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Select item 111051051.

Evidence for miR-548c-5p regulation of FOXC2 transcription through a distal genomic target site in human podocytes

Andrea Christofides, Gregory Papagregoriou, Harsh Dweep, Neoklis Makrides, Norbert Gretz, Kyriacos Felekkis, Constantinos Deltas

Cell Mol Life Sci. 2020 Jun; 77(12): 2441–2459. Published online 2019 Sep 17. doi: 10.1007/s00018-019-03294-z

PMCID:: PMC11105105

Abstract Article PDF–4.9M

Select item 110182052.

The role of transcription factor FOXA1/C2/M1/O3/P1/Q1 in breast cancer

Hui Yuan, Yu Liang, Shaorun Hu, Jinxiang Chen, Jingcan You, Jun Jiang, Mao Luo, Min Zeng

Medicine (Baltimore) 2024 Apr 12; 103(15): e37709. Published online 2024 Apr 12. doi: 10.1097/MD.0000000000037709

PMCID:: PMC11018205

Abstract Article PDF–3.3M

Select item 105242063.

Defects In Vein Valve PROX1/FOXC2 Antithrombotic Pathway in Endothelial Cells Drive the Hypercoagulable State Induced by Trauma and Critical Illness

Mark H. Hoofnagle, Annie Hess, Margaret Nalugo, Sarbani Ghosh, Shin-Wen Hughes, Anja Fuchs, John Welsh, Mark Kahn, Grant V Bochicchio, Gwendalyn J Randolph, Jennifer M. Leonard, Isaiah R Turnbull

J Trauma Acute Care Surg. Author manuscript; available in PMC 2024 Aug 1.

Published in final edited form as: J Trauma Acute Care Surg. 2023 Aug 1; 95(2): 197–204. Published online 2023 Apr 19. doi: 10.1097/TA.0000000000003945

PMCID:: PMC10524206

Abstract Article PDF–952K

Select item 104965014.

FOXC2-AS1/FOXC2 axis mediates matrix stiffness-induced trans-differentiation of hepatic stellate cells into fibrosis-promoting myofibroblasts

Liankang Sun, Yue Li, Hao Wang, Xuelian Xiao, Xuenan Luo, Ruida Yang, Jinyan Li, Yifei Ma, Qingguang Liu, Kangsheng Tu, Yu Shi

Int J Biol Sci. 2023; 19(13): 4206–4222. Published online 2023 Aug 6. doi: 10.7150/ijbs.81581

PMCID:: PMC10496501

Abstract Article PDF–2.9M

Select item 99030435.

The FOXC2 Transcription Factor: A Master Regulator of Chemoresistance in Cancer

Kristian M. Hargadon, Elijah W. Strong

Technol Cancer Res Treat. 2023; 22: 15330338231155284. Published online 2023 Feb 6. doi: 10.1177/15330338231155284

PMCID:: PMC9903043

Abstract Article PDF–3.0M

Select item 89393016.

Digenic Inheritance of a FOXC2 Mutation and Two PIEZO1 Mutations Underlies Congenital Lymphedema in a Multigeneration Family

Debbie J. Mustacich, Li-Wen Lai, Michael J. Bernas, Jazmine A. Jones, Reginald J. Myles, Phillip H. Kuo, Walter H. Williams, Charles L. Witte, Robert P. Erickson, Marlys Hearst Witte

Am J Med. Author manuscript; available in PMC 2023 Feb 1.

Published in final edited form as: Am J Med. 2022 Feb; 135(2): e31–e41. Published online 2021 Oct 15. doi: 10.1016/j.amjmed.2021.09.007

PMCID:: PMC8939301

Abstract Article PDF–1.4M

Select item 82812997.

MicroRNA-199a-5p regulates FOXC2 to control human vascular smooth muscle cell phenotypic switch

Yushi Cao, Zhongwen Cao, Weitie Wang, Xiangyu Jie, Lei Li

Mol Med Rep. 2021 Sep; 24(3): 627. Published online 2021 Jul 1. doi: 10.3892/mmr.2021.12266

PMCID:: PMC8281299

Abstract Article PDF–3.8M

Select item 82596458.

Super-Enhancer-Associated Transcription Factors Maintain Transcriptional Regulation in Mature Podocytes

Jingping Yang, Difei Zhang, Masaru Motojima, Tsutomu Kume, Qing Hou, Yu Pan, Aiping Duan, Mingchao Zhang, Song Jiang, Jinhua Hou, Jingsong Shi, Zhaohui Qin, Zhihong Liu

J Am Soc Nephrol. 2021 Jun; 32(6): 1323–1337. Published online 2021 Jun 1. doi: 10.1681/ASN.2020081177

PMCID:: PMC8259645

Abstract Article

Select item 81468689.

Imbalance between Expression of FOXC2 and Its lncRNA in Lymphedema-Distichiasis Caused by Frameshift Mutations

Sara Missaglia, Daniela Tavian, Sandro Michelini, Paolo Enrico Maltese, Andrea Bonanomi, Matteo Bertelli

Genes (Basel) 2021 May; 12(5): 650. Published online 2021 Apr 27. doi: 10.3390/genes12050650

PMCID:: PMC8146868

Abstract Article PDF–16M

Select item 800904810.

