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Select item 88543811.

High PGD₂ receptor 2 levels are associated with poor prognosis in colorectal cancer patients and induce VEGF expression in colon cancer cells and migration in a zebrafish xenograft model

Pujarini Dash, Souvik Ghatak, Geriolda Topi, Shakti Ranjan Satapathy, Fredrik Ek, Karin Hellman, Roger Olsson, Lubna M. Mehdawi, Anita Sjölander

Br J Cancer. 2022 Mar 9; 126(4): 586–597. Published online 2021 Nov 8. doi: 10.1038/s41416-021-01595-4

PMCID:: PMC8854381

Abstract Article PDF–3.2M

Select item 72333402.

Loss of DP1 Aggravates Vascular Remodeling in Pulmonary Arterial Hypertension via mTORC1 Signaling

Yuhu He, Caojian Zuo, Daile Jia, Peiyuan Bai, Deping Kong, Di Chen, Guizhu Liu, Juanjuan Li, Yuanyang Wang, Guilin Chen, Shuai Yan, Bing Xiao, Jian Zhang, Lingjuan Piao, Yanli Li, Yi Deng, Bin Li, Philippe P. Roux, Katrin I. Andreasson, Richard M. Breyer, Yunchao Su, Jian Wang, Ankang Lyu, Yujun Shen, Ying Yu

Am J Respir Crit Care Med. 2020 May 15; 201(10): 1263–1276. Published online 2020 May 15. doi: 10.1164/rccm.201911-2137OC

PMCID:: PMC7233340

Abstract Article PDF–2.5M

Select item 68513113.

L-type prostaglandin D synthase regulates the trafficking of the PGD₂ DP1 receptor by interacting with the GTPase Rab4

Chantal Binda, Samuel Génier, Jade Degrandmaison, Samuel Picard, Louis Fréchette, Steve Jean, Eric Marsault, Jean-Luc Parent

J Biol Chem. 2019 Nov 8; 294(45): 16865–16883. Published online 2019 Oct 1. doi: 10.1074/jbc.RA119.008233

PMCID:: PMC6851311

Abstract Article PDF–3.8M

Select item 60328304.

DP1 receptor signaling prevents the onset of intrinsic apoptosis in eosinophils and functions as a transcriptional modulator

Miriam Peinhaupt, David Roula, Anna Theiler, Miriam Sedej, Rudolf Schicho, Gunther Marsche, Eva M. Sturm, Ian Sabroe, Marc E. Rothenberg, Akos Heinemann

J Leukoc Biol. 2018 Jul; 104(1): 159–171. Published online 2018 Apr 1. doi: 10.1002/JLB.3MA1017-404R

PMCID:: PMC6032830

Abstract Article PDF–1.6M

Select item 56633845.

PTGDR gene expression and response to dexamethasone treatment in an in vitro model

Elena Marcos-Vadillo, Asunción García-Sánchez, Catalina Sanz, Ignacio Davila, María Isidoro-García

PLoS One. 2017; 12(10): e0186957. Published online 2017 Oct 31. doi: 10.1371/journal.pone.0186957

PMCID:: PMC5663384

Abstract Article PDF–1.3M

Select item 55026306.

Virus-induced inflammasome activation is suppressed by prostaglandin D₂/DP1 signaling

Rahul Vijay, Anthony R. Fehr, Ann M. Janowski, Jeremiah Athmer, Dorthea L. Wheeler, Matthew Grunewald, Ramakrishna Sompallae, Samarchith P. Kurup, David K. Meyerholz, Fayyaz S. Sutterwala, Shuh Narumiya, Stanley Perlman

Proc Natl Acad Sci U S A. 2017 Jul 3; 114(27): E5444–E5453. Published online 2017 Jun 19. doi: 10.1073/pnas.1704099114

PMCID:: PMC5502630

Abstract Article PDF–1.5M

Select item 49546067.

