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Select item 109176601.

Genetic determinants of micronucleus formation in vivo

D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus

Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0

PMCID:: PMC10917660

Abstract Article PDF–4.8M

Select item 102203882.

ATP13A2 activates the pentose phosphate pathway to promote colorectal cancer growth though TFEB‐PGD axis

Fan Zhang, Zhiwei Wu, Bowen Yu, Zhengping Ning, Zhixing Lu, Liang Li, Fei Long, Qionggui Hu, Chonglei Zhong, Yi Zhang, Changwei Lin

Clin Transl Med. 2023 May; 13(5): e1272. Published online 2023 May 26. doi: 10.1002/ctm2.1272

PMCID:: PMC10220388

Abstract Article PDF–8.4M

Select item 101789823.

The Effect of Manganese Exposure in Atp13a2-deficient Mice

Sheila M. Fleming, Nicholas A. Santiago, Elizabeth J. Mullin, Shanta Pamphile, Swagata Karkare, Andrew Lemkuhl, Osunde R. Ekhator, Stephen C. Linn, John G. Holden, Diana S. Aga, Jerome A. Roth, Benjamin Liou, Ying Sun, Gary E. Shull, Patrick J. Schultheis

Neurotoxicology. Author manuscript; available in PMC 2023 May 12.

Published in final edited form as: Neurotoxicology. 2018 Jan; 64: 256–266. Published online 2017 Jun 6. doi: 10.1016/j.neuro.2017.06.005

PMCID:: PMC10178982

Abstract Article PDF–958K

Select item 93185804.

ATP13A2 Declines Zinc-Induced Accumulation of α-Synuclein in a Parkinson’s Disease Model

Huiling Gao, Hehong Sun, Nan Yan, Pu Zhao, He Xu, Wei Zheng, Xiaoyu Zhang, Tao Wang, Chuang Guo, Manli Zhong

Int J Mol Sci. 2022 Jul; 23(14): 8035. Published online 2022 Jul 21. doi: 10.3390/ijms23148035

PMCID:: PMC9318580

Abstract Article PDF–5.1M

Select item 74159915.

BioID screening of biotinylation sites using the avidin-like protein Tamavidin 2-REV identifies global interactors of stimulator of interferon genes (STING)

Kou Motani, Hidetaka Kosako

J Biol Chem. 2020 Aug 7; 295(32): 11174–11183. Published online 2020 Jun 17. doi: 10.1074/jbc.RA120.014323

PMCID:: PMC7415991

Abstract Article PDF–2.0M

Select item 64928106.

Atp13a2 Deficiency Aggravates Astrocyte‐Mediated Neuroinflammation via NLRP3 Inflammasome Activation

Chen Qiao, Nuo Yin, Huan‐Yu Gu, Jia‐Lei Zhu, Jian‐Hua Ding, Ming Lu, Gang Hu

CNS Neurosci Ther. 2016 Jun; 22(6): 451–460. Published online 2016 Feb 5. doi: 10.1111/cns.12514

PMCID:: PMC6492810

Abstract Article PDF–851K

Select item 63145527.

ATP13A2 facilitates HDAC6 recruitment to lysosome to promote autophagosome–lysosome fusion

Ruoxi Wang, Jieqiong Tan, Tingting Chen, Hailong Han, Runyi Tian, Ya Tan, Yiming Wu, Jingyi Cui, Fang Chen, Jie Li, Lu Lv, Xinjie Guan, Shuai Shang, Jiahong Lu, Zhuohua Zhang

J Cell Biol. 2019 Jan 7; 218(1): 267–284. doi: 10.1083/jcb.201804165

PMCID:: PMC6314552

Abstract Article PDF–5.0M

Select item 58290108.

Exacerbation of sensorimotor dysfunction in mice deficient in Atp13a2 and overexpressing human wildtype alpha-synuclein

Emily R. Dirr, Osunde R. Ekhator, Rachel Blackwood, John G. Holden, Eliezer Masliah, Patrick J. Schultheis, Sheila M. Fleming

Behav Brain Res. Author manuscript; available in PMC 2019 May 2.

Published in final edited form as: Behav Brain Res. 2018 May 2; 343: 41–49. Published online 2018 Feb 3. doi: 10.1016/j.bbr.2018.01.029

PMCID:: PMC5829010

Abstract Article PDF–802K

Select item 50610519.

Endolysosomal Dysfunction in Parkinson Disease: Recent Developments and Future Challenges

Lauren R. Kett, William T. Dauer

Mov Disord. Author manuscript; available in PMC 2017 Oct 1.

Published in final edited form as: Mov Disord. 2016 Oct; 31(10): 1433–1443. doi: 10.1002/mds.26797

PMCID:: PMC5061051

Abstract Article PDF–1.0M

Select item 490623110.

The Parkinson's disease-associated genes ATP13A2 and SYT11 regulate autophagy via a common pathway

Carla F. Bento, Avraham Ashkenazi, Maria Jimenez-Sanchez, David C. Rubinsztein

Nat Commun. 2016; 7: 11803. Published online 2016 Jun 9. doi: 10.1038/ncomms11803

PMCID:: PMC4906231

Abstract Article PDF–3.5M

Select item 438892811.

