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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 109332672.

Interaction network of human early embryonic transcription factors

Lisa Gawriyski, Zenglai Tan, Xiaonan Liu, Iftekhar Chowdhury, Dicle Malaymar Pinar, Qin Zhang, Jere Weltner, Eeva-Mari Jouhilahti, Gong-Hong Wei, Juha Kere, Markku Varjosalo

EMBO Rep. 2024 Mar; 25(3): 1589–1622. Published online 2024 Jan 31. doi: 10.1038/s44319-024-00074-0

PMCID:: PMC10933267

Abstract Article PDF–2.9M

Select item 108975213.

UCHL1 is a potential molecular indicator and therapeutic target for neuroendocrine carcinomas

Shiqin Liu, Timothy Chai, Fernando Garcia-Marques, Qingqing Yin, En-Chi Hsu, Michelle Shen, Angus Martin Shaw Toland, Abel Bermudez, Alifiani B. Hartono, Christopher F. Massey, Chung S. Lee, Liwei Zheng, Maya Baron, Caden J. Denning, Merve Aslan, Holly M. Nguyen, Rosalie Nolley, Amina Zoubeidi, Millie Das, Christian A. Kunder, Brooke E. Howitt, H. Tom Soh, Irving L. Weissman, Michael A. Liss, Arnold I. Chin, James D. Brooks, Eva Corey, Sharon J. Pitteri, Jiaoti Huang, Tanya Stoyanova

Cell Rep Med. 2024 Feb 20; 5(2): 101381. Published online 2024 Jan 19. doi: 10.1016/j.xcrm.2023.101381

PMCID:: PMC10897521

Abstract Article PDF–7.7M

Select item 108164764.

Ubiquitin Carboxyl-Terminal Hydrolase L1 and Its Role in Parkinson’s Disease

Olga Buneeva, Alexei Medvedev

Int J Mol Sci. 2024 Jan; 25(2): 1303. Published online 2024 Jan 21. doi: 10.3390/ijms25021303

PMCID:: PMC10816476

Abstract Article PDF–664K

Select item 105997325.

UCHL1-PKM2 axis dysregulation is associated with promoted proliferation and invasiveness of urothelial bladder cancer cells

Yuhui Zheng, Dongliang Shi, Linlin Chen, Yinghong Yang, Meihong Yao

Aging (Albany NY) 2023 Oct 15; 15(19): 10593–10606. Published online 2023 Oct 9. doi: 10.18632/aging.205097

PMCID:: PMC10599732

Abstract Article PDF–1.6M

Select item 103825056.

UCHL1 facilitates protein aggregates clearance to enhance neural stem cell activation in spinal cord injury

Lu Ding, Weiwei Chu, Yu Xia, Ming Shi, Tian Li, Feng-Quan Zhou, David Y. B. Deng

Cell Death Dis. 2023 Jul; 14(7): 479. Published online 2023 Jul 28. doi: 10.1038/s41419-023-06003-8

PMCID:: PMC10382505

Abstract Article PDF–18M

Select item 102374227.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101741698.

Inhibiting the Deubiquitinase UCHL1 Reduces SARS-CoV-2 Viral Uptake by ACE2

Joseph S. Bednash, Finny Johns, Daniela Farkas, Ajit Elhance, Jessica Adair, Kirstin Cress, Jacob S. Yount, Adam D. Kenney, James D. Londino, Rama K. Mallampalli

Am J Respir Cell Mol Biol. 2023 May 1; 68(5): 566–576. Published online 2023 Feb 2. doi: 10.1165/rcmb.2022-0331OC

PMCID:: PMC10174169

Abstract Article PDF–1.5M

Select item 101488439.

mTORC2 interactome and localization determine aggressiveness of high-grade glioma cells through association with gelsolin

Naphat Chantaravisoot, Piriya Wongkongkathep, Nuttiya Kalpongnukul, Narawit Pacharakullanon, Pornchai Kaewsapsak, Chaiyaboot Ariyachet, Joseph A. Loo, Fuyuhiko Tamanoi, Trairak Pisitkun

Sci Rep. 2023; 13: 7037. Published online 2023 Apr 29. doi: 10.1038/s41598-023-33872-y

PMCID:: PMC10148843

Abstract Article PDF–11M

Select item 1010202210.

Non-functional ubiquitin C-terminal hydrolase L1 drives podocyte injury through impairing proteasomes in autoimmune glomerulonephritis

Julia Reichelt, Wiebke Sachs, Sarah Frömbling, Julia Fehlert, Maja Studencka-Turski, Anna Betz, Desiree Loreth, Lukas Blume, Susanne Witt, Sandra Pohl, Johannes Brand, Maire Czesla, Jan Knop, Bogdan I. Florea, Stephanie Zielinski, Marlies Sachs, Elion Hoxha, Irm Hermans-Borgmeyer, Gunther Zahner, Thorsten Wiech, Elke Krüger, Catherine Meyer-Schwesinger

Nat Commun. 2023; 14: 2114. Published online 2023 Apr 13. doi: 10.1038/s41467-023-37836-8

Correction in:: Nat Commun. 2023; 14: 2453.

