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Select item 112264491.

IRF5 suppresses metastasis through the regulation of tumor-derived extracellular vesicles and pre-metastatic niche formation

Bailey K. Roberts, Dan Iris Li, Carter Somerville, Bharati Matta, Vaishali Jha, Adison Steinke, Zarina Brune, Lionel Blanc, Samuel Z. Soffer, Betsy J. Barnes

Sci Rep. 2024; 14: 15557. Published online 2024 Jul 5. doi: 10.1038/s41598-024-66168-w

PMCID:: PMC11226449

Abstract Article PDF–5.2M

Select item 111439662.

IRF5 governs macrophage adventitial infiltration to fuel abdominal aortic aneurysm formation

Yidong Wang, Zhenjie Liu, Shen Song, Jianfang Wang, Chunna Jin, Liangliang Jia, Yuankun Ma, Tan Yuan, Zhejun Cai, Meixiang Xiang

JCI Insight. 2024 Feb 8; 9(3): e171488. Published online 2024 Jan 4. doi: 10.1172/jci.insight.171488

PMCID:: PMC11143966

Abstract Article PDF–3.3M

Select item 99844253.

An autoimmune pleiotropic SNP modulates IRF5 alternative promoter usage through ZBTB3-mediated chromatin looping

Zhao Wang, Qian Liang, Xinyi Qian, Bolang Hu, Zhanye Zheng, Jianhua Wang, Yuelin Hu, Zhengkai Bao, Ke Zhao, Yao Zhou, Xiangling Feng, Xianfu Yi, Jin Li, Jiandang Shi, Zhe Liu, Jihui Hao, Kexin Chen, Ying Yu, Pak Chung Sham, Wange Lu, Xiaoyan Wang, Weihong Song, Mulin Jun Li

Nat Commun. 2023; 14: 1208. Published online 2023 Mar 3. doi: 10.1038/s41467-023-36897-z

PMCID:: PMC9984425

Abstract Article PDF–4.5M

Select item 97446804.

Frequency of IRF5+ dendritic cells is associated with the TLR7-induced inflammatory cytokine response in SARS-CoV-2 infection

Leon Cords, Robin Woost, Silke Kummer, Thomas T. Brehm, Stefan Kluge, Stefan Schmiedel, Sabine Jordan, Ansgar W. Lohse, Marcus Altfeld, Marylyn M. Addo, Julian Schulze zur Wiesch, Claudia Beisel

Cytokine. 2023 Feb; 162: 156109. Published online 2022 Dec 13. doi: 10.1016/j.cyto.2022.156109

PMCID:: PMC9744680

Abstract Article PDF–3.7M

Select item 93724655.

microRNA-144/451 decreases dendritic cell bioactivity via targeting interferon-regulatory factor 5 to limit DSS-induced colitis

Zhijie Lin, Xiaoyan Xie, Min Gu, Qian Chen, Guotao Lu, Xiaoqin Jia, Weiming Xiao, Jun Zhang, Duonan Yu, Weijuan Gong

Front Immunol. 2022; 13: 928593. Published online 2022 Jul 29. doi: 10.3389/fimmu.2022.928593

PMCID:: PMC9372465

Abstract Article PDF–41M

Select item 92626146.

A dual-activity topoisomerase complex regulates mRNA translation and turnover

Shuaikun Su, Yutong Xue, Alexei Sharov, Yongqing Zhang, Seung Kyu Lee, Jennifer L Martindale, Wen Li, Wai Lim Ku, Keji Zhao, Supriyo De, Weiping Shen, Payel Sen, Myriam Gorospe, Dongyi Xu, Weidong Wang

Nucleic Acids Res. 2022 Jul 8; 50(12): 7013–7033. Published online 2022 Jun 24. doi: 10.1093/nar/gkac538

PMCID:: PMC9262614

Abstract Article PDF–3.6M

Select item 91954027.

CXCL4 synergizes with TLR8 for TBK1-IRF5 activation, epigenomic remodeling and inflammatory response in human monocytes

Chao Yang, Mahesh Bachu, Yong Du, Caroline Brauner, Ruoxi Yuan, Marie Dominique Ah Kioon, Giancarlo Chesi, Franck J. Barrat, Lionel B. Ivashkiv

Nat Commun. 2022; 13: 3426. Published online 2022 Jun 14. doi: 10.1038/s41467-022-31132-7

PMCID:: PMC9195402

Abstract Article PDF–3.4M

Select item 89851988.