Activated prostaglandin D₂ receptors on macrophages enhance neutrophil recruitment into the lung

Katharina Jandl, Elvira Stacher, Zoltán Bálint, Eva Maria Sturm, Jovana Maric, Miriam Peinhaupt, Petra Luschnig, Ida Aringer, Alexander Fauland, Viktoria Konya, Sven-Erik Dahlen, Craig E. Wheelock, Dagmar Kratky, Andrea Olschewski, Gunther Marsche, Rufina Schuligoi, Akos Heinemann

J Allergy Clin Immunol. Author manuscript; available in PMC 2016 Jul 20.

Published in final edited form as: J Allergy Clin Immunol. 2016 Mar; 137(3): 833–843. Published online 2016 Jan 12. doi: 10.1016/j.jaci.2015.11.012

PMCID:: PMC4954606

Abstract Article PDF–2.4M

Select item 40687978.

Large-scale genetic study in East Asians identifies six new loci associated with colorectal cancer risk

Ben Zhang, Wei-Hua Jia, Koichi Matsuda, Sun-Seog Kweon, Keitaro Matsuo, Yong-Bing Xiang, Aesun Shin, Sun Ha Jee, Dong-Hyun Kim, Qiuyin Cai, Jirong Long, Jiajun Shi, Wanqing Wen, Gong Yang, Yanfeng Zhang, Chun Li, Bingshan Li, Yan Guo, Zefang Ren, Bu-Tian Ji, Zhi-Zhong Pan, Atsushi Takahashi, Min-Ho Shin, Fumihiko Matsuda, Yu-Tang Gao, Jae Hwan Oh, Soriul Kim, Yoon-Ok Ahn, Genetics and Epidemiology of Colorectal Cancer Consortium (GECCO), Andrew T Chan, Jenny Chang-Claude, Martha L. Slattery, Colorectal Transdisciplinary (CORECT) Study, Stephen B. Gruber, Fredrick R. Schumacher, Stephanie L. Stenzel, Colon Cancer Family Registry (CCFR), Graham Casey, Hyeong-Rok Kim, Jin-Young Jeong, Ji Won Park, Hong-Lan Li, Satoyo Hosono, Sang-Hee Cho, Michiaki Kubo, Xiao-Ou Shu, Yi-Xin Zeng, Wei Zheng

Nat Genet. Author manuscript; available in PMC 2014 Dec 1.

Published in final edited form as: Nat Genet. 2014 Jun; 46(6): 533–542. Published online 2014 May 18. doi: 10.1038/ng.2985

PMCID:: PMC4068797

Abstract Article PDF–597K

Select item 39125379.

A G protein–coupled receptor and the intracellular synthase of its agonist functionally cooperate

Chantal Binda, Samuel Génier, Andréane Cartier, Jean-François Larrivée, Jana Stankova, Jason C. Young, Jean-Luc Parent

J Cell Biol. 2014 Feb 3; 204(3): 377–393. doi: 10.1083/jcb.201304015

PMCID:: PMC3912537

Abstract Article PDF–3.5M

Select item 382655410.

No Association of PTGDR −441C/T Polymorphism with Asthma in a North Indian Population

Niti Birbian, Jagtar Singh, Surinder Kumar Jindal, Amit Joshi, Navneet Batra

Dis Markers. 2011; 31(6): 353–359. Published online 2011 Dec 19. doi: 10.3233/DMA-2011-0850

PMCID:: PMC3826554

Summary PDF–342K

Select item 372992711.

