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Select item 110502201.

G-Protein Signaling Modulator 2 as a Potential Biomarker in Colorectal Cancer: Integrative Analysis Using Genetic Profiling and Pan-Cancer Studies

Doaa Jawad Kadhim, Hanieh Azari, Saeideh Khorshid Sokhangouy, Seyed Mahdi Hassanian, Hawraa Ibrahim Alshekarchi, Ladan Goshayeshi, Lena Goshayeshi, Mohammad Reza Abbaszadegan, Fatemeh Khojasteh-Leylakoohi, Majid Khazaei, Ibrahim Saeed Gataa, Godefridus J. Peters, Gordon A. Ferns, Jyotsna Batra, Alfred King-Yin Lam, Elisa Giovannetti, Amir Avan

Genes (Basel) 2024 Apr; 15(4): 474. Published online 2024 Apr 9. doi: 10.3390/genes15040474

PMCID:: PMC11050220

Abstract Article PDF–4.4M

Select item 93643942.

Truncated isoforms of GPSM2 containing the GoLoco motif region promote CD4⁺ T-cell migration in SLE

Ruth L Esser, Carolin Brück, Jan Thiele, Viktoria Golumba-Nagy, Anja Meyer, Eva Steinbach-Knödgen, Shuaifeng Yan, Carola tho Pesch, David Stahl, Joanna Schiller, David M Kofler

Lupus Sci Med. 2022; 9(1): e000742. Published online 2022 Aug 8. doi: 10.1136/lupus-2022-000742

PMCID:: PMC9364394

Abstract Article PDF–776K

Select item 93485763.

Chr21 protein–protein interactions: enrichment in proteins involved in intellectual disability, autism, and late-onset Alzheimer’s disease

Julia Viard, Yann Loe-Mie, Rachel Daudin, Malik Khelfaoui, Christine Plancon, Anne Boland, Francisco Tejedor, Richard L Huganir, Eunjoon Kim, Makoto Kinoshita, Guofa Liu, Volker Haucke, Thomas Moncion, Eugene Yu, Valérie Hindie, Henri Bléhaut, Clotilde Mircher, Yann Herault, Jean-François Deleuze, Jean-Christophe Rain, Michel Simonneau, Aude-Marie Lepagnol-Bestel

Life Sci Alliance. 2022 Dec; 5(12): e202101205. Published online 2022 Aug 1. doi: 10.26508/lsa.202101205

PMCID:: PMC9348576

Abstract Article PDF–3.0M

Select item 88970224.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 83529645.

Integrative oncogene-dependency mapping identifies RIT1 vulnerabilities and synergies in lung cancer

Athea Vichas, Amanda K. Riley, Naomi T. Nkinsi, Shriya Kamlapurkar, Phoebe C. R. Parrish, April Lo, Fujiko Duke, Jennifer Chen, Iris Fung, Jacqueline Watson, Matthew Rees, Austin M. Gabel, James D. Thomas, Robert K. Bradley, John K. Lee, Emily M. Hatch, Marina K. Baine, Natasha Rekhtman, Marc Ladanyi, Federica Piccioni, Alice H. Berger

Nat Commun. 2021; 12: 4789. Published online 2021 Aug 9. doi: 10.1038/s41467-021-24841-y

PMCID:: PMC8352964

Abstract Article PDF–4.5M

Select item 81650306.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 74407407.

GPSM2 Serves as an Independent Prognostic Biomarker for Liver Cancer Survival

Dingquan Yang, Fujian Ji, Yanqing Li, Yan Jiao, Xuedong Fang

Technol Cancer Res Treat. 2020; 19: 1533033820945817. Published online 2020 Aug 19. doi: 10.1177/1533033820945817

PMCID:: PMC7440740

Abstract Article PDF–1.0M

Select item 71699838.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 70411739.

Downregulation of GPSM2 is associated with primary resistance to paclitaxel in breast cancer

Zhe Zhang, Zhi Li, Mingming Deng, Bofang Liu, Xing Xin, Zhenkun Zhao, Ye Zhang, Qingjie Lv

Oncol Rep. 2020 Mar; 43(3): 965–974. Published online 2020 Jan 17. doi: 10.3892/or.2020.7471

PMCID:: PMC7041173

Abstract Article PDF–1.4M

Select item 692645910.

