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Select item 112591781.

Beta2 adrenergic receptor–mediated abnormal myelopoiesis drives neuroinflammation in aged patients with traumatic brain injury

Rui Jiang, Zhichao Lu, Chenxing Wang, Jun Xiao, Qianqian Liu, Xide Xu, Jinlong Shi, Jianhong Shen, Xingjia Zhu, Peipei Gong, Qian-Xing Zhuang, Kaibin Shi, Wei Shi

Sci Adv. 2024 Jul 19; 10(29): eadp5239. Published online 2024 Jul 19. doi: 10.1126/sciadv.adp5239

PMCID:: PMC11259178

Abstract Article PDF–8.6M

Select item 105703092.

ADRA2A and IRX1 are putative risk genes for Raynaud’s phenomenon

Sylvia Hartmann, Summaira Yasmeen, Benjamin M. Jacobs, Spiros Denaxas, Munir Pirmohamed, Eric R. Gamazon, Mark J. Caulfield, Genes & Health Research Team, Harry Hemingway, Maik Pietzner, Claudia Langenberg

Nat Commun. 2023; 14: 6156. Published online 2023 Oct 12. doi: 10.1038/s41467-023-41876-5

PMCID:: PMC10570309

Abstract Article PDF–1.3M

Select item 100805303.

Scientific rationale for the use of α2A-adrenoceptor agonists in treating neuroinflammatory cognitive disorders

Amy F. T. Arnsten, Yumiko Ishizawa, Zhongcong Xie

Mol Psychiatry. 2023; 28(11): 4540–4552. Published online 2023 Apr 7. doi: 10.1038/s41380-023-02057-4

PMCID:: PMC10080530

Abstract Article PDF–2.4M

Select item 98858604.

Heteromerization between α_2A adrenoceptors and different polymorphic variants of the dopamine D₄ receptor determines pharmacological and functional differences. Implications for impulsive-control disorders

Verònica Casadó-Anguera, Estefanía Moreno, Marta Sánchez-Soto, Ning Sheng Cai, Jordi Bonaventura, Patricia Homar-Ruano, Marcelo Rubinstein, Antoni Cortés, Enric I. Canela, Sergi Ferré, Vicent Casadó

Pharmacol Res. Author manuscript; available in PMC 2023 Jan 30.

Published in final edited form as: Pharmacol Res. 2021 Aug; 170: 105745. Published online 2021 Jun 26. doi: 10.1016/j.phrs.2021.105745

PMCID:: PMC9885860

Abstract Article PDF–1.2M

Select item 93254915.

A pilot study of ADRA2A genotype association with doses of dexmedetomidine for sedation in pediatric patients

Katherine A. Gallaway, Todd C. Skaar, Ashwin Biju, James Slaven, Emma M. Tillman

Pharmacotherapy. 2022 Jun; 42(6): 453–459. Published online 2022 Apr 20. doi: 10.1002/phar.2684

PMCID:: PMC9325491

Abstract Article PDF–492K

Select item 87012406.

The Predictive Role of ADRA2A rs1800544 and HTR3B rs3758987 Polymorphisms in Motion Sickness Susceptibility

Xinchen Zhang, Yeqing Sun

Int J Environ Res Public Health. 2021 Dec; 18(24): 13163. Published online 2021 Dec 14. doi: 10.3390/ijerph182413163

PMCID:: PMC8701240

Abstract Article PDF–1.2M

Select item 73823707.

Watching helical membrane proteins fold reveals a common N- to C-terminal folding pathway

Hyun-Kyu Choi, Duyoung Min, Hyunook Kang, Min Ju Shon, Sang-Hyun Rah, Hak Chan Kim, Hawoong Jeong, Hee-Jung Choi, James U. Bowie, Tae-Young Yoon

Science. Author manuscript; available in PMC 2020 Nov 29.

Published in final edited form as: Science. 2019 Nov 29; 366(6469): 1150–1156. doi: 10.1126/science.aaw8208

PMCID:: PMC7382370

Abstract Article PDF–1.9M

Select item 69088098.

Genetic Influences on Delayed Reward Discounting: A Genome-wide Prioritized Subset Approach

James MacKillop, Joshua C. Gray, Jessica Weafer, Sandra Sanchez-Roige, Abraham A. Palmer, Harriet de Wit

Exp Clin Psychopharmacol. Author manuscript; available in PMC 2020 Feb 1.

Published in final edited form as: Exp Clin Psychopharmacol. 2019 Feb; 27(1): 29–37. Published online 2018 Sep 27. doi: 10.1037/pha0000227

PMCID:: PMC6908809

Abstract Article PDF–686K

Select item 67605499.

The relationship between MMP9 and ADRA2A gene polymorphisms and mothers–newborns’ nutritional status: an exploratory path model (STROBE compliant article)

Cristina Oana Mărginean, Claudiu Mărginean, Claudia Bănescu, Lorena Elena Meliţ, Florin Tripon, Mihaela Iancu

Pediatr Res. 2019; 85(6): 822–829. Published online 2019 Feb 21. doi: 10.1038/s41390-019-0347-2

PMCID:: PMC6760549

Abstract Article PDF–611K

Select item 671052910.