Interferon regulatory factor 5-induced upregulation of zinc-finger protein 217 promotes pancreatic carcinoma progression

Xiao Qiao, Shengxiang Lv, Yan Qiao, Fei Wang, Lin Miao

Mol Med Rep. 2022 May; 25(5): 189. Published online 2022 Mar 30. doi: 10.3892/mmr.2022.12705

PMCID:: PMC8985198

Abstract Article PDF–6.0M

Select item 88288959.

Human transcription factor protein interaction networks

Helka Göös, Matias Kinnunen, Kari Salokas, Zenglai Tan, Xiaonan Liu, Leena Yadav, Qin Zhang, Gong-Hong Wei, Markku Varjosalo

Nat Commun. 2022; 13: 766. Published online 2022 Feb 9. doi: 10.1038/s41467-022-28341-5

PMCID:: PMC8828895

Abstract Article PDF–1.7M

Select item 829000310.

Genetic and chemical inhibition of IRF5 suppresses pre-existing mouse lupus-like disease

Tatsuma Ban, Masako Kikuchi, Go R. Sato, Akio Manabe, Noriko Tagata, Kayo Harita, Akira Nishiyama, Kenichi Nishimura, Ryusuke Yoshimi, Yohei Kirino, Hideyuki Yanai, Yoshiko Matsumoto, Shuichi Suzuki, Hiroe Hihara, Masashi Ito, Kappei Tsukahara, Kentaro Yoshimatsu, Tadashi Yamamoto, Tadatsugu Taniguchi, Hideaki Nakajima, Shuichi Ito, Tomohiko Tamura

Nat Commun. 2021; 12: 4379. Published online 2021 Jul 19. doi: 10.1038/s41467-021-24609-4

PMCID:: PMC8290003

Abstract Article PDF–1.9M

Select item 812373511.

Association of the STAT4, CDKN1A, and IRF5 variants with risk of lupus nephritis and renal biopsy classification in patients in Vietnam

Trung Dung Nghiem, Gia Tuyen Do, Long Hoang Luong, Quy Linh Nguyen, Ha Viet Dang, Anh Nguyen Viet, Thuy Thu Nguyen, Van Khanh Tran, Thanh Van Ta, Thinh Huy Tran

Mol Genet Genomic Med. 2021 Apr; 9(4): e1648. Published online 2021 Mar 9. doi: 10.1002/mgg3.1648

PMCID:: PMC8123735

Abstract Article PDF–319K

Select item 800904812.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 800249613.

Interferon Regulatory Factor 5 (IRF5) Gene Haplotypes Are Associated with Premature Coronary Artery Disease. Association of the IRF5 Polymorphisms with Cardiometabolic Parameters. The Genetics of Atherosclerotic Disease (GEA) Mexican Study

Rosalinda Posadas-Sánchez, Guillermo Cardoso-Saldaña, José Manuel Fragoso, Gilberto Vargas-Alarcón

Biomolecules. 2021 Mar; 11(3): 443. Published online 2021 Mar 17. doi: 10.3390/biom11030443

PMCID:: PMC8002496

Abstract Article PDF–1.1M

Select item 795373714.

The GM-CSF–IRF5 signaling axis in eosinophils promotes antitumor immunity through activation of type 1 T cell responses

Isabelle C. Arnold, Mariela Artola-Boran, Alessandra Gurtner, Katrin Bertram, Michael Bauer, Ziva Frangez, Burkhard Becher, Manfred Kopf, Shida Yousefi, Hans-Uwe Simon, Alexandar Tzankov, Anne Müller

J Exp Med. 2020 Dec 7; 217(12): e20190706. Published online 2020 Sep 24. doi: 10.1084/jem.20190706

PMCID:: PMC7953737

Abstract Article PDF–5.7M

Select item 789382715.

Polymorphisms in IRF5 and TYK2 Genes Are Associated with Rheumatoid Arthritis in a Chinese Han Population

Yuqin Peng, Bingqian Chen, Xiaowen Sheng, Yufeng Qian

Med Sci Monit. 2021; 27: e928455-1–e928455-8. Prepublished online 2020 Dec 11. Published online 2021 Feb 15. doi: 10.12659/MSM.928455

PMCID:: PMC7893827

Abstract Article PDF–395K

Select item 774652216.

