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Select item 111094831.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 108856172.

Loss of mitochondrial pyruvate carrier 1 supports proline-dependent proliferation and collagen biosynthesis in ovarian cancer

M. Rufaik Farook, Zack Croxford, Steffan Morgan, Anthony D. Horlock, Amy K. Holt, April Rees, Benjamin J. Jenkins, Carmen Tse, Emma Stanton, D. Mark Davies, Catherine A. Thornton, Nicholas Jones, I. Martin Sheldon, Emma E. Vincent, James G. Cronin

Mol Metab. 2024 Mar; 81: 101900. Published online 2024 Feb 13. doi: 10.1016/j.molmet.2024.101900

PMCID:: PMC10885617

Abstract Article PDF–3.5M

Select item 99381893.

KIF15 is essential for USP10-mediated PGK1 deubiquitination during the glycolysis of pancreatic cancer

Gang Quan, Jian Xu, Jie Wang, Xinyuan Liu, Jichuan Xu, Jianxin Jiang

Cell Death Dis. 2023 Feb; 14(2): 137. Published online 2023 Feb 17. doi: 10.1038/s41419-023-05679-2

PMCID:: PMC9938189

Abstract Article PDF–8.4M

Select item 89680634.

Key features of inhibitor binding to the human mitochondrial pyruvate carrier hetero-dimer

Sotiria Tavoulari, Tom J.J. Schirris, Vasiliki Mavridou, Chancievan Thangaratnarajah, Martin S. King, Daniel T.D. Jones, Shujing Ding, Ian M. Fearnley, Edmund R.S. Kunji

Mol Metab. 2022 Jun; 60: 101469. Published online 2022 Mar 10. doi: 10.1016/j.molmet.2022.101469

PMCID:: PMC8968063

Abstract Article PDF–3.0M

Select item 89006675.

Structural Insights into the Human Mitochondrial Pyruvate Carrier Complexes

Liang Xu, Clyde F. Phelix, Liao Y. Chen

J Chem Inf Model. Author manuscript; available in PMC 2022 Nov 22.

Published in final edited form as: J Chem Inf Model. 2021 Nov 22; 61(11): 5614–5625. Published online 2021 Oct 19. doi: 10.1021/acs.jcim.1c00879

PMCID:: PMC8900667

Abstract Article PDF–2.2M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 75668817.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 74397888.

MPC1 Deficiency Promotes CRC Liver Metastasis via Facilitating Nuclear Translocation of β-Catenin

Guang-Ang Tian, Chun-Jie Xu, Kai-Xia Zhou, Zhi-Gang Zhang, Jian-Ren Gu, Xue-Li Zhang, Ya-Hui Wang

J Immunol Res. 2020; 2020: 8340329. Published online 2020 Aug 19. doi: 10.1155/2020/8340329

PMCID:: PMC7439788

Abstract Article PDF–3.0M

Select item 74078329.

The Multifaceted Pyruvate Metabolism: Role of the Mitochondrial Pyruvate Carrier

Joséphine Zangari, Francesco Petrelli, Benoît Maillot, Jean-Claude Martinou

Biomolecules. 2020 Jul; 10(7): 1068. Published online 2020 Jul 17. doi: 10.3390/biom10071068

PMCID:: PMC7407832

Abstract Article PDF–991K

Select item 736244410.

Mitochondrial pyruvate carrier: a potential target for diabetic nephropathy

Huanhuan Zhu, Huiting Wan, Lin Wu, Qing Li, Simeng Liu, Suyan Duan, Zhimin Huang, Chengning Zhang, Bo Zhang, Changying Xing, Yanggang Yuan

BMC Nephrol. 2020; 21: 274. Published online 2020 Jul 14. doi: 10.1186/s12882-020-01931-5

PMCID:: PMC7362444

Abstract Article PDF–11M

Select item 724699911.

Characteristic Analysis of Homo- and Heterodimeric Complexes of Human Mitochondrial Pyruvate Carrier Related to Metabolic Diseases

Jinyi Lee, Zeyu Jin, Donghan Lee, Ji-Hye Yun, Weontae Lee

Int J Mol Sci. 2020 May; 21(9): 3403. Published online 2020 May 11. doi: 10.3390/ijms21093403

PMCID:: PMC7246999

Abstract Article PDF–3.0M

Select item 716998312.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 662923813.

Two human patient mitochondrial pyruvate carrier mutations reveal distinct molecular mechanisms of dysfunction

Lalita Oonthonpan, Adam J. Rauckhorst, Lawrence R. Gray, Audrey C. Boutron, Eric B. Taylor

JCI Insight. 2019 Jul 11; 4(13): e126132. Published online 2019 Jul 11. doi: 10.1172/jci.insight.126132

PMCID:: PMC6629238

Abstract Article PDF–1.6M

Select item 644795414.

