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Select item 108874571.

Human Platelet Derived Mitochondrial OPA-1 Isoforms and Interaction With TDP-43 in Neurodegenerative Diseases

Su Han Lee, Duyen Pham, Edina Kosa, Abdulbaki Agbas

Mo Med. 2024 Jan-Feb; 121(1): 87–92.

Correction in:: Mo Med. 2024 Mar-Apr; 121(2): 123.

PMCID:: PMC10887457

Abstract Article PDF–490K

Select item 108759622.

Structural mechanism of mitochondrial membrane remodelling by human OPA1

Alexander von der Malsburg, Gracie M. Sapp, Kelly E. Zuccaro, Alexander von Appen, Frank R. Moss, III, Raghav Kalia, Jeremy A. Bennett, Luciano A. Abriata, Matteo Dal Peraro, Martin van der Laan, Adam Frost, Halil Aydin

Nature. Author manuscript; available in PMC 2024 Feb 23.

Published in final edited form as: Nature. 2023 Aug; 620(7976): 1101–1108. Published online 2023 Aug 23. doi: 10.1038/s41586-023-06441-6

PMCID:: PMC10875962

Abstract Article PDF–6.0M

Select item 108753473.

p32/OPA1 axis-mediated mitochondrial dynamics contributes to cisplatin resistance in non-small cell lung cancer: p32/OPA1 contributes to cisplatin resistance

Chun-Xia Yu, Zhe-Qing Peng, Tao Wang, Xin-Hui Qu, Ping Yang, Shao-Rong Huang, Li-Ping Jiang, Fang-Fang Tou, Xiao-Jian Han

Acta Biochim Biophys Sin (Shanghai) 2024 Jan 25; 56(1): 34–43. Published online 2023 Dec 26. doi: 10.3724/abbs.2023247

PMCID:: PMC10875347

Abstract Article PDF–1.7M

Select item 108508184.

Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord

Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537

PMCID:: PMC10850818

Abstract Article PDF–2.7M

Select item 108286845.

Human retinal organoids with an OPA1 mutation are defective in retinal ganglion cell differentiation and function

Qiannan Lei, Kangjian Xiang, Lin Cheng, Mengqing Xiang

Stem Cell Reports. 2024 Jan 9; 19(1): 68–83. Published online 2023 Dec 14. doi: 10.1016/j.stemcr.2023.11.004

PMCID:: PMC10828684

Abstract Article PDF–7.8M

Select item 107265946.

Role of mitochondrial fusion proteins MFN2 and OPA1 on lung cellular senescence in chronic obstructive pulmonary disease

Chenfei Li, Qi Liu, Qing Chang, Meiqin Xie, Jiali Weng, Xiaohui Wang, Mengnan Li, Jiani Chen, Yan Huang, Xiaohua Yang, Kai Wang, Na Zhang, Kian Fan Chung, Ian M. Adcock, Hai Zhang, Feng Li

Respir Res. 2023; 24: 319. Published online 2023 Dec 18. doi: 10.1186/s12931-023-02634-9

PMCID:: PMC10726594

Abstract Article PDF–9.6M

Select item 107134067.

Multi-omics analysis of the oncogenic role of optic atrophy 1 in human cancer

Ziyi Wu, Nuo Xu, Guoqing Li, Wen Yang, Chen Zhang, Hua Zhong, Gen Wu, Fei Chen, Dianqing Li

Aging (Albany NY) 2023 Nov 30; 15(22): 12982–12997. Published online 2023 Nov 16. doi: 10.18632/aging.205214

PMCID:: PMC10713406

Abstract Article PDF–2.8M

Select item 105382958.

OPA1 deficiency impairs oxidative metabolism in cycling cells, underlining a translational approach for degenerative diseases

Aurélie M. C. Millet, Corentin Coustham, Camille Champigny, Marlène Botella, Christine Demeilliers, Anne Devin, Anne Galinier, Pascale Belenguer, Joel Bordeneuve-Guibé, Noélie Davezac

Dis Model Mech. 2023 Sep 1; 16(9): dmm050266. Published online 2023 Sep 20. doi: 10.1242/dmm.050266

Correction in:: Dis Model Mech. 2024 Apr 1; 17(4): dmm050815.

PMCID:: PMC10538295

Abstract Article

Select item 104164289.

Mitochondrial dynamics-related genes DRP1 and OPA1 contributes to early diagnosis of cognitive impairment in diabetes

Mengqian Liu, Chen Gong, Xiaozhu Shen, Yi Jiang, Yiwen Xu, Wen Zhong, Yujiao Chen, Nan Dong, Jingxian Liao, Ning Yin

BMC Geriatr. 2023; 23: 484. Published online 2023 Aug 10. doi: 10.1186/s12877-023-04156-x

PMCID:: PMC10416428

Abstract Article PDF–1.3M

Select item 1027724310.

