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Select item 108959571.

Homeodomain-only protein suppresses proliferation and contributes to differentiation- and age-related reduced CD8⁺ T cell expansion

Qian Yang, Michael Patrick, Jian Lu, Joseph Chen, Yongqing Zhang, Humza Hemani, Elin Lehrmann, Supriyo De, Nan-ping Weng

Front Immunol. 2024; 15: 1360229. Published online 2024 Feb 12. doi: 10.3389/fimmu.2024.1360229

PMCID:: PMC10895957

Abstract Article PDF–2.5M

Select item 87003282.

HOPX Plays a Critical Role in Antiretroviral Drugs Induced Epigenetic Modification and Cardiac Hypertrophy

Shiridhar Kashyap, Maryam Rabbani, Isabela de Lima, Olena Kondrachuk, Raj Patel, Mahnoush Sophia Shafiei, Avni Mukker, Aishwarya Rajakumar, Manish Kumar Gupta

Cells. 2021 Dec; 10(12): 3458. Published online 2021 Dec 8. doi: 10.3390/cells10123458

PMCID:: PMC8700328

Abstract Article PDF–3.0M

Select item 79802233.

The IMiD target CRBN determines HSP90 activity toward transmembrane proteins essential in multiple myeloma

Michael Heider, Ruth Eichner, Jacob Stroh, Volker Morath, Anna Kuisl, Jana Zecha, Jannis Lawatscheck, Kheewoong Baek, Anne-Kathrin Garz, Martina Rudelius, Friedrich-Christian Deuschle, Ulrich Keller, Simone Lemeer, Mareike Verbeek, Katharina S. Götze, Arne Skerra, Wolfgang A. Weber, Johannes Buchner, Brenda A. Schulman, Bernhard Kuster, Vanesa Fernández-Sáiz, Florian Bassermann

Mol Cell. 2021 Mar 18; 81(6): 1170–1186.e10. doi: 10.1016/j.molcel.2020.12.046

PMCID:: PMC7980223

Abstract Article

Select item 76799674.

Molecular basis of the interaction of Hsp90 with its co‐chaperone Hop

Antonia Lott, Javier Oroz, Markus Zweckstetter

Protein Sci. 2020 Dec; 29(12): 2422–2432. Published online 2020 Oct 19. doi: 10.1002/pro.3969

PMCID:: PMC7679967

Abstract Article PDF–2.1M

Select item 73478855.

HOPX regulates bone marrow-derived mesenchymal stromal cell fate determination via suppression of adipogenic gene pathways

Chee Ho Hng, Esther Camp, Peter Anderson, James Breen, Andrew Zannettino, Stan Gronthos

Sci Rep. 2020; 10: 11345. Published online 2020 Jul 9. doi: 10.1038/s41598-020-68261-2

PMCID:: PMC7347885

Abstract Article PDF–2.0M

Select item 71699836.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 67087277.

HOPX is a ZNF750 target that promotes late epidermal differentiation

Selena Y. Chen, Mitsuhiro A. Ishii, Binbin Cheng, Auke B.C. Otten, Bryan K. Sun

J Invest Dermatol. Author manuscript; available in PMC 2020 Sep 1.

Published in final edited form as: J Invest Dermatol. 2019 Sep; 139(9): 2039–2042.e2. Published online 2019 Apr 5. doi: 10.1016/j.jid.2019.03.1141

PMCID:: PMC6708727

Article PDF–463K

Select item 65800238.

MicroRNA-421 promotes the progression of non-small cell lung cancer by targeting HOPX and regulating the Wnt/β-catenin signaling pathway

Huagang Liang, Chao Wang, Kun Gao, Jian Li, Rui Jia

Mol Med Rep. 2019 Jul; 20(1): 151–161. Published online 2019 May 9. doi: 10.3892/mmr.2019.10226

PMCID:: PMC6580023

Abstract Article PDF–2.4M

Select item 62201229.

