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Select item 99224681.

FBXO22 promotes leukemogenesis by targeting BACH1 in MLL-rearranged acute myeloid leukemia

Xiao-Na Zhu, Yu-Sheng Wei, Qian Yang, Hao-Ran Liu, Zhe Zhi, Di Zhu, Li Xia, Deng-Li Hong, Yun Yu, Guo-Qiang Chen

J Hematol Oncol. 2023; 16: 9. Published online 2023 Feb 11. doi: 10.1186/s13045-023-01400-0

PMCID:: PMC9922468

Abstract Article PDF–4.9M

Select item 85462432.

Severe Pulmonary Arterial Hypertension Is Characterized by Increased Neutrophil Elastase and Relative Elafin Deficiency

Andrew J. Sweatt, Kazuya Miyagawa, Christopher J. Rhodes, Shalina Taylor, Patricia A. Del Rosario, Andrew Hsi, Francois Haddad, Edda Spiekerkoetter, Michal Bental-Roof, Richard D. Bland, Emilia M. Swietlik, Stefan Gräf, Martin R. Wilkins, Nicholas W. Morrell, Mark R. Nicolls, Marlene Rabinovitch, Roham T. Zamanian

Chest. 2021 Oct; 160(4): 1442–1458. Published online 2021 Jun 26. doi: 10.1016/j.chest.2021.06.028

PMCID:: PMC8546243

Abstract Article PDF–1.8M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79334674.

Elafin as a Predictive Biomarker of Acute Skin Graft-Versus-Host Disease After Haploidentical Stem Cell Transplantation Using Post-Transplant High-Dose Cyclophosphamide

Laura Solán, Diego Carbonell, Paula Muñiz, Nieves Dorado, Elena Landete, María Chicano-Lavilla, Javier Anguita, Jorge Gayoso, Mi Kwon, José Luis Díez-Martín, Carolina Martínez-Laperche, Ismael Buño

Front Immunol. 2021; 12: 516078. Published online 2021 Feb 19. doi: 10.3389/fimmu.2021.516078

PMCID:: PMC7933467

Abstract Article PDF–748K

Select item 74606155.

Metabolic Syndrome, Clusterin and Elafin in Patients with Psoriasis Vulgaris

Drahomira Holmannova, Pavel Borsky, Lenka Borska, Ctirad Andrys, Kvetoslava Hamakova, Vit Rehacek, Tereza Svadlakova, Andrea Malkova, Martin Beranek, Vladimir Palicka, Jan Krejsek, Zdenek Fiala

Int J Mol Sci. 2020 Aug; 21(16): 5617. Published online 2020 Aug 5. doi: 10.3390/ijms21165617

PMCID:: PMC7460615

Abstract Article PDF–865K

Select item 71560986.

High circulating elafin levels are associated with Crohn’s disease-associated intestinal strictures

Jiani Wang, Christina Ortiz, Lindsey Fontenot, Ying Xie, Wendy Ho, S. Anjani Mattai, David Q. Shih, Hon Wai Koon

PLoS One. 2020; 15(4): e0231796. Published online 2020 Apr 14. doi: 10.1371/journal.pone.0231796

PMCID:: PMC7156098

Abstract Article PDF–3.1M

Select item 65260017.

In-depth serum proteomics reveals biomarkers of psoriasis severity and response to traditional Chinese medicine

Meng Xu, Jingwen Deng, Kaikun Xu, Tiansheng Zhu, Ling Han, Yuhong Yan, Danni Yao, Hao Deng, Dan Wang, Yaoting Sun, Cheng Chang, Xiaomei Zhang, Jiayu Dai, Liang Yue, Qiushi Zhang, Xue Cai, Yi Zhu, Hu Duan, Yuan Liu, Dong Li, Yunping Zhu, Timothy R. D. J. Radstake, Deepak M.W. Balak, Danke Xu, Tiannan Guo, Chuanjian Lu, Xiaobo Yu

Theranostics. 2019; 9(9): 2475–2488. Published online 2019 Apr 13. doi: 10.7150/thno.31144

PMCID:: PMC6526001

Abstract Article PDF–2.3M

Select item 43627828.

