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Select item 110506331.

Myeloid Cell-Derived IL-1 Signaling Damps Neuregulin-1 from Fibroblasts to Suppress Colitis-Induced Early Repair of the Intestinal Epithelium

Ding Qiu, Shaoting Xu, Kaile Ji, Ce Tang

Int J Mol Sci. 2024 Apr; 25(8): 4469. Published online 2024 Apr 18. doi: 10.3390/ijms25084469

PMCID:: PMC11050633

Abstract Article PDF–7.6M

Select item 109118052.

Adipocyte Precursor-Derived NRG1 Promotes Resistance to FGFR Inhibition in Urothelial Carcinoma

Sana Hosni, Viola Kilian, Niklas Klümper, Daniela Gabbia, Katharina Sieckmann, Dillon Corvino, Anja Winkler, Miriam Saponaro, Karin Wörsdörfer, Doris Schmidt, Oliver Hahn, Ilaria Zanotto, Marina Bertlich, Marieta Toma, Tobias Bald, Markus Eckstein, Michael Hölzel, Matthias Geyer, Manuel Ritter, Dagmar Wachten, Sara De Martin, Abdullah Alajati

Cancer Res. 2024 Mar 4; 84(5): 725–740. Published online 2024 Jan 4. doi: 10.1158/0008-5472.CAN-23-1398

PMCID:: PMC10911805

Abstract Article PDF–18M

Select item 108758263.

Neuregulin-1 and ALS19 (ERBB4): at the crossroads of amyotrophic lateral sclerosis and cancer

Jacob J. Adashek, Chinmayi Pandya, Nicholas J. Maragakis, Pradip De, Philip R. Cohen, Shumei Kato, Razelle Kurzrock

BMC Med. 2024; 22: 74. Published online 2024 Feb 19. doi: 10.1186/s12916-024-03293-3

PMCID:: PMC10875826

Abstract Article PDF–2.2M

Select item 108680914.

The involvement of Neuregulin-1 in the process of facial nerve injury repair through the utilization of dental pulp stem cells

Lihong Yao, Wanqiu Xu, Lixue Liu, Xiaohang Xu, Hualei Xi, Bing Xue, Xiaofang Cao, Song Lin, Guiyan Piao, Jian Sun, Xiumei Wang

BMC Oral Health. 2024; 24: 238. Published online 2024 Feb 14. doi: 10.1186/s12903-024-03953-z

PMCID:: PMC10868091

Abstract Article PDF–12M

Select item 108515005.

Diagnostic potential of NRG1 in benign nerve sheath tumors and its influence on the PI3K-Akt signaling and tumor immunity

Suwei Yan, Jingnan Zhao, Pengyang Gao, Zhaoxu Li, Zhao Li, Xiaobing Liu, Pengfei Wang

Diagn Pathol. 2024; 19: 28. Published online 2024 Feb 8. doi: 10.1186/s13000-024-01438-9

PMCID:: PMC10851500

Abstract Article PDF–10M

Select item 105030406.

Is neuregulin-1 (NRG-1) a potential blood biomarker linking depression to obesity? A case-control study

Heba Ahmed Abdelaziz, Tamer Nabil Abdelbaki, Yomna E. Dean, Sara Assem

BMC Psychiatry. 2023; 23: 670. Published online 2023 Sep 14. doi: 10.1186/s12888-023-05160-6

PMCID:: PMC10503040

Abstract Article PDF–2.0M

Select item 104488327.

Neuregulin-1 Attenuates Hemolysis- and Ischemia Induced-Cerebrovascular Inflammation Associated with Sickle Cell Disease

Christopher Chambliss, Jonathan K. Stiles, Beatrice E. Gee

J Stroke Cerebrovasc Dis. Author manuscript; available in PMC 2024 Feb 1.