Genome-wide Association Study Identifies Multiple Risk Loci for Chronic Lymphocytic Leukemia

Sonja I. Berndt, Christine F. Skibola, Vijai Joseph, Nicola J. Camp, Alexandra Nieters, Zhaoming Wang, Wendy Cozen, Alain Monnereau, Sophia S. Wang, Rachel S. Kelly, Qing Lan, Lauren R. Teras, Nilanjan Chatterjee, Charles C. Chung, Meredith Yeager, Angela R. Brooks-Wilson, Patricia Hartge, Mark P. Purdue, Brenda M. Birmann, Bruce K. Armstrong, Pierluigi Cocco, Yawei Zhang, Gianluca Severi, Anne Zeleniuch-Jacquotte, Charles Lawrence, Laurie Burdette, Jeffrey Yuenger, Amy Hutchinson, Kevin B. Jacobs, Timothy G. Call, Tait D. Shanafelt, Anne J. Novak, Neil E. Kay, Mark Liebow, Alice H. Wang, Karin E Smedby, Hans-Olov Adami, Mads Melbye, Bengt Glimelius, Ellen T. Chang, Martha Glenn, Karen Curtin, Lisa A. Cannon-Albright, Brandt Jones, W. Ryan Diver, Brian K. Link, George J. Weiner, Lucia Conde, Paige M. Bracci, Jacques Riby, Elizabeth A. Holly, Martyn T. Smith, Rebecca D. Jackson, Lesley F. Tinker, Yolanda Benavente, Nikolaus Becker, Paolo Boffetta, Paul Brennan, Lenka Foretova, Marc Maynadie, James McKay, Anthony Staines, Kari G. Rabe, Sara J. Achenbach, Celine M. Vachon, Lynn R Goldin, Sara S. Strom, Mark C. Lanasa, Logan G. Spector, Jose F. Leis, Julie M. Cunningham, J. Brice Weinberg, Vicki A. Morrison, Neil E. Caporaso, Aaron D. Norman, Martha S. Linet, Anneclaire J. De Roos, Lindsay M. Morton, Richard K. Severson, Elio Riboli, Paolo Vineis, Rudolph Kaaks, Dimitrios Trichopoulos, Giovanna Masala, Elisabete Weiderpass, María-Dolores Chirlaque, Roel C H Vermeulen, Ruth C. Travis, Graham G. Giles, Demetrius Albanes, Jarmo Virtamo, Stephanie Weinstein, Jacqueline Clavel, Tongzhang Zheng, Theodore R Holford, Kenneth Offit, Andrew Zelenetz, Robert J. Klein, John J. Spinelli, Kimberly A. Bertrand, Francine Laden, Edward Giovannucci, Peter Kraft, Anne Kricker, Jenny Turner, Claire M. Vajdic, Maria Grazia Ennas, Giovanni M. Ferri, Lucia Miligi, Liming Liang, Joshua Sampson, Simon Crouch, Ju-hyun Park, Kari E. North, Angela Cox, John A. Snowden, Josh Wright, Angel Carracedo, Carlos Lopez-Otin, Silvia Bea, Itziar Salaverria, David Martin, Elias Campo, Joseph F. Fraumeni, Jr, Silvia de Sanjose, Henrik Hjalgrim, James R. Cerhan, Stephen J. Chanock, Nathaniel Rothman, Susan L. Slager

Nat Genet. Author manuscript; available in PMC 2014 Feb 1.

Published in final edited form as: Nat Genet. 2013 Aug; 45(8): 868–876. Published online 2013 Jun 16. doi: 10.1038/ng.2652

PMCID:: PMC3729927

Article PDF–1.8M

Select item 367793712.

Inverse Agonist and Pharmacochaperone Properties of MK-0524 on the Prostanoid DP1 Receptor

Pascale Labrecque, Sébastien J. Roy, Louis Fréchette, Christian Iorio-Morin, Maxime A. Gallant, Jean-Luc Parent

PLoS One. 2013; 8(6): e65767. Published online 2013 Jun 10. doi: 10.1371/journal.pone.0065767

PMCID:: PMC3677937

Abstract Article PDF–3.9M

Select item 347474013.

E2F6 Associates with BRG1 in Transcriptional Regulation

Janet Y. Leung, Joseph R. Nevins

PLoS One. 2012; 7(10): e47967. Published online 2012 Oct 17. doi: 10.1371/journal.pone.0047967

PMCID:: PMC3474740

Abstract Article PDF–647K

Select item 319082614.

