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Select item 100278301.

Sialoadhesin (CD169/Siglec-1) is an extended molecule that escapes inhibitory cis-interactions and synergizes with other macrophage receptors to promote phagocytosis

Mariliis Klaas, Stuart Dubock, David J. P. Ferguson, Paul R. Crocker

Glycoconj J. 2023; 40(2): 213–223. Published online 2023 Feb 4. doi: 10.1007/s10719-022-10097-1

PMCID:: PMC10027830

Abstract Article PDF–2.2M

Select item 96329192.

CD169-mediated restrictive SARS-CoV-2 infection of macrophages induces pro-inflammatory responses

Sallieu Jalloh, Judith Olejnik, Jacob Berrigan, Annuurun Nisa, Ellen L. Suder, Hisashi Akiyama, Maohua Lei, Sita Ramaswamy, Sanjay Tyagi, Yuri Bushkin, Elke Mühlberger, Suryaram Gummuluru

PLoS Pathog. 2022 Oct; 18(10): e1010479. Published online 2022 Oct 24. doi: 10.1371/journal.ppat.1010479

PMCID:: PMC9632919

Abstract Article PDF–3.5M

Select item 90715683.

Siglec-1 expression on monocytes is associated with the interferon signature in juvenile dermatomyositis and can predict treatment response

Butsabong Lerkvaleekul, Saskia R Veldkamp, M Marlot van der Wal, Ellen J H Schatorjé, Sylvia S M Kamphuis, J Merlijn van den Berg, Petra C E Hissink Muller, Wineke Armbrust, Sebastiaan J Vastert, Judith Wienke, Marc H A Jansen, Annet van Royen-Kerkhof, Femke van Wijk

Rheumatology (Oxford) 2022 May; 61(5): 2144–2155. Published online 2021 Aug 13. doi: 10.1093/rheumatology/keab601

PMCID:: PMC9071568

Abstract Article PDF–896K

Select item 88600734.

SIGLEC1 enables straightforward assessment of type I interferon activity in idiopathic inflammatory myopathies

Manuel Graf, Sae Lim von Stuckrad, Akinori Uruha, Jens Klotsche, Lydia Zorn-Pauly, Nadine Unterwalder, Thomas Buttgereit, Martin Krusche, Christian Meisel, Gerd R Burmester, Falk Hiepe, Robert Biesen, Tilmann Kallinich, Werner Stenzel, Udo Schneider, Thomas Rose

RMD Open. 2022; 8(1): e001934. Published online 2022 Feb 17. doi: 10.1136/rmdopen-2021-001934

PMCID:: PMC8860073

Abstract Article PDF–907K

Select item 88069655.

Prognostic value of CD169-positive macrophages in various tumors: a meta-analysis

Weihao Kong, Meng Wei, Rongqiang Liu, Jianlin Zhang, Xingyu Wang

Bioengineered. 2021; 12(1): 8505–8514. Published online 2021 Oct 22. doi: 10.1080/21655979.2021.1985857

PMCID:: PMC8806965

Abstract Article PDF–536K

Select item 82656676.

CyTOF Profiling of Zika and Dengue Virus-Infected Human Peripheral Blood Mononuclear Cells Identifies Phenotypic Signatures of Monotype Subsets and Upregulation of the Interferon-Inducible Protein CD169

Rafael Fenutria, Kevin Maringer, Uma Potla, Dabeiba Bernal-Rubio, Matthew J. Evans, Eva Harris, Adeeb H. Rahman, Ana Fernandez-Sesma, Irene Ramos

mSphere. 2021 May-Jun; 6(3): e00505-21. Published online 2021 Jun 23. doi: 10.1128/mSphere.00505-21

PMCID:: PMC8265667

Abstract Article PDF–3.7M

Select item 81194137.

SIGLEC1 (CD169): a marker of active neuroinflammation in the brain but not in the blood of multiple sclerosis patients

Lennard Ostendorf, Philipp Dittert, Robert Biesen, Ankelien Duchow, Victoria Stiglbauer, Klemens Ruprecht, Judith Bellmann-Strobl, Dominik Seelow, Werner Stenzel, Raluca A. Niesner, Anja E. Hauser, Friedemann Paul, Helena Radbruch

Sci Rep. 2021; 11: 10299. Published online 2021 May 13. doi: 10.1038/s41598-021-89786-0

PMCID:: PMC8119413

Abstract Article PDF–1.9M

Select item 80235468.