The Serine Protease Inhibitor Elafin Maintains Normal Growth Control by Opposing the Mitogenic Effects of Neutrophil Elastase

Joseph A. Caruso, Said Akli, Laura Pageon, Kelly K. Hunt, Khandan Keyomarsi

Oncogene. Author manuscript; available in PMC 2016 Jan 1.

Published in final edited form as: Oncogene. 2015 Jul; 34(27): 3556–3567. Published online 2014 Sep 8. doi: 10.1038/onc.2014.284

PMCID:: PMC4362782

Abstract Article PDF–1.3M

Select item 43264859.

Elafin is downregulated during breast and ovarian tumorigenesis but its residual expression predicts recurrence

Joseph A Caruso, Cansu Karakas, Jing Zhang, Min Yi, Constance Albarracin, Aysegul Sahin, Melissa Bondy, Jinsong Liu, Kelly K Hunt, Khandan Keyomarsi

Breast Cancer Res. 2014; 16: 3417. Published online 2014 Dec 31. doi: 10.1186/s13058-014-0497-4

Correction in:: Breast Cancer Res. 2015; 17(1): 87.

PMCID:: PMC4326485

Abstract Article PDF–1.5M

Select item 428440310.

Urinary Elafin and Kidney Injury in Hematopoietic Cell Transplant Recipients

Sangeeta Hingorani, Laura S. Finn, Emily Pao, Rick Lawler, Gary Schoch, George B. McDonald, Behzad Najafian, Brenda Sandmaier, Ted Gooley

Clin J Am Soc Nephrol. 2015 Jan 7; 10(1): 12–20. Published online 2014 Nov 11. doi: 10.2215/CJN.01840214

PMCID:: PMC4284403

Abstract Article

Select item 421953211.

Novel role of the serine protease inhibitor elafin in gluten-related disorders

Heather J. Galipeau, Michelle Wiepjes, Jean-Paul Motta, Jessica D. Schulz, Jennifer Jury, Jane M. Natividad, Ines Pinto-Sanchez, Daniel Sinclair, Perrine Rousset, Rebeca Martin-Rosique, Luis Bermudez-Humaran, Jean Christophe Leroux, Joseph Murray, Edgardo Smecuol, Julio C. Bai, Nathalie Vergnolle, Philippe Langella, Elena F Verdu

Am J Gastroenterol. Author manuscript; available in PMC 2015 May 1.

Published in final edited form as: Am J Gastroenterol. 2014 May; 109(5): 748–756. Published online 2014 Apr 8. doi: 10.1038/ajg.2014.48

PMCID:: PMC4219532

Abstract Article PDF–1.1M

Select item 414803712.

Functional Characterization of Polymorphisms in the Peptidase Inhibitor 3 (Elafin) Gene and Validation of Their Contribution to Risk of Acute Respiratory Distress Syndrome

Paula Tejera, D. Shane O’Mahony, Caroline A. Owen, Yongyue Wei, Zhaoxi Wang, Kushagra Gupta, Li Su, Jesus Villar, Mark Wurfel, David C. Christiani

Am J Respir Cell Mol Biol. 2014 Aug; 51(2): 262–272. doi: 10.1165/rcmb.2013-0238OC

PMCID:: PMC4148037

Abstract Article PDF–780K

Select item 411217613.

Elafin drives poor outcome in high grade serous ovarian cancers and basal-like breast tumors

S. Intidhar Labidi-Galy, Adam Clauss, Vivian Ng, Sekhar Duraisamy, Kevin M. Elias, Hui-Ying Piao, Erhan Bilal, Rachel A. Davidowitz, Yiling Lu, Gayane Badalian-Very, Balázs Györffy, Un-Beom Kang, Scott B. Ficarro, Shridar Ganesan, Gordon B. Mills, Jarrod A. Marto, Ronny Drapkin

Oncogene. Author manuscript; available in PMC 2015 Jul 15.

Published in final edited form as: Oncogene. 2015 Jan 15; 34(3): 373–383. Published online 2014 Jan 27. doi: 10.1038/onc.2013.562

PMCID:: PMC4112176

Abstract Article PDF–1.2M

Select item 383734914.

