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Select item 113024561.

Kinase-inactivated CDK6 preserves the long-term functionality of adult hematopoietic stem cells

Isabella M. Mayer, Eszter Doma, Thorsten Klampfl, Michaela Prchal-Murphy, Sebastian Kollmann, Alessia Schirripa, Lisa Scheiblecker, Markus Zojer, Natalia Kunowska, Lea Gebrail, Lisa E. Shaw, Ulrike Mann, Alex Farr, Reinhard Grausenburger, Gerwin Heller, Eva Zebedin-Brandl, Matthias Farlik, Marcos Malumbres, Veronika Sexl, Karoline Kollmann

Blood. 2024 Jul 11; 144(2): 156–170. Published online 2024 May 3. doi: 10.1182/blood.2023021985

PMCID:: PMC11302456

Abstract Article

Select item 110637612.

Comprehensive Transcriptomic Analysis of EWSR1::WT1 Targets Identifies CDK4/6 Inhibitors as an Effective Therapy for Desmoplastic Small Round Cell Tumors

Justin W. Magrath, Shruthi Sanjitha Sampath, Dane A. Flinchum, Alifiani B. Hartono, Ilon N. Goldberg, Julia R. Boehling, Suzana D. Savkovic, Sean B. Lee

Cancer Res. 2024 May 2; 84(9): 1426–1442. Published online 2024 Apr 8. doi: 10.1158/0008-5472.CAN-23-3334

PMCID:: PMC11063761

Abstract Article PDF–24M

Select item 110204943.

CircPRMT5 promotes progression of osteosarcoma by recruiting CNBP to regulate the translation and stability of CDK6 mRNA

Yunlu Liu, Hongyan Jiang, Keli Hu, Hui Zou, Weiguo Zhang, Jiangtao Liu, Xiaofei Jian

PLoS One. 2024; 19(4): e0298947. Published online 2024 Apr 16. doi: 10.1371/journal.pone.0298947

PMCID:: PMC11020494

Abstract Article PDF–4.3M

Select item 105759374.

DNA damage induced by CDK4 and CDK6 blockade triggers anti-tumor immune responses through cGAS-STING pathway

Huimin Fan, Wancheng Liu, Yanqiong Zeng, Ying Zhou, Meiling Gao, Liping Yang, Hao Liu, Yueyue Shi, Lili Li, Jiayuan Ma, Jiayin Ruan, Ruyun Cao, Xiaoxia Jin, Jian Chen, Genhong Cheng, Heng Yang

Commun Biol. 2023; 6: 1041. Published online 2023 Oct 13. doi: 10.1038/s42003-023-05412-x

PMCID:: PMC10575937

Abstract Article PDF–4.6M

Select item 105658765.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 105139436.

Long non-coding RNA H19 promotes proliferation in hepatocellular carcinoma cells via H19/miR-107/CDK6 axis

ARCHITTAPON NOKKEAW, PANNATHON THAMJAMRASSRI, NAPHAT CHANTARAVISOOT, PISIT TANGKIJVANICH, CHAIYABOOT ARIYACHET

Oncol Res. 2023; 31(6): 989–1005. Published online 2023 Sep 15. doi: 10.32604/or.2023.030395

PMCID:: PMC10513943

Abstract Article PDF–12M

Select item 104879947.

FOXM1, MEK, and CDK4/6: New Targets for Malignant Peripheral Nerve Sheath Tumor Therapy

Ellen Voigt, Dawn E. Quelle

Int J Mol Sci. 2023 Sep; 24(17): 13596. Published online 2023 Sep 2. doi: 10.3390/ijms241713596

PMCID:: PMC10487994

Abstract Article PDF–1.4M

Select item 104805358.

Mapping the MOB proteins’ proximity network reveals a unique interaction between human MOB3C and the RNase P complex

Islam E. Elkholi, Jonathan Boulais, Marie-Pier Thibault, Hong-Duc Phan, Amélie Robert, Lien B. Lai, Denis Faubert, Matthew J. Smith, Venkat Gopalan, Jean-Franҫois Côté

J Biol Chem. 2023 Sep; 299(9): 105123. Published online 2023 Aug 1. doi: 10.1016/j.jbc.2023.105123

PMCID:: PMC10480535

Abstract Article PDF–2.4M

Select item 103238929.

