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Select item 111158521.

15-Deoxy-Δ^12,14-prostaglandin-J₂ reveals a new pVHL-independent, lysosomal-dependent mechanism of HIF-1α degradation

Gemma Olmos, María I. Arenas, Raquel Bienes, María Jose Calzada, Julián Aragonés, Maria Laura Garcia-Bermejo, Manuel O. Landazuri, Javier Lucio-Cazaña

Cell Mol Life Sci. 2009 Jul; 66(13): 2167–2180. Published online 2009 May 21. doi: 10.1007/s00018-009-0039-x

PMCID:: PMC11115852

Abstract Article PDF–657K

Select item 110788442.

LAMP2A regulates cisplatin resistance in colorectal cancer through mediating autophagy

Zhiliang Shi, Shuting Yang, Chenglong Shen, Jiazhe Shao, Fang Zhou, Haichen Liu, Guoqiang Zhou

J Cancer Res Clin Oncol. 2024; 150(5): 242. Published online 2024 May 8. doi: 10.1007/s00432-024-05775-6

PMCID:: PMC11078844

Abstract Article PDF–5.0M

Select item 108210703.

Altered Splicing of LAMP2 in a Multigenerational Family from Latvia Affected by Danon Disease

Janis Stavusis, Ieva Micule, Ieva Grinfelde, Anna Zdanovica, Janis Pudulis, Sandra Valeina, Svetlana Sepetiene, Baiba Lace, Inna Inashkina

Medicina (Kaunas) 2024 Jan; 60(1): 99. Published online 2024 Jan 5. doi: 10.3390/medicina60010099

PMCID:: PMC10821070

Abstract Article PDF–699K

Select item 105289284.

Lysosomal LAMP proteins regulate lysosomal pH by direct inhibition of the TMEM175 channel

Jiyuan Zhang, Weizhong Zeng, Yan Han, Wan-Ru Lee, Jen Liou, Youxing Jiang

Mol Cell. Author manuscript; available in PMC 2024 Jul 20.

Published in final edited form as: Mol Cell. 2023 Jul 20; 83(14): 2524–2539.e7. Published online 2023 Jun 29. doi: 10.1016/j.molcel.2023.06.004

PMCID:: PMC10528928

Abstract Article PDF–2.8M

Select item 104960705.

Identification and functional analysis of a novel de novo missense mutation located in the initiation codon of LAMP2 associated with early onset female Danon disease

Yongxiang Wang, Ming Bai, Piyi Zhang, Yu Peng, Zixian Chen, Zhiyu He, Jin Xu, Youqi Zhu, Dongdong Yan, Runqing Wang, Zheng Zhang

Mol Genet Genomic Med. 2023 Sep; 11(9): e2216. Published online 2023 Jun 8. doi: 10.1002/mgg3.2216

PMCID:: PMC10496070

Abstract Article PDF–9.6M

Select item 104548236.

Danon Disease: Entire LAMP2 Gene Deletion with Unusual Clinical Presentation—Case Report and Review of the Literature

Adel Shalata, Marina Bar-Shai, Yarin Hadid, Muhammad Mahroum, Hila Mintz, Zaher Eldin Shalata, Evgeny Radzishevsky, Jacob Genizi, Avraham Lorber, Tamar Ben-Yosef, Liat Yaniv

Genes (Basel) 2023 Aug; 14(8): 1539. Published online 2023 Jul 27. doi: 10.3390/genes14081539

PMCID:: PMC10454823

Abstract Article PDF–3.0M

Select item 103750817.

Identification of a novel splicing‐altering LAMP2 variant in a Chinese family with Danon disease

Di Fu, Shuai Wang, Yonghong Luo, Sha Wu, Daoquan Peng

ESC Heart Fail. 2023 Aug; 10(4): 2479–2486. Published online 2023 Jun 5. doi: 10.1002/ehf2.14417

PMCID:: PMC10375081

Abstract Article PDF–1.0M

Select item 102799138.

AdipoR2 recruits protein interactors to promote fatty acid elongation and membrane fluidity

Mario Ruiz, Ranjan Devkota, Delaney Kaper, Hanna Ruhanen, Kiran Busayavalasa, Uroš Radović, Marcus Henricsson, Reijo Käkelä, Jan Borén, Marc Pilon

J Biol Chem. 2023 Jun; 299(6): 104799. Published online 2023 May 8. doi: 10.1016/j.jbc.2023.104799

PMCID:: PMC10279913

Abstract Article PDF–4.1M

Select item 102409989.

PTP4A2 promotes lysophagy by dephosphorylation of VCP/p97 at Tyr805

Yunpeng Bai, Guimei Yu, Hong-Ming Zhou, Ovini Amarasinghe, Yuan Zhou, Peipei Zhu, Qinglin Li, Lujuan Zhang, Frederick Nguele Meke, Yiming Miao, Eli Chapman, W. Andy Tao, Zhong-Yin Zhang

Autophagy. 2023; 19(5): 1562–1581. Published online 2022 Nov 7. doi: 10.1080/15548627.2022.2140558

PMCID:: PMC10240998

Abstract Article PDF–4.4M

Select item 1023742210.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1002450011.

