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Select item 111496301.

FLT3L governs the development of partially overlapping hematopoietic lineages in humans and mice

Mana Momenilandi, Romain Lévy, Steicy Sobrino, Jingwei Li, Chantal Lagresle-Peyrou, Hossein Esmaeilzadeh, Antoine Fayand, Corentin Le Floc’h, Antoine Guérin, Erika Della Mina, Debra Shearer, Ottavia M. Delmonte, Ahmad Yatim, Kevin Mulder, Mathieu Mancini, Darawan Rinchai, Adeline Denis, Anna-Lena Neehus, Karla Balogh, Sarah Brendle, Hassan Rokni-Zadeh, Majid Changi-Ashtiani, Yoann Seeleuthner, Caroline Deswarte, Boris Bessot, Cassandre Cremades, Marie Materna, Axel Cederholm, Masato Ogishi, Quentin Philippot, Omer Beganovic, Mania Ackermann, Margareta Wuyts, Taushif Khan, Sébastien Fouéré, Florian Herms, Johan Chanal, Boaz Palterer, Julie Bruneau, Thierry Molina, Stéphanie Leclerc-Mercier, Jean-Luc Prétet, Leila Youssefian, Hassan Vahidnezhad, Nima Parvaneh, Kristl G. Claeys, Rik Schrijvers, Marine Luka, Philippe Pérot, Jacques Fourgeaud, Céline Nourrisson, Philippe Poirier, Emmanuelle Jouanguy, Stéphanie Boisson-Dupuis, Jacinta Bustamante, Luigi D. Notarangelo, Neil Christensen, Nils Landegren, Laurent Abel, Nico Marr, Emmanuelle Six, David Langlais, Tim Waterboer, Florent Ginhoux, Cindy S. Ma, Stuart G Tangye, Isabelle Meyts, Nico Lachmann, Jiafen Hu, Mohammad Shahrooei, Xavier Bossuyt, Jean-Laurent Casanova, Vivien Béziat

Cell. Author manuscript; available in PMC 2024 Jun 4.

Published in final edited form as: Cell. 2024 May 23; 187(11): 2817–2837.e31. Published online 2024 May 3. doi: 10.1016/j.cell.2024.04.009

PMCID:: PMC11149630

Abstract Article PDF–3.3M

Select item 105262282.

Interaction of S100A6 Protein with the Four-Helical Cytokines

Alexey S. Kazakov, Evgenia I. Deryusheva, Victoria A. Rastrygina, Andrey S. Sokolov, Maria E. Permyakova, Ekaterina A. Litus, Vladimir N. Uversky, Eugene A. Permyakov, Sergei E. Permyakov

Biomolecules. 2023 Sep; 13(9): 1345. Published online 2023 Sep 4. doi: 10.3390/biom13091345

PMCID:: PMC10526228

Abstract Article PDF–13M

Select item 99507363.

Early-life hyperoxia-induced Flt3L drives neonatal lung dendritic cell expansion and proinflammatory responses

Tracy X. Cui, Alexander E. Brady, Ying-Jian Zhang, Christina T. Fulton, Adam M. Goldsmith, Antonia P. Popova

Front Immunol. 2023; 14: 1116675. Published online 2023 Feb 10. doi: 10.3389/fimmu.2023.1116675

PMCID:: PMC9950736

Abstract Article PDF–4.9M

Select item 94452534.

FLT3LG and IFITM3P6 consolidate T cell activity in the bone marrow microenvironment and are prognostic factors in acute myelocytic leukemia

Haiyan Chen, Meng Wu, Hongping Xia, Songjie Du, Guoren Zhou, Guangfeng Long, Yanan Zhu, Xu Huang, Daheng Yang

Front Immunol. 2022; 13: 980911. Published online 2022 Aug 23. doi: 10.3389/fimmu.2022.980911

PMCID:: PMC9445253

Abstract Article PDF–17M

Select item 91063035.

Genome-wide CRISPR screens using isogenic cells reveal vulnerabilities conferred by loss of tumor suppressors

Xu Feng, Mengfan Tang, Merve Dede, Dan Su, Guangsheng Pei, Dadi Jiang, Chao Wang, Zhen Chen, Mi Li, Litong Nie, Yun Xiong, Siting Li, Jeong-Min Park, Huimin Zhang, Min Huang, Klaudia Szymonowicz, Zhongming Zhao, Traver Hart, Junjie Chen

Sci Adv. 2022 May; 8(19): eabm6638. Published online 2022 May 13. doi: 10.1126/sciadv.abm6638

PMCID:: PMC9106303

Abstract Article PDF–918K

Select item 89071496.

