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Select item 111362531.

Pyruvate dehydrogenase kinase regulatory mechanisms and inhibition in treating diabetes, heart ischemia, and cancer

T. E. Roche, Y. Hiromasa

Cell Mol Life Sci. 2007 Apr; 64(7-8): 830. Published online 2007 Feb 19. doi: 10.1007/s00018-007-6380-z

PMCID:: PMC11136253

Abstract Article PDF–855K

Select item 111314782.

Pyruvate dehydrogenase kinase 4 expression is synergistically induced by AMP-activated protein kinase and fatty acids

S. M. Houten, M. Chegary, H. te Brinke, W. J. Wijnen, J. F. C. Glatz, J. J. F. P. Luiken, F. A. Wijburg, R. J. A. Wanders

Cell Mol Life Sci. 2009 Apr; 66(7): 1283–1294. Published online 2009 Feb 17. doi: 10.1007/s00018-009-9066-x

PMCID:: PMC11131478

Abstract Article PDF–1.4M

Select item 88067243.

MicroRNA -148 alleviates cardiac dysfunction, immune disorders and myocardial apoptosis in myocardial ischemia-reperfusion (MI/R) injury by targeting pyruvate dehydrogenase kinase (PDK4): Myocardial protection of miR-148/PDK4 in immature rats.

Qi Yin, Ping Wang, Xiaohua Wu

Bioengineered. 2021; 12(1): 5552–5565. Published online 2021 Sep 14. doi: 10.1080/21655979.2021.1965812

PMCID:: PMC8806724

Abstract Article PDF–3.6M

Select item 76730244.

PDK4 promotes vascular calcification by interfering with autophagic activity and metabolic reprogramming

Wen-Qi Ma, Xue-Jiao Sun, Yi Zhu, Nai-Feng Liu

Cell Death Dis. 2020 Nov; 11(11): 991. Published online 2020 Nov 17. doi: 10.1038/s41419-020-03162-w

PMCID:: PMC7673024

Abstract Article PDF–4.5M

Select item 61370845.

Advanced glycation end products accelerate calcification in VSMCs through HIF-1α/PDK4 activation and suppress glucose metabolism

Yi Zhu, Wen-Qi Ma, Xi-Qiong Han, Ying Wang, Xin Wang, Nai-Feng Liu

Sci Rep. 2018; 8: 13730. Published online 2018 Sep 13. doi: 10.1038/s41598-018-31877-6

PMCID:: PMC6137084

Abstract Article PDF–3.3M

Select item 47867336.

Pyruvate Dehydrogenase Kinase-mediated Glycolytic Metabolic Shift in the Dorsal Root Ganglion Drives Painful Diabetic Neuropathy

Md Habibur Rahman, Mithilesh Kumar Jha, Jong-Heon Kim, Youngpyo Nam, Maan Gee Lee, Younghoon Go, Robert A. Harris, Dong Ho Park, Hyun Kook, In-Kyu Lee, Kyoungho Suk

J Biol Chem. 2016 Mar 11; 291(11): 6011–6025. Published online 2016 Jan 14. doi: 10.1074/jbc.M115.699215

PMCID:: PMC4786733

Abstract Article PDF–3.1M

Select item 43231617.

Fasting induces ketoacidosis and hypothermia in PDHK2/PDHK4-double-knockout mice

Nam Ho Jeoung, Yasmeen Rahimi, Pengfei Wu, W. N. Paul Lee, Robert A. Harris

Biochem J. Author manuscript; available in PMC 2015 Feb 10.

Published in final edited form as: Biochem J. 2012 May 1; 443(3): 829–839. doi: 10.1042/BJ20112197

PMCID:: PMC4323161

Abstract Article PDF–437K

Select item 35842018.

FOXO1-mediated Upregulation of Pyruvate Dehydrogenase Kinase-4 (PDK4) Decreases Glucose Oxidation and Impairs Right Ventricular Function in Pulmonary Hypertension: Therapeutic Benefits of Dichloroacetate

Lin Piao, Vaninder K. Sidhu, Yong-Hu Fang, John J. Ryan, Kishan S. Parikh, Zhigang Hong, Peter T. Toth, Erik Morrow, Shelby Kutty, Gary D. Lopaschuk, Stephen L. Archer

J Mol Med (Berl) Author manuscript; available in PMC 2014 Mar 1.

Published in final edited form as: J Mol Med (Berl). 2013 Mar; 91(3): 333–346. Published online 2012 Dec 18. doi: 10.1007/s00109-012-0982-0

PMCID:: PMC3584201

Abstract Article PDF–3.5M

Select item 31780599.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 316593610.

Erk regulation of pyruvate dehydrogenase flux through PDK4 modulates cell proliferation

Alexandra R. Grassian, Christian M. Metallo, Jonathan L. Coloff, Gregory Stephanopoulos, Joan S. Brugge

Genes Dev. 2011 Aug 15; 25(16): 1716–1733. doi: 10.1101/gad.16771811

PMCID:: PMC3165936

Abstract Article PDF–2.4M

Select item 312916111.

Regulation of Pyruvate Dehydrogenase Kinase 4 (PDK4) by CCAAT/Enhancer-binding Protein β (C/EBPβ)

Ramy R. Attia, Pragya Sharma, Rachel C. Janssen, Jacob E. Friedman, Xiong Deng, Jae Seung Lee, Marshall B. Elam, George A. Cook, Edwards A. Park

J Biol Chem. 2011 Jul 8; 286(27): 23799–23807. Published online 2011 May 17. doi: 10.1074/jbc.M111.246389

PMCID:: PMC3129161

Abstract Article PDF–1.2M

Select item 281520612.

Regulation of pyruvate dehydrogenase kinase isoform 4 (PDK4) gene expression by glucocorticoids and insulin

Sara Connaughton, Farhana Chowdhury, Ramy R. Attia, Shulan Song, Yi Zhang, Marshall B. Elam, George A. Cook, Edwards A. Park

Mol Cell Endocrinol. Author manuscript; available in PMC 2011 Feb 5.

Published in final edited form as: Mol Cell Endocrinol. 2010 Feb 5; 315(1-2): 159. Published online 2009 Aug 22. doi: 10.1016/j.mce.2009.08.011

PMCID:: PMC2815206

Abstract Article PDF–1.0M

Select item 280729613.

Regulation of Pyruvate Dehydrogenase Kinase 4 (PDK4) by Thyroid Hormone: ROLE OF THE PEROXISOME PROLIFERATOR-ACTIVATED RECEPTOR γ COACTIVATOR (PGC-1α)

Ramy R. Attia, Sara Connnaughton, Lindsey R. Boone, Fang Wang, Marshall B. Elam, Gene C. Ness, George A. Cook, Edwards A. Park

J Biol Chem. 2010 Jan 22; 285(4): 2375–2385. Published online 2009 Nov 30. doi: 10.1074/jbc.M109.039081

PMCID:: PMC2807296

Abstract Article PDF–1.6M

Select item 277884414.

A mitochondrial protein compendium elucidates complex I disease biology

David J. Pagliarini, Sarah E. Calvo, Betty Chang, Sunil A. Sheth, Scott B. Vafai, Shao-En Ong, Geoffrey A. Walford, Canny Sugiana, Avihu Boneh, William K. Chen, David E. Hill, Marc Vidal, James G. Evans, David R. Thorburn, Steven A. Carr, Vamsi K. Mootha

Cell. Author manuscript; available in PMC 2009 Nov 18.

Published in final edited form as: Cell. 2008 Jul 11; 134(1): 112–123. doi: 10.1016/j.cell.2008.06.016