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Select item 102374221.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 85664732.

Competitive binding of E3 ligases TRIM26 and WWP2 controls SOX2 in glioblastoma

Tatenda Mahlokozera, Bhuvic Patel, Hao Chen, Patrick Desouza, Xuan Qu, Diane D. Mao, Daniel Hafez, Wei Yang, Rukayat Taiwo, Mounica Paturu, Afshin Salehi, Amit D. Gujar, Gavin P. Dunn, Nima Mosammaparast, Allegra A. Petti, Hiroko Yano, Albert H. Kim

Nat Commun. 2021; 12: 6321. Published online 2021 Nov 3. doi: 10.1038/s41467-021-26653-6

PMCID:: PMC8566473

Abstract Article PDF–2.7M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 63865884.

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Joanna R. Kovalski, Aparna Bhaduri, Ashley M. Zehnder, Poornima H. Neela, Yonglu Che, Glenn G. Wozniak, Paul A. Khavari

Mol Cell. Author manuscript; available in PMC 2020 Feb 21.

Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 830–844.e12. Published online 2019 Jan 10. doi: 10.1016/j.molcel.2018.12.001

PMCID:: PMC6386588

Abstract Article PDF–1.7M

Select item 61666825.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 55316116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 50652927.

FRMD4A: A potential therapeutic target for the treatment of tongue squamous cell carcinoma

Xianghuai Zheng, Bo Jia, Xi Lin, Jiusong Han, Xiaoling Qiu, Hongxing Chu, Xiang Sun, Weitao Hu, Jie Pan, Jun Chen, Jianjiang Zhao

Int J Mol Med. 2016 Nov; 38(5): 1443–1449. Published online 2016 Sep 21. doi: 10.3892/ijmm.2016.2745

PMCID:: PMC5065292

Abstract Article PDF–898K

Select item 47951928.

A syndrome of congenital microcephaly, intellectual disability and dysmorphism with a homozygous mutation in FRMD4A

Dina Fine, Hagit Flusser, Barak Markus, Zamir Shorer, Libe Gradstein, Shareef Khateeb, Yshia Langer, Ginat Narkis, Ruth Birk, Aharon Galil, Ilan Shelef, Ohad S Birk

Eur J Hum Genet. 2015 Dec; 23(12): 1729–1734. Published online 2014 Nov 12. doi: 10.1038/ejhg.2014.241

PMCID:: PMC4795192

Abstract Article PDF–1.4M

Select item 46172119.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 458886810.

DNA methylation mediates the effect of maternal smoking during pregnancy on birthweight of the offspring

Leanne K Küpers, Xiaojing Xu, Soesma A Jankipersadsing, Ahmad Vaez, Sacha la Bastide-van Gemert, Salome Scholtens, Ilja M Nolte, Rebecca C Richmond, Caroline L Relton, Janine F Felix, Liesbeth Duijts, Joyce B van Meurs, Henning Tiemeier, Vincent W Jaddoe, Xiaoling Wang, Eva Corpeleijn, Harold Snieder

Int J Epidemiol. 2015 Aug; 44(4): 1224–1237. Published online 2015 Apr 10. doi: 10.1093/ije/dyv048

PMCID:: PMC4588868

Abstract Article PDF–410K

Select item 449890311.

Systematic Analysis of the Protein Interaction Network for the Human Transcription Machinery Reveals the Identity of the 7SK Capping Enzyme

Célia Jeronimo, Diane Forget, Annie Bouchard, Qintong Li, Gordon Chua, Christian Poitras, Cynthia Thérien, Dominique Bergeron, Sylvie Bourassa, Jack Greenblatt, Benoit Chabot, Guy G. Poirier, Timothy R. Hughes, Mathieu Blanchette, David H. Price, Benoit Coulombe

Mol Cell. Author manuscript; available in PMC 2015 Jul 10.

Published in final edited form as: Mol Cell. 2007 Jul 20; 27(2): 262–274. doi: 10.1016/j.molcel.2007.06.027

PMCID:: PMC4498903

Abstract Article PDF–1.5M

Select item 427556912.

Large-scale genome-wide association study of Asian population reveals genetic factors in FRMD4A and other loci influencing smoking initiation and nicotine dependence

Dankyu Yoon, Young-Jin Kim, Wen-Yan Cui, Andrew Van der Vaart, Yoon Shin Cho, Jong-Young Lee, Jennie Z. Ma, Thomas J. Payne, Ming D. Li, Taesung Park

Hum Genet. Author manuscript; available in PMC 2014 Dec 24.

Published in final edited form as: Hum Genet. 2012 Jun; 131(6): 1009–1021. Published online 2011 Oct 18. doi: 10.1007/s00439-011-1102-x

PMCID:: PMC4275569

Abstract Article PDF–1.1M

Select item 418192813.

Identification of DNA Methylation Changes in Newborns Related to Maternal Smoking during Pregnancy

Christina A. Markunas, Zongli Xu, Sophia Harlid, Paul A. Wade, Rolv T. Lie, Jack A. Taylor, Allen J. Wilcox

Environ Health Perspect. 2014 Oct; 122(10): 1147–1153. Published online 2014 Jun 6. doi: 10.1289/ehp.1307892

PMCID:: PMC4181928

Abstract Article PDF–447K

Select item 407090914.