视神经萎缩因子1介导的线粒体动力学在骨骼系统疾病中的研究进展

凯博孙, 元刚吴, 羿曾, 明阳李, 立民武, 彬沈

Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. 2023 Jun; 37(6): 758–763. Chinese. doi: 10.7507/1002-1892.202302056

PMCID:: PMC10277243

Abstract Article PDF–531K

Select item 1026564911.

Opa1 and Drp1 reciprocally regulate cristae morphology, ETC function, and NAD⁺ regeneration in KRas-mutant lung adenocarcinoma

Dane T. Sessions, Kee-Beom Kim, Jennifer A. Kashatus, Nikolas Churchill, Kwon-Sik Park, Marty W. Mayo, Hiromi Sesaki, David F. Kashatus

Cell Rep. Author manuscript; available in PMC 2023 Jun 14.

Published in final edited form as: Cell Rep. 2022 Dec 13; 41(11): 111818. doi: 10.1016/j.celrep.2022.111818

PMCID:: PMC10265649

Abstract Article PDF–2.8M

Select item 1023742212.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1004843613.

Reduced OPA1, Mitochondrial Fragmentation and Increased Susceptibility to Apoptosis in Granular Corneal Dystrophy Type 2 Corneal Fibroblasts

Seung-Il Choi, Ga-Hyun Lee, Jong-Hwan Woo, Ikhyun Jun, Eung Kweon Kim

Genes (Basel) 2023 Mar; 14(3): 566. Published online 2023 Feb 24. doi: 10.3390/genes14030566

PMCID:: PMC10048436

Abstract Article PDF–4.8M

Select item 1004112114.

OPA1 disease-causing mutants have domain-specific effects on mitochondrial ultrastructure and fusion

Benjamín Cartes-Saavedra, Daniel Lagos, Josefa Macuada, Duxan Arancibia, Florence Burté, Marcela K. Sjöberg-Herrera, María Estela Andrés, Rita Horvath, Patrick Yu-Wai-Man, György Hajnóczky, Verónica Eisner

Proc Natl Acad Sci U S A. 2023 Mar 21; 120(12): e2207471120. Published online 2023 Mar 16. doi: 10.1073/pnas.2207471120

PMCID:: PMC10041121

Abstract Article PDF–4.0M

Select item 1000589815.

The p97/VCP segregase is essential for arsenic-induced degradation of PML and PML-RARA

Ellis G. Jaffray, Michael H. Tatham, Barbara Mojsa, Magda Liczmanska, Alejandro Rojas-Fernandez, Yili Yin, Graeme Ball, Ronald T. Hay

J Cell Biol. 2023 Apr 3; 222(4): e202201027. Published online 2023 Feb 28. doi: 10.1083/jcb.202201027

PMCID:: PMC10005898

Abstract Article PDF–6.7M

Select item 995018316.

CLEC16A interacts with retromer and TRIM27, and its loss impairs endosomal trafficking and neurodevelopment

Daphne J. Smits, Jordy Dekker, Rachel Schot, Brahim Tabarki, Amal Alhashem, Jeroen A. A. Demmers, Dick H. W. Dekkers, Antonio Romito, Peter J. van der Spek, Tjakko J. van Ham, Aida M. Bertoli-Avella, Grazia M. S. Mancini

Hum Genet. 2023; 142(3): 379–397. Published online 2022 Dec 20. doi: 10.1007/s00439-022-02511-3

PMCID:: PMC9950183

Abstract Article PDF–2.4M

Select item 992246817.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Abstract Article PDF–4.9M

Select item 986422018.

p53 Regulates Mitochondrial Dynamics in Vascular Smooth Muscle Cell Calcification

Kanchan Phadwal, Qi-Yu Tang, Ineke Luijten, Jin-Feng Zhao, Brendan Corcoran, Robert K. Semple, Ian G. Ganley, Vicky E. MacRae

Int J Mol Sci. 2023 Jan; 24(2): 1643. Published online 2023 Jan 13. doi: 10.3390/ijms24021643

PMCID:: PMC9864220

Abstract Article PDF–2.5M

Select item 976969819.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 959735220.

RUFY1 binds Arl8b and mediates endosome-to-TGN CI-M6PR retrieval for cargo sorting to lysosomes

Shalini Rawat, Dhruba Chatterjee, Rituraj Marwaha, Gitanjali Charak, Gaurav Kumar, Shrestha Shaw, Divya Khatter, Sheetal Sharma, Cecilia de Heus, Nalan Liv, Judith Klumperman, Amit Tuli, Mahak Sharma

J Cell Biol. 2023 Jan 2; 222(1): e202108001. Published online 2022 Oct 25. doi: 10.1083/jcb.202108001