PMCID:: PMC10102022

Abstract Article PDF–9.7M

Select item 999226711.

Role of UCHL1 in the pathogenesis of neurodegenerative diseases and brain injury

Zhiping Mi, Steven H Graham

Ageing Res Rev. Author manuscript; available in PMC 2024 Apr 1.

Published in final edited form as: Ageing Res Rev. 2023 Apr; 86: 101856. Published online 2023 Jan 19. doi: 10.1016/j.arr.2023.101856

PMCID:: PMC9992267

Abstract Article PDF–629K

Select item 998490112.

P300 Interacted With N-Myc and Regulated Its Protein Stability via Altering Its Post-Translational Modifications in Neuroblastoma

Cheng Cheng, Tian He, Kai Chen, Yuanxia Cai, Yaoyao Gu, Lijia Pan, Peiwen Duan, Yeming Wu, Zhixiang Wu

Mol Cell Proteomics. 2023 Mar; 22(3): 100504. Published online 2023 Jan 26. doi: 10.1016/j.mcpro.2023.100504

PMCID:: PMC9984901

Abstract Article PDF–4.3M

Select item 998064813.

Targeted epigenetic silencing of UCHL1 expression suppresses collagen-1 production in human lung epithelial cells

Dan-Dan Wu, Andy T. Y. Lau, Yan-Ming Xu, Marjan Reinders-Luinge, Mihaly Koncz, Antal Kiss, Wim Timens, Marianne G. Rots, Machteld N. Hylkema

Epigenetics. 2023; 18(1): 2175522. Published online 2023 Feb 22. doi: 10.1080/15592294.2023.2175522

PMCID:: PMC9980648

Abstract Article PDF–4.4M

Select item 995352314.

Pivotal Role of Ubiquitin Carboxyl-Terminal Hydrolase L1 (UCHL1) in Uterine Leiomyoma

Tomoo Suzuki, Yidan Dai, Masanori Ono, Junya Kojima, Toru Sasaki, Hiroshi Fujiwara, Naoaki Kuji, Hirotaka Nishi

Biomolecules. 2023 Feb; 13(2): 193. Published online 2023 Jan 18. doi: 10.3390/biom13020193

PMCID:: PMC9953523

Abstract Article PDF–2.1M

Select item 977255815.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 959976916.

MMP-1, UCH-L1, and 20S Proteasome as Potential Biomarkers Supporting the Diagnosis of Brain Glioma

Lukasz Oldak, Sylwia Chludzinska-Kasperuk, Patrycja Milewska, Kamil Grubczak, Joanna Reszec, Ewa Gorodkiewicz

Biomolecules. 2022 Oct; 12(10): 1477. Published online 2022 Oct 13. doi: 10.3390/biom12101477

PMCID:: PMC9599769

Abstract Article PDF–3.3M

Select item 955026617.

Spike S1 domain interactome in non-pulmonary systems: A role beyond the receptor recognition

Ilaria Iacobucci, Vittoria Monaco, Luisa Canè, Francesca Bibbò, Valentina Cioffi, Flora Cozzolino, Alfredo Guarino, Massimo Zollo, Maria Monti

Front Mol Biosci. 2022; 9: 975570. Published online 2022 Sep 26. doi: 10.3389/fmolb.2022.975570

PMCID:: PMC9550266

Abstract Article PDF–2.5M

Select item 954903018.

Structural basis for specific inhibition of the deubiquitinase UCHL1

Christian Grethe, Mirko Schmidt, Gian-Marvin Kipka, Rachel O’Dea, Kai Gallant, Petra Janning, Malte Gersch

Nat Commun. 2022; 13: 5950. Published online 2022 Oct 10. doi: 10.1038/s41467-022-33559-4

PMCID:: PMC9549030

Abstract Article PDF–4.9M

Select item 948160219.

Electrostatic and steric effects underlie acetylation-induced changes in ubiquitin structure and function

Simon Maria Kienle, Tobias Schneider, Katrin Stuber, Christoph Globisch, Jasmin Jansen, Florian Stengel, Christine Peter, Andreas Marx, Michael Kovermann, Martin Scheffner

Nat Commun. 2022; 13: 5435. Published online 2022 Sep 16. doi: 10.1038/s41467-022-33087-1

PMCID:: PMC9481602

Abstract Article PDF–3.7M

Select item 947374520.

Identification and validation of Selective Deubiquitinase Inhibitors

Anthony C. Varca, Dominick Casalena, Wai Cheung Chan, Bin Hu, Robert S. Magin, Rebekka M. Roberts, Xiaoxi Liu, He Zhu, Hyuk-Soo Seo, Sirano Dhe-Paganon, Jarrod A. Marto, Douglas Auld, Sara J. Buhrlage

Cell Chem Biol. Author manuscript; available in PMC 2022 Dec 16.

Published in final edited form as: Cell Chem Biol. 2021 Dec 16; 28(12): 1758–1771.e13. Published online 2021 Jun 14. doi: 10.1016/j.chembiol.2021.05.012

PMCID:: PMC9473745

Abstract Article PDF–2.3M

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