Published in final edited form as: J Stroke Cerebrovasc Dis. 2023 Feb; 32(2): 106912. Published online 2022 Dec 5. doi: 10.1016/j.jstrokecerebrovasdis.2022.106912

PMCID:: PMC10448832

Abstract Article PDF–4.6M

Select item 101104008.

Fibroblast-derived EGF ligand neuregulin 1 induces fetal-like reprogramming of the intestinal epithelium without supporting tumorigenic growth

Toni T. Lemmetyinen, Emma W. Viitala, Linnea Wartiovaara, Tuomas Kaprio, Jaana Hagström, Caj Haglund, Pekka Katajisto, Timothy C. Wang, Eva Domènech-Moreno, Saara Ollila

Dis Model Mech. 2023 Apr 1; 16(4): dmm049692. Published online 2023 Apr 3. doi: 10.1242/dmm.049692

PMCID:: PMC10110400

Abstract Article

Select item 100617919.

Boosting neuregulin 1 type-III expression hastens SMA motor axon maturation

Lingling Kong, Cera W. Hassinan, Florian Gerstner, Jannik M. Buettner, Jeffrey B. Petigrow, David O. Valdivia, Michelle H. Chan-Cortés, Amy Mistri, Annie Cao, Scott Alan McGaugh, Madeline Denton, Stephen Brown, Joshua Ross, Markus H. Schwab, Christian M. Simon, Charlotte J. Sumner

Acta Neuropathol Commun. 2023; 11: 53. Published online 2023 Mar 30. doi: 10.1186/s40478-023-01551-8

PMCID:: PMC10061791

Abstract Article PDF–2.0M

Select item 992246810.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Abstract Article PDF–4.9M

Select item 929818011.

Structures of the HER2/HER3/NRG1β complex reveal a dynamic dimer interface

Devan Diwanji, Raphael Trenker, Tarjani M. Thaker, Feng Wang, David A. Agard, Kliment A. Verba, Natalia Jura

Nature. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: Nature. 2021 Dec; 600(7888): 339–343. Published online 2021 Nov 10. doi: 10.1038/s41586-021-04084-z

Correction in:: Nature. 2022 Feb 7

PMCID:: PMC9298180

Abstract Article PDF–5.8M

Select item 903524712.

AXL regulates neuregulin1 expression leading to cetuximab resistance in head and neck cancer

Mari Iida, Nellie K. McDaniel, Kourtney L. Kostecki, Noah B. Welke, Carlene A. Kranjac, Peng Liu, Colin Longhurst, Justine Y. Bruce, Seungpyo Hong, Ravi Salgia, Deric L. Wheeler

BMC Cancer. 2022; 22: 447. Published online 2022 Apr 23. doi: 10.1186/s12885-022-09511-6

PMCID:: PMC9035247

Abstract Article PDF–1.5M

Select item 901999213.

The impact of NRG1 expressions and methylation on multifactorial Hirschsprung disease

Gunadi, Alvin Santoso Kalim, Marcellus, Nova Yuli Prasetyo Budi, Kristy Iskandar

BMC Pediatr. 2022; 22: 216. Published online 2022 Apr 20. doi: 10.1186/s12887-022-03287-1

PMCID:: PMC9019992

Abstract Article PDF–1.0M

Select item 892296014.

New Insight into the human genetic diversity in North African populations by genotyping of SNPs in DRD3, CSMD1 and NRG1 genes

Souhir Mestiri, Sami Boussetta, Andrew J. Pakstis, Sarra El Kamel, Amel Ben Ammar El Gaaied, Kenneth K. Kidd, Lotfi Cherni

Mol Genet Genomic Med. 2022 Mar; 10(3): e1871. Published online 2022 Feb 7. doi: 10.1002/mgg3.1871

PMCID:: PMC8922960

Abstract Article PDF–1.4M

Select item 880487415.

Neuregulin 1 (NRG1) fusion-positive high-grade spindle cell sarcoma: a distinct group of soft tissue tumors with metastatic potential

Josephine K. Dermawan, Youran Zou, Cristina R. Antonescu

Genes Chromosomes Cancer. Author manuscript; available in PMC 2023 Mar 1.

