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Select item 106763871.

Negative modulation of mitochondrial calcium uniporter complex protects neurons against ferroptosis

Alejandro Marmolejo-Garza, Inge E. Krabbendam, Minh Danh Anh Luu, Famke Brouwer, Marina Trombetta-Lima, Osman Unal, Shane J. O’Connor, Naďa Majerníková, Carolina R. S. Elzinga, Cristina Mammucari, Martina Schmidt, Muniswamy Madesh, Erik Boddeke, Amalia M. Dolga

Cell Death Dis. 2023 Nov; 14(11): 772. Published online 2023 Nov 25. doi: 10.1038/s41419-023-06290-1

PMCID:: PMC10676387

Abstract Article PDF–5.8M

Select item 103634492.

The mitochondrial calcium uniporter (MCU) activates mitochondrial respiration and enhances mobility by regulating mitochondrial redox state

Anna Weiser, Aurélie Hermant, Flavien Bermont, Federico Sizzano, Sonia Karaz, Pilar Alvarez-Illera, Jaime Santo-Domingo, Vincenzo Sorrentino, Jerome N. Feige, Umberto De Marchi

Redox Biol. 2023 Aug; 64: 102759. Published online 2023 Jun 4. doi: 10.1016/j.redox.2023.102759

PMCID:: PMC10363449

Abstract Article PDF–6.7M

Select item 102374223.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 99501834.

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini

Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3

PMCID:: PMC9950183

Abstract Article PDF–2.4M

Select item 96291215.

Therapeutic targeting of the USP2-E2F4 axis inhibits autophagic machinery essential for zinc homeostasis in cancer progression

Wenjing Xiao, Jianqun Wang, Xiaojing Wang, Shuang Cai, Yanhua Guo, Lin Ye, Dan Li, Anpei Hu, Shikai Jin, Boling Yuan, Yi Zhou, Qilan Li, Qiangsong Tong, Liduan Zheng

Autophagy. 2022; 18(11): 2615–2635. Published online 2022 Mar 6. doi: 10.1080/15548627.2022.2044651

PMCID:: PMC9629121

Abstract Article PDF–8.1M

Select item 94819336.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 92039797.

Mitochondrial calcium uniporter drives metastasis and confers a targetable cystine dependency in pancreatic cancer

Xiuchao Wang, Yunzhan Li, Zekun Li, Shengchen Lin, Hongwei Wang, Jianwei Sun, Chungen Lan, Liangliang Wu, Dongxiao Sun, Chongbiao Huang, Pankaj K. Singh, Nadine Hempel, Mohamed Trebak, Gina M. DeNicola, Jihui Hao, Shengyu Yang

Cancer Res. Author manuscript; available in PMC 2022 Dec 15.

Published in final edited form as: Cancer Res. 2022 Jun 15; 82(12): 2254–2268. doi: 10.1158/0008-5472.CAN-21-3230

PMCID:: PMC9203979

Abstract Article PDF–5.4M

Select item 91197368.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 90405569.

A protein interaction landscape of breast cancer

Minkyu Kim, Jisoo Park, Mehdi Bouhaddou, Kyumin Kim, Ajda Rojc, Maya Modak, Margaret Soucheray, Michael J. McGregor, Patrick O’Leary, Denise Wolf, Erica Stevenson, Tzeh Keong Foo, Dominique Mitchell, Kari A. Herrington, Denise P. Muñoz, Beril Tutuncuoglu, Kuei-Ho Chen, Fan Zheng, Jason F. Kreisberg, Morgan E. Diolaiti, John D. Gordan, Jean-Philippe Coppé, Danielle L. Swaney, Bing Xia, Laura van ’t Veer, Alan Ashworth, Trey Ideker, Nevan Krogan

Science. Author manuscript; available in PMC 2022 Apr 26.

Published in final edited form as: Science. 2021 Oct; 374(6563): eabf3066. Published online 2021 Oct 1. doi: 10.1126/science.abf3066

PMCID:: PMC9040556

Abstract Article PDF–2.2M

Select item 880584510.

Dihydroartemisinin represses oral squamous cell carcinoma progression through downregulating mitochondrial calcium uniporter

Shen Zheng, Ran Wu, Yunlong Deng, Qiang Zhang

Bioengineered. 2022; 13(1): 227–241. Published online 2021 Dec 29. doi: 10.1080/21655979.2021.2012951

PMCID:: PMC8805845

Abstract Article PDF–5.7M

Select item 849618411.