Fast Maturation of Splenic Dendritic Cells Upon TBI Is Associated With FLT3/FLT3L Signaling

Jin Zhang, Zhenghui Li, Akila Chandrasekar, Shun Li, Albert Ludolph, Tobias Maria Boeckers, Markus Huber-Lang, Francesco Roselli, Florian olde Heuvel

Front Immunol. 2022; 13: 824459. Published online 2022 Feb 24. doi: 10.3389/fimmu.2022.824459

PMCID:: PMC8907149

Abstract Article PDF–33M

Select item 78773587.

A new cytokine‐based dynamic stratification during induction is highly predictive of survivals in acute myeloid leukemia

Pierre Peterlin, Joelle Gaschet, Thierry Guillaume, Alice Garnier, Marion Eveillard, Amandine Le Bourgeois, Michel Cherel, Camille Debord, Yannick Le Bris, Olivier Theisen, Catherine Godon, Béatrice Mahé, Viviane Dubruille, Soraya Wuilleme, Cyrille Touzeau, Thomas Gastinne, Nicolas Blin, Anne Lok, Benoît Tessoulin, Steven Le Gouill, Philippe Moreau, Marie‐C Béné, Patrice Chevallier

Cancer Med. 2021 Jan; 10(2): 642–648. Published online 2020 Dec 25. doi: 10.1002/cam4.3648

PMCID:: PMC7877358

Abstract Article PDF–282K

Select item 71768538.

Wild‐type FLT3 and FLT3 ITD exhibit similar ligand‐induced internalization characteristics

Fabienne Kellner, Andreas Keil, Katrin Schindler, Todor Tschongov, Kerstin Hünninger, Hannah Loercher, Peter Rhein, Sylvia‐Annette Böhmer, Frank‐D. Böhmer, Jörg P. Müller

J Cell Mol Med. 2020 Apr; 24(8): 4668–4676. Published online 2020 Mar 10. doi: 10.1111/jcmm.15132

PMCID:: PMC7176853

Abstract Article PDF–721K

Select item 71699839.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 655580010.

Mesenchymal stem cell therapy induces FLT3L and CD1c⁺ dendritic cells in systemic lupus erythematosus patients

Xinran Yuan, Xiaodong Qin, Dandan Wang, Zhuoya Zhang, Xiaojun Tang, Xiang Gao, Wanjun Chen, Lingyun Sun

Nat Commun. 2019; 10: 2498. Published online 2019 Jun 7. doi: 10.1038/s41467-019-10491-8

PMCID:: PMC6555800

Abstract Article PDF–1.6M

Select item 654583111.

FLT3 ligand plasma levels in acute myeloid leukemia

Pierre Peterlin, Joelle Gaschet, Thierry Guillaume, Alice Garnier, Marion Eveillard, Amandine Le Bourgeois, Michel Cherel, Camille Debord, Yannick Le Bris, Olivier Theisen, Béatrice Mahé, Viviane Dubruille, Catherine Godon, Nelly Robillard, Soraya Wuilleme, Cyrille Touzeau, Thomas Gastinne, Nicolas Blin, Anne Lok, Antoine Bonnet, Steven Le Gouill, Philippe Moreau, Marie-C Béné, Patrice Chevallier

Haematologica. 2019 Jun; 104(6): e240–e243. doi: 10.3324/haematol.2018.209460

PMCID:: PMC6545831

Article PDF–288K

Select item 598530412.

Introduction of Human Flt3-L and GM-CSF into Humanized Mice Enhances the Reconstitution and Maturation of Myeloid Dendritic Cells and the Development of Foxp3⁺CD4⁺ T Cells

Ryutaro Iwabuchi, Shota Ikeno, Mie Kobayashi-Ishihara, Haruko Takeyama, Manabu Ato, Yasuko Tsunetsugu-Yokota, Kazutaka Terahara

Front Immunol. 2018; 9: 1042. Published online 2018 May 28. doi: 10.3389/fimmu.2018.01042

PMCID:: PMC5985304

Abstract Article PDF–3.2M

Select item 595992713.

