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Items: 1 to 20 of 50

1.
Mapping catalytically engaged TOP2B in neurons reveals the principles of topoisomerase action within the genome
Amir Segev, Lance Heady, Morgan Crewe, Ram Madabhushi
Cell Rep. Author manuscript; available in PMC 2024 May 2.
Published in final edited form as: Cell Rep. 2024 Feb 27; 43(2): 113809. Published online 2024 Feb 19. doi: 10.1016/j.celrep.2024.113809
PMCID:
PMC11064056
AbstractArticlePDF–3.0M
2.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
3.
Nucleophagy contributes to genome stability through degradation of type II topoisomerases A and B and nucleolar components
Gabriel Muciño-Hernández, Pilar Sarah Acevo-Rodríguez, Sandra Cabrera-Benitez, Adán Oswaldo Guerrero, Horacio Merchant-Larios, Susana Castro-Obregón
J Cell Sci. 2023 Jan 1; 136(1): jcs260563. Published online 2023 Jan 12. doi: 10.1242/jcs.260563
PMCID:
PMC10112964
AbstractArticle
4.
Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks
Ilse Delint-Ramirez, Lahiri Konada, Lance Heady, Richard Rueda, Alvaro Sebastian Vaca Jacome, Eric Marlin, Charlotte Marchioni, Amir Segev, Oleg Kritskiy, Satoko Yamakawa, Andrew H. Reiter, Li-Huei Tsai, Ram Madabhushi
Mol Cell. Author manuscript; available in PMC 2023 Oct 20.
Published in final edited form as: Mol Cell. 2022 Oct 20; 82(20): 3794–3809.e8. Published online 2022 Oct 6. doi: 10.1016/j.molcel.2022.09.012
PMCID:
PMC9990814
AbstractArticlePDF–2.6M
5.
Rescue of deficits by Brwd1 copy number restoration in the Ts65Dn mouse model of Down syndrome
Sasha L. Fulton, Wendy Wenderski, Ashley E. Lepack, Andrew L. Eagle, Tomas Fanutza, Ryan M. Bastle, Aarthi Ramakrishnan, Emma C. Hays, Arianna Neal, Jaroslav Bendl, Lorna A. Farrelly, Amni Al-Kachak, Yang Lyu, Bulent Cetin, Jennifer C. Chan, Tina N. Tran, Rachael L. Neve, Randall J. Roper, Kristen J. Brennand, Panos Roussos, John C. Schimenti, Allyson K. Friedman, Li Shen, Robert D. Blitzer, Alfred J. Robison, Gerald R. Crabtree, Ian Maze
Nat Commun. 2022; 13: 6384. Published online 2022 Oct 26. doi: 10.1038/s41467-022-34200-0
PMCID:
PMC9606253
AbstractArticlePDF–4.0M
6.
Cell-Type-Specific Gene Expression in Developing Mouse Neocortex: Intermediate Progenitors Implicated in Axon Development
Francesco Bedogni, Robert F. Hevner
Front Mol Neurosci. 2021; 14: 686034. Published online 2021 Jul 12. doi: 10.3389/fnmol.2021.686034
PMCID:
PMC8313239
AbstractArticlePDF–1.6M
7.
Topoisomerase II-Induced Chromosome Breakage and Translocation Is Determined by Chromosome Architecture and Transcriptional Activity
Andres Canela, Yaakov Maman, Shar-yin N. Huang, Gordana Wutz, Wen Tang, Guido Zagnoli-Vieira, Elsa Callen, Nancy Wong, Amanda Day, Jan-Michael Peters, Keith W. Caldecott, Yves Pommier, André Nussenzweig
Mol Cell. Author manuscript; available in PMC 2021 Jun 2.
Published in final edited form as: Mol Cell. 2019 Jul 25; 75(2): 252–266.e8. Published online 2019 Jun 12. doi: 10.1016/j.molcel.2019.04.030
PMCID:
PMC8170508
AbstractArticlePDF–2.4M
8.
