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Select item 81650301.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 73220672.

RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation

Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen

Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117

PMCID:: PMC7322067

Abstract Article PDF–2.7M

Select item 71699833.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 67509084.

SLC36A1-mTORC1 signaling drives acquired resistance to CDK4/6 inhibitors

Akihiro Yoshida, Yiwen Bu, Shuo Qie, John Wrangle, E. Ramsay Camp, E. Starr Hazard, Gary Hardiman, Renée de Leeuw, Karen E. Knudsen, J. Alan Diehl

Sci Adv. 2019 Sep; 5(9): eaax6352. Published online 2019 Sep 18. doi: 10.1126/sciadv.aax6352

PMCID:: PMC6750908

Abstract Article PDF–3.1M

Select item 67422895.

The H⁺-Coupled Electrogenic Lysosomal Amino Acid Transporter LYAAT1 Localizes to the Axon and Plasma Membrane of Hippocampal Neurons

Christopher C. Wreden, Juliette Johnson, Cindy Tran, Rebecca P. Seal, David R. Copenhagen, Richard J. Reimer, Robert H. Edwards

J Neurosci. 2003 Feb 15; 23(4): 1265–1275. doi: 10.1523/JNEUROSCI.23-04-01265.2003

PMCID:: PMC6742289

Abstract Article PDF–1.1M

Select item 55316116.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 46172117.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 43559758.

PAT1 inversely regulates the surface Amyloid Precursor Protein level in mouse primary neurons

Aysegul Dilsizoglu Senol, Lidia Tagliafierro, Léa Huguet, Lucie Gorisse-Hussonnois, Stéphanie Chasseigneaux, Bernadette Allinquant

BMC Neurosci. 2015; 16: 10. Published online 2015 Mar 7. doi: 10.1186/s12868-015-0152-8

PMCID:: PMC4355975

Abstract Article PDF–3.8M

Select item 42534289.

Mutational analysis of genes coding for cell surface proteins in colorectal cancer cell lines reveal novel altered pathways, druggable mutations and mutated epitopes for targeted therapy

Elisa Donnard, Paula F. Asprino, Bruna R. Correa, Fabiana Bettoni, Fernanda C. Koyama, Fabio C.P. Navarro, Rodrigo O. Perez, John Mariadason, Oliver M. Sieber, Robert L. Strausberg, Andrew J.G. Simpson, Denis L.F. Jardim, Luiz Fernando L. Reis, Raphael B. Parmigiani, Pedro A.F. Galante, Anamaria A. Camargo

Oncotarget. 2014 Oct; 5(19): 9199–9213. Published online 2014 Aug 25. doi: 10.18632/oncotarget.2374

PMCID:: PMC4253428

Abstract Article PDF–1.7M

Select item 420008410.

Identification of 33 candidate oncogenes by screening for base-specific mutations

S Tuupanen, U A Hänninen, J Kondelin, P von Nandelstadh, T Cajuso, A E Gylfe, R Katainen, T Tanskanen, H Ristolainen, J Böhm, J-P Mecklin, H Järvinen, L Renkonen-Sinisalo, C L Andersen, M Taipale, J Taipale, P Vahteristo, K Lehti, E Pitkänen, L A Aaltonen

Br J Cancer. 2014 Oct 14; 111(8): 1657–1662. Published online 2014 Aug 12. doi: 10.1038/bjc.2014.429

PMCID:: PMC4200084

Abstract Article PDF–740K

Select item 400222711.

Insulin increases mRNA abundance of the amino acid transporter SLC7A5/LAT1 via an mTORC1‐dependent mechanism in skeletal muscle cells

Dillon K. Walker, Micah J. Drummond, Jared M. Dickinson, Michael S. Borack, Kristofer Jennings, Elena Volpi, Blake B. Rasmussen

Physiol Rep. 2014 Mar; 2(3): e00238. Published online 2014 Mar 20. doi: 10.1002/phy2.238

PMCID:: PMC4002227

Abstract Article PDF–468K

Select item 394965212.

Sertraline inhibits the transport of PAT1 substrates in vivo and in vitro

C U Nielsen, S Frølund, S Abdulhadi, H Sari, L Langthaler, M K Nøhr, M A Kall, B Brodin, R Holm

Br J Pharmacol. 2013 Nov; 170(5): 1041–1052. Published online 2013 Oct 15. doi: 10.1111/bph.12341

PMCID:: PMC3949652

Abstract Article PDF–1.1M

Select item 381740413.

