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Select item 89515561.

A BioID-Derived Proximity Interactome for SARS-CoV-2 Proteins

Danielle G. May, Laura Martin-Sancho, Valesca Anschau, Sophie Liu, Rachel J. Chrisopulos, Kelsey L. Scott, Charles T. Halfmann, Ramon Díaz Peña, Dexter Pratt, Alexandre R. Campos, Kyle J. Roux

Viruses. 2022 Mar; 14(3): 611. Published online 2022 Mar 15. doi: 10.3390/v14030611

PMCID:: PMC8951556

Abstract Article PDF–4.4M

Select item 87605192.

DNA demethylase ALKBH1 promotes adipogenic differentiation via regulation of HIF-1 signaling

Yuting Liu, Yaqian Chen, Yuan Wang, Shuang Jiang, Weimin Lin, Yunshu Wu, Qiwen Li, Yuchen Guo, Weiqing Liu, Quan Yuan

J Biol Chem. 2022 Jan; 298(1): 101499. Published online 2021 Dec 17. doi: 10.1016/j.jbc.2021.101499

PMCID:: PMC8760519

Abstract Article PDF–3.9M

Select item 82795893.

ALKBH1-demethylated DNA N⁶-methyladenine modification triggers vascular calcification via osteogenic reprogramming in chronic kidney disease

Liu Ouyang, Xiaoyan Su, Wenxin Li, Liangqiu Tang, Mengbi Zhang, Yongjun Zhu, Changming Xie, Puhua Zhang, Jie Chen, Hui Huang

J Clin Invest. 2021 Jul 15; 131(14): e146985. Published online 2021 Jul 15. doi: 10.1172/JCI146985

PMCID:: PMC8279589

Abstract Article PDF–13M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 80459325.

A novel p53 regulator, C16ORF72/TAPR1, buffers against telomerase inhibition

Yahya Benslimane, María Sánchez‐Osuna, Jasmin Coulombe‐Huntington, Thierry Bertomeu, Danielle Henry, Caroline Huard, Éric Bonneil, Pierre Thibault, Mike Tyers, Lea Harrington

Aging Cell. 2021 Apr; 20(4): e13331. Published online 2021 Mar 4. doi: 10.1111/acel.13331

PMCID:: PMC8045932

Abstract Article PDF–1.9M

Select item 74529656.

ALKBH1 deficiency leads to loss of homeostasis in human diploid somatic cells

Hongyu Li, Zeming Wu, Xiaoqian Liu, Sheng Zhang, Qianzhao Ji, Xiaoyu Jiang, Zunpeng Liu, Si Wang, Jing Qu, Weiqi Zhang, Moshi Song, Eli Song, Guang-Hui Liu

Protein Cell. 2020 Sep; 11(9): 688–695. Published online 2020 Jul 13. doi: 10.1007/s13238-020-00744-4

PMCID:: PMC7452965

Article PDF–1.2M

Select item 70543957.

Structural basis of nucleic acid recognition and 6mA demethylation by human ALKBH1

Li-Fei Tian, Yan-Ping Liu, Lianqi Chen, Qun Tang, Wei Wu, Wei Sun, Zhongzhou Chen, Xiao-Xue Yan

Cell Res. 2020 Mar; 30(3): 272–275. Published online 2020 Feb 12. doi: 10.1038/s41422-019-0233-9

PMCID:: PMC7054395

Article PDF–1.6M

Select item 65823178.

DNA repair enzymes ALKBH2, ALKBH3, and AlkB oxidize 5-methylcytosine to 5-hydroxymethylcytosine, 5-formylcytosine and 5-carboxylcytosine in vitro

Ke Bian, Stefan A P Lenz, Qi Tang, Fangyi Chen, Rui Qi, Marco Jost, Catherine L Drennan, John M Essigmann, Stacey D Wetmore, Deyu Li

Nucleic Acids Res. 2019 Jun 20; 47(11): 5522–5529. Published online 2019 May 22. doi: 10.1093/nar/gkz395

PMCID:: PMC6582317

Abstract Article PDF–1.7M

Select item 65224489.

