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Items: 1 to 20 of 70

1.
Genetic determinants of micronucleus formation in vivo
D. J. Adams, B. Barlas, R. E. McIntyre, I. Salguero, L. van der Weyden, A. Barros, J. R. Vicente, N. Karimpour, A. Haider, M. Ranzani, G. Turner, N. A. Thompson, V. Harle, R. Olvera-León, C. D. Robles-Espinoza, A. O. Speak, N. Geisler, W. J. Weninger, S. H. Geyer, J. Hewinson, N. A. Karp, The Sanger Mouse Genetics Project, B. Fu, F. Yang, Z. Kozik, J. Choudhary, L. Yu, M. S. van Ruiten, B. D. Rowland, C. J. Lelliott, M. del Castillo Velasco-Herrera, R. Verstraten, L. Bruckner, A. G. Henssen, M. A. Rooimans, J. de Lange, T. J. Mohun, M. J. Arends, K. A. Kentistou, P. A. Coelho, Y. Zhao, H. Zecchini, J. R. B. Perry, S. P. Jackson, G. Balmus
Nature. 2024; 627(8002): 130–136. Published online 2024 Feb 14. doi: 10.1038/s41586-023-07009-0
PMCID:
PMC10917660
AbstractArticlePDF–4.8M
2.
Loss of endothelial glucocorticoid receptor accelerates organ fibrosis in db/db mice
Swayam Prakash Srivastava, Julie E. Goodwin
Am J Physiol Renal Physiol. 2023 Oct 1; 325(4): F519–F526. Published online 2023 Aug 17. doi: 10.1152/ajprenal.00105.2023
PMCID:
PMC10639025
AbstractArticle
3.
Endogenous renal adiponectin drives gluconeogenesis through enhancing pyruvate and fatty acid utilization
Toshiharu Onodera, May-Yun Wang, Joseph M. Rutkowski, Stanislaw Deja, Shiuhwei Chen, Michael S. Balzer, Dae-Seok Kim, Xuenan Sun, Yu A. An, Bianca C. Field, Charlotte Lee, Ei-ichi Matsuo, Monika Mizerska, Ina Sanjana, Naoto Fujiwara, Christine M. Kusminski, Ruth Gordillo, Laurent Gautron, Denise K. Marciano, Ming Chang Hu, Shawn C. Burgess, Katalin Susztak, Orson W. Moe, Philipp E. Scherer
Nat Commun. 2023; 14: 6531. Published online 2023 Oct 17. doi: 10.1038/s41467-023-42188-4
PMCID:
PMC10582045
AbstractArticlePDF–4.6M
4.
Glucagon receptor antagonism impairs and glucagon receptor agonism enhances triglycerides metabolism in mice
Katrine D. Galsgaard, Emilie Elmelund, Christian D. Johansen, Anna B. Bomholt, Hüsün S. Kizilkaya, Frederik Ceutz, Jenna E. Hunt, Hannelouise Kissow, Marie Winther-Sørensen, Charlotte M. Sørensen, Thomas Kruse, Jesper F. Lau, Mette M. Rosenkilde, Cathrine Ørskov, Christina Christoffersen, Jens J. Holst, Nicolai J. Wewer Albrechtsen
Mol Metab. 2022 Dec; 66: 101639. Published online 2022 Nov 15. doi: 10.1016/j.molmet.2022.101639
PMCID:
PMC9706156
AbstractArticlePDF–2.9M
5.
Opposing effects of chronic glucagon receptor agonism and antagonism on amino acids, hepatic gene expression, and alpha cells
Emilie Elmelund, Katrine D. Galsgaard, Christian D. Johansen, Samuel A.J. Trammell, Anna B. Bomholt, Marie Winther-Sørensen, Jenna E. Hunt, Charlotte M. Sørensen, Thomas Kruse, Jesper F. Lau, Trisha J. Grevengoed, Jens J. Holst, Nicolai J. Wewer Albrechtsen
iScience. 2022 Nov 18; 25(11): 105296. Published online 2022 Oct 6. doi: 10.1016/j.isci.2022.105296
PMCID:
PMC9618771
AbstractArticlePDF–2.9M
6.
Glucagon receptor signaling at white adipose tissue does not regulate lipolysis
Anastasiia Vasileva, Tyler Marx, Jacqueline L. Beaudry, Jennifer H. Stern
Am J Physiol Endocrinol Metab. 2022 Oct 1; 323(4): E389–E401. Published online 2022 Aug 24. doi: 10.1152/ajpendo.00078.2022
PMCID:
PMC9576180
AbstractArticle
7.