Impact of cytosine methylation on DNA binding specificities of human transcription factors

Yimeng Yin, Ekaterina Morgunova, Arttu Jolma, Eevi Kaasinen, Biswajyoti Sahu, Syed Khund-Sayeed, Pratyush K. Das, Teemu Kivioja, Kashyap Dave, Fan Zhong, Kazuhiro R. Nitta, Minna Taipale, Alexander Popov, Paul A. Ginno, Silvia Domcke, Jian Yan, Dirk Schübeler, Charles Vinson, Jussi Taipale

Science. Author manuscript; available in PMC 2021 Mar 30.

Published in final edited form as: Science. 2017 May 5; 356(6337): eaaj2239. doi: 10.1126/science.aaj2239

PMCID:: PMC8009048

Abstract Article PDF–2.6M

Select item 765800711.

The Effect of FOXC2-AS1 on White Adipocyte Browning and the Possible Regulatory Mechanism

Yan Wang, Siyu Hua, Xianwei Cui, Yan Cao, Juan Wen, Xia Chi, Chenbo Ji, LingXia Pang, Lianghui You

Front Endocrinol (Lausanne) 2020; 11: 565483. Published online 2020 Oct 29. doi: 10.3389/fendo.2020.565483

PMCID:: PMC7658007

Abstract Article PDF–2.4M

Select item 765424312.

Forkhead box protein C2 contributes to invasion and metastasis of extrahepatic cholangiocarcinoma, resulting in a poor prognosis

Akira Watanabe, Hideki Suzuki, Takehiko Yokobori, Bolag Altan, Norio Kubo, Kenichiro Araki, Satoshi Wada, Yasushi Mochida, Shigeru Sasaki, Kenji Kashiwabara, Yasuo Hosouchi, Hiroyuki Kuwano

Cancer Sci. 2013 Nov; 104(11): 1427–1432. Published online 2013 Sep 15. doi: 10.1111/cas.12249

PMCID:: PMC7654243

Abstract Article PDF–678K

Select item 740414613.

FOXC2 Disease Mutations Identified in Lymphedema Distichiasis Patients Impair Transcriptional Activity and Cell Proliferation

Daniela Tavian, Sara Missaglia, Sandro Michelini, Paolo Enrico Maltese, Elena Manara, Alvaro Mordente, Matteo Bertelli

Int J Mol Sci. 2020 Jul; 21(14): 5112. Published online 2020 Jul 20. doi: 10.3390/ijms21145112

PMCID:: PMC7404146

Abstract Article PDF–7.1M

Select item 728053314.

LncRNA FOXC2-AS1 enhances FOXC2 mRNA stability to promote colorectal cancer progression via activation of Ca²⁺-FAK signal pathway

Ke Pan, Yong Xie

Cell Death Dis. 2020 Jun; 11(6): 434. Published online 2020 Jun 8. doi: 10.1038/s41419-020-2633-7

PMCID:: PMC7280533

Abstract Article PDF–3.4M

Select item 721416715.

Circular RNA PVT1 promotes metastasis via regulating of miR‐526b/FOXC2 signals in OS cells

Ming Yan, Hang Gao, Zhenshan Lv, Ying Liu, Song Zhao, Weiquan Gong, Wei Liu

J Cell Mol Med. 2020 May; 24(10): 5593–5604. Published online 2020 Apr 5. doi: 10.1111/jcmm.15215

PMCID:: PMC7214167

Abstract Article PDF–2.3M

Select item 716998316.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 710306617.

Functional polymorphisms in FOXC2 gene and Epithelial ovarian Cancer susceptibility in Chinese population

Zhijiao Zhou, Xiang Ou, Qiong Zou, Ling Chu, Xiyun Quan, Yong Chen, Yang Liu

J Ovarian Res. 2020; 13: 34. Published online 2020 Mar 28. doi: 10.1186/s13048-020-00634-7

PMCID:: PMC7103066

Abstract Article PDF–1.4M

Select item 681783418.

FOXC2 expression and epithelial–mesenchymal phenotypes are associated with castration resistance, metastasis and survival in prostate cancer

Astrid Børretzen, Karsten Gravdal, Svein A Haukaas, Christian Beisland, Lars A Akslen, Ole J Halvorsen

J Pathol Clin Res. 2019 Oct; 5(4): 272–286. Published online 2019 Oct 1. doi: 10.1002/cjp2.142

PMCID:: PMC6817834

Abstract Article PDF–1.9M

Select item 646829219.

Structural basis for DNA recognition by FOXC2

Xiaojuan Chen, Hudie Wei, Jun Li, Xujun Liang, Shuyan Dai, Longying Jiang, Ming Guo, Lingzhi Qu, Zhuchu Chen, Lin Chen, Yongheng Chen

Nucleic Acids Res. 2019 Apr 23; 47(7): 3752–3764. Published online 2019 Feb 5. doi: 10.1093/nar/gkz077

PMCID:: PMC6468292

Abstract Article PDF–3.6M

Select item 633836020.

Role of FOXC2 and PITX2 rare variants associated with mild functional alterations as modifier factors in congenital glaucoma

Cristina Medina-Trillo, José-Daniel Aroca-Aguilar, Jesús-José Ferre-Fernández, Susana Alexandre-Moreno, Laura Morales, Carmen-Dora Méndez-Hernández, Julián García-Feijoo, Julio Escribano

PLoS One. 2019; 14(1): e0211029. Published online 2019 Jan 18. doi: 10.1371/journal.pone.0211029

PMCID:: PMC6338360

Abstract Article PDF–2.3M

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