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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 111099572.

SIRT2 promotes base excision repair by transcriptionally activating OGG1 in an ATM/ATR-dependent manner

Anke Geng, Jiahui Sun, Huanyin Tang, Yang Yu, Xiyue Wang, Jingyuan Zhang, Xiaona Wang, Xiaoxiang Sun, Xiaofang Zhou, Neng Gao, Rong Tan, Zhu Xu, Ying Jiang, Zhiyong Mao

Nucleic Acids Res. 2024 May 22; 52(9): 5107–5120. Published online 2024 Mar 30. doi: 10.1093/nar/gkae190

PMCID:: PMC11109957

Abstract Article PDF–2.3M

Select item 109454903.

沉默信息调节因子2在胆管癌中的表达及其对可切除胆管癌患者预后的预测价值

王威, 季文斌, 吕振宇, 孙万亮, 邵玉, 刘静, 杨燕

Zhejiang Da Xue Xue Bao Yi Xue Ban. 2024 Feb 25; 53(1): 98–107. Chinese. Published online 2023 Dec 5. doi: 10.3724/zdxbyxb-2023-0413

PMCID:: PMC10945490

Abstract Article PDF–5.8M

Select item 107946444.

Decoding the multifaceted interventions between human sirtuin 2 and dynamic hepatitis B viral proteins to confirm their roles in HBV replication

Zahra Zahid Piracha, Umar Saeed, Irfan Ellahi Piracha, Seneen Noor, Elyeen Noor

Front Cell Infect Microbiol. 2023; 13: 1234903. Published online 2024 Jan 4. doi: 10.3389/fcimb.2023.1234903

PMCID:: PMC10794644

Abstract Article PDF–787K

Select item 107869075.

FBXO31 is upregulated by METTL3 to promote pancreatic cancer progression via regulating SIRT2 ubiquitination and degradation

Kai Chen, Yue Wang, Xingna Dai, Jingjing Luo, Shangshang Hu, Zhihui Zhou, Jinglong Shi, Xueshan Pan, Tong Cao, Jun Xia, Yuyun Li, Zhiwei Wang, Jia Ma

Cell Death Dis. 2024 Jan; 15(1): 37. Published online 2024 Jan 12. doi: 10.1038/s41419-024-06425-y

PMCID:: PMC10786907

Abstract Article PDF–5.1M

Select item 107345356.

Sirtuin 2 promotes human cytomegalovirus replication by regulating cell cycle progression

Cora N. Betsinger, Joshua L. Justice, Matthew D. Tyl, Julia E. Edgar, Hanna G. Budayeva, Yaa F. Abu, Ileana M. Cristea

mSystems. 2023 Nov-Dec; 8(6): e00510-23. Published online 2023 Nov 2. doi: 10.1128/msystems.00510-23

PMCID:: PMC10734535

Abstract Article PDF–4.5M

Select item 107024277.

Effects of Dimerization on the Deacylase Activities of Human SIRT2

Jie Yang, Nathan I. Nicely, Brian P. Weiser

Biochemistry. 2023 Dec 5; 62(23): 3383–3395. Published online 2023 Nov 15. doi: 10.1021/acs.biochem.3c00381

PMCID:: PMC10702427

Abstract Article PDF–9.2M

Select item 106016658.

Pro-Inflammatory of PRDM1/SIRT2/NLRP3 Axis in Monosodium Urate-Induced Acute Gouty Arthritis

Qingsong Zhao, Nan Xia, Jinmei Xu, Yingnan Wang, Luwen Feng, Dihan Su, Zhifeng Cheng

J Innate Immun. 2023 Jan-Dec; 15(1): 614–628. Published online 2023 Jun 29. doi: 10.1159/000530966

PMCID:: PMC10601665

Abstract Article PDF–1.8M

Select item 105423819.

SIRT2 alleviated renal fibrosis by deacetylating SMAD2 and SMAD3 in renal tubular epithelial cells

Shu Yang, Guangyan Yang, Xinyu Wang, Jiaqing Xiang, Lin Kang, Zhen Liang

Cell Death Dis. 2023 Sep; 14(9): 646. Published online 2023 Sep 30. doi: 10.1038/s41419-023-06169-1

PMCID:: PMC10542381

Abstract Article PDF–21M

Select item 1045017010.

DNA-PK is activated by SIRT2 deacetylation to promote DNA double-strand break repair by non-homologous end joining

PamelaSara E Head, Priya Kapoor-Vazirani, Ganji P Nagaraju, Hui Zhang, Sandip K Rath, Nho C Luong, Ramona Haji-Seyed-Javadi, Fatmata Sesay, Shi-Ya Wang, Duc M Duong, Waaqo Daddacha, Elizabeth V Minten, Boying Song, Diana Danelia, Xu Liu, Shuyi Li, Eric A Ortlund, Nicholas T Seyfried, David M Smalley, Ya Wang, Xingming Deng, William S Dynan, Bassel El-Rayes, Anthony J Davis, David S Yu

Nucleic Acids Res. 2023 Aug 25; 51(15): 7972–7987. Published online 2023 Jul 3. doi: 10.1093/nar/gkad549

Correction in:: Nucleic Acids Res. 2023 Sep 22; 51(17): 9507.

PMCID:: PMC10450170

Abstract Article PDF–2.2M

Select item 1022942811.

