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Select item 110991271.

FOXF1 promotes tumor vessel normalization and prevents lung cancer progression through FZD4

Fenghua Bian, Chinmayee Goda, Guolun Wang, Ying-Wei Lan, Zicheng Deng, Wen Gao, Anusha Acharya, Abid A Reza, Jose Gomez-Arroyo, Nawal Merjaneh, Xiaomeng Ren, Jermaine Goveia, Peter Carmeliet, Vladimir V Kalinichenko, Tanya V Kalin

EMBO Mol Med. 2024 May; 16(5): 1063–1090. Published online 2024 Apr 8. doi: 10.1038/s44321-024-00064-8

PMCID:: PMC11099127

Abstract Article PDF–18M

Select item 109969362.

Identification of Novel FZD4 Mutations in Familial Exudative Vitreoretinopathy and Investigating the Pathogenic Mechanisms of FZD4 Mutations

Erkuan Dai, Min Liu, Shujin Li, Xiang Zhang, Shiyuan Wang, Rulian Zhao, Yunqi He, Li Peng, Liting Lv, Haodong Xiao, Mu Yang, Zhenglin Yang, Peiquan Zhao

Invest Ophthalmol Vis Sci. 2024 Apr; 65(4): 1. Published online 2024 Apr 1. doi: 10.1167/iovs.65.4.1

PMCID:: PMC10996936

Abstract Article PDF–12M

Select item 109811643.

Investigating the Impact of Dimer Interface Mutations on Norrin's Secretion and Norrin/β-Catenin Pathway Activation

Min Liu, Erkuan Dai, Mu Yang, Shujin Li, Lin Fan, Yining Liu, Haodong Xiao, Peiquan Zhao, Zhenglin Yang

Invest Ophthalmol Vis Sci. 2024 Mar; 65(3): 31. Published online 2024 Mar 22. doi: 10.1167/iovs.65.3.31

PMCID:: PMC10981164

Abstract Article PDF–6.2M

Select item 107814594.

A regulatory circuit of lncRNA NLGN1-AS1 and Wnt signalling controls clear cell renal cell carcinoma phenotypes through FZD4-modulated pathways

Haifeng Gao, Wei Chen, Gaojian Pan, Hui Liu, Jinke Qian, Weijun Tang, Wei Wang, Shilei Qian

Aging (Albany NY) 2023 Dec 31; 15(24): 15624–15639. Published online 2022 Sep 27. doi: 10.18632/aging.204263

PMCID:: PMC10781459

Abstract Article PDF–1.5M

Select item 101153615.

Whole exome sequencing revealed novel pathogenic variants in Vietnamese patients with FEVR

Duong Thu Trang, Nguyen Minh Phu, Do Manh Hung, Vu Phuong Nhung, Nguyen Ngan Ha, Ma Thi Huyen Thuong, Tran Thi Bich Ngoc, Nguyen Xuan Hiep, Nguyen Dang Ton, Nong Van Hai, Nguyen Hai Ha

Mol Vis. 2022; 28: 480–491. Published online 2022 Dec 21.

PMCID:: PMC10115361

Abstract Article PDF–4.4M

Select item 89941676.

FZD4 in a Large Chinese Population With Familial Exudative Vitreoretinopathy: Molecular Characteristics and Clinical Manifestations

Jinglin Lu, Li Huang, Limei Sun, Songshan Li, Zhaotian Zhang, Zhaoxin Jiang, Jiaqing Li, Xiaoyan Ding

Invest Ophthalmol Vis Sci. 2022 Apr; 63(4): 7. Published online 2022 Apr 8. doi: 10.1167/iovs.63.4.7

PMCID:: PMC8994167

Abstract Article PDF–4.9M

Select item 87538947.

Ocular phenotype and genetical analysis in patients with retinopathy of prematurity

Tianchang Tao, Xianfen Meng, Ningda Xu, Jiarui Li, Yong Cheng, Yi Chen, Lvzhen Huang

BMC Ophthalmol. 2022; 22: 22. Published online 2022 Jan 12. doi: 10.1186/s12886-022-02252-x

PMCID:: PMC8753894

Abstract Article PDF–1023K

Select item 86480648.

Ocular Features and Mutation Spectrum of Patients With Familial Exudative Vitreoretinopathy

Tianchang Tao, Ningda Xu, Jiarui Li, Hongyan Li, Jinfeng Qu, Hong Yin, Jianhong Liang, Mingwei Zhao, Xiaoxin Li, Lvzhen Huang

Invest Ophthalmol Vis Sci. 2021 Dec; 62(15): 4. Published online 2021 Dec 3. doi: 10.1167/iovs.62.15.4

PMCID:: PMC8648064

Abstract Article PDF–3.2M

Select item 83066499.

Whole-Gene Deletions of FZD4 Cause Familial Exudative Vitreoretinopathy

Li Huang, Jinglin Lu, Linyan Zhang, Zhaotian Zhang, Limei Sun, Songshan Li, Ting Zhang, Limei Chen, Liming Cao, Xiaoyan Ding

Genes (Basel) 2021 Jul; 12(7): 980. Published online 2021 Jun 27. doi: 10.3390/genes12070980

PMCID:: PMC8306649

Abstract Article PDF–3.8M

Select item 816503010.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 738297811.