Expression of Demethylase Genes, FTO and ALKBH1, Is Associated with Prognosis of Gastric Cancer

Yue Li, Danyang Zheng, Fang Wang, Yuxia Xu, Hongyang Yu, Huizhong Zhang

Dig Dis Sci. 2019; 64(6): 1503–1513. Published online 2019 Jan 14. doi: 10.1007/s10620-018-5452-2

PMCID:: PMC6522448

Abstract Article PDF–4.4M

Select item 644186810.

POH1 contributes to hyperactivation of TGF-β signaling and facilitates hepatocellular carcinoma metastasis through deubiquitinating TGF-β receptors and caveolin-1

Boshi Wang, Xiaoli Xu, Zhaojuan Yang, Li Zhang, Yun Liu, Aihui Ma, Guiqin Xu, Ming Tang, Tiantian Jing, Lin Wu, Yongzhong Liu

EBioMedicine. 2019 Mar; 41: 320–332. Published online 2019 Feb 7. doi: 10.1016/j.ebiom.2019.01.058

PMCID:: PMC6441868

Abstract Article PDF–7.0M

Select item 643346911.

N⁶-methyladenine DNA Modification in Glioblastoma

Qi Xie, Tao P. Wu, Ryan C. Gimple, Zheng Li, Briana C. Prager, Qiulian Wu, Yang Yu, Pengcheng Wang, Yinsheng Wang, David U. Gorkin, Cheng Zhang, Alexis V. Dowiak, Kaixuan Lin, Chun Zeng, Yinghui Sui, Leo J. Y. Kim, Tyler E. Miller, Li Jiang, Christine Lee-Poturalski, Zhi Huang, Xiaoguang Fang, Kui Zhai, Stephen C. Mack, Maike Sander, Shideng Bao, Amber E. Kerstetter-Fogle, Andrew E. Sloan, Andrew Z. Xiao, Jeremy N. Rich

Cell. Author manuscript; available in PMC 2019 Nov 15.

Published in final edited form as: Cell. 2018 Nov 15; 175(5): 1228–1243.e20. Published online 2018 Nov 1. doi: 10.1016/j.cell.2018.10.006

PMCID:: PMC6433469

Abstract Article PDF–3.5M

Select item 629451712.

Single-nucleotide-resolution sequencing of human N⁶-methyldeoxyadenosine reveals strand-asymmetric clusters associated with SSBP1 on the mitochondrial genome

Casslynn W Q Koh, Yeek Teck Goh, Joel D W Toh, Suat Peng Neo, Sarah B Ng, Jayantha Gunaratne, Yong-Gui Gao, Stephen R Quake, William F Burkholder, Wee Siong S Goh

Nucleic Acids Res. 2018 Dec 14; 46(22): 11659–11670. Published online 2018 Nov 9. doi: 10.1093/nar/gky1104

PMCID:: PMC6294517

Abstract Article PDF–5.6M

Select item 589141713.

Proteomic profiling of VCP substrates links VCP to K6‐linked ubiquitylation and c‐Myc function

Jan B Heidelberger, Andrea Voigt, Marina E Borisova, Giuseppe Petrosino, Stefanie Ruf, Sebastian A Wagner, Petra Beli

EMBO Rep. 2018 Apr; 19(4): e44754. Published online 2018 Feb 21. doi: 10.15252/embr.201744754

PMCID:: PMC5891417

Abstract Article PDF–1.0M

Select item 573640314.

Characterization of human AlkB homolog 1 produced in mammalian cells and demonstration of mitochondrial dysfunction in ALKBH1-deficient cells

Tina A. Müller, Sarah L. Struble, Katheryn Meek, Robert P. Hausinger

Biochem Biophys Res Commun. Author manuscript; available in PMC 2019 Jan 1.