A negative genetic interaction map in isogenic cancer cell lines reveals cancer cell vulnerabilities

Franco J Vizeacoumar, Roland Arnold, Frederick S Vizeacoumar, Megha Chandrashekhar, Alla Buzina, Jordan T F Young, Julian H M Kwan, Azin Sayad, Patricia Mero, Steffen Lawo, Hiromasa Tanaka, Kevin R Brown, Anastasia Baryshnikova, Anthony B Mak, Yaroslav Fedyshyn, Yadong Wang, Glauber C Brito, Dahlia Kasimer, Taras Makhnevych, Troy Ketela, Alessandro Datti, Mohan Babu, Andrew Emili, Laurence Pelletier, Jeff Wrana, Zev Wainberg, Philip M Kim, Robert Rottapel, Catherine A O’Brien, Brenda Andrews, Charles Boone, Jason Moffat

Mol Syst Biol. 2013; 9: 696. Published online 2013 Oct 8. doi: 10.1038/msb.2013.54

PMCID:: PMC3817404

Abstract Article PDF–13M

Select item 334491514.

Proton-Assisted Amino Acid Transporter PAT1 Complexes with Rag GTPases and Activates TORC1 on Late Endosomal and Lysosomal Membranes

Margrét H. Ögmundsdóttir, Sabine Heublein, Shubana Kazi, Bruno Reynolds, Shivanthy M. Visvalingam, Michael K. Shaw, Deborah C. I. Goberdhan

PLoS One. 2012; 7(5): e36616. Published online 2012 May 4. doi: 10.1371/journal.pone.0036616

PMCID:: PMC3344915

Abstract Article PDF–2.9M

Select item 317805915.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 301827716.

Proton-assisted amino acid transporters are conserved regulators of proliferation and amino acid-dependent mTORC1 activation

S Heublein, S Kazi, M H Ögmundsdóttir, E V Attwood, S Kala, C A R Boyd, C Wilson, D C I Goberdhan

Oncogene. Author manuscript; available in PMC 2011 Jan 10.

Published in final edited form as: Oncogene. 2010 Jul 15; 29(28): 4068–4079. Published online 2010 May 24. doi: 10.1038/onc.2010.177

PMCID:: PMC3018277

Abstract Article PDF–2.3M

Select item 275593617.

Identification of a Disulfide Bridge Essential for Transport Function of the Human Proton-coupled Amino Acid Transporter hPAT1

Madlen Dorn, Matthias Weiwad, Fritz Markwardt, Linda Laug, Rainer Rudolph, Matthias Brandsch, Eva Bosse-Doenecke

J Biol Chem. 2009 Aug 14; 284(33): 22123–22132. Published online 2009 Jun 23. doi: 10.1074/jbc.M109.023713

PMCID:: PMC2755936

Abstract Article PDF–1.8M

Select item 266996718.

Taurine uptake across the human intestinal brush-border membrane is via two transporters: H⁺-coupled PAT1 (SLC36A1) and Na⁺- and Cl⁻-dependent TauT (SLC6A6)

Catriona M H Anderson, Alison Howard, Julian R F Walters, Vadivel Ganapathy, David T Thwaites

J Physiol. 2009 Feb 15; 587(Pt 4): 731–744. Published online 2008 Dec 22. doi: 10.1113/jphysiol.2008.164228

PMCID:: PMC2669967

Abstract Article PDF–433K

Select item 234250819.

Structure, function and immunolocalization of a proton-coupled amino acid transporter (hPAT1) in the human intestinal cell line Caco-2

Zhong Chen, You-Jun Fei, Catriona M H Anderson, Katherine A Wake, Seiji Miyauchi, Wei Huang, David T Thwaites, Vadivel Ganapathy

J Physiol. 2003 Jan 15; 546(Pt 2): 349–361. Published online 2002 Dec 13. doi: 10.1113/jphysiol.2002.026500

PMCID:: PMC2342508

Abstract Article PDF–535K

Select item 175130320.

Vigabatrin transport across the human intestinal epithelial (Caco-2) brush-border membrane is via the H⁺-coupled amino-acid transporter hPAT1

Emily L Abbot, Danielle S Grenade, David J Kennedy, Kelly M Gatfield, David T Thwaites

Br J Pharmacol. 2006 Feb; 147(3): 298–306. Published online 2005 Dec 5. doi: 10.1038/sj.bjp.0706557

PMCID:: PMC1751303

Abstract Article PDF–251K

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