Downregulation of Lysosome-Associated Membrane Protein-2A Contributes to the Pathogenesis of COPD

Yun-Jeong Jeong, Kyoung-Hee Lee, Jisu Woo, Ji Yeon Kim, Chang-Hoon Lee, Chul-Gyu Yoo

Int J Chron Obstruct Pulmon Dis. 2023; 18: 289–303. Published online 2023 Mar 14. doi: 10.2147/COPD.S378386

PMCID:: PMC10024500

Abstract Article PDF–8.1M

Select item 995008512.

Deficiency of cancer/testis antigen gene CT55 causes male infertility in humans and mice

Guohui Zhang, Chuan Jiang, Yushang Yang, Yan Wang, Haimeng Zhou, Siyu Dai, Mohan Liu, Yanting Yang, Li Yang, Qiongyan Shen, Tao Zhang, Xiaodong Zhang, Yihong Yang, Ying Shen

Cell Death Differ. 2023 Feb; 30(2): 500–514. Published online 2022 Dec 8. doi: 10.1038/s41418-022-01098-6

PMCID:: PMC9950085

Abstract Article PDF–8.2M

Select item 985542413.

Metabolic Maturation Exaggerates Abnormal Calcium Handling in a Lamp2 Knockout Human Pluripotent Stem Cell-Derived Cardiomyocyte Model of Danon Disease

Robert J. Barndt, Qing Liu, Ying Tang, Michael P. Haugh, Jeffery Cui, Stephen Y. Chan, Haodi Wu

Biomolecules. 2023 Jan; 13(1): 69. Published online 2022 Dec 29. doi: 10.3390/biom13010069

PMCID:: PMC9855424

Abstract Article PDF–5.4M

Select item 977255814.

HDLBP Promotes Hepatocellular Carcinoma Proliferation and Sorafenib Resistance by Suppressing Trim71-dependent RAF1 Degradation

Jingsheng Yuan, Tao Lv, Jian Yang, Zhenru Wu, Lvnan Yan, Jiayin Yang, Yujun Shi, Li Jiang

Cell Mol Gastroenterol Hepatol. 2023; 15(2): 307–325. Published online 2022 Oct 14. doi: 10.1016/j.jcmgh.2022.10.005

PMCID:: PMC9772558

Abstract Article PDF–8.2M

Select item 947546215.

ARHGAP24 represses β-catenin transactivation-induced invasiveness in hepatocellular carcinoma mainly by acting as a GTPase-independent scaffold

Wenjing Yang, Beili Wang, Qian Yu, Te Liu, Tong Li, Tongtong Tian, Anli Jin, Lin Ding, Wei Chen, Hao Wang, Jingrong Xian, Baishen Pan, Jian Zhou, Jia Fan, Xinrong Yang, Wei Guo

Theranostics. 2022; 12(14): 6189–6206. Published online 2022 Aug 21. doi: 10.7150/thno.72134

PMCID:: PMC9475462

Abstract Article PDF–4.6M

Select item 923162316.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 920606217.

Chaperone-mediated Autophagy Regulates Cell Growth by Targeting SMAD3 in Glioma

Hanqun Liu, Yuxuan Yong, Xingjian Li, Panghai Ye, Kai Tao, Guoyou Peng, Mingshu Mo, Wenyuan Guo, Xiang Chen, Yangfu Luo, Yuwan Lin, Jiewen Qiu, Zhiling Zhang, Liuyan Ding, Miaomiao Zhou, Xinling Yang, Lin Lu, Qian Yang, Pingyi Xu

Neurosci Bull. 2022 Jun; 38(6): 637–651. Published online 2022 Mar 10. doi: 10.1007/s12264-022-00818-9

PMCID:: PMC9206062

Abstract Article PDF–3.0M

Select item 919685018.

DYNC1LI2 regulates localization of the chaperone-mediated autophagy receptor LAMP2A and improves cellular homeostasis in cystinosis

Farhana Rahman, Jennifer L. Johnson, Jinzhong Zhang, Jing He, Kersi Pestonjamasp, Stephanie Cherqui, Sergio D. Catz

Autophagy. 2022; 18(5): 1108–1126. Published online 2021 Oct 13. doi: 10.1080/15548627.2021.1971937

PMCID:: PMC9196850

Abstract Article PDF–5.6M

Select item 917177819.

SNAT7 regulates mTORC1 via macropinocytosis

Delong Meng, Qianmei Yang, Mi-Hyeon Jeong, Adna Curukovic, Shweta Tiwary, Chase H. Melick, Tshering D. Lama-Sherpa, Huanyu Wang, Mariela Huerta-Rosario, Greg Urquhart, Lauren G. Zacharias, Cheryl Lewis, Ralph J. DeBerardinis, Jenna L. Jewell

Proc Natl Acad Sci U S A. 2022 May 17; 119(20): e2123261119. Published online 2022 May 13. doi: 10.1073/pnas.2123261119

PMCID:: PMC9171778

Abstract Article PDF–1.9M

Select item 911973620.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

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