CD169/SIGLEC1 is expressed on circulating monocytes in COVID-19 and expression levels are associated with disease severity

Jan-Moritz Doehn, Christoph Tabeling, Robert Biesen, Jacopo Saccomanno, Elena Madlung, Eva Pappe, Frieder Gabriel, Florian Kurth, Christian Meisel, Victor M. Corman, Leif G. Hanitsch, Sascha Treskatsch, Kathrin Heim, Miriam S. Stegemann, Christoph Ruwwe-Glösenkamp, Holger C. Müller-Redetzky, Alexander Uhrig, Rajan Somasundaram, Claudia Spies, Horst von Bernuth, Jörg Hofmann, Christian Drosten, Norbert Suttorp, Martin Witzenrath, Leif E. Sander, Ralf-Harto Hübner

Infection. 2021; 49(4): 757–762. Published online 2021 Apr 6. doi: 10.1007/s15010-021-01606-9

PMCID:: PMC8023546

Abstract Article PDF–650K

Select item 80144669.

CD169 and CD64 could help differentiate bacterial from CoVID‐19 or other viral infections in the Emergency Department

Pénélope Bourgoin, Thomas Soliveres, Alexandra Barbaresi, Anderson Loundou, Inès Ait Belkacem, Isabelle Arnoux, Denis Bernot, Marie Loosveld, Pierre‐Emmanuel Morange, Pierre Michelet, Fabrice Malergue, Thibaut Markarian

Cytometry A. 2021 May; 99(5): 435–445. Published online 2021 Feb 8. doi: 10.1002/cyto.a.24314

PMCID:: PMC8014466

Abstract Article PDF–1011K

Select item 801409410.

Monocyte CD169 expression in COVID‐19 patients upon intensive care unit admission

Marine Ortillon, Remy Coudereau, Martin Cour, Thomas Rimmelé, Marine Godignon, Morgane Gossez, Hodane Yonis, Laurent Argaud, Anne‐Claire Lukaszewicz, Fabienne Venet, Guillaume Monneret

Cytometry A. 2021 May; 99(5): 466–471. Published online 2021 Feb 5. doi: 10.1002/cyto.a.24315

PMCID:: PMC8014094

Abstract Article PDF–886K

Select item 780748511.

Dissemination of Mycobacterium tuberculosis is associated to a SIGLEC1 null variant that limits antigen exchange via trafficking extracellular vesicles

Susana Benet, Cristina Gálvez, Francis Drobniewski, Irina Kontsevaya, Lilibeth Arias, Marta Monguió‐Tortajada, Itziar Erkizia, Victor Urrea, Ruo‐Yan Ong, Marina Luquin, Maeva Dupont, Jakub Chojnacki, Judith Dalmau, Paula Cardona, Olivier Neyrolles, Geanncarlo Lugo‐Villarino, Christel Vérollet, Esther Julián, Hansjakob Furrer, Huldrych F. Günthard, Paul R. Crocker, Gustavo Tapia, Francesc E. Borràs, Jacques Fellay, Paul J. McLaren, Amalio Telenti, Pere‐Joan Cardona, Bonaventura Clotet, Cristina Vilaplana, Javier Martinez‐Picado, Nuria Izquierdo‐Useros

J Extracell Vesicles. 2021 Jan; 10(3): e12046. Published online 2021 Jan 14. doi: 10.1002/jev2.12046

PMCID:: PMC7807485

Abstract Article PDF–2.5M

Select item 771734712.

Monocyte CD169 expression as a biomarker in the early diagnosis of COVID-19

Anne-Sophie Bedin, Alain Makinson, Marie-Christine Picot, Frank Mennechet, Fabrice Malergue, Amandine Pisoni, Esperance Nyiramigisha, Lise Montagnier, Karine Bollore, Ségolène Debiesse, David Morquin, Penelope Bourgoin, Nicolas Veyrenche, Constance Renault, Vincent Foulongne, Caroline Bret, Arnaud Bourdin, Vincent Le Moing, Philippe Van de Perre, Edouard Tuaillon

J Infect Dis. 2020 Nov 18 : jiaa724. Published online 2020 Nov 18. doi: 10.1093/infdis/jiaa724

Correction in:: J Infect Dis. 2022 Feb 15; 225(4): 744.

PMCID:: PMC7717347

Abstract PDF–646K

Select item 768479613.

SIGLEC1 (CD169) is a sensitive biomarker for the deterioration of the clinical course in childhood systemic lupus erythematosus

Sae Lim von Stuckrad, Jens Klotsche, Robert Biesen, Mareike Lieber, Julia Thumfart, Christian Meisel, Nadine Unterwalder, Tilmann Kallinich

Lupus. 2020 Dec; 29(14): 1914–1925. Published online 2020 Oct 20. doi: 10.1177/0961203320965699

PMCID:: PMC7684796

Abstract Article PDF–573K

Select item 765717414.

