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Select item 110716631.

B-cell immune dysregulation with low soluble CD22 levels in refractory seronegative myasthenia gravis

Yuumi Okuzono, Shuuichi Miyakawa, Tatsuo Itou, Masaki Sagara, Masashi Iwata, Kei Ishizuchi, Koji Sekiguchi, Haruhiko Motegi, Munenori Oyama, Dnyaneshwar Warude, Yusuke Kikukawa, Shigeaki Suzuki

Front Immunol. 2024; 15: 1382320. Published online 2024 Apr 22. doi: 10.3389/fimmu.2024.1382320

PMCID:: PMC11071663

Abstract Article PDF–3.4M

Select item 110146562.

Immunotherapy-resistant acute lymphoblastic leukemia cells exhibit reduced CD19 and CD22 expression and BTK pathway dependency

Sarah Aminov, Orsi Giricz, David T. Melnekoff, R. Alejandro Sica, Veronika Polishchuk, Cristian Papazoglu, Bonnie Yates, Hao-Wei Wang, Srabani Sahu, Yanhua Wang, Shanisha Gordon-Mitchell, Violetta V. Leshchenko, Carolina Schinke, Kith Pradhan, Srinivas Aluri, Moah Sohn, Stefan K. Barta, Beamon Agarwal, Mendel Goldfinger, Ioannis Mantzaris, Aditi Shastri, William Matsui, Ulrich Steidl, Joshua D. Brody, Nirali N. Shah, Samir Parekh, Amit Verma

J Clin Invest. 2024 Apr 15; 134(8): e175199. Published online 2024 Feb 20. doi: 10.1172/JCI175199

PMCID:: PMC11014656

Abstract Article PDF–1.5M

Select item 109385863.

Associations of plasma soluble CD22 levels with brain amyloid burden and cognitive decline in Alzheimer’s disease

Xian-Le Bu, Pu-Yang Sun, Dong-Yu Fan, Jun Wang, Hao-Lun Sun, Yuan Cheng, Gui-Hua Zeng, Dong-Wan Chen, Hui-Yun Li, Xu Yi, Ying-Ying Shen, Luke A. Miles, Paul Maruff, Ben J. Gu, Christopher J. Fowler, Colin L. Masters, Yan-Jiang Wang

Sci Adv. 2022 Apr; 8(13): eabm5667. Published online 2022 Apr 1. doi: 10.1126/sciadv.abm5667

PMCID:: PMC10938586

Abstract Article PDF–1018K

Select item 109168664.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 95242185.

HIV-1 Nef intersects the macrophage CD40L signalling pathway to promote resting-cell infection

Simon Swingler, Beda Brichacek, Jean-Marc Jacque, Catherine Ulich, Jin Zhou, Mario Stevenson

Nature. Author manuscript; available in PMC 2022 Sep 30.

Published in final edited form as: Nature. 2003 Jul 10; 424(6945): 213–219. doi: 10.1038/nature01749

PMCID:: PMC9524218

Abstract Article PDF–1.5M

Select item 88421656.

CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system

Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar

Mol Syst Biol. 2022 Feb; 18(2): e10629. Published online 2022 Feb 14. doi: 10.15252/msb.202110629

PMCID:: PMC8842165

Abstract Article PDF–3.0M

Select item 85166487.

CAR T cells with dual targeting of CD19 and CD22 in pediatric and young adult patients with relapsed or refractory B cell acute lymphoblastic leukemia: a phase 1 trial

Shaun Cordoba, Shimobi Onuoha, Simon Thomas, Daniela Soriano Pignataro, Rachael Hough, Sara Ghorashian, Ajay Vora, Denise Bonney, Paul Veys, Kanchan Rao, Giovanna Lucchini, Robert Chiesa, Jan Chu, Liz Clark, Mei Mei Fung, Koval Smith, Carlotta Peticone, Muhammad Al-Hajj, Vania Baldan, Mathieu Ferrari, Saket Srivastava, Ram Jha, Frederick Arce Vargas, Kevin Duffy, William Day, Paul Virgo, Lucy Wheeler, Jeremy Hancock, Farzin Farzaneh, Sabine Domning, Yiyun Zhang, Nushmia Z. Khokhar, Vijay G. R. Peddareddigari, Robert Wynn, Martin Pule, Persis J. Amrolia

Nat Med. 2021; 27(10): 1797–1805. Published online 2021 Oct 12. doi: 10.1038/s41591-021-01497-1

PMCID:: PMC8516648

Abstract Article PDF–7.9M

Select item 85088228.

Human CD22-Transgenic, Primary Murine Lymphoma Challenges Immunotherapies in Organ-Specific Tumor Microenvironments

Franziska Gsottberger, Carolin Brandl, Kerstin Wendland, Srdjan Petkovic, Charlotte Emmerich, Ramona Erber, Carol Geppert, Arndt Hartmann, Andreas Mackensen, Lars Nitschke, Fabian Müller

Int J Mol Sci. 2021 Oct; 22(19): 10433. Published online 2021 Sep 28. doi: 10.3390/ijms221910433

PMCID:: PMC8508822

Abstract Article PDF–4.1M

Select item 79807869.