Interactions of Pathological Hallmark Proteins: TUBULIN POLYMERIZATION PROMOTING PROTEIN/p25, β-AMYLOID, AND α-SYNUCLEIN

Judit Oláh, Orsolya Vincze, Dezső Virók, Dóra Simon, Zsolt Bozsó, Natália Tőkési, István Horváth, Emma Hlavanda, János Kovács, Anna Magyar, Mária Szűcs, Ferenc Orosz, Botond Penke, Judit Ovádi

J Biol Chem. 2011 Sep 30; 286(39): 34088–34100. Published online 2011 Aug 8. doi: 10.1074/jbc.M111.243907

PMCID:: PMC3190826

Abstract Article PDF–5.7M

Select item 319077215.

The Extracellular Signal-regulated Kinase Mitogen-activated Protein Kinase/Ribosomal S6 Protein Kinase 1 Cascade Phosphorylates cAMP Response Element-binding Protein to Induce MUC5B Gene Expression via d-Prostanoid Receptor Signaling

Yeon Ho Choi, Sang-Nam Lee, Hiroki Aoyagi, Yasundo Yamasaki, Jung-Yoon Yoo, Boryung Park, Dong Min Shin, Ho-Geun Yoon, Joo-Heon Yoon

J Biol Chem. 2011 Sep 30; 286(39): 34199–34214. Published online 2011 Aug 10. doi: 10.1074/jbc.M111.247684

PMCID:: PMC3190772

Abstract Article PDF–2.7M

Select item 317805916.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 316916717.

Risk of Meningioma and Common Variation in Genes related to Innate Immunity

Preetha Rajaraman, Alina V. Brenner, Gila Neta, Ruth Pfeiffer, Sophia S. Wang, Meredith Yeager, Gilles Thomas, Howard A. Fine, Martha S. Linet, Nathaniel Rothman, Stephen J. Chanock, Peter D. Inskip

Cancer Epidemiol Biomarkers Prev. Author manuscript; available in PMC 2011 Sep 7.

Published in final edited form as: Cancer Epidemiol Biomarkers Prev. 2010 May; 19(5): 1356–1361. Published online 2010 Apr 20. doi: 10.1158/1055-9965.EPI-09-1151

PMCID:: PMC3169167

Abstract Article PDF–61K

Select item 308111318.

Co-operative signalling through DP₁ and DP₂ prostanoid receptors is required to enhance leukotriene C₄ synthesis induced by prostaglandin D₂ in eosinophils

FP Mesquita-Santos, I Bakker-Abreu, T Luna-Gomes, PT Bozza, BL Diaz, C Bandeira-Melo

Br J Pharmacol. 2011 Apr; 162(8): 1674–1685. doi: 10.1111/j.1476-5381.2010.01086.x

PMCID:: PMC3081113

Abstract Article PDF–1.1M

Select item 308111219.

R2D₂ for C₄Eo: an ‘alliance’ of PGD₂ receptors is required for LTC₄ production by human eosinophils

Graham A Mackay, Alastair G Stewart

Br J Pharmacol. 2011 Apr; 162(8): 1671–1673. doi: 10.1111/j.1476-5381.2011.01236.x

PMCID:: PMC3081112

Abstract Article PDF–274K

Select item 300338520.

ANKRD13C Acts as a Molecular Chaperone for G Protein-coupled Receptors

Audrey Parent, Sébastien J. Roy, Christian Iorio-Morin, Marie-Claude Lépine, Pascale Labrecque, Maxime A. Gallant, Deborah Slipetz, Jean-Luc Parent

J Biol Chem. 2010 Dec 24; 285(52): 40838–40851. Published online 2010 Oct 19. doi: 10.1074/jbc.M110.142257

PMCID:: PMC3003385

Abstract Article PDF–4.7M

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