Intramolecular interaction in LGN, an adaptor protein that regulates mitotic spindle orientation

Hiroki Takayanagi, Junya Hayase, Sachiko Kamakura, Kei Miyano, Kanako Chishiki, Satoru Yuzawa, Hideki Sumimoto

J Biol Chem. 2019 Dec 20; 294(51): 19655–19666. Published online 2019 Nov 15. doi: 10.1074/jbc.RA119.011457

PMCID:: PMC6926459

Abstract Article PDF–3.0M

Select item 652523911.

Hexameric NuMA:LGN structures promote multivalent interactions required for planar epithelial divisions

Laura Pirovano, Simone Culurgioni, Manuel Carminati, Andrea Alfieri, Silvia Monzani, Valentina Cecatiello, Chiara Gaddoni, Francesca Rizzelli, James Foadi, Sebastiano Pasqualato, Marina Mapelli

Nat Commun. 2019; 10: 2208. Published online 2019 May 17. doi: 10.1038/s41467-019-09999-w

PMCID:: PMC6525239

Abstract Article PDF–4.0M

Select item 638658812.

The Functional Proximal Proteome of Oncogenic Ras Includes mTORC2

Joanna R. Kovalski, Aparna Bhaduri, Ashley M. Zehnder, Poornima H. Neela, Yonglu Che, Glenn G. Wozniak, Paul A. Khavari

Mol Cell. Author manuscript; available in PMC 2020 Feb 21.

Published in final edited form as: Mol Cell. 2019 Feb 21; 73(4): 830–844.e12. Published online 2019 Jan 10. doi: 10.1016/j.molcel.2018.12.001

PMCID:: PMC6386588

Abstract Article PDF–1.7M

Select item 591337513.

The GPSM2/LGN GoLoco motifs are essential for hearing

Yoni Bhonker, Amal Abu-Rayyan, Kathy Ushakov, Liat Amir-Zilberstein, Shaked Shivatzki, Ofer Yizhar-Barnea, Tal Elkan-Miller, Einav Tayeb-Fligelman, Sun Myoung Kim, Meytal Landau, Moien Kanaan, Ping Chen, Fumio Matsuzaki, David Sprinzak, Karen B. Avraham

Mamm Genome. Author manuscript; available in PMC 2018 Apr 24.

Published in final edited form as: Mamm Genome. 2016 Feb; 27(1-2): 29–46. Published online 2015 Dec 11. doi: 10.1007/s00335-015-9614-7

PMCID:: PMC5913375

Abstract Article PDF–2.3M

Select item 584495414.

Insc:LGN tetramers promote asymmetric divisions of mammary stem cells

Simone Culurgioni, Sara Mari, Paola Bonetti, Sara Gallini, Greta Bonetto, Martha Brennich, Adam Round, Francesco Nicassio, Marina Mapelli

Nat Commun. 2018; 9: 1025. Published online 2018 Mar 9. doi: 10.1038/s41467-018-03343-4

PMCID:: PMC5844954

Abstract Article PDF–2.6M

Select item 567858115.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski

BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9

PMCID:: PMC5678581

Abstract Article PDF–3.2M

Select item 566792016.

VE-cadherin phosphorylation regulates endothelial fluid shear stress responses through the polarity protein LGN

Daniel E. Conway, Brian G. Coon, Madhusuthan Budatha, Paul T. Arsenovic, Fabrizio Orsenigo, Florian Wessel, Jiasheng Zhang, Zhen W. Zhuang, Elisabetta Dejana, Dietmar Vestweber, Martin A. Schwartz

Curr Biol. Author manuscript; available in PMC 2018 Jul 24.

Published in final edited form as: Curr Biol. 2017 Jul 24; 27(14): 2219–2225.e5. Published online 2017 Jul 14. doi: 10.1016/j.cub.2017.06.020