Glycoengineering of NK cells with glycan ligands of CD22 and selectins for B-cell lymphoma therapy

Senlian Hong, Chenhua Yu, Peng Wang, Yujie Shi, Weiqian Cao, Bo Cheng, Digantkumar G. Chapla, Yuanhui Ma, Jie Li, Emily Rodrigues, Yoshiki Narimatsu, John R. Yates, III, Xing Chen, Henrik Clausen, Kelly W. Moremen, Matthew Scott Macauley, James C. Paulson, Peng Wu

Angew Chem Int Ed Engl. Author manuscript; available in PMC 2022 Feb 15.

Published in final edited form as: Angew Chem Int Ed Engl. 2021 Feb 15; 60(7): 3603–3610. Published online 2020 Dec 14. doi: 10.1002/anie.202005934

PMCID:: PMC7980786

Abstract Article PDF–2.0M

Select item 716998310.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 645830711.

N-Linked Glycosylation Regulates CD22 Organization and Function

Laabiah Wasim, Fathima Hifza Mohamed Buhari, Myuran Yoganathan, Taylor Sicard, June Ereño-Orbea, Jean-Philippe Julien, Bebhinn Treanor

Front Immunol. 2019; 10: 699. Published online 2019 Apr 4. doi: 10.3389/fimmu.2019.00699

PMCID:: PMC6458307

Abstract Article PDF–5.3M

Select item 633346012.

ATG5 is required for B cell polarization and presentation of particulate antigens

Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros

Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327

PMCID:: PMC6333460

Abstract Article PDF–2.7M

Select item 625901413.

Down-regulation of siglec-2 (CD22) predicts worse overall survival from HBV-related early-stage hepatocellular carcinoma: a preliminary analysis from Gene Expression Omnibus

Xiaojing Ren, Yuanyuan Ji, Xuhua Jiang, Xun Qi

Biosci Rep. 2018 Dec 21; 38(6): BSR20181423. Prepublished online 2018 Oct 24. Published online 2018 Nov 28. doi: 10.1042/BSR20181423

PMCID:: PMC6259014

Abstract Article PDF–785K

Select item 617312914.

CD22: A Regulator of Innate and Adaptive B Cell Responses and Autoimmunity

Edward A. Clark, Natalia V. Giltiay

Front Immunol. 2018; 9: 2235. Published online 2018 Sep 28. doi: 10.3389/fimmu.2018.02235

PMCID:: PMC6173129

Abstract Article PDF–1011K

Select item 575597115.

CD22 Ligands on a Natural N-Glycan Scaffold Efficiently Delivers Toxins to B-Lymphoma Cells

Wenjie Peng, James C. Paulson

J Am Chem Soc. Author manuscript; available in PMC 2018 Sep 13.

Published in final edited form as: J Am Chem Soc. 2017 Sep 13; 139(36): 12450–12458. Published online 2017 Aug 31. doi: 10.1021/jacs.7b03208

PMCID:: PMC5755971

Abstract Article PDF–1.3M

Select item 567947116.

Human CD22 Inhibits Murine B-cell Receptor Activation in a Human CD22 Transgenic Mouse Model

Kyle J Bednar, Elena Shanina, Romain Ballet, Edward P Connors, Shiteng Duan, Joana Juan, Britni M. Arlian, Michael D Kulis, Eugene C Butcher, Wai-Ping Fung-Leung, Tadimeti S Rao, James C Paulson, Matthew S Macauley

J Immunol. Author manuscript; available in PMC 2018 Nov 1.

Published in final edited form as: J Immunol. 2017 Nov 1; 199(9): 3116–3128. Published online 2017 Sep 29. doi: 10.4049/jimmunol.1700898

PMCID:: PMC5679471

Abstract Article PDF–1.0M

Select item 562492617.

Molecular basis of human CD22 function and therapeutic targeting

June Ereño-Orbea, Taylor Sicard, Hong Cui, Mohammad T. Mazhab-Jafari, Samir Benlekbir, Alba Guarné, John L. Rubinstein, Jean-Philippe Julien

Nat Commun. 2017; 8: 764. Published online 2017 Oct 2. doi: 10.1038/s41467-017-00836-6

PMCID:: PMC5624926

Abstract Article PDF–1.7M

Select item 555729218.

Synergistic drug combinations for cancer identified in a CRISPR screen for pairwise genetic interactions

Kyuho Han, Edwin E. Jeng, Gaelen T. Hess, David W. Morgens, Amy Li, Michael C. Bassik

Nat Biotechnol. Author manuscript; available in PMC 2017 Sep 20.

Published in final edited form as: Nat Biotechnol. 2017 May; 35(5): 463–474. Published online 2017 Mar 20. doi: 10.1038/nbt.3834

PMCID:: PMC5557292

Abstract Article PDF–3.4M

Select item 553161119.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 509362220.

Structural characterisation of high affinity Siglec-2 (CD22) ligands in complex with whole Burkitt’s lymphoma (BL) Daudi cells by NMR spectroscopy

Paul D. Madge, Andrea Maggioni, Mauro Pascolutti, Moein Amin, Mario Waespy, Bernadette Bellette, Robin J. Thomson, Sørge Kelm, Mark von Itzstein, Thomas Haselhorst

Sci Rep. 2016; 6: 36012. Published online 2016 Nov 3. doi: 10.1038/srep36012

PMCID:: PMC5093622

Abstract Article PDF–1.4M

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