BraInMap elucidates the macromolecular connectivity landscape of mammalian brain
Reza Pourhaghighi, Peter E. A. Ash, Sadhna Phanse, Florian Goebels, Lucas Z. M. Hu, Siwei Chen, Yingying Zhang, Shayne D. Wierbowski, Samantha Boudeau, Mohamed T. Moutaoufik, Ramy H. Malty, Edyta Malolepsza, Kalliopi Tsafou, Aparna Nathan, Graham Cromar, Hongbo Guo, Ali Al Abdullatif, Daniel J. Apicco, Lindsay A. Becker, Aaron D. Gitler, Stefan M. Pulst, Ahmed Youssef, Ryan Hekman, Pierre C. Havugimana, Carl A. White, Benjamin C. Blum, Antonia Ratti, Camron D. Bryant, John Parkinson, Kasper Lage, Mohan Babu, Haiyuan Yu, Gary D. Bader, Benjamin Wolozin, Andrew Emili
Cell Syst. Author manuscript; available in PMC 2021 Apr 22.
Published in final edited form as: Cell Syst. 2020 Apr 22; 10(4): 333–350.e14. doi: 10.1016/j.cels.2020.03.003
Correction in:
Cell Syst. 2020 Aug 26; 11(2): 208.
PMCID:
PMC7938770
AbstractArticlePDF–2.0M
9.
Mouse Models of Inherited Retinal Degeneration with Photoreceptor Cell Loss
Gayle B. Collin, Navdeep Gogna, Bo Chang, Nattaya Damkham, Jai Pinkney, Lillian F. Hyde, Lisa Stone, Jürgen K. Naggert, Patsy M. Nishina, Mark P. Krebs
Cells. 2020 Apr; 9(4): 931. Published online 2020 Apr 10. doi: 10.3390/cells9040931
PMCID:
PMC7227028
AbstractArticlePDF–5.4M
10.
Spatiotemporal Gradient of Cortical Neuron Death Contributes to Microcephaly in Knock-In Mouse Model of Ligase 4 Syndrome
Melody P. Lun, Morgan L. Shannon, Sevgi Keles, Ismail Reisli, Nicole Luche, Douglas Ryan, Kelly Capuder, Luigi D. Notarangelo, Maria K. Lehtinen
Am J Pathol. 2019 Dec; 189(12): 2440–2449. doi: 10.1016/j.ajpath.2019.08.010
PMCID:
PMC6897336
AbstractArticlePDF–2.5M
11.
Hdac4 Interactions in Huntington's Disease Viewed Through the Prism of Multiomics
Joel D. Federspiel, Todd M. Greco, Krystal K. Lum, Ileana M. Cristea
Mol Cell Proteomics. 2019 Aug 9; 18(8 Suppl 1): S92–S113. Published online 2019 Apr 30. doi: 10.1074/mcp.RA118.001253
PMCID:
PMC6692770
AbstractArticlePDF–7.7M
12.
Mutations in topoisomerase IIβ result in a B cell immunodeficiency
Lori Broderick, Shawn Yost, Dong Li, Matthew D. McGeough, Laela M. Booshehri, Marisela Guaderrama, Susannah D. Brydges, Karolina Kucharova, Niraj C. Patel, Margaret Harr, Hakon Hakonarson, Elaine Zackai, Ian G. Cowell, Caroline A. Austin, Boris Hügle, Corinna Gebauer, Jianguo Zhang, Xun Xu, Jian Wang, Ben A. Croker, Kelly A. Frazer, Christopher D. Putnam, Hal M. Hoffman
Nat Commun. 2019; 10: 3644. Published online 2019 Aug 13. doi: 10.1038/s41467-019-11570-6
PMCID:
PMC6692411
AbstractArticlePDF–2.0M
13.
MACF1 links Rapsyn to microtubule- and actin-binding proteins to maintain neuromuscular synapses
Julien Oury, Yun Liu, Ana Töpf, Slobodanka Todorovic, Esthelle Hoedt, Veeramani Preethish-Kumar, Thomas A. Neubert, Weichun Lin, Hanns Lochmüller, Steven J. Burden
J Cell Biol. 2019 May 6; 218(5): 1686–1705. Published online 2019 Mar 6. doi: 10.1083/jcb.201810023
PMCID:
PMC6504910
AbstractArticlePDF–4.2M
14.