The Mitochondrial Ca²⁺ uniporter is a central regulator of interorganellar Ca²⁺ transfer and NFAT activation

Ryan E. Yoast, Scott M. Emrich, Xuexin Zhang, Ping Xin, Vikas Arige, Trayambak Pathak, J. Cory Benson, Martin T. Johnson, Ahmed Emam Abdelnaby, Natalia Lakomski, Nadine Hempel, Jung Min Han, Geneviève Dupont, David I. Yule, James Sneyd, Mohamed Trebak

J Biol Chem. 2021 Oct; 297(4): 101174. Published online 2021 Sep 6. doi: 10.1016/j.jbc.2021.101174

PMCID:: PMC8496184

Abstract Article PDF–4.6M

Select item 816503012.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 789587113.

Structure of intact human MCU supercomplex with the auxiliary MICU subunits

Wei Zhuo, Heng Zhou, Runyu Guo, Jingbo Yi, Laixing Zhang, Lei Yu, Yinqiang Sui, Wenwen Zeng, Peiyi Wang, Maojun Yang

Protein Cell. 2021 Mar; 12(3): 220–229. Published online 2020 Aug 30. doi: 10.1007/s13238-020-00776-w

PMCID:: PMC7895871

Article PDF–2.5M

Select item 776445114.

Mechanisms of EMRE-Dependent MCU Opening in the Mitochondrial Calcium Uniporter Complex

Anna M. Van Keuren, Chen-Wei Tsai, Enrique Balderas, Madison X. Rodriguez, Dipayan Chaudhuri, Ming-Feng Tsai

Cell Rep. Author manuscript; available in PMC 2020 Dec 26.

Published in final edited form as: Cell Rep. 2020 Dec 8; 33(10): 108486. doi: 10.1016/j.celrep.2020.108486

PMCID:: PMC7764451

Abstract Article PDF–1.3M

Select item 766799815.

Mitochondrial Pyruvate and Fatty Acid Flux Modulate MICU1-Dependent Control of MCU Activity

Neeharika Nemani, Zhiwei Dong, Cassidy C. Daw, Travis R. Madaris, Karthik Ramachandran, Benjamin T. Enslow, Cherubina S. Rubannelsonkumar, Santhanam Shanmughapriya, Varshini Mallireddigari, Soumya Maity, Pragya SinghMalla, Kalimuthusamy Natarajanseenivasan, Robert Hooper, Christopher E. Shannon, Warren G. Tourtellotte, Brij B. Singh, Brian W. Reeves, Kumar Sharma, Luke Norton, Subramanya Srikantan, Johnathan Soboloff, Muniswamy Madesh

Sci Signal. Author manuscript; available in PMC 2020 Nov 16.

Published in final edited form as: Sci Signal. 2020 Apr 21; 13(628): eaaz6206. Published online 2020 Apr 21. doi: 10.1126/scisignal.aaz6206

PMCID:: PMC7667998

Abstract Article PDF–3.1M

Select item 754443116.

Structure and mechanism of the mitochondrial Ca²⁺ uniporter holocomplex

Minrui Fan, Jinru Zhang, Chen-Wei Tsai, Benjamin J. Orlando, Madison Rodriguez, Yan Xu, Maofu Liao, Ming-Feng Tsai, Liang Feng

Nature. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nature. 2020 Jun; 582(7810): 129–133. Published online 2020 May 20. doi: 10.1038/s41586-020-2309-6

PMCID:: PMC7544431

Abstract Article PDF–7.2M

Select item 753008417.

Uncorking MCU to let the calcium flow

J. Kevin Foskett

Cell Calcium. Author manuscript; available in PMC 2021 Nov 1.

Published in final edited form as: Cell Calcium. 2020 Nov; 91: 102257. Published online 2020 Jul 28. doi: 10.1016/j.ceca.2020.102257

PMCID:: PMC7530084

Abstract Article PDF–588K

Select item 744249018.

Structural insights into the Ca²⁺-dependent gating of the human mitochondrial calcium uniporter

Yan Wang, Yan Han, Ji She, Nam X Nguyen, Vamsi K Mootha, Xiao-chen Bai, Youxing Jiang

eLife. 2020; 9: e60513. Published online 2020 Aug 7. doi: 10.7554/eLife.60513

PMCID:: PMC7442490

Abstract Article PDF–5.7M

Select item 742522719.

Evolutionary divergence reveals the molecular basis of EMRE dependence of the human MCU

Melissa JS MacEwen, Andrew L Markhard, Mert Bozbeyoglu, Forrest Bradford, Olga Goldberger, Vamsi K Mootha, Yasemin Sancak

Life Sci Alliance. 2020 Oct; 3(10): e202000718. Published online 2020 Aug 7. doi: 10.26508/lsa.202000718

PMCID:: PMC7425227

Abstract Article PDF–2.3M

Select item 732206720.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

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