Single cell transcriptomic analysis of cardiac differentiation from human PSCs reveals HOPX-dependent cardiomyocyte maturation

Clayton E Friedman, Quan Nguyen, Samuel W Lukowski, Abbigail Helfer, Han Sheng Chiu, Jason Miklas, Shiri Levy, Shengbao Suo, Jing-Dong Jackie Han, Pierre Osteil, Guangdun Peng, Naihe Jing, Greg J Baillie, Anne Senabouth, Angelika N Christ, Timothy J Bruxner, Charles E Murry, Emily S Wong, Jun Ding, Yuliang Wang, James Hudson, Hannele Ruohola-Baker, Ziv Bar-Joseph, Patrick P L Tam, Joseph E Powell, Nathan J Palpant

Cell Stem Cell. Author manuscript; available in PMC 2019 Oct 4.

Published in final edited form as: Cell Stem Cell. 2018 Oct 4; 23(4): 586–598.e8. doi: 10.1016/j.stem.2018.09.009

PMCID:: PMC6220122

Abstract Article PDF–3.0M

Select item 621963310.

ΔNp63α Suppresses TGFB2 Expression and RHOA Activity to Drive Cell Proliferation in Squamous Cell Carcinomas

Christopher G. Abraham, Michael P. Ludwig, Zdenek Andrysik, Ahwan Pandey, Molishree Joshi, Matthew D. Galbraith, Kelly D. Sullivan, Joaquin M. Espinosa

Cell Rep. Author manuscript; available in PMC 2018 Nov 6.

Published in final edited form as: Cell Rep. 2018 Sep 18; 24(12): 3224–3236. doi: 10.1016/j.celrep.2018.08.058

PMCID:: PMC6219633

Abstract Article PDF–1.1M

Select item 611321011.

Dynamic expression of HOPX in alveolar epithelial cells reflects injury and repair during the progression of pulmonary fibrosis

Chiharu Ota, John-Poul Ng-Blichfeldt, Martina Korfei, Hani N. Alsafadi, Mareike Lehmann, Wioletta Skronska-Wasek, Martina M. De Santis, Andreas Guenther, Darcy E. Wagner, Melanie Königshoff

Sci Rep. 2018; 8: 12983. Published online 2018 Aug 28. doi: 10.1038/s41598-018-31214-x

PMCID:: PMC6113210

Abstract Article PDF–8.4M

Select item 557651012.

Chromatin and transcriptional analysis of mesoderm progenitor cells identifies HOPX as a regulator of primitive hematopoiesis

Nathan J. Palpant, Yuliang Wang, Brandon Hadland, Rebecca J. Zaunbrecher, Meredith Redd, Daniel Jones, Lil Pabon, Rajan Jain, Jonathan Epstein, Walter L. Ruzzo, Ying Zheng, Irwin Bernstein, Adam Margolin, Charles E. Murry

Cell Rep. Author manuscript; available in PMC 2017 Aug 30.

Published in final edited form as: Cell Rep. 2017 Aug 15; 20(7): 1597–1608. doi: 10.1016/j.celrep.2017.07.067

PMCID:: PMC5576510

Abstract Article PDF–2.3M

Select item 553161113.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 545133614.

Higher HOPX expression is associated with distinct clinical and biological features and predicts poor prognosis in de novo acute myeloid leukemia

Chien-Chin Lin, Yueh-Chwen Hsu, Yi-Hung Li, Yuan-Yeh Kuo, Hsin-An Hou, Keng-Hsueh Lan, Tsung-Chih Chen, Yi-Shiuan Tzeng, Yi-Yi Kuo, Chein-Jun Kao, Po-Han Chuang, Mei-Hsuan Tseng, Yu-Chiao Chiu, Wen-Chien Chou, Hwei-Fang Tien

Haematologica. 2017 Jun; 102(6): 1044–1053. doi: 10.3324/haematol.2016.161257

PMCID:: PMC5451336

Abstract Article PDF–2.0M

Select item 537173015.