A glucagon analogue decreases body weight in mice via signalling in the liver
Charlotte E. Hinds, Bryn M. Owen, David C. D. Hope, Philip Pickford, Ben Jones, Tricia M. Tan, James S. Minnion, Stephen R. Bloom
Sci Rep. 2021; 11: 22577. Published online 2021 Nov 19. doi: 10.1038/s41598-021-01912-0
PMCID:
PMC8604983
AbstractArticlePDF–1.2M
8.
Amino Acid Transporter Slc38a5 Controls Glucagon Receptor Inhibition-Induced Pancreatic α Cell Hyperplasia in Mice
Jinrang Kim, Haruka Okamoto, ZhiJiang Huang, Guillermo Anguiano, Shiuhwei Chen, Qing Liu, Katie Cavino, Yurong Xin, Erqian Na, Rachid Hamid, Joseph Lee, Brian Zambrowicz, Roger Unger, Andrew J. Murphy, Yan Xu, George D. Yancopoulos, Wen-hong Li, Jesper Gromada
Cell Metab. Author manuscript; available in PMC 2021 Jun 16.
Published in final edited form as: Cell Metab. 2017 Jun 6; 25(6): 1348–1361.e8. doi: 10.1016/j.cmet.2017.05.006
PMCID:
PMC8206958
AbstractArticlePDF–3.1M
9.
Intestinal Growth in Glucagon Receptor Knockout Mice Is Not Associated With the Formation of AOM/DSS-Induced Tumors
Jenna Elizabeth Hunt, Mohammad Yassin, Jørgen Olsen, Bolette Hartmann, Jens Juul Holst, Hannelouise Kissow
Front Endocrinol (Lausanne) 2021; 12: 695145. Published online 2021 May 24. doi: 10.3389/fendo.2021.695145
PMCID:
PMC8181411
AbstractArticlePDF–945K
10.
Deleterious mutation V369M in the mouse GCGR gene causes abnormal plasma amino acid levels indicative of a possible liver–α-cell axis
Qiaofeng Liu, Guangyao Lin, Yan Chen, Wenbo Feng, Yingna Xu, Jianjun Lyu, Dehua Yang, Ming-Wei Wang
Biosci Rep. 2021 Jun 25; 41(6): BSR20210758. Published online 2021 Jun 2. doi: 10.1042/BSR20210758
PMCID:
PMC8173527
AbstractArticlePDF–3.4M
11.
Glucagon blockade restores functional β-cell mass in type 1 diabetic mice and enhances function of human islets
May-Yun Wang, E. Danielle Dean, Ezekiel Quittner-Strom, Yi Zhu, Kamrul H. Chowdhury, Zhuzhen Zhang, Shangang Zhao, Na Li, Reshing Ye, Young Lee, Yiyi Zhang, Shiuhwei Chen, Xinxin Yu, Derek C. Leonard, Greg Poffenberger, Alison Von Deylen, S. Kay McCorkle, Amnon Schlegel, Kyle W. Sloop, Alexander M. Efanov, Ruth E. Gimeno, Philipp E. Scherer, Alvin C. Powers, Roger H. Unger, William L. Holland
Proc Natl Acad Sci U S A. 2021 Mar 2; 118(9): e2022142118. Published online 2021 Feb 22. doi: 10.1073/pnas.2022142118
PMCID:
PMC7936318
AbstractArticlePDF–2.4M
12.
Identification of an anti-diabetic, orally available, small molecule that regulates TXNIP expression and glucagon action
Lance A. Thielen, Junqin Chen, Gu Jing, Omar Moukha-Chafiq, Guanlan Xu, SeongHo Jo, Truman B. Grayson, Brian Lu, Peng Li, Corinne E. Augelli-Szafran, Mark J. Suto, Matt Kanke, Praveen Sethupathy, Jason K. Kim, Anath Shalev
Cell Metab. Author manuscript; available in PMC 2021 Sep 1.
Published in final edited form as: Cell Metab. 2020 Sep 1; 32(3): 353–365.e8. Published online 2020 Jul 28. doi: 10.1016/j.cmet.2020.07.002
PMCID:
PMC7501995
AbstractArticlePDF–2.3M
13.
Discordance between GLP-1R gene and protein expression in mouse pancreatic islet cells
Sarah M. Gray, Yurong Xin, Elizabeth C. Ross, Bryanna M. Chazotte, Megan E. Capozzi, Kimberley El, Berit Svendsen, Peter Ravn, Kyle W. Sloop, Jenny Tong, Jesper Gromada, Jonathan E. Campbell, David A. D'Alessio
J Biol Chem. 2020 Aug 14; 295(33): 11529–11541. Published online 2020 Jun 18. doi: 10.1074/jbc.RA120.014368
PMCID:
PMC7450118
AbstractArticlePDF–2.6M
14.
