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Select item 111583791.

Proto‐oncogene, Pim‐3 with serine/threonine kinase activity, is aberrantly expressed in human colon cancer cells and can prevent Bad‐mediated apoptosis

Boryana Konstantinova Popivanova, Ying‐Yi Li, Huachuan Zheng, Kenji Omura, Chifumi Fujii, Koichi Tsuneyama, Naofumi Mukaida

Cancer Sci. 2007 Mar; 98(3): 321–328. Published online 2007 Feb 1. doi: 10.1111/j.1349-7006.2007.00390.x

PMCID:: PMC11158379

Abstract Article PDF–296K

Select item 103126742.

AI-guided pipeline for protein-protein interaction drug discovery identifies a SARS-CoV-2 inhibitor

Philipp Trepte, Christopher Secker, Simona Kostova, Sibusiso B. Maseko, Soon Gang Choi, Jeremy Blavier, Igor Minia, Eduardo Silva Ramos, Patricia Cassonnet, Sabrina Golusik, Martina Zenkner, Stephanie Beetz, Mara J. Liebich, Nadine Scharek, Anja Schütz, Marcel Sperling, Michael Lisurek, Yang Wang, Kerstin Spirohn, Tong Hao, Michael A. Calderwood, David E. Hill, Markus Landthaler, Julien Olivet, Jean-Claude Twizere, Marc Vidal, Erich E. Wanker

Version 1. bioRxiv. Preprint. 2023 Jun 14. doi: 10.1101/2023.06.14.544560

Published in:: Mol Syst Biol. 2024 Apr; 20(4): 428–457.

PMCID:: PMC10312674

Abstract Article PDF–9.6M

Select item 100774713.

mTOR inhibition overcomes RSK3-mediated resistance to BET inhibitors in small cell lung cancer

Anju Kumari, Lisa Gesumaria, Yan-Jin Liu, V. Keith Hughitt, Xiaohu Zhang, Michele Ceribelli, Kelli M. Wilson, Carleen Klumpp-Thomas, Lu Chen, Crystal McKnight, Zina Itkin, Craig J. Thomas, Beverly A. Mock, David S. Schrump, Haobin Chen

JCI Insight. 2023 Mar 8; 8(5): e156657. Published online 2023 Mar 8. doi: 10.1172/jci.insight.156657

PMCID:: PMC10077471

Abstract Article PDF–7.2M

Select item 81650304.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 81345045.

BAD regulates mammary gland morphogenesis by 4E-BP1-mediated control of localized translation in mouse and human models

John Maringa Githaka, Namita Tripathi, Raven Kirschenman, Namrata Patel, Vrajesh Pandya, David A. Kramer, Rachel Montpetit, Lin Fu Zhu, Nahum Sonenberg, Richard P. Fahlman, Nika N. Danial, D. Alan Underhill, Ing Swie Goping

Nat Commun. 2021; 12: 2939. Published online 2021 May 19. doi: 10.1038/s41467-021-23269-8

PMCID:: PMC8134504

Abstract Article PDF–14M

Select item 78407316.

MicroRNA-377 Downregulates Bcl-xL and Increases Apoptosis in Hepatocellular Carcinoma Cells

Hongyan Ge, Di Zou, Yingshu Wang, Hao Jiang, Liping Wang

Oncol Res. 2017; 25(1): 29–34. Published online 2017 Jan 2. doi: 10.3727/096504016X14719078133168

PMCID:: PMC7840731

Abstract Article PDF–8.8M

Select item 77143947.

BAD inactivation exacerbates rheumatoid arthritis pathology by promoting survival of sublining macrophages

Jie Li, Liansheng Zhang, Yongwei Zheng, Rui Shao, Qianqian Liang, Weida Yu, Hongyan Wang, Weiguo Zou, Demin Wang, Jialing Xiang, Anning Lin

eLife. 2020; 9: e56309. Published online 2020 Dec 3. doi: 10.7554/eLife.56309

PMCID:: PMC7714394

Abstract Article PDF–11M

Select item 71699838.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 69812069.

