PMC Links for GEO Profiles (Select 59283632) - PMC

Select item 98448531.

The LHX2-OTX2 transcriptional regulatory module controls retinal pigmented epithelium differentiation and underlies genetic risk for age-related macular degeneration

Mazal Cohen-Gulkar, Ahuvit David, Naama Messika-Gold, Mai Eshel, Shai Ovadia, Nitay Zuk-Bar, Maria Idelson, Yamit Cohen-Tayar, Benjamin Reubinoff, Tamar Ziv, Meir Shamay, Ran Elkon, Ruth Ashery-Padan

PLoS Biol. 2023 Jan; 21(1): e3001924. Published online 2023 Jan 17. doi: 10.1371/journal.pbio.3001924

PMCID:: PMC9844853

Abstract Article PDF–2.8M

Select item 95199042.

LHX2 facilitates the progression of nasopharyngeal carcinoma via activation of the FGF1/FGFR axis

Tao Xie, Kunpeng Du, Wei Liu, Chunshan Liu, Baiyao Wang, Yunhong Tian, Rong Li, Xiaoting Huang, Jie Lin, Haifeng Jian, Jian Zhang, Yawei Yuan

Br J Cancer. 2022 Oct 19; 127(7): 1239–1253. Published online 2022 Jul 21. doi: 10.1038/s41416-022-01902-7

PMCID:: PMC9519904

Abstract Article PDF–7.0M

Select item 88288953.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 71699835.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 68744326.

LHX2 promotes malignancy and inhibits autophagy via mTOR in osteosarcoma and is negatively regulated by miR-129-5p

Honghai Song, Jiaming Liu, Xin Wu, Yang Zhou, Xuanyin Chen, Jiangwei Chen, Keyu Deng, Chunxia Mao, Shanhu Huang, Zhili Liu

Aging (Albany NY) 2019 Nov 15; 11(21): 9794–9810. Published online 2019 Nov 13. doi: 10.18632/aging.102427

PMCID:: PMC6874432

Abstract Article PDF–5.7M

Select item 63761337.

LIM homeobox 2 promotes interaction between human iPS-derived hepatic progenitors and iPS-derived hepatic stellate-like cells

Masato Miyoshi, Sei Kakinuma, Akihide Kamiya, Tomoyuki Tsunoda, Jun Tsuchiya, Ayako Sato, Shun Kaneko, Sayuri Nitta, Fukiko Kawai-Kitahata, Miyako Murakawa, Yasuhiro Itsui, Mina Nakagawa, Seishin Azuma, Hiromitsu Nakauchi, Yasuhiro Asahina, Mamoru Watanabe

Sci Rep. 2019; 9: 2072. Published online 2019 Feb 14. doi: 10.1038/s41598-018-37430-9

PMCID:: PMC6376133

Abstract Article PDF–6.0M

Select item 55285418.

LIM‐homeobox gene 2 promotes tumor growth and metastasis by inducing autocrine and paracrine PDGF‐B signaling

Aleksandar Kuzmanov, Ulrike Hopfer, Patricia Marti, Nathalie Meyer-Schaller, Mahmut Yilmaz, Gerhard Christofori

Mol Oncol. 2014 Mar; 8(2): 401–416. Published online 2013 Dec 25. doi: 10.1016/j.molonc.2013.12.009

PMCID:: PMC5528541

Abstract Article PDF–4.7M

Select item 46624749.

miR-1238 inhibits cell proliferation by targeting LHX2 in non-small cell lung cancer

Xiangguang Shi, Lei Zhan, Can Xiao, Zhe Lei, Haiping Yang, Longqiang Wang, Jun Zhao, Hong-Tao Zhang

Oncotarget. 2015 Aug 7; 6(22): 19043–19054. Published online 2015 May 22. doi: 10.18632/oncotarget.4232

PMCID:: PMC4662474

Abstract Article PDF–5.4M

Select item 426110310.

The LIM Homeodomain Factor Lhx2 Is Required for Hypothalamic Tanycyte Specification and Differentiation

Juan Salvatierra, Daniel A. Lee, Cristina Zibetti, Maria Duran-Moreno, Sooyeon Yoo, Elizabeth A. Newman, Hong Wang, Joseph L. Bedont, Jimmy de Melo, Ana L. Miranda-Angulo, Sara Gil-Perotin, Jose Manuel Garcia-Verdugo, Seth Blackshaw

J Neurosci. 2014 Dec 10; 34(50): 16809–16820. doi: 10.1523/JNEUROSCI.1711-14.2014

PMCID:: PMC4261103

Abstract Article PDF–5.1M

Select item 397762411.