Innate Immunity in the Vagina (Part I): Estradiol Inhibits HBD2 and Elafin Secretion by Human Vaginal Epithelial Cells

Mickey V. Patel, John V. Fahey, Richard M. Rossoll, Charles R. Wira

Am J Reprod Immunol. Author manuscript; available in PMC 2013 Nov 22.

Published in final edited form as: Am J Reprod Immunol. 2013 May; 69(5): 10.1111/aji.12078. Published online 2013 Feb 8. doi: 10.1111/aji.12078

PMCID:: PMC3837349

Abstract Article PDF–1.4M

Select item 370028215.

Antiviral Activity of Trappin-2 and Elafin In Vitro and In Vivo against Genital Herpes

Anna G. Drannik, Kakon Nag, Jean-Michel Sallenave, Kenneth L. Rosenthal

J Virol. 2013 Jul; 87(13): 7526–7538. doi: 10.1128/JVI.02243-12

PMCID:: PMC3700282

Abstract Article PDF–3.8M

Select item 367277016.

Elafin, an inhibitor of elastase, is a prognostic indicator in breast cancer

Kelly K Hunt, Hannah Wingate, Tomoya Yokota, Yanna Liu, Gordon B Mills, Fan Zhang, Bingliang Fang, Chun-Hui Su, Ming Zhang, Min Yi, Khandan Keyomarsi

Breast Cancer Res. 2013; 15(1): R3. Published online 2013 Jan 15. doi: 10.1186/bcr3374

PMCID:: PMC3672770

Abstract Article PDF–1.7M

Select item 355934717.

Modulation of Cytokine Release and Gene Expression by the Immunosuppressive Domain of gp41 of HIV-1

Joachim Denner, Magdalena Eschricht, Michael Lauck, Marwan Semaan, Philipp Schlaermann, Hyunmi Ryu, Levent Akyüz

PLoS One. 2013; 8(1): e55199. Published online 2013 Jan 30. doi: 10.1371/journal.pone.0055199

PMCID:: PMC3559347

Abstract Article PDF–1.0M

Select item 353137218.

Anti-HIV-1 Activity of Elafin Depends on Its Nuclear Localization and Altered Innate Immune Activation in Female Genital Epithelial Cells

Anna G. Drannik, Kakon Nag, Xiao-Dan Yao, Bethany M. Henrick, T. Blake Ball, Francis A. Plummer, Charles Wachihi, Joshua Kimani, Kenneth L. Rosenthal

PLoS One. 2012; 7(12): e52738. Published online 2012 Dec 27. doi: 10.1371/journal.pone.0052738

PMCID:: PMC3531372

Abstract Article PDF–3.5M

Select item 317805919.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 311016520.

Effects of Chronic Ascariasis and Trichuriasis on Cytokine Production and Gene Expression in Human Blood: A Cross-Sectional Study

Miguel Reina Ortiz, Fernanda Schreiber, Susana Benitez, Nely Broncano, Martha E. Chico, Maritza Vaca, Neal Alexander, David J. Lewis, Gordon Dougan, Philip J. Cooper

PLoS Negl Trop Dis. 2011 Jun; 5(6): e1157. Published online 2011 Jun 7. doi: 10.1371/journal.pntd.0001157

PMCID:: PMC3110165

Abstract Article PDF–366K

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PMC Links for GEO Profiles (Select 64561304) (39)
PMC
SPACDR sperm acrosome developmental regulator [Homo sapiens]
SPACDR sperm acrosome developmental regulator [Homo sapiens]
Gene ID:402573

Gene
Gene Links for Protein (Select 51972226) (1)
Gene
RecName: Full=Inositol-trisphosphate 3-kinase A; AltName: Full=Inositol 1,4,5-tr...
RecName: Full=Inositol-trisphosphate 3-kinase A; AltName: Full=Inositol 1,4,5-trisphosphate 3-kinase A; Short=IP3 3-kinase A; Short=IP3K A; Short=InsP 3-kinase A
gi|124807|sp|P23677.1|IP3KA_HUMAN

Protein

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