. doi: 10.1016/j.cmet.2020.06.006

PMCID:: PMC7437516

Abstract Article PDF–2.2M

Select item 70315298.

Cysteine redox state regulates human β2-adrenergic receptor binding and function

Kalyn M. Rambacher, Nader H. Moniri

Sci Rep. 2020; 10: 2934. Published online 2020 Feb 19. doi: 10.1038/s41598-020-59983-4

PMCID:: PMC7031529

Abstract Article PDF–3.3M

Select item 69811269.

CD73 on cancer-associated fibroblasts enhanced by the A_2B-mediated feedforward circuit enforces an immune checkpoint

Miao Yu, Gang Guo, Lei Huang, Libin Deng, Chang-Sheng Chang, Bhagelu R. Achyut, Madison Canning, Ningchun Xu, Ali S. Arbab, Roni J. Bollag, Paulo C. Rodriguez, Andrew L. Mellor, Huidong Shi, David H. Munn, Yan Cui

Nat Commun. 2020; 11: 515. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14060-x

PMCID:: PMC6981126

Abstract Article PDF–4.3M

Select item 668372210.

Erythrocyte Adenosine A2B Receptor-Mediated AMPK Activation: A Missing Component Counteracting CKD by Promoting Oxygen Delivery

Zhangzhe Peng, Renna Luo, Tingting Xie, Weiru Zhang, Hong Liu, Wei Wang, Lijian Tao, Rodney E. Kellems, Yang Xia

J Am Soc Nephrol. 2019 Aug; 30(8): 1413–1424. Published online 2019 Jul 5. doi: 10.1681/ASN.2018080862

PMCID:: PMC6683722

Abstract Article

Select item 662862011.

The Adenosine A_2B Receptor Drives Osteoclast-Mediated Bone Resorption in Hypoxic Microenvironments

Helen J. Knowles

Cells. 2019 Jun; 8(6): 624. Published online 2019 Jun 21. doi: 10.3390/cells8060624

PMCID:: PMC6628620

Abstract Article PDF–1.9M

Select item 660292912.

Cardioprotective role of APIP in myocardial infarction through ADORA2B

Bitna Lim, Kwangmin Jung, Youngdae Gwon, Jae Gyun Oh, Jae-il Roh, Se-Hoon Hong, Changwon Kho, Woo-Jin Park, Han-Woong Lee, Jang-Whan Bae, Yong-Keun Jung

Cell Death Dis. 2019 Jul; 10(7): 511. Published online 2019 Jul 1. doi: 10.1038/s41419-019-1746-3

PMCID:: PMC6602929

Abstract Article PDF–2.0M

Select item 629304913.

Adenosinergic signaling inhibits oxalate transport by human intestinal Caco2-BBE cells through the A_2B adenosine receptor

Daniel Jung, Altayeb Alshaikh, Sireesha Ratakonda, Mohamed Bashir, Ruhul Amin, Sohee Jeon, Jan Stevens, Sapna Sharma, Wahaj Ahmed, Mark Musch, Hatim Hassan

Am J Physiol Cell Physiol. 2018 Nov 1; 315(5): C687–C698. Published online 2018 Jul 18. doi: 10.1152/ajpcell.00024.2017

PMCID:: PMC6293049

Abstract Article

Select item 618715714.

Hypoxia-inducible factor 1-dependent expression of adenosine receptor 2B promotes breast cancer stem cell enrichment

Jie Lan, Haiquan Lu, Debangshu Samanta, Shaima Salman, You Lu, Gregg L. Semenza

Proc Natl Acad Sci U S A. 2018 Oct 9; 115(41): E9640–E9648. Published online 2018 Sep 21. doi: 10.1073/pnas.1809695115

Correction in:: Proc Natl Acad Sci U S A. 2022 Sep 20; 119(38): e2210925119.

PMCID:: PMC6187157

Abstract Article PDF–1.9M

Select item 616819515.

Beneficial Role of Erythrocyte Adenosine A2B Receptor-Mediated AMPK Activation in High Altitude Hypoxia

Hong Liu, Yujin Zhang, Hongyu Wu, Angelo D’Alessandro, Gennady G. Yegutkin, Anren Song, Kaiqi Sun, Jessica Li, Ning-Yuan Cheng, Aji Huang, Yuan Edward Wen, Ting Ting Weng, Fayong Luo, Travis Nemkov, Hong Sun, Rodney E. Kellems, Harry Karmouty-Quintana, Kirk C. Hansen, Bihong Zhao, Andrew W. Subudhi, Sonja Jameson-Van Houten, Colleen G. Julian, Andrew T. Lovering, Holger K. Eltzschig, Michael R Blackburn, Robert C. Roach, Yang Xia

Circulation. Author manuscript; available in PMC 2018 Oct 2.

Published in final edited form as: Circulation. 2016 Aug 2; 134(5): 405–421. doi: 10.1161/CIRCULATIONAHA.116.021311

PMCID:: PMC6168195

Abstract Article PDF–1.9M

Select item 611486416.

The A_2B adenosine receptor in MDA-MB-231 breast cancer cells diminishes ERK1/2 phosphorylation by activation of MAPK-phosphatase-1

Marthe Koussémou, Kristina Lorenz, Karl-Norbert Klotz

PLoS One. 2018; 13(8): e0202914. Published online 2018 Aug 29. doi: 10.1371/journal.pone.0202914

PMCID:: PMC6114864

Abstract Article PDF–4.6M

Select item 586260117.

Adenosine A_2A receptor ligand recognition and signaling is blocked by A_2B receptors

Sonja Hinz, Gemma Navarro, Dasiel Borroto-Escuela, Benjamin F. Seibt, York-Christoph Ammon, Elisabetta de Filippo, Azeem Danish, Svenja K. Lacher, Barbora Červinková, Muhammad Rafehi, Kjell Fuxe, Anke C. Schiedel, Rafael Franco, Christa E. Müller

Oncotarget. 2018 Mar 2; 9(17): 13593–13611. Published online 2018 Feb 6. doi: 10.18632/oncotarget.24423

PMCID:: PMC5862601

Abstract Article PDF–3.6M

Select item 563670418.

HIF1A up-regulates the ADORA2B receptor on alternatively activated macrophages and contributes to pulmonary fibrosis

Kemly Philip, Tingting Weng Mills, Jonathan Davies, Ning-Yuan Chen, Harry Karmouty-Quintana, Fayong Luo, Jose G. Molina, Javier Amione-Guerra, Neeraj Sinha, Ashrith Guha, Holger K. Eltzschig, Michael R. Blackburn

FASEB J. 2017 Nov; 31(11): 4745–4758. Published online 2017 Jul 12. doi: 10.1096/fj.201700219R

PMCID:: PMC5636704

Abstract Article

Select item 545955119.

Adenosine A2B Receptor and Hyaluronan Modulate Pulmonary Hypertension Associated with Chronic Obstructive Pulmonary Disease

Harry Karmouty-Quintana, Tingting Weng, Luis J. Garcia-Morales, Ning-Yuan Chen, Mesias Pedroza, Hongyan Zhong, Jose G. Molina, Raquel Bunge, Brian A. Bruckner, Yang Xia, Richard A. Johnston, Matthias Loebe, Dewan Zeng, Harish Seethamraju, Luiz Belardinelli, Michael R. Blackburn

Am J Respir Cell Mol Biol. 2013 Dec; 49(6): 1038–1047. doi: 10.1165/rcmb.2013-0089OC