CDK6 is activated by the atypical cyclin I to promote E2F‐mediated gene expression and cancer cell proliferation

Eva Quandt, Núria Masip, Sara Hernández‐Ortega, Abril Sánchez‐Botet, Laura Gasa, Ainhoa Fernández‐Elorduy, Sara Plutta, Joan Marc Martínez‐Láinez, Samuel Bru, Pau M. Munoz‐Torres, Martin Floor, Jordi Villà‐Freixa, May C. Morris, August Vidal, Alberto Villanueva, Josep Clotet, Mariana P. C. Ribeiro

Mol Oncol. 2023 Jul; 17(7): 1228–1245. Published online 2023 May 31. doi: 10.1002/1878-0261.13438

PMCID:: PMC10323892

Abstract Article PDF–4.2M

Select item 1023742210.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 1007290611.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 997863512.

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons

Tagan A. Griffin, Paul D. Schnier, Elisa M. Cleveland, Robert W. Newberry, Julia Becker, George A. Carlson

J Biol Chem. 2023 Mar; 299(3): 102888. Published online 2023 Jan 10. doi: 10.1016/j.jbc.2023.102888

PMCID:: PMC9978635

Abstract Article PDF–10M

Select item 991654713.

Deciphering the Immunomodulatory Role of Cyclin-Dependent Kinase 4/6 Inhibitors in the Tumor Microenvironment

Pratibha Pandey, Fahad Khan, Tarun Kumar Upadhyay, Amit Baran Sharangi

Int J Mol Sci. 2023 Feb; 24(3): 2236. Published online 2023 Jan 23. doi: 10.3390/ijms24032236

PMCID:: PMC9916547

Abstract Article PDF–858K

Select item 976969814.

A whole genome CRISPR screen identifies AHR loss as a mechanism of resistance to a PARP7 inhibitor

Huadong Chen, Morgan E. Diolaiti, Patrick C. O’Leary, Ajda Rojc, Nevan J. Krogan, Minkyu Kim, Alan Ashworth

Mol Cancer Ther. Author manuscript; available in PMC 2023 Jan 5.

Published in final edited form as: Mol Cancer Ther. 2022 Jul 5; 21(7): 1076–1089. doi: 10.1158/1535-7163.MCT-21-0841

PMCID:: PMC9769698

Abstract Article PDF–2.7M

Select item 962397915.

Viral protein engagement of GBF1 induces host cell vulnerability through synthetic lethality

Arti T. Navare, Fred D. Mast, Jean Paul Olivier, Thierry Bertomeu, Maxwell L. Neal, Lindsay N. Carpp, Alexis Kaushansky, Jasmin Coulombe-Huntington, Mike Tyers, John D. Aitchison

J Cell Biol. 2022 Nov 7; 221(11): e202011050. Published online 2022 Oct 28. doi: 10.1083/jcb.202011050

PMCID:: PMC9623979

Abstract Article PDF–3.7M

Select item 944065316.

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy

Shouheng Jin, Xing He, Ling Ma, Zhen Zhuang, Yiliang Wang, Meng Lin, Sihui Cai, Lu Wei, Zheyu Wang, Zhiyao Zhao, Yaoxing Wu, Lin Sun, Chunwei Li, Weihong Xie, Yong Zhao, Zhou Songyang, Ke Peng, Jincun Zhao, Jun Cui

Nat Commun. 2022; 13: 5204. Published online 2022 Sep 3. doi: 10.1038/s41467-022-32957-y

PMCID:: PMC9440653

Abstract Article PDF–2.9M

Select item 927928517.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 925019018.

CDK6 is upregulated and may be a potential therapeutic target in enzalutamide-resistant castration-resistant prostate cancer

Xi Chen, Yechen Wu, Xinan Wang, Chengdang Xu, Licheng Wang, Jingang Jian, Denglong Wu, Gang Wu

Eur J Med Res. 2022; 27: 105. Published online 2022 Jul 2. doi: 10.1186/s40001-022-00730-y

PMCID:: PMC9250190

Abstract Article PDF–2.7M

Select item 918465019.

Stabilization of CDK6 by ribosomal protein uS7, a target protein of the natural product fucoxanthinol

Yosuke Iizumi, Yoshihiro Sowa, Wakana Goi, Yuichi Aono, Motoki Watanabe, Yoichi Kurumida, Tomoshi Kameda, Kenichi Akaji, Masatoshi Kitagawa, Toshiyuki Sakai

Commun Biol. 2022; 5: 564. Published online 2022 Jun 9. doi: 10.1038/s42003-022-03522-6