Prenatal Tobacco Smoke Exposure Is Associated with Childhood DNA CpG Methylation

Carrie V. Breton, Kimberly D. Siegmund, Bonnie R. Joubert, Xinhui Wang, Weiliang Qui, Vincent Carey, Wenche Nystad, Siri E. Håberg, Carole Ober, Dan Nicolae, Kathleen C. Barnes, Fernando Martinez, Andy Liu, Robert Lemanske, Robert Strunk, Scott Weiss, Stephanie London, Frank Gilliland, Benjamin Raby, on behalf of the Asthma BRIDGE consortium

PLoS One. 2014; 9(6): e99716. Published online 2014 Jun 25. doi: 10.1371/journal.pone.0099716

Correction in:: PLoS One. 2014; 9(10): e112422.

PMCID:: PMC4070909

Abstract Article PDF–330K

Select item 404112315.

Genome-wide meta-analysis identifies new susceptibility loci for migraine

Verneri Anttila, Bendik S. Winsvold, Padhraig Gormley, Tobias Kurth, Francesco Bettella, George McMahon, Mikko Kallela, Rainer Malik, Boukje de Vries, Gisela Terwindt, Sarah E. Medland, Unda Todt, Wendy L. McArdle, Lydia Quaye, Markku Koiranen, M. Arfan Ikram, Terho Lehtimäki, Anine H. Stam, Lannie Ligthart, Juho Wedenoja, Ian Dunham, Benjamin M. Neale, Priit Palta, Eija Hamalainen, Markus Schürks, Lynda M Rose, Julie E. Buring, Paul M. Ridker, Stacy Steinberg, Hreinn Stefansson, Finnbogi Jakobsson, Debbie A. Lawlor, David M. Evans, Susan M. Ring, Markus Färkkilä, Ville Artto, Mari A Kaunisto, Tobias Freilinger, Jean Schoenen, Rune R. Frants, Nadine Pelzer, Claudia M. Weller, Ronald Zielman, Andrew C. Heath, Pamela A.F. Madden, Grant W. Montgomery, Nicholas G. Martin, Guntram Borck, Hartmut Göbel, Axel Heinze, Katja Heinze-Kuhn, Frances M.K. Williams, Anna-Liisa Hartikainen, Anneli Pouta, Joyce van den Ende, Andre G. Uitterlinden, Albert Hofman, Najaf Amin, Jouke-Jan Hottenga, Jacqueline M. Vink, Kauko Heikkilä, Michael Alexander, Bertram Muller-Myhsok, Stefan Schreiber, Thomas Meitinger, Heinz Erich Wichmann, Arpo Aromaa, Johan G. Eriksson, Bryan Traynor, Daniah Trabzuni, North American Brain Expression Consortium, UK Brain Expression Consortium, Elizabeth Rossin, Kasper Lage, Suzanne B.R. Jacobs, J. Raphael Gibbs, Ewan Birney, Jaakko Kaprio, Brenda W. Penninx, Dorret I. Boomsma, Cornelia van Duijn, Olli Raitakari, Marjo-Riitta Jarvelin, John-Anker Zwart, Lynn Cherkas, David P. Strachan, Christian Kubisch, Michel D. Ferrari, Arn M.J.M. van den Maagdenberg, Martin Dichgans, Maija Wessman, George Davey Smith, Kari Stefansson, Mark J. Daly, Dale R. Nyholt, Daniel Chasman, Aarno Palotie

Nat Genet. Author manuscript; available in PMC 2014 Jun 2.

Published in final edited form as: Nat Genet. 2013 Aug; 45(8): 912–917. Published online 2013 Jun 23. doi: 10.1038/ng.2676

PMCID:: PMC4041123

Article PDF–571K

Select item 385466916.

Genome Wide Association Study (GWAS) of Chagas Cardiomyopathy in Trypanosoma cruzi Seropositive Subjects

Xutao Deng, Ester C. Sabino, Edecio Cunha-Neto, Antonio L. Ribeiro, Barbara Ianni, Charles Mady, Michael P. Busch, Mark Seielstad, the REDSII Chagas study group from the NHLBI Retrovirus Epidemiology Donor Study-II (REDS-II), International Component

PLoS One. 2013; 8(11): e79629. Published online 2013 Nov 20. doi: 10.1371/journal.pone.0079629

PMCID:: PMC3854669

Abstract Article PDF–408K

Select item 360694317.

Genome-wide haplotype association study identifies the FRMD4A gene as a risk locus for Alzheimer's disease

J-C Lambert, B Grenier-Boley, D Harold, D Zelenika, V Chouraki, Y Kamatani, K Sleegers, M A Ikram, M Hiltunen, C Reitz, I Mateo, T Feulner, M Bullido, D Galimberti, L Concari, V Alvarez, R Sims, A Gerrish, J Chapman, C Deniz-Naranjo, V Solfrizzi, S Sorbi, B Arosio, G Spalletta, G Siciliano, J Epelbaum, D Hannequin, J-F Dartigues, C Tzourio, C Berr, E M C Schrijvers, R Rogers, G Tosto, F Pasquier, K Bettens, C Van Cauwenberghe, L Fratiglioni, C Graff, M Delepine, R Ferri, C A Reynolds, L Lannfelt, M Ingelsson, J A Prince, C Chillotti, A Pilotto, D Seripa, A Boland, M Mancuso, P Bossù, G Annoni, B Nacmias, P Bosco, F Panza, F Sanchez-Garcia, M Del Zompo, E Coto, M Owen, M O'Donovan, F Valdivieso, P Caffara, E Scarpini, O Combarros, L Buée, D Campion, H Soininen, M Breteler, M Riemenschneider, C Van Broeckhoven, A Alpérovitch, M Lathrop, D-A Trégouët, J Williams, P Amouyel, EADI consortium, GERAD consortium

Mol Psychiatry. 2013 Apr; 18(4): 461–470. Published online 2012 Mar 20. doi: 10.1038/mp.2012.14