CD169‐positive macrophages in regional lymph nodes are associated with a favorable prognosis in patients with colorectal carcinoma

Koji Ohnishi, Yoshihiro Komohara, Yoichi Saito, Yuji Miyamoto, Masayuki Watanabe, Hideo Baba, Motohiro Takeya

Cancer Sci. 2013 Sep; 104(9): 1237–1244. Published online 2013 Jul 9. doi: 10.1111/cas.12212

PMCID:: PMC7657174

Abstract Article PDF–2.1M

Select item 717396315.

Tuberculosis-associated IFN-I induces Siglec-1 on tunneling nanotubes and favors HIV-1 spread in macrophages

Maeva Dupont, Shanti Souriant, Luciana Balboa, Thien-Phong Vu Manh, Karine Pingris, Stella Rousset, Céline Cougoule, Yoann Rombouts, Renaud Poincloux, Myriam Ben Neji, Carolina Allers, Deepak Kaushal, Marcelo J Kuroda, Susana Benet, Javier Martinez-Picado, Nuria Izquierdo-Useros, Maria del Carmen Sasiain, Isabelle Maridonneau-Parini, Olivier Neyrolles, Christel Vérollet, Geanncarlo Lugo-Villarino

eLife. 2020; 9: e52535. Published online 2020 Mar 30. doi: 10.7554/eLife.52535

PMCID:: PMC7173963

Abstract Article PDF–4.0M

Select item 698602416.

Decreased expression of a phagocytic receptor Siglec-1 on alveolar macrophages in chronic obstructive pulmonary disease

Atsushi Tanno, Naoya Fujino, Mitsuhiro Yamada, Hisatoshi Sugiura, Taizou Hirano, Rie Tanaka, Hirohito Sano, Satoshi Suzuki, Yoshinori Okada, Masakazu Ichinose

Respir Res. 2020; 21: 30. Published online 2020 Jan 28. doi: 10.1186/s12931-020-1297-2

PMCID:: PMC6986024

Abstract Article PDF–1.8M

Select item 694204417.

Systematic bromodomain protein screens identify homologous recombination and R-loop suppression pathways involved in genome integrity

Jae Jin Kim, Seo Yun Lee, Fade Gong, Anna M. Battenhouse, Daniel R. Boutz, Aarti Bashyal, Samantha T. Refvik, Cheng-Ming Chiang, Blerta Xhemalce, Tanya T. Paull, Jennifer S. Brodbelt, Edward M. Marcotte, Kyle M. Miller

Genes Dev. 2019 Dec 1; 33(23-24): 1751–1774. doi: 10.1101/gad.331231.119

PMCID:: PMC6942044

Abstract Article PDF–10M

Select item 681513618.

Constitutive Siglec-1 expression confers susceptibility to HIV-1 infection of human dendritic cell precursors

Nicolas Ruffin, Ester Gea-Mallorquí, Flavien Brouiller, Mabel Jouve, Aymeric Silvin, Peter See, Charles-Antoine Dutertre, Florent Ginhoux, Philippe Benaroch

Proc Natl Acad Sci U S A. 2019 Oct 22; 116(43): 21685–21693. Published online 2019 Oct 7. doi: 10.1073/pnas.1911007116

PMCID:: PMC6815136

Abstract Article PDF–1.9M

Select item 594759419.

Siglec‐1 inhibits RSV‐induced interferon gamma production by adult T cells in contrast to newborn T cells

Jop Jans, Wendy W.J. Unger, Marloes Vissers, Inge M.L. Ahout, Inge Schreurs, Arthur Wickenhagen, Ronald de Groot, Marien I. de Jonge, Gerben Ferwerda

Eur J Immunol. 2018 Apr; 48(4): 621–631. Published online 2018 Jan 18. doi: 10.1002/eji.201747161

PMCID:: PMC5947594

Abstract Article PDF–2.0M

Select item 565690720.

Reduced number of CD169⁺ macrophages in pre‐metastatic regional lymph nodes is associated with subsequent metastatic disease in an animal model and with poor outcome in prostate cancer patients

Kerstin Strömvall, Kristoffer Sundkvist, Börje Ljungberg, Sofia Halin Bergström, Anders Bergh

Prostate. 2017 Nov 1; 77(15): 1468–1477. Published online 2017 Sep 7. doi: 10.1002/pros.23407

PMCID:: PMC5656907

Abstract Article PDF–1.9M

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