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Select item 111148941.

VRK2 anchors KSR1-MEK1 to endoplasmic reticulum forming a macromolecular complex that compartmentalizes MAPK signaling

Isabel F. Fernández, Luis G. Pérez-Rivas, Sandra Blanco, Adrián A. Castillo-Dominguez, José Lozano, Pedro A. Lazo

Cell Mol Life Sci. 2012 Nov; 69(22): 3881–3893. Published online 2012 Jul 4. doi: 10.1007/s00018-012-1056-8

PMCID:: PMC11114894

Abstract Article PDF–1.1M

Select item 109424672.

Mitochondrial Raf1 Regulates Glutamine Catabolism

Ronald L. Shanderson, Ian D. Ferguson, Zurab Siprashvili, Luca Ducoli, Albert M. Li, Weili Miao, Suhas Srinivasan, Mary Grace Velasco, Yang Li, Jiangbin Ye, Paul A. Khavari

Version 1. bioRxiv. Preprint. 2024 Mar 9. doi: 10.1101/2024.03.08.581297

PMCID:: PMC10942467

Abstract Article PDF–6.5M

Select item 108728823.

Activating mutations drive human MEK1 kinase using a gear-shifting mechanism

Keshav Patil, Yiming Wang, Zhangtao Chen, Krishna Suresh, Ravi Radhakrishnan

Biochem J. Author manuscript; available in PMC 2024 Feb 16.

Published in final edited form as: Biochem J. 2023 Nov 15; 480(21): 1733–1751. doi: 10.1042/BCJ20230281

PMCID:: PMC10872882

Abstract Article PDF–1.9M

Select item 104506724.

Evolutionary history of MEK1 illuminates the nature of deleterious mutations

Ekaterina P. Andrianova, Robert A. Marmion, Stanislav Y. Shvartsman, Igor B. Zhulin

Proc Natl Acad Sci U S A. 2023 Aug 22; 120(34): e2304184120. Published online 2023 Aug 14. doi: 10.1073/pnas.2304184120

PMCID:: PMC10450672

Abstract Article PDF–3.7M

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100729066.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 98918737.

Tripartite motif containing 69 elicits ERK2-dependent EYA4 turnover to impart pancreatic tumorigenesis

Yu Jia, Hui-Yan Li, Jue Wang, Xing Chen, Lu Lou, Yan-Yan Wei, Ying Wang, Shi-Jing Mo

J Cancer. 2023; 14(2): 200–218. Published online 2023 Jan 1. doi: 10.7150/jca.79905

PMCID:: PMC9891873

Abstract Article PDF–5.6M

Select item 98901408.

High-Throughput Functional Evaluation of MAP2K1 Variants in Cancer

Sho Mizuno, Masachika Ikegami, Takafumi Koyama, Kuniko Sunami, Dai Ogata, Hidenori Kage, Mitsuru Yanagaki, Hiroshi Ikeuchi, Toshihide Ueno, Michihiro Tanikawa, Katsutoshi Oda, Yutaka Osuga, Hiroyuki Mano, Shinji Kohsaka

Mol Cancer Ther. 2023 Feb 1; 22(2): 227–239. Published online 2022 Nov 28. doi: 10.1158/1535-7163.MCT-22-0302

PMCID:: PMC9890140

Abstract Article PDF–8.0M

Select item 98051349.

SPOP inhibits BRAF-dependent tumorigenesis through promoting non-degradative ubiquitination of BRAF

Kai Feng, Qing Shi, Dongyue Jiao, Yingji Chen, Wanqi Yang, Ke Su, Yalan Wang, Yan Huang, Pingzhao Zhang, Yao Li, Chenji Wang

Cell Biosci. 2022; 12: 211. Published online 2022 Dec 30. doi: 10.1186/s13578-022-00950-z

PMCID:: PMC9805134

Abstract Article PDF–9.4M

Select item 976969810.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 937474011.

Identification of a BRAF/PA28γ/MEK1 signaling axis and its role in epithelial-mesenchymal transition in oral submucous fibrosis

Changqing Xie, Zaiye Li, Yufei Hua, Silu Sun, Liang Zhong, Qian Chen, Hui Feng, Ning Ji, Taiwen Li, Xikun Zhou, Xin Zeng, Zhangui Tang, Chongkui Sun, Jing Li, Qianming Chen

Cell Death Dis. 2022 Aug; 13(8): 701. Published online 2022 Aug 12. doi: 10.1038/s41419-022-05152-6

PMCID:: PMC9374740

Abstract Article PDF–6.5M

Select item 927928512.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 911973613.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 905883614.