Mitochondrial pyruvate carrier 1 expression controls cancer epithelial‐mesenchymal transition and radioresistance

Yuji Takaoka, Masamitsu Konno, Jun Koseki, Hugh Colvin, Ayumu Asai, Keisuke Tamari, Taroh Satoh, Masaki Mori, Yuichiro Doki, Kazuhiko Ogawa, Hideshi Ishii

Cancer Sci. 2019 Apr; 110(4): 1331–1339. Published online 2019 Apr 4. doi: 10.1111/cas.13980

PMCID:: PMC6447954

Abstract Article PDF–1.0M

Select item 639759315.

Loss of MPC1 reprograms retinal metabolism to impair visual function

Allison Grenell, Yekai Wang, Michelle Yam, Aditi Swarup, Tanya L. Dilan, Allison Hauer, Jonathan D. Linton, Nancy J. Philp, Elizabeth Gregor, Siyan Zhu, Quan Shi, Joseph Murphy, Tongju Guan, Daniel Lohner, Saravanan Kolandaivelu, Visvanathan Ramamurthy, Andrew F. X. Goldberg, James B. Hurley, Jianhai Du

Proc Natl Acad Sci U S A. 2019 Feb 26; 116(9): 3530–3535. Published online 2019 Feb 11. doi: 10.1073/pnas.1812941116

PMCID:: PMC6397593

Abstract Article PDF–1.4M

Select item 637763916.

MPC1 deficiency accelerates lung adenocarcinoma progression through the STAT3 pathway

Hongbo Zou, Qian Chen, Anmei Zhang, Songtao Wang, Hong Wu, Ye Yuan, Shuang Wang, Jing Yu, Mao Luo, Xianmei Wen, Wei Cui, Wenjuan Fu, Ruilian Yu, Lin Chen, Ming Zhang, Haitao Lan, Xia Zhang, Qichao Xie, Guoxiang Jin, Chuan Xu

Cell Death Dis. 2019 Mar; 10(3): 148. Published online 2019 Feb 15. doi: 10.1038/s41419-019-1324-8

PMCID:: PMC6377639

Abstract Article PDF–4.7M

Select item 621382417.

C-Terminal Binding Protein 1 Modulates Cellular Redox via Feedback Regulation of MPC1 and MPC2 in Melanoma Cells

Yu Deng, Hong Li, Xinyi Yin, Hongbin Liu, Jing Liu, Dongjie Guo, Zheng Shi

Med Sci Monit. 2018; 24: 7614–7624. Published online 2018 Oct 25. doi: 10.12659/MSM.912735

PMCID:: PMC6213824

Abstract Article PDF–1.1M

Select item 591993218.

PGC1α promotes cholangiocarcinoma metastasis by upregulating PDHA1 and MPC1 expression to reverse the Warburg effect

Dan Li, Chaoqun Wang, Panfei Ma, Qingan Yu, Mingqi Gu, Liqian Dong, Wenjing Jiang, Shangha Pan, Changming Xie, Jihua Han, Yaliang Lan, Jing Sun, Ping Sheng, Kunpeng Liu, Yaohua Wu, Lianxin Liu, Yong Ma, Hongchi Jiang

Cell Death Dis. 2018 May; 9(5): 466. Published online 2018 Apr 27. doi: 10.1038/s41419-018-0494-0

PMCID:: PMC5919932

Abstract Article PDF–5.5M

Select item 582390819.

Human mitochondrial pyruvate carrier 2 as an autonomous membrane transporter

Raghavendra Sashi Krishna Nagampalli, José Edwin Neciosup Quesñay, Douglas Adamoski, Zeyaul Islam, James Birch, Heitor Gobbi Sebinelli, Richard Marcel Bruno Moreira Girard, Carolline Fernanda Rodrigues Ascenção, Angela Maria Fala, Bianca Alves Pauletti, Sílvio Roberto Consonni, Juliana Ferreira de Oliveira, Amanda Cristina Teixeira Silva, Kleber Gomes Franchini, Adriana Franco Paes Leme, Ariel Mariano Silber, Pietro Ciancaglini, Isabel Moraes, Sandra Martha Gomes Dias, Andre Luis Berteli Ambrosio

Sci Rep. 2018; 8: 3510. Published online 2018 Feb 22. doi: 10.1038/s41598-018-21740-z

PMCID:: PMC5823908

Abstract Article PDF–3.6M

Select item 538853420.

A metabolic switch controls intestinal differentiation downstream of Adenomatous polyposis coli (APC)

Imelda T Sandoval, Richard Glenn C Delacruz, Braden N Miller, Shauna Hill, Kristofor A Olson, Ana E Gabriel, Kevin Boyd, Christeena Satterfield, Holly Van Remmen, Jared Rutter, David A Jones

eLife. 2017; 6: e22706. Published online 2017 Apr 11. doi: 10.7554/eLife.22706

PMCID:: PMC5388534

Abstract Article PDF–958K

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