Frizzled-4 is required for normal bone acquisition despite compensation by Frizzled-8

Priyanka Kushwaha, Soohyun Kim, Gabrielle E. Foxa, Megan N. Michalski, Bart O. Williams, Ryan E. Tomlinson, Ryan C. Riddle

J Cell Physiol. Author manuscript; available in PMC 2021 Oct 1.

Published in final edited form as: J Cell Physiol. 2020 Oct; 235(10): 6673–6683. Published online 2020 Jan 27. doi: 10.1002/jcp.29563

PMCID:: PMC7382978

Abstract Article PDF–1.0M

Select item 720172112.

Role of NDP- and FZD4-Related Novel Mutations Identified in Patients with FEVR in Norrin/β-Catenin Signaling Pathway

Shuai Han, Junhui Sun, Liwei Yang, Ming Qi

Biomed Res Int. 2020; 2020: 7681926. Published online 2020 Apr 27. doi: 10.1155/2020/7681926

PMCID:: PMC7201721

Abstract Article PDF–2.4M

Select item 640882113.

Molecular evolutionary and structural analysis of familial exudative vitreoretinopathy associated FZD4 gene

Suman Seemab, Nashaiman Pervaiz, Rabail Zehra, Saneela Anwar, Yiming Bao, Amir Ali Abbasi

BMC Evol Biol. 2019; 19: 72. Published online 2019 Mar 8. doi: 10.1186/s12862-019-1400-9

PMCID:: PMC6408821

Abstract Article PDF–3.5M

Select item 637737614.

Variable reduction in Norrin signaling activity caused by novel mutations in FZD4 identified in patients with familial exudative vitreoretinopathy

Tian Tian, Xiang Zhang, Qi Zhang, Peiquan Zhao

Mol Vis. 2019; 25: 60–69. Published online 2019 Feb 7.

PMCID:: PMC6377376

Abstract Article PDF–3.3M

Select item 563670315.

Mapping of Wnt-Frizzled interactions by multiplex CRISPR targeting of receptor gene families

Oksana Voloshanenko, Philipp Gmach, Jan Winter, Dominique Kranz, Michael Boutros

FASEB J. 2017 Nov; 31(11): 4832–4844. Published online 2017 Jul 21. doi: 10.1096/fj.201700144R

PMCID:: PMC5636703

Abstract Article

Select item 556722816.

A miR-SNP biomarker linked to an increased lung cancer survival by miRNA-mediated down-regulation of FZD4 expression and Wnt signaling

Jing Lin, Roza Zandi, Ruping Shao, Jian Gu, Yuanqin Ye, Jing Wang, Yang Zhao, Alexander Pertsemlidis, Ignacio I. Wistuba, Xifeng Wu, Jack A. Roth, Lin Ji

Sci Rep. 2017; 7: 9029. Published online 2017 Aug 22. doi: 10.1038/s41598-017-09604-4

PMCID:: PMC5567228

Abstract Article PDF–2.2M

Select item 553358117.

TSPAN12 is a Norrin Co-Receptor that Amplifies Frizzled4 Ligand Selectivity and Signaling

Maria B. Lai, Chi Zhang, Jianli Shi, Verity Johnson, Lavan Khandan, John McVey, Michael W. Klymkowsky, Zhe Chen, Harald J. Junge

Cell Rep. Author manuscript; available in PMC 2017 Jul 28.

Published in final edited form as: Cell Rep. 2017 Jun 27; 19(13): 2809–2822. doi: 10.1016/j.celrep.2017.06.004

PMCID:: PMC5533581

Abstract Article PDF–3.1M

Select item 545875818.

Wnt5a promotes Frizzled-4 signalosome assembly by stabilizing cysteine-rich domain dimerization

Zachary J. DeBruine, Jiyuan Ke, Kaleeckal G. Harikumar, Xin Gu, Peter Borowsky, Bart O. Williams, Wenqing Xu, Laurence J. Miller, H. Eric Xu, Karsten Melcher

Genes Dev. 2017 May 1; 31(9): 916–926. doi: 10.1101/gad.298331.117

PMCID:: PMC5458758

Abstract Article PDF–447K

Select item 503469119.

WNT Stimulation Dissociates a Frizzled 4 Inactive-State Complex with Gα_12/13

Elisa Arthofer, Belma Hot, Julian Petersen, Katerina Strakova, Stefan Jäger, Manuel Grundmann, Evi Kostenis, J. Silvio Gutkind, Gunnar Schulte

Mol Pharmacol. 2016 Oct; 90(4): 447–459. Published online 2016 Oct. doi: 10.1124/mol.116.104919

PMCID:: PMC5034691

Abstract Article PDF–3.1M

Select item 496860920.

Novel mutations in FZD4 and phenotype–genotype correlation in Chinese patients with familial exudative vitreoretinopathy

Miao Tang, Xiaoyan Ding, Jiaqing Li, Andina Hu, Miner Yuan, Yu Yang, Zongyi Zhan, Zijing Li, Lin Lu

Mol Vis. 2016; 22: 917–932. Published online 2016 Jul 30.

PMCID:: PMC4968609

Abstract Article PDF–2.9M

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