The involvement of Parkin-dependent mitophagy in the anti-cancer activity of Ginsenoside

Xin Sun, Yeting Hong, Yuhan Shu, Caixia Wu, Guiqin Ye, Hanxiao Chen, Hongying Zhou, Ruilan Gao, Jianbin Zhang

J Ginseng Res. 2022 Mar; 46(2): 266–274. Published online 2021 Jul 8. doi: 10.1016/j.jgr.2021.06.009

PMCID:: PMC9058836

Abstract Article PDF–2.9M

Select item 889702215.

Histone deacetylase inhibitors inhibit cervical cancer growth through Parkin acetylation-mediated mitophagy

Xin Sun, Yuhan Shu, Guiqin Ye, Caixia Wu, Mengting Xu, Ruilan Gao, Dongsheng Huang, Jianbin Zhang

Acta Pharm Sin B. 2022 Feb; 12(2): 838–852. Published online 2021 Jul 21. doi: 10.1016/j.apsb.2021.07.003

PMCID:: PMC8897022

Abstract Article PDF–3.0M

Select item 878771516.

Immune regulator LGP2 targets Ubc13/UBE2N to mediate widespread interference with K63 polyubiquitination and NF-κB activation

Jessica J. Lenoir, Jean-Patrick Parisien, Curt M. Horvath

Cell Rep. Author manuscript; available in PMC 2022 Jan 25.

Published in final edited form as: Cell Rep. 2021 Dec 28; 37(13): 110175. doi: 10.1016/j.celrep.2021.110175

PMCID:: PMC8787715

Abstract Article PDF–4.2M

Select item 877082817.

The Predictive Value of MAP2K1/2 Mutations on Efficiency of Immunotherapy in Melanoma

Ting Ye, Jie-Ying Zhang, Xin-Yi Liu, Yu-Han Zhou, Si-Yue Yuan, Meng-Mei Yang, Wen-Zhuan Xie, Chan Gao, Yao-Xu Chen, Meng-Li Huang, Cheng-Zhi Ye, Jing Chen

Front Immunol. 2021; 12: 785526. Published online 2022 Jan 6. doi: 10.3389/fimmu.2021.785526

PMCID:: PMC8770828

Abstract Article PDF–2.8M

Select item 866102518.

The copper chaperone CCS facilitates copper binding to MEK1/2 to promote kinase activation

Michael Grasso, Gavin J. Bond, Ye-Jin Kim, Stefanie Boyd, Maria Matson Dzebo, Sebastian Valenzuela, Tiffany Tsang, Natalie A. Schibrowsky, Katherine B. Alwan, Ninian J. Blackburn, George M. Burslem, Pernilla Wittung-Stafshede, Duane D. Winkler, Ronen Marmorstein, Donita C. Brady

J Biol Chem. 2021 Dec; 297(6): 101314. Published online 2021 Oct 27. doi: 10.1016/j.jbc.2021.101314

PMCID:: PMC8661025

Abstract Article PDF–2.7M

Select item 864987119.

Biallelic mutations in MOS cause female infertility characterized by human early embryonic arrest and fragmentation

Yin‐Li Zhang, Wei Zheng, Peipei Ren, Huiling Hu, Xiaomei Tong, Shuo‐Ping Zhang, Xiang Li, Haichao Wang, Jun‐Chao Jiang, Jiamin Jin, Weijie Yang, Lanrui Cao, Yuanlin He, Yerong Ma, Yingyi Zhang, Yifan Gu, Liang Hu, Keli Luo, Fei Gong, Guang‐Xiu Lu, Ge Lin, Heng‐Yu Fan, Songying Zhang

EMBO Mol Med. 2021 Dec 7; 13(12): e14887. Published online 2021 Nov 15. doi: 10.15252/emmm.202114887

PMCID:: PMC8649871

Abstract Article PDF–3.4M

Select item 864721320.

Structure of mitogen-activated protein kinase kinase 1 in the DFG-out conformation

Setsu Nakae, Maho Kitamura, Daisuke Fujiwara, Masaaki Sawa, Tsuyoshi Shirai, Ikuo Fujii, Toshiji Tada

Acta Crystallogr F Struct Biol Commun. 2021 Dec 1; 77(Pt 12): 459–464. Published online 2021 Nov 25. doi: 10.1107/S2053230X21011687

PMCID:: PMC8647213

Abstract Article PDF–974K

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PMC Links for GEO Profiles (Select 60787019) (252)
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McrB family protein [Staphylococcus haemolyticus]
McrB family protein [Staphylococcus haemolyticus]
gi|499593694|ref|WP_011274428.1|

Protein
Homo sapiens platelet activating factor acetylhydrolase 1b regulatory subunit 1 ...
Homo sapiens platelet activating factor acetylhydrolase 1b regulatory subunit 1 (PAFAH1B1), mRNA
gi|1519312863|ref|NM_000430.4|

Nucleotide

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