Prognostic significance of α‐ and β2‐adrenoceptor gene expression in breast cancer patients

Ezequiel Mariano Rivero, Leandro Marcelo Martinez, Carlos David Bruque, Lucia Gargiulo, Ariana Bruzzone, Isabel Alicia Lüthy

Br J Clin Pharmacol. 2019 Sep; 85(9): 2143–2154. Published online 2019 Jul 31. doi: 10.1111/bcp.14030

PMCID:: PMC6710529

Abstract Article PDF–2.2M

Select item 658699711.

Relationship between genetic variation in the α_2A-adrenergic receptor and the cardiovascular effects of dexmedetomidine in the Chinese Han population

Shao-jun Zhu, Kui-rong Wang, Xiong-xin Zhang, Sheng-mei Zhu

J Zhejiang Univ Sci B. 2019 Jul; 20(7): 598–604. doi: 10.1631/jzus.B1800647

PMCID:: PMC6586997

Abstract Article PDF–990K

Select item 628455012.

Human Placenta Expresses α₂-Adrenergic Receptors and May Be Implicated in Pathogenesis of Preeclampsia and Fetal Growth Restriction

Hanaa K.B. Motawea, Maqsood A. Chotani, Mehboob Ali, William Ackerman, Guomao Zhao, Amany A.E. Ahmed, Catalin S. Buhimschi, Irina A. Buhimschi

Am J Pathol. 2018 Dec; 188(12): 2774–2785. doi: 10.1016/j.ajpath.2018.08.011

PMCID:: PMC6284550

Abstract Article

Select item 615500013.

Discovering human diabetes-risk gene function with genetics and physiological assays

Heshan Peiris, Sangbin Park, Shreya Louis, Xueying Gu, Jonathan Y. Lam, Olof Asplund, Gregory C. Ippolito, Rita Bottino, Leif Groop, Haley Tucker, Seung K. Kim

Nat Commun. 2018; 9: 3855. Published online 2018 Sep 21. doi: 10.1038/s41467-018-06249-3

PMCID:: PMC6155000

Abstract Article PDF–2.2M

Select item 606701814.

Association of Adrenergic Receptor α2A (α2A-AR) Gene rs1800544 Polymorphism with Bone Mineral Density and Bone Turnover Markers in an Elderly Chinese Population

Qi-Fei Wang, Zhe Sun, Fan-Rong Zheng, Guang-Wu Zhang, Zheng Liu

Med Sci Monit. 2018; 24: 5102–5109. Published online 2018 Jul 23. doi: 10.12659/MSM.908376

PMCID:: PMC6067018

Abstract Article PDF–250K

Select item 569401815.

Variation in the α_2A-adrenergic receptor gene and risk of gestational diabetes

Vivian K Kawai, Rebecca T Levinson, Abiodun Adefurin, Daniel Kurnik, Sarah P Collier, Douglas Conway, Charles Michael Stein

Pharmacogenomics. 2017 Oct; 18(15): 1381–1386. Published online 2017 Oct 4. doi: 10.2217/pgs-2017-0079

PMCID:: PMC5694018

Abstract Article PDF–461K

Select item 564721816.

Adrenergic Receptor Genotypes Influence Post-operative Outcomes in Infants in the Single Ventricle Reconstruction Trial

Ronand Ramroop, George Manase, Danny Lu, Dorin Manase, Shan Chen, Richard Kim, Teresa Lee, William T Mahle, Kimberly McHugh, Mike Mitchell, Martin Tristani-Firouzi, Stephanie B Wechsler, Nicole S Wilder, Victor Zak, Myriam Lafreniere-Roula, Jane W Newburger, J William Gaynor, Mark W Russell, Seema Mital

J Thorac Cardiovasc Surg. Author manuscript; available in PMC 2018 Nov 1.

Published in final edited form as: J Thorac Cardiovasc Surg. 2017 Nov; 154(5): 1703–1710.e3. Published online 2017 Jun 24. doi: 10.1016/j.jtcvs.2017.06.041

PMCID:: PMC5647218

Abstract Article PDF–1.1M

Select item 546549217.

The G protein G_i1 exhibits basal coupling but not preassembly with G protein-coupled receptors

Alexey Bondar, Josef Lazar

J Biol Chem. 2017 Jun 9; 292(23): 9690–9698. Published online 2017 Apr 24. doi: 10.1074/jbc.M116.768127

PMCID:: PMC5465492

Abstract Article PDF–1.1M

Select item 523973918.

Genetic variant rs3750625 in the 3′UTR of ADRA2A affects stress-dependent acute pain severity after trauma and alters a microRNA-34a regulatory site

Sarah D. Linnstaedt, Margaret G. Walker, Kyle D. Riker, Jennifer E. Nyland, JunMei Hu, Catherine Rossi, Robert A. Swor, Jeffrey S. Jones, Luda Diatchenko, Andrey V. Bortsov, David A. Peak, Samuel A. McLean

Pain. Author manuscript; available in PMC 2018 Feb 1.

Published in final edited form as: Pain. 2017 Feb; 158(2): 230–239. doi: 10.1097/j.pain.0000000000000742