Extensive rewiring of the EGFR network in colorectal cancer cells expressing transforming levels of KRAS^G13D

Susan A. Kennedy, Mohamed-Ali Jarboui, Sriganesh Srihari, Cinzia Raso, Kenneth Bryan, Layal Dernayka, Theodosia Charitou, Manuel Bernal-Llinares, Carlos Herrera-Montavez, Aleksandar Krstic, David Matallanas, Max Kotlyar, Igor Jurisica, Jasna Curak, Victoria Wong, Igor Stagljar, Thierry LeBihan, Lisa Imrie, Priyanka Pillai, Miriam A. Lynn, Erik Fasterius, Cristina Al-Khalili Szigyarto, James Breen, Christina Kiel, Luis Serrano, Nora Rauch, Oleksii Rukhlenko, Boris N. Kholodenko, Luis F. Iglesias-Martinez, Colm J. Ryan, Ruth Pilkington, Patrizia Cammareri, Owen Sansom, Steven Shave, Manfred Auer, Nicola Horn, Franziska Klose, Marius Ueffing, Karsten Boldt, David J. Lynn, Walter Kolch

Nat Commun. 2020; 11: 499. Published online 2020 Jan 24. doi: 10.1038/s41467-019-14224-9

PMCID:: PMC6981206

Abstract Article PDF–3.7M

Select item 694578010.

Evaluation of apoptosis and angiogenesis in ectopic and eutopic stromal cells of patients with endometriosis compared to non-endometriotic controls

Ali-Akbar Delbandi, Mahmoud Mahmoudi, Adel Shervin, Sahel Heidari, Roya Kolahdouz-Mohammadi, Amir-Hassan Zarnani

BMC Womens Health. 2020; 20: 3. Published online 2020 Jan 6. doi: 10.1186/s12905-019-0865-4

PMCID:: PMC6945780

Abstract Article PDF–2.5M

Select item 678308111.

α-Synuclein Shares Physical and Functional Homology with 14-3-3 Proteins

Natalie Ostrerova, Leonard Petrucelli, Matthew Farrer, Nitinkumar Mehta, Peter Choi, John Hardy, Benjamin Wolozin

J Neurosci. 1999 Jul 15; 19(14): 5782–5791. doi: 10.1523/JNEUROSCI.19-14-05782.1999

PMCID:: PMC6783081

Abstract Article PDF–852K

Select item 675601612.

Non-canonical BAD activity regulates breast cancer cell and tumor growth via 14-3-3 binding and mitochondrial metabolism

Jasdeep Mann, John Maringa Githaka, Timothy W. Buckland, Ning Yang, Rachel Montpetit, Namrata Patel, Lei Li, Shairaz Baksh, Roseline Godbout, Hélène Lemieux, Ing Swie Goping

Oncogene. 2019; 38(18): 3325–3339. Published online 2019 Jan 11. doi: 10.1038/s41388-018-0673-6

PMCID:: PMC6756016

Abstract Article PDF–3.8M

Select item 674837113.

Targeting Rho GTPase effector p21 activated kinase 4 (PAK4) suppresses p-Bad-microRNA drug resistance axis leading to inhibition of pancreatic ductal adenocarcinoma proliferation

Ramzi M. Mohammad, Yiwei Li, Irfana Muqbil, Amro Aboukameel, William Senapedis, Erkan Baloglu, Yosef Landesman, Philip A. Philip, Asfar S. Azmi

Small GTPases. 2019 Sep; 10(5): 367–377. Published online 2017 Jun 23. doi: 10.1080/21541248.2017.1329694

PMCID:: PMC6748371

Abstract Article PDF–1.2M

Select item 674264614.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 671572515.