α-Synuclein-Independent Histopathological and Motor Deficits in Mice Lacking the Endolysosomal Parkinsonism Protein Atp13a2

Lauren R. Kett, Barbara Stiller, Megan M. Bernath, Inmaculada Tasset, Javier Blesa, Vernice Jackson-Lewis, Robin B. Chan, Bowen Zhou, Gilbert Di Paolo, Serge Przedborski, Ana Maria Cuervo, William T. Dauer

J Neurosci. 2015 Apr 8; 35(14): 5724–5742. doi: 10.1523/JNEUROSCI.0632-14.2015

PMCID:: PMC4388928

Abstract Article PDF–8.0M

Select item 422813112.

ATP13A2/PARK9 Regulates Secretion of Exosomes and α-Synuclein

Taiji Tsunemi, Kana Hamada, Dimitri Krainc

J Neurosci. 2014 Nov 12; 34(46): 15281–15287. doi: 10.1523/JNEUROSCI.1629-14.2014

PMCID:: PMC4228131

Abstract Article PDF–1.2M

Select item 401418613.

Zn²⁺ dyshomeostasis caused by loss of ATP13A2/PARK9 leads to lysosomal dysfunction and alpha-synuclein accumulation

Taiji Tsunemi, Dimitri Krainc

Hum Mol Genet. 2014 Jun 1; 23(11): 2791–2801. Published online 2013 Dec 13. doi: 10.1093/hmg/ddt572

PMCID:: PMC4014186

Abstract Article PDF–757K

Select item 396495514.

The International Mouse Phenotyping Consortium Web Portal, a unified point of access for knockout mice and related phenotyping data

Gautier Koscielny, Gagarine Yaikhom, Vivek Iyer, Terrence F. Meehan, Hugh Morgan, Julian Atienza-Herrero, Andrew Blake, Chao-Kung Chen, Richard Easty, Armida Di Fenza, Tanja Fiegel, Mark Grifiths, Alan Horne, Natasha A. Karp, Natalja Kurbatova, Jeremy C. Mason, Peter Matthews, Darren J. Oakley, Asfand Qazi, Jack Regnart, Ahmad Retha, Luis A. Santos, Duncan J. Sneddon, Jonathan Warren, Henrik Westerberg, Robert J. Wilson, David G. Melvin, Damian Smedley, Steve D. M. Brown, Paul Flicek, William C. Skarnes, Ann-Marie Mallon, Helen Parkinson

Nucleic Acids Res. 2014 Jan 1; 42(Database issue): D802–D809. Published online 2013 Nov 3. doi: 10.1093/nar/gkt977

PMCID:: PMC3964955

Abstract Article PDF–5.7M

Select item 363337315.

Atp13a2-deficient mice exhibit neuronal ceroid lipofuscinosis, limited α-synuclein accumulation and age-dependent sensorimotor deficits

Patrick J. Schultheis, Sheila M. Fleming, Amy K. Clippinger, Jada Lewis, Taiji Tsunemi, Benoit Giasson, Dennis W. Dickson, Joseph R. Mazzulli, Mark E. Bardgett, Kristi L. Haik, Osunde Ekhator, Anil Kumar Chava, John Howard, Matt Gannon, Elizabeth Hoffman, Yinhuai Chen, Vikram Prasad, Stephen C. Linn, Rafael J. Tamargo, Wendy Westbroek, Ellen Sidransky, Dimitri Krainc, Gary E. Shull

Hum Mol Genet. 2013 May 15; 22(10): 2067–2082. Published online 2013 Feb 7. doi: 10.1093/hmg/ddt057

PMCID:: PMC3633373

Abstract Article PDF–620K

Select item 357241016.

A conditional knockout resource for the genome–wide study of mouse gene function

William C. Skarnes, Barry Rosen, Anthony P. West, Manousos Koutsourakis, Wendy Bushell, Vivek Iyer, Alejandro O. Mujica, Mark Thomas, Jennifer Harrow, Tony Cox, David Jackson, Jessica Severin, Patrick Biggs, Jun Fu, Michael Nefedov, Pieter J. de Jong, A. Francis Stewart, Allan Bradley

Nature. Author manuscript; available in PMC 2013 Feb 14.

Published in final edited form as: Nature. 2011 Jun 15; 474(7351): 337–342. Published online 2011 Jun 15. doi: 10.1038/nature10163

PMCID:: PMC3572410

Abstract Article PDF–1.1M

Select item 346569417.

PARK9-associated ATP13A2 localizes to intracellular acidic vesicles and regulates cation homeostasis and neuronal integrity

David Ramonet, Agata Podhajska, Klodjan Stafa, Sarah Sonnay, Alzbeta Trancikova, Elpida Tsika, Olga Pletnikova, Juan C. Troncoso, Liliane Glauser, Darren J. Moore

Hum Mol Genet. 2012 Apr 15; 21(8): 1725–1743. Published online 2011 Dec 20. doi: 10.1093/hmg/ddr606