Systematic protein–protein interaction mapping for clinically relevant human GPCRs

Kate Sokolina, Saranya Kittanakom, Jamie Snider, Max Kotlyar, Pascal Maurice, Jorge Gandía, Abla Benleulmi‐Chaachoua, Kenjiro Tadagaki, Atsuro Oishi, Victoria Wong, Ramy H Malty, Viktor Deineko, Hiroyuki Aoki, Shahreen Amin, Zhong Yao, Xavier Morató, David Otasek, Hiroyuki Kobayashi, Javier Menendez, Daniel Auerbach, Stephane Angers, Natasa Pržulj, Michel Bouvier, Mohan Babu, Francisco Ciruela, Ralf Jockers, Igor Jurisica, Igor Stagljar

Mol Syst Biol. 2017 Mar; 13(3): 918. Published online 2017 Mar 15. doi: 10.15252/msb.20167430

PMCID:: PMC5371730

Abstract Article PDF–4.1M

Select item 529665116.

HOPX hypermethylation promotes metastasis via activating SNAIL transcription in nasopharyngeal carcinoma

Xianyue Ren, Xiaojing Yang, Bin Cheng, Xiaozhong Chen, Tianpeng Zhang, Qingmei He, Bin Li, Yingqin Li, Xinran Tang, Xin Wen, Qian Zhong, Tiebang Kang, Musheng Zeng, Na Liu, Jun Ma

Nat Commun. 2017; 8: 14053. Published online 2017 Feb 1. doi: 10.1038/ncomms14053

PMCID:: PMC5296651

Abstract Article PDF–6.7M

Select item 514693017.

HOPX functions as a tumour suppressor in head and neck cancer

Lee Fah Yap, Sook Ling Lai, Sathya Narayanan Patmanathan, Ravindran Gokulan, C. Max Robinson, Joe B. White, San Jiun Chai, Pathmanathan Rajadurai, Narayanan Prepageran, Yew Toong Liew, Victor Lopes, Wenbin Wei, Robert J. Hollows, Paul G. Murray, Daniel W. Lambert, Keith D. Hunter, Ian C. Paterson

Sci Rep. 2016; 6: 38758. Published online 2016 Dec 9. doi: 10.1038/srep38758

PMCID:: PMC5146930

Abstract Article PDF–1.6M

Select item 505964218.

ARD1-mediated Hsp70 acetylation balances stress-induced protein refolding and degradation

Ji Hae Seo, Ji-Hyeon Park, Eun Ji Lee, Tam Thuy Lu Vo, Hoon Choi, Jun Yong Kim, Jae Kyung Jang, Hee-Jun Wee, Hye Shin Lee, Se Hwan Jang, Zee Yong Park, Jaeho Jeong, Kong-Joo Lee, Seung-Hyeon Seok, Jin Young Park, Bong Jin Lee, Mi-Ni Lee, Goo Taeg Oh, Kyu-Won Kim

Nat Commun. 2016; 7: 12882. Published online 2016 Oct 6. doi: 10.1038/ncomms12882

PMCID:: PMC5059642

Abstract Article PDF–2.0M

Select item 490295119.

Extracting a low-dimensional description of multiple gene expression datasets reveals a potential driver for tumor-associated stroma in ovarian cancer

Safiye Celik, Benjamin A. Logsdon, Stephanie Battle, Charles W. Drescher, Mara Rendi, R. David Hawkins, Su-In Lee

Genome Med. 2016; 8: 66. Published online 2016 Jun 10. doi: 10.1186/s13073-016-0319-7

PMCID:: PMC4902951

Abstract Article PDF–4.4M

Select item 462189020.

The joining of the Hsp90 and Hsp70 chaperone cycles yields transient interactions and stable intermediates: insights from mass spectrometry

Carla Schmidt, Victoria Beilsten-Edmands, Carol V. Robinson

Oncotarget. 2015 Jul 30; 6(21): 18276–18281. Published online 2015 Jul 22. doi: 10.18632/oncotarget.4954

PMCID:: PMC4621890

Abstract Article PDF–2.9M

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