Maximizing binary interactome mapping with a minimal number of assays

Soon Gang Choi, Julien Olivet, Patricia Cassonnet, Pierre-Olivier Vidalain, Katja Luck, Luke Lambourne, Kerstin Spirohn, Irma Lemmens, Mélanie Dos Santos, Caroline Demeret, Louis Jones, Sudharshan Rangarajan, Wenting Bian, Eloi P. Coutant, Yves L. Janin, Sylvie van der Werf, Philipp Trepte, Erich E. Wanker, Javier De Las Rivas, Jan Tavernier, Jean-Claude Twizere, Tong Hao, David E. Hill, Marc Vidal, Michael A. Calderwood, Yves Jacob

Nat Commun. 2019; 10: 3907. Published online 2019 Aug 29. doi: 10.1038/s41467-019-11809-2

PMCID:: PMC6715725

Abstract Article PDF–1.7M

Select item 634140416.

Targeting BCL-xL improves the efficacy of bromodomain and extra-terminal protein inhibitors in triple-negative breast cancer by eliciting the death of senescent cells

Sylvia S. Gayle, Jennifer M. Sahni, Bryan M. Webb, Kristen L. Weber-Bonk, Melyssa S. Shively, Raffaella Spina, Eli E. Bar, Mathew K. Summers, Ruth A. Keri

J Biol Chem. 2019 Jan 18; 294(3): 875–886. Published online 2018 Nov 27. doi: 10.1074/jbc.RA118.004712

PMCID:: PMC6341404

Abstract Article PDF–4.0M

Select item 623322617.

Hypoxia-mediated mitochondria apoptosis inhibition induces temozolomide treatment resistance through miR-26a/Bad/Bax axis

Xin Ge, Min-Hong Pan, Lin Wang, Wei Li, Chengfei Jiang, Jun He, Khaled Abouzid, Ling-Zhi Liu, Zhumei Shi, Bing-Hua Jiang

Cell Death Dis. 2018 Nov; 9(11): 1128. Published online 2018 Nov 13. doi: 10.1038/s41419-018-1176-7

PMCID:: PMC6233226

Abstract Article PDF–2.8M

Select item 615528018.

High PGAM5 expression induces chemoresistance by enhancing Bcl-xL-mediated anti-apoptotic signaling and predicts poor prognosis in hepatocellular carcinoma patients

Jingjing Cheng, Dong Qian, Xiaofeng Ding, Tianqiang Song, Muyan Cai, Dan Xie, Yuwen Wang, Jinlin Zhao, Zhuang Liu, Zhiqiang Wu, Qingsong Pang, Li Zhu, Ping Wang, Xishan Hao, Zhiyong Yuan

Cell Death Dis. 2018 Oct; 9(10): 991. Published online 2018 Sep 24. doi: 10.1038/s41419-018-1017-8

PMCID:: PMC6155280

Abstract Article PDF–3.0M

Select item 603987019.

LuTHy: a double‐readout bioluminescence‐based two‐hybrid technology for quantitative mapping of protein–protein interactions in mammalian cells

Philipp Trepte, Sabrina Kruse, Simona Kostova, Sheila Hoffmann, Alexander Buntru, Anne Tempelmeier, Christopher Secker, Lisa Diez, Aline Schulz, Konrad Klockmeier, Martina Zenkner, Sabrina Golusik, Kirstin Rau, Sigrid Schnoegl, Craig C Garner, Erich E Wanker

Mol Syst Biol. 2018 Jul; 14(7): e8071. Published online 2018 Jul 11. doi: 10.15252/msb.20178071

PMCID:: PMC6039870

Abstract Article PDF–2.1M

Select item 600080820.

Association of Pro-apoptotic Bad Gene Expression Changes with Benign Thyroid Nodules

NURDAN GÜL, BERNA TEMEL, DURAN USTEK, SEMA SIRMA-EKMEKÇI, YERSU KAPRAN, FATIH TUNCA, YASEMIN GILES-ŞENYÜREK, UĞUR ÖZBEK, FARUK ALAGÖL

In Vivo. 2018 May-Jun; 32(3): 555–559. Published online 2018 May 3. doi: 10.21873/invivo.112275

PMCID:: PMC6000808

Abstract Article PDF–88K

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