Lhx2 Regulates the Development of the Forebrain Hem System

Achira Roy, Miriam Gonzalez-Gomez, Alessandra Pierani, Gundela Meyer, Shubha Tole

Cereb Cortex. 2014 May; 24(5): 1361–1372. Published online 2013 Jan 10. doi: 10.1093/cercor/bhs421

PMCID:: PMC3977624

Abstract Article PDF–19M

Select item 376355012.

LHX2 regulates the neural differentiation of human embryonic stem cells via transcriptional modulation of PAX6 and CER1

Pei-Shan Hou, Ching-Yu Chuang, Cheng-Fu Kao, Shen-Ju Chou, Lee Stone, Hong-Nerng Ho, Chung-Liang Chien, Hung-Chih Kuo

Nucleic Acids Res. 2013 Sep; 41(16): 7753–7770. Published online 2013 Jun 25. doi: 10.1093/nar/gkt567

PMCID:: PMC3763550

Abstract Article PDF–24M

Select item 374444313.

Genome-Wide Association of Body Fat Distribution in African Ancestry Populations Suggests New Loci

Ching-Ti Liu, Keri L. Monda, Kira C. Taylor, Leslie Lange, Ellen W. Demerath, Walter Palmas, Mary K. Wojczynski, Jaclyn C. Ellis, Mara Z. Vitolins, Simin Liu, George J. Papanicolaou, Marguerite R. Irvin, Luting Xue, Paula J. Griffin, Michael A. Nalls, Adebowale Adeyemo, Jiankang Liu, Guo Li, Edward A. Ruiz-Narvaez, Wei-Min Chen, Fang Chen, Brian E. Henderson, Robert C. Millikan, Christine B. Ambrosone, Sara S. Strom, Xiuqing Guo, Jeanette S. Andrews, Yan V. Sun, Thomas H. Mosley, Lisa R. Yanek, Daniel Shriner, Talin Haritunians, Jerome I. Rotter, Elizabeth K. Speliotes, Megan Smith, Lynn Rosenberg, Josyf Mychaleckyj, Uma Nayak, Ida Spruill, W. Timothy Garvey, Curtis Pettaway, Sarah Nyante, Elisa V. Bandera, Angela F. Britton, Alan B. Zonderman, Laura J. Rasmussen-Torvik, Yii-Der Ida Chen, Jingzhong Ding, Kurt Lohman, Stephen B. Kritchevsky, Wei Zhao, Patricia A. Peyser, Sharon L. R. Kardia, Edmond Kabagambe, Ulrich Broeckel, Guanjie Chen, Jie Zhou, Sylvia Wassertheil-Smoller, Marian L. Neuhouser, Evadnie Rampersaud, Bruce Psaty, Charles Kooperberg, JoAnn E. Manson, Lewis H. Kuller, Heather M. Ochs-Balcom, Karen C. Johnson, Lara Sucheston, Jose M. Ordovas, Julie R. Palmer, Christopher A. Haiman, Barbara McKnight, Barbara V. Howard, Diane M. Becker, Lawrence F. Bielak, Yongmei Liu, Matthew A. Allison, Struan F. A. Grant, Gregory L. Burke, Sanjay R. Patel, Pamela J. Schreiner, Ingrid B. Borecki, Michele K. Evans, Herman Taylor, Michele M. Sale, Virginia Howard, Christopher S. Carlson, Charles N. Rotimi, Mary Cushman, Tamara B. Harris, Alexander P. Reiner, L. Adrienne Cupples, Kari E. North, Caroline S. Fox

PLoS Genet. 2013 Aug; 9(8): e1003681. Published online 2013 Aug 15. doi: 10.1371/journal.pgen.1003681

PMCID:: PMC3744443

Abstract Article PDF–2.2M

Select item 317805914.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 301265115.

Mutations in the LHX2 gene are not a frequent cause of micro/anophthalmia

Annaïck Desmaison, Adeline Vigouroux, Claudine Rieubland, Christine Peres, Patrick Calvas, Nicolas Chassaing

Mol Vis. 2010; 16: 2847–2849. Published online 2010 Dec 18.

PMCID:: PMC3012651

Abstract Article PDF–2.5M

Select item 296529516.

Candidate Gene Sequencing of LHX2, HESX1, and SOX2 in a Large Schizencephaly Cohort

Cecilia Mellado, Annapurna Poduri, Danielle Gleason, Princess C Elhosary, Brenda J Barry, Jennifer N Partlow, Bernard S Chang, Gary M Shaw, A James Barkovich, Christopher A Walsh

Am J Med Genet A. 2010 Nov; 152A(11): 2736–2742. Published online 2010 Oct 11. doi: 10.1002/ajmg.a.33684