Systemic immune response induced by oxaliplatin-based neoadjuvant therapy favours survival without metastatic progression in high-risk rectal cancer

Erta Kalanxhi, Sebastian Meltzer, Jakob Vasehus Schou, Finn Ole Larsen, Svein Dueland, Kjersti Flatmark, Benny Vittrup Jensen, Knut Håkon Hole, Therese Seierstad, Kathrine Røe Redalen, Dorte Lisbet Nielsen, Anne Hansen Ree

Br J Cancer. 2018 May 15; 118(10): 1322–1328. Published online 2018 Apr 26. doi: 10.1038/s41416-018-0085-y

PMCID:: PMC5959927

Abstract Article PDF–387K

Select item 576064214.

Flt3 ligand expands bona fide innate lymphoid cell precursors in vivo

Sara M. Parigi, Paulo Czarnewski, Srustidhar Das, Christiane Steeg, Leonie Brockmann, Sara Fernandez-Gaitero, Victor Yman, Marianne Forkel, Charlotte Höög, Jenny Mjösberg, Lisa Westerberg, Anna Färnert, Samuel Huber, Thomas Jacobs, Eduardo J. Villablanca

Sci Rep. 2018; 8: 154. Published online 2018 Jan 9. doi: 10.1038/s41598-017-18283-0

PMCID:: PMC5760642

Abstract Article PDF–4.6M

Select item 548593915.

The Cytokine Flt3-Ligand in Normal and Malignant Hematopoiesis

Panagiotis Tsapogas, Ciaran James Mooney, Geoffrey Brown, Antonius Rolink

Int J Mol Sci. 2017 Jun; 18(6): 1115. Published online 2017 May 24. doi: 10.3390/ijms18061115

PMCID:: PMC5485939

Abstract Article PDF–1.6M

Select item 521692016.

Co-expression of wild-type FLT3 attenuates the inhibitory effect of FLT3 inhibitor on FLT3 mutated leukemia cells

Fangli Chen, Yuichi Ishikawa, Akimi Akashi, Tomoki Naoe, Hitoshi Kiyoi

Oncotarget. 2016 Jul 26; 7(30): 47018–47032. Published online 2016 Jun 17. doi: 10.18632/oncotarget.10147

PMCID:: PMC5216920

Abstract Article PDF–4.4M

Select item 414473517.

Classical Flt3L-dependent dendritic cells control immunity to protein vaccine

Niroshana Anandasabapathy, Rachel Feder, Shamim Mollah, Sze-Wah Tse, Maria Paula Longhi, Saurabh Mehandru, Ines Matos, Cheolho Cheong, Darren Ruane, Lucas Brane, Angela Teixeira, Joseph Dobrin, Olga Mizenina, Chae Gyu Park, Matthew Meredith, Björn E. Clausen, Michel C. Nussenzweig, Ralph M. Steinman

J Exp Med. 2014 Aug 25; 211(9): 1875–1891. doi: 10.1084/jem.20131397

PMCID:: PMC4144735

Abstract Article PDF–3.6M

Select item 397861118.

Maria I Ramos, Samuel Garcia Perez, Saida Aarrass, Boy Helder, Pleun Broekstra, Daan M Gerlag, Kris A Reedquist, Paul Peter Tak, Maria C Lebre

Arthritis Res Ther. 2013; 15(6): R209. Published online 2013 Dec 6. doi: 10.1186/ar4403

PMCID:: PMC3978611

Abstract Article PDF–2.0M

Select item 328634519.

Blockade of prostaglandin E₂ signaling through EP1 and EP3 receptors attenuates Flt3L-dependent dendritic cell development from hematopoietic progenitor cells

Pratibha Singh, Jonathan Hoggatt, Peirong Hu, Jennifer M. Speth, Seiji Fukuda, Richard M. Breyer, Louis M. Pelus

Blood. 2012 Feb 16; 119(7): 1671–1682. Prepublished online 2011 Nov 22. doi: 10.1182/blood-2011-03-342428

PMCID:: PMC3286345

Abstract Article

Select item 318875620.

Combined Flt3L/TK Gene Therapy Induces Immunological Surveillance Which Mediates an Immune Response Against a Surrogate Brain Tumor Neoantigen

Gwendalyn D King, AKM Ghulam Muhammad, Daniel Larocque, Kyle R Kelson, Weidong Xiong, Chunyan Liu, Nicholas SR Sanderson, Kurt M Kroeger, Maria G Castro, Pedro R Lowenstein

Mol Ther. 2011 Oct; 19(10): 1793–1801. Published online 2011 Apr 19. doi: 10.1038/mt.2011.77

PMCID:: PMC3188756

Abstract Article PDF–616K

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