Irf5 deficiency in myeloid cells prevents necrotizing enterocolitis by inhibiting M1 macrophage polarization

Jia Wei, Daxing Tang, Chengjie Lu, Jin Yang, Yulei Lu, Yidong Wang, Liangliang Jia, Jianfang Wang, Wei Ru, Yi Lu, Zhejun Cai, Qiang Shu

Mucosal Immunol. 2019; 12(4): 888–896. Published online 2019 May 13. doi: 10.1038/s41385-019-0169-x

PMCID:: PMC7746522

Abstract Article PDF–3.2M

Select item 768573917.

Inhibition of IRF5 hyperactivation protects from lupus onset and severity

Su Song, Saurav De, Victoria Nelson, Samin Chopra, Margaret LaPan, Kyle Kampta, Shan Sun, Mingzhu He, Cherrie D. Thompson, Dan Li, Tiffany Shih, Natalie Tan, Yousef Al-Abed, Eugenio Capitle, Cynthia Aranow, Meggan Mackay, William L. Clapp, Betsy J. Barnes

J Clin Invest. 2020 Dec 1; 130(12): 6700–6717. Published online 2020 Nov 16. doi: 10.1172/JCI120288

PMCID:: PMC7685739

Abstract Article PDF–14M

Select item 761094418.

TASL is the SLC15A4-associated adaptor for IRF5 activation by TLR7-9

Leonhard X. Heinz, JangEun Lee, Utkarsh Kapoor, Felix Kartnig, Vitaly Sedlyarov, Konstantinos Papakostas, Adrian César-Razquin, Patrick Essletzbichler, Ulrich Goldmann, Adrijana Stefanovic, Johannes W. Bigenzahn, Stefania Scorzoni, Mattia D. Pizzagalli, Ariel Bensimon, André C. Müller, F. James King, Jun Li, Enrico Girardi, M. Lamine Mbow, Charles E. Whitehurst, Manuele Rebsamen, Giulio Superti-Furga

Nature. Author manuscript; available in PMC 2021 Jun 9.

Published in final edited form as: Nature. 2020 May 1; 581(7808): 316–322. Published online 2020 May 13. doi: 10.1038/s41586-020-2282-0

PMCID:: PMC7610944

Abstract Article PDF–6.7M

Select item 740953619.

T Cell-Intrinsic IRF5 Regulates T Cell Signaling, Migration, and Differentiation and Promotes Intestinal Inflammation

Jie Yan, Surya P. Pandey, Betsy J. Barnes, Jerrold R. Turner, Clara Abraham

Cell Rep. Author manuscript; available in PMC 2021 Jun 30.

Published in final edited form as: Cell Rep. 2020 Jun 30; 31(13): 107820. doi: 10.1016/j.celrep.2020.107820

PMCID:: PMC7409536

Abstract Article PDF–2.2M

Select item 715990920.

O-GlcNAc transferase promotes influenza A virus–induced cytokine storm by targeting interferon regulatory factor–5

Qiming Wang, Peining Fang, Rui He, Mengqi Li, Haisheng Yu, Li Zhou, Yu Yi, Fubing Wang, Yuan Rong, Yi Zhang, Aidong Chen, Nanfang Peng, Yong Lin, Mengji Lu, Ying Zhu, Guoping Peng, Liqun Rao, Shi Liu

Sci Adv. 2020 Apr; 6(16): eaaz7086. Published online 2020 Apr 15. doi: 10.1126/sciadv.aaz7086

PMCID:: PMC7159909

Abstract Article PDF–5.0M

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PMC Links for GEO Profiles (Select 61680416) (137)
PMC
50S ribosomal protein L34 [Acinetobacter baumannii]
50S ribosomal protein L34 [Acinetobacter baumannii]
gi|1051000318|emb|SCD17795.1|

Protein
Homo sapiens lysine demethylase 5C (KDM5C), transcript variant 6, mRNA
Homo sapiens lysine demethylase 5C (KDM5C), transcript variant 6, mRNA
gi|1677498729|ref|NM_001353981.2|

Nucleotide
Homo sapiens lysine demethylase 5C (KDM5C), transcript variant 9, non-coding RNA
Homo sapiens lysine demethylase 5C (KDM5C), transcript variant 9, non-coding RNA
gi|1700447764|ref|NR_148672.2|

Nucleotide

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