SIRT2 regulates extracellular vesicle-mediated liver–bone communication

Longshuai Lin, Zengya Guo, Enjun He, Xidai Long, Difei Wang, Yingting Zhang, Weihong Guo, Qian Wei, Wei He, Wanying Wu, Jingchi Li, Lulu Wo, Dengli Hong, Junke Zheng, Ming He, Qinghua Zhao

Nat Metab. 2023; 5(5): 821–841. Published online 2023 May 15. doi: 10.1038/s42255-023-00803-0

PMCID:: PMC10229428

Abstract Article PDF–21M

Select item 1019613712.

SIRT2 plays complex roles in neuroinflammation neuroimmunology-associated disorders

Wenmei Lu, Haonan Ji, Danhong Wu

Front Immunol. 2023; 14: 1174180. Published online 2023 May 5. doi: 10.3389/fimmu.2023.1174180

PMCID:: PMC10196137

Abstract Article PDF–2.4M

Select item 1015361113.

Frequency of the rs2015 (T>G) and rs2241703 (G>A) polymorphisms in the miRNA-SIRT2 gene in type 2 diabetes mellitus in Saudi Arabia

Nahla A. Alshaikh, Siddig I. Abdelwahab, Mahmoud M. Habibullah, Ahmed A. Jerah, Mohammed A. Bakri, Yahia A. Kaabi

Saudi Med J. 2023 Apr; 44(4): 363–367. doi: 10.15537/smj.2023.44.4.20220863

PMCID:: PMC10153611

Abstract Article PDF–410K

Select item 987567714.

Promotion of Lung Cancer Metastasis by SIRT2‐Mediated Extracellular Protein Deacetylation

Meng Wu, Jian‐Bin Zhang, Yi‐Wei Xiong, Yong‐Xu Zhao, Meng‐Ge Zheng, Xia‐Li Huang, Fang Huang, Xing‐Xing Wu, Xue Li, Wei‐Jiao Fan, Lin Hu, Yuan‐Yuan Zeng, Xia‐Ju Cheng, Ji‐Cheng Yue, Juan‐Juan Du, Nan‐Nan Chen, Wen‐Xiang Wei, Qing‐Hua Yao, Xiao‐mei Lu, Chao Huang, Jiong Deng, Zhi‐Jie Chang, He‐Bin Liu, Ting C. Zhao, Y. Eugene Chinn

Adv Sci (Weinh) 2023 Jan; 10(3): 2205462. Published online 2022 Dec 1. doi: 10.1002/advs.202205462

PMCID:: PMC9875677

Abstract Article PDF–7.4M

Select item 964053615.

SIRT2 promotes the viability, invasion and metastasis of osteosarcoma cells by inhibiting the degradation of Snail

Yonghao Tian, Ruijuan Liu, Xiaoyan Hou, Zhixiao Gao, Xinyu Liu, Weifang Zhang

Cell Death Dis. 2022 Nov; 13(11): 935. Published online 2022 Nov 7. doi: 10.1038/s41419-022-05388-2

PMCID:: PMC9640536

Abstract Article PDF–4.1M

Select item 951327116.

Proximity labeling of endogenous RICTOR identifies mTOR complex 2 regulation by ADP ribosylation factor ARF1

Amelia K. Luciano, Ekaterina D. Korobkina, Scott P. Lyons, John A. Haley, Shelagh M. Fluharty, Su Myung Jung, Arminja N. Kettenbach, David A. Guertin

J Biol Chem. 2022 Oct; 298(10): 102379. Published online 2022 Aug 13. doi: 10.1016/j.jbc.2022.102379

PMCID:: PMC9513271

Abstract Article PDF–2.7M

Select item 937865817.

Sirt2 promotes white matter oligodendrogenesis during development and in models of neonatal hypoxia

Beata Jablonska, Katrina L. Adams, Panagiotis Kratimenos, Zhen Li, Emma Strickland, Tarik F. Haydar, Katharina Kusch, Klaus-Armin Nave, Vittorio Gallo

Nat Commun. 2022; 13: 4771. Published online 2022 Aug 15. doi: 10.1038/s41467-022-32462-2

PMCID:: PMC9378658

Abstract Article PDF–12M

Select item 926261418.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 915179519.

The deacetylase SIRT2 contributes to autoimmune disease pathogenesis by modulating IL-17A and IL-2 transcription

Ryo Hisada, Nobuya Yoshida, Masataka Umeda, Catalina Burbano, Rhea Bhargava, Marc Scherlinger, Michihito Kono, Vasileios C. Kyttaris, Suzanne Krishfield, George C. Tsokos

Cell Mol Immunol. 2022 Jun; 19(6): 738–750. Published online 2022 May 6. doi: 10.1038/s41423-022-00874-1

PMCID:: PMC9151795

Abstract Article PDF–3.8M

Select item 890734420.

Quantitative proteomic analysis of the lysine acetylome reveals diverse SIRT2 substrates

Hui Zhang, Eric B. Dammer, Duc M. Duong, Diana Danelia, Nicholas T. Seyfried, David S. Yu

Sci Rep. 2022; 12: 3822. Published online 2022 Mar 9. doi: 10.1038/s41598-022-06793-5

PMCID:: PMC8907344

Abstract Article PDF–5.0M

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