Published in final edited form as: Genes Chromosomes Cancer. 2022 Mar; 61(3): 123–130. Published online 2021 Nov 30. doi: 10.1002/gcc.23008

PMCID:: PMC8804874

Abstract Article PDF–1.7M

Select item 853389816.

Sertoli Cells Improve Myogenic Differentiation, Reduce Fibrogenic Markers, and Induce Utrophin Expression in Human DMD Myoblasts

Laura Salvadori, Sara Chiappalupi, Iva Arato, Francesca Mancuso, Mario Calvitti, Maria Cristina Marchetti, Francesca Riuzzi, Riccardo Calafiore, Giovanni Luca, Guglielmo Sorci

Biomolecules. 2021 Oct; 11(10): 1504. Published online 2021 Oct 12. doi: 10.3390/biom11101504

PMCID:: PMC8533898

Abstract Article PDF–3.4M

Select item 852675117.

Multiple, independent, common variants at RET, SEMA3 and NRG1 gut enhancers specify Hirschsprung disease risk in European ancestry subjects

Ashish Kapoor, Priyanka Nandakumar, Dallas R. Auer, Maria X. Sosa, Holly Ross, Juli Bollinger, Jia Yan, Courtney Berrios, The Hirschsprung Disease Research Collaborative (HDRC), Aravinda Chakravarti

J Pediatr Surg. Author manuscript; available in PMC 2022 Dec 1.

Published in final edited form as: J Pediatr Surg. 2021 Dec; 56(12): 2286–2294. Published online 2021 Apr 20. doi: 10.1016/j.jpedsurg.2021.04.010

PMCID:: PMC8526751

Abstract Article PDF–647K

Select item 833709418.

Human endothelial colony-forming cells provide trophic support for pluripotent stem cell-derived cardiomyocytes via distinctively high expression of neuregulin-1

Xuechong Hong, Nicholas Oh, Kai Wang, Joseph Neumeyer, Chin Nien Lee, Ruei-Zeng Lin, Breanna Piekarski, Sitaram Emani, Arin K. Greene, Ingeborg Friehs, Pedro J. del Nido, Juan M. Melero-Martin

Angiogenesis. Author manuscript; available in PMC 2022 May 1.

Published in final edited form as: Angiogenesis. 2021 May; 24(2): 327–344. Published online 2021 Jan 17. doi: 10.1007/s10456-020-09765-3

PMCID:: PMC8337094

Abstract Article PDF–1.6M

Select item 817245819.

The anti-HER3 monoclonal antibody seribantumab effectively inhibits growth of patient-derived and isogenic cell line and xenograft models with oncogenic NRG1 fusions

Igor Odintsov, Allan J W Lui, Whitney J Sisso, Eric Gladstone, Zebing Liu, Lukas Delasos, Renate I Kurth, Exequiel M Sisso, Morana Vojnic, Inna Khodos, Marissa S Mattar, Elisa de Stanchina, Shawn M Leland, Marc Ladanyi, Romel Somwar

Clin Cancer Res. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: Clin Cancer Res. 2021 Jun 1; 27(11): 3154–3166. Published online 2021 Apr 6. doi: 10.1158/1078-0432.CCR-20-3605

PMCID:: PMC8172458

Abstract Article PDF–3.0M

Select item 816503020.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

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PMC Links for GEO Profiles (Select 60674052) (220)
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Pdcd2l programmed cell death 2-like [Mus musculus]
Pdcd2l programmed cell death 2-like [Mus musculus]
Gene ID:68079

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Homo sapiens vascular endothelial growth factor A (VEGFA), transcript variant 7,...
Homo sapiens vascular endothelial growth factor A (VEGFA), transcript variant 7, mRNA
gi|1677499259|ref|NM_001033756.3|

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LOC129929037[gene] (36)
ClinVar

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