ATG5 is required for B cell polarization and presentation of particulate antigens
Florent Arbogast, Johan Arnold, Philippe Hammann, Lauriane Kuhn, Johana Chicher, Diane Murera, Justine Weishaar, Sylviane Muller, Jean-Daniel Fauny, Frédéric Gros
Autophagy. 2019; 15(2): 280–294. Published online 2018 Sep 22. doi: 10.1080/15548627.2018.1516327
PMCID:
PMC6333460
AbstractArticlePDF–2.7M
15.
Genome Organization Drives Chromosome Fragility
Andres Canela, Yaakov Maman, Seolkyoung Jung, Nancy Wong, Elsa Callen, Amanda Day, Kyong-Rim Kieffer-Kwon, Aleksandra Pekowska, Hongliang Zhang, Suhas S.P. Rao, Su-Chen Huang, Peter J. Mckinnon, Peter D. Aplan, Yves Pommier, Erez Lieberman Aiden, Rafael Casellas, André Nussenzweig
Cell. Author manuscript; available in PMC 2018 Sep 11.
Published in final edited form as: Cell. 2017 Jul 27; 170(3): 507–521.e18. Published online 2017 Jul 20. doi: 10.1016/j.cell.2017.06.034
PMCID:
PMC6133249
AbstractArticlePDF–3.0M
16.
Topoisomerase IIβ Selectively Regulates Motor Neuron Identity and Peripheral Connectivity through Hox/Pbx-Dependent Transcriptional Programs
Michaela Edmond, Olivia Hanley, Polyxeni Philippidou
eNeuro. 2017 Nov-Dec; 4(6): ENEURO.0404-17.2017. Prepublished online 2017 Dec 11. Published online 2017 Dec 14. doi: 10.1523/ENEURO.0404-17.2017
PMCID:
PMC5779120
AbstractArticlePDF–7.0M
17.
Top2b is involved in the formation of outer segment and synapse during late-stage photoreceptor differentiation by controlling key genes of photoreceptor transcriptional regulatory network
Ying Li, Hailing Hao, Mavis R. Swerdel, Hyeon-Yeol Cho, Ki-Bum Lee, Ronald P. Hart, Yi Lisa Lyu, Li Cai
J Neurosci Res. Author manuscript; available in PMC 2018 Apr 1.
Published in final edited form as: J Neurosci Res. 2017 Oct; 95(10): 1951–1964. Published online 2017 Mar 30. doi: 10.1002/jnr.24037
PMCID:
PMC5561520
AbstractArticlePDF–3.0M
18.
TOP2β Is Essential for Ovarian Follicles That Are Hypersensitive to Chemotherapeutic Drugs
Yin-Li Zhang, Chao Yu, Shu-Yan Ji, Xiao-Meng Li, Yong-Ping Zhang, Dan Zhang, Dawang Zhou, Heng-Yu Fan
Mol Endocrinol. 2013 Oct; 27(10): 1678–1691. Published online 2013 Sep 3. doi: 10.1210/me.2013-1108
PMCID:
PMC5427880
AbstractArticle
19.
Fancd2 in vivo interaction network reveals a non-canonical role in mitochondrial function
Tingting Zhang, Wei Du, Andrew F. Wilson, Satoshi H. Namekawa, Paul R. Andreassen, Amom Ruhikanta Meetei, Qishen Pang
Sci Rep. 2017; 7: 45626. Published online 2017 Apr 5. doi: 10.1038/srep45626
PMCID:
PMC5381226
AbstractArticlePDF–1.4M
20.
Chd7 is indispensable for mammalian brain development through activation of a neuronal differentiation programme
Weijun Feng, Daisuke Kawauchi, Huiqin Körkel-Qu, Huan Deng, Elisabeth Serger, Laura Sieber, Jenna Ariel Lieberman, Silvia Jimeno-González, Sander Lambo, Bola S. Hanna, Yassin Harim, Malin Jansen, Anna Neuerburg, Olga Friesen, Marc Zuckermann, Vijayanad Rajendran, Jan Gronych, Olivier Ayrault, Andrey Korshunov, David T. W. Jones, Marcel Kool, Paul A. Northcott, Peter Lichter, Felipe Cortés-Ledesma, Stefan M. Pfister, Hai-Kun Liu
Nat Commun. 2017; 8: 14758. Published online 2017 Mar 20. doi: 10.1038/ncomms14758
PMCID:
PMC5364396
AbstractArticlePDF–3.2M

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