Published in final edited form as: Biochem Biophys Res Commun. 2018 Jan 1; 495(1): 98–103. Published online 2017 Oct 31. doi: 10.1016/j.bbrc.2017.10.158

PMCID:: PMC5736403

Abstract Article PDF–540K

Select item 549954515.

ALKBH1 is an RNA dioxygenase responsible for cytoplasmic and mitochondrial tRNA modifications

Layla Kawarada, Takeo Suzuki, Takayuki Ohira, Shoji Hirata, Kenjyo Miyauchi, Tsutomu Suzuki

Nucleic Acids Res. 2017 Jul 7; 45(12): 7401–7415. Published online 2017 May 2. doi: 10.1093/nar/gkx354

PMCID:: PMC5499545

Abstract Article PDF–2.2M

Select item 544438716.

Biochemical characterization of AP lyase and m⁶A demethylase activities of human AlkB homolog 1 (ALKBH1)

Tina A. Müller, Michael A. Tobar, Madison N. Perian, Robert P. Hausinger

Biochemistry. Author manuscript; available in PMC 2018 Apr 4.

Published in final edited form as: Biochemistry. 2017 Apr 4; 56(13): 1899–1910. Published online 2017 Mar 21. doi: 10.1021/acs.biochem.7b00060

PMCID:: PMC5444387

Abstract Article PDF–755K

Select item 511977317.

ALKBH1-Mediated tRNA Demethylation Regulates Translation

Fange Liu, Wesley Clark, Guanzheng Luo, Xiaoyun Wang, Ye Fu, Jiangbo Wei, Xiao Wang, Ziyang Hao, Qing Dai, Guanqun Zheng, Honghui Ma, Dali Han, Molly Evans, Arne Klungland, Tao Pan, Chuan He

Cell. Author manuscript; available in PMC 2017 Oct 20.

Published in final edited form as: Cell. 2016 Oct 20; 167(3): 816–828.e16. Published online 2016 Oct 13. doi: 10.1016/j.cell.2016.09.038

PMCID:: PMC5119773

Abstract Article PDF–1.2M

Select item 504834618.

NSUN3 and ABH1 modify the wobble position of mt‐tRNA^Met to expand codon recognition in mitochondrial translation

Sara Haag, Katherine E Sloan, Namit Ranjan, Ahmed S Warda, Jens Kretschmer, Charlotte Blessing, Benedikt Hübner, Jan Seikowski, Sven Dennerlein, Peter Rehling, Marina V Rodnina, Claudia Höbartner, Markus T Bohnsack

EMBO J. 2016 Oct 4; 35(19): 2104–2119. Published online 2016 Aug 6. doi: 10.15252/embj.201694885

PMCID:: PMC5048346

Abstract Article PDF–1.9M

Select item 454363519.

The AlkB Family of Fe(II)/α-Ketoglutarate-dependent Dioxygenases: Repairing Nucleic Acid Alkylation Damage and Beyond

Bogdan I. Fedeles, Vipender Singh, James C. Delaney, Deyu Li, John M. Essigmann

J Biol Chem. 2015 Aug 21; 290(34): 20734–20742. Published online 2015 Jul 7. doi: 10.1074/jbc.R115.656462

PMCID:: PMC4543635

Abstract Article PDF–1.6M

Select item 412616720.

A Covalent Protein-DNA 5′-Product Adduct is Generated Following AP Lyase Activity of Human AlkB Homolog 1 (ALKBH1)

Tina A. Müller, Megan M. Andrzejak, Robert P. Hausinger

Biochem J. Author manuscript; available in PMC 2014 Aug 8.

Published in final edited form as: Biochem J. 2013 Jun 15; 452(3): 509–518. doi: 10.1042/BJ20121908

PMCID:: PMC4126167

Abstract Article PDF–1.1M

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