Glucagon-Receptor Signaling Reverses Hepatic Steatosis Independent of Leptin Receptor Expression
Shelly R Nason, Teayoun Kim, Jessica P Antipenko, Brian Finan, Richard DiMarchi, Chad S Hunter, Kirk M Habegger
Endocrinology. 2020 Jan; 161(1): bqz013. Published online 2019 Nov 1. doi: 10.1210/endocr/bqz013
PMCID:
PMC7188084
AbstractArticle
15.
β Cell tone is defined by proglucagon peptides through cAMP signaling
Megan E. Capozzi, Berit Svendsen, Sara E. Encisco, Sophie L. Lewandowski, Mackenzie D. Martin, Haopeng Lin, Justin L. Jaffe, Reilly W. Coch, Jonathan M. Haldeman, Patrick E. MacDonald, Matthew J. Merrins, David A. D’Alessio, Jonathan E. Campbell
JCI Insight. 2019 Mar 7; 4(5): e126742. Published online 2019 Mar 7. doi: 10.1172/jci.insight.126742
PMCID:
PMC6483521
AbstractArticlePDF–1.6M
16.
The brown adipose tissue glucagon receptor is functional but not essential for control of energy homeostasis in mice
Jacqueline L. Beaudry, Kiran Deep Kaur, Elodie M. Varin, Laurie L. Baggio, Xiemin Cao, Erin E. Mulvihill, Jennifer H. Stern, Jonathan E. Campbell, Phillip E. Scherer, Daniel J. Drucker
Mol Metab. 2019 Apr; 22: 37–48. Published online 2019 Feb 5. doi: 10.1016/j.molmet.2019.01.011
PMCID:
PMC6437632
AbstractArticlePDF–2.3M
17.
Hepatic Glucagon Receptor Signaling Enhances Insulin-Stimulated Glucose Disposal in Rodents
Teayoun Kim, Cassie L. Holleman, Shelly Nason, Deanna M. Arble, Nickki Ottaway, Joseph Chabenne, Christine Loyd, Jeong-a Kim, Darleen Sandoval, Daniel J. Drucker, Richard DiMarchi, Diego Perez-Tilve, Kirk M. Habegger
Diabetes. 2018 Nov; 67(11): 2157–2166. Published online 2018 Aug 27. doi: 10.2337/db18-0068
PMCID:
PMC6198333
AbstractArticlePDF–1.3M
18.
Deletion of the glucagon receptor gene before and after experimental diabetes reveals differential protection from hyperglycemia
Belen Rivero-Gutierrez, April Haller, Jenna Holland, Emily Yates, Radha Khrisna, Kirk Habegger, Richard Dimarchi, David D'Alessio, Diego Perez-Tilve
Mol Metab. 2018 Nov; 17: 28–38. Published online 2018 Aug 20. doi: 10.1016/j.molmet.2018.07.012
PMCID:
PMC6197675
AbstractArticlePDF–1.0M
19.
Glucagon Receptor Signaling Regulates Energy Metabolism via Hepatic Farnesoid X Receptor and Fibroblast Growth Factor 21
Teayoun Kim, Shelly Nason, Cassie Holleman, Mark Pepin, Landon Wilson, Taylor F. Berryhill, Adam R. Wende, Chad Steele, Martin E. Young, Stephen Barnes, Daniel J. Drucker, Brian Finan, Richard DiMarchi, Diego Perez-Tilve, Matthias Tschöp, Kirk M. Habegger
Diabetes. 2018 Sep; 67(9): 1773–1782. Published online 2018 Jun 20. doi: 10.2337/db17-1502
PMCID:
PMC6110317
AbstractArticlePDF–1.5M
20.
Disruption of glucagon receptor signaling causes hyperaminoacidemia exposing a possible liver-alpha-cell axis
Katrine D. Galsgaard, Marie Winther-Sørensen, Cathrine Ørskov, Hannelouise Kissow, Steen S. Poulsen, Hendrik Vilstrup, Cornelia Prehn, Jerzy Adamski, Sara L. Jepsen, Bolette Hartmann, Jenna Hunt, Maureen J. Charron, Jens Pedersen, Nicolai J. Wewer Albrechtsen, Jens J. Holst
Am J Physiol Endocrinol Metab. 2018 Jan 1; 314(1): E93–E103. Published online 2017 Oct 3. doi: 10.1152/ajpendo.00198.2017
PMCID:
PMC6048389
AbstractArticle

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