PMC Links for GEO Profiles (Select 64565195) - PMC

Select item 85259241.

RNF186 regulates EFNB1 (ephrin B1)-EPHB2-induced autophagy in the colonic epithelial cells for the maintenance of intestinal homeostasis

Huazhi Zhang, Zhihui Cui, Du Cheng, Yanyun Du, Xiaoli Guo, Ru Gao, Jianwen Chen, Wanwei Sun, Ruirui He, Xiaojian Ma, Qianwen Peng, Bradley N. Martin, Wei Yan, Yueguang Rong, Chenhui Wang

Autophagy. 2021; 17(10): 3030–3047. Published online 2020 Dec 17. doi: 10.1080/15548627.2020.1851496

PMCID:: PMC8525924

Abstract Article PDF–18M

Select item 84095912.

Ubiquitination of ATF6 by disease-associated RNF186 promotes the innate receptor-induced unfolded protein response

Kishu Ranjan, Matija Hedl, Saloni Sinha, Xuchen Zhang, Clara Abraham

J Clin Invest. 2021 Sep 1; 131(17): e145472. Published online 2021 Sep 1. doi: 10.1172/JCI145472

PMCID:: PMC8409591

Abstract Article PDF–18M

Select item 83642153.

The E3 ubiquitin ligase RNF186 and RNF186 risk variants regulate innate receptor-induced outcomes

Kishu Ranjan, Matija Hedl, Clara Abraham

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2013500118. Published online 2021 Aug 5. doi: 10.1073/pnas.2013500118

PMCID:: PMC8364215

Abstract Article PDF–1.4M

Select item 73130264.

The Role of Tissue-Specific Ubiquitin Ligases, RNF183, RNF186, RNF182 and RNF152, in Disease and Biological Function

Takumi Okamoto, Kazunori Imaizumi, Masayuki Kaneko

Int J Mol Sci. 2020 Jun; 21(11): 3921. Published online 2020 May 30. doi: 10.3390/ijms21113921

PMCID:: PMC7313026

Abstract Article PDF–1.0M

Select item 71699835.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 70531696.

MARCH8 Ubiquitinates the Hepatitis C Virus Nonstructural 2 Protein and Mediates Viral Envelopment

Sathish Kumar, Rina Barouch-Bentov, Fei Xiao, Stanford Schor, Szuyuan Pu, Elise Biquand, Albert Lu, Brett D. Lindenbach, Yves Jacob, Caroline Demeret, Shirit Einav

Cell Rep. Author manuscript; available in PMC 2020 Mar 3.

Published in final edited form as: Cell Rep. 2019 Feb 12; 26(7): 1800–1814.e5. doi: 10.1016/j.celrep.2019.01.075

PMCID:: PMC7053169

Abstract Article PDF–2.3M

Select item 68513357.

The RING-type E3 ligase RNF186 ubiquitinates Sestrin-2 and thereby controls nutrient sensing

Travis B. Lear, Karina C. Lockwood, Yurong Ouyang, John W. Evankovich, Mads B. Larsen, Bo Lin, Yuan Liu, Bill B. Chen

J Biol Chem. 2019 Nov 8; 294(45): 16527–16534. Published online 2019 Oct 4. doi: 10.1074/jbc.AC119.010671

PMCID:: PMC6851335

Abstract Article PDF–1.4M

Select item 49804828.

A protein-truncating R179X variant in RNF186 confers protection against ulcerative colitis

Manuel A. Rivas, Daniel Graham, Patrick Sulem, Christine Stevens, A. Nicole Desch, Philippe Goyette, Daniel Gudbjartsson, Ingileif Jonsdottir, Unnur Thorsteinsdottir, Frauke Degenhardt, Sören Mucha, Mitja I. Kurki, Dalin Li, Mauro D'Amato, Vito Annese, Severine Vermeire, Rinse K. Weersma, Jonas Halfvarson, Paulina Paavola-Sakki, Maarit Lappalainen, Monkol Lek, Beryl Cummings, Taru Tukiainen, Talin Haritunians, Leena Halme, Lotta L. E. Koskinen, Ashwin N. Ananthakrishnan, Yang Luo, Graham A. Heap, Marijn C. Visschedijk, UK IBD Genetics Consortium, NIDDK IBD Genetics Consortium, Daniel G. MacArthur, Benjamin M. Neale, Tariq Ahmad, Carl A. Anderson, Steven R. Brant, Richard H. Duerr, Mark S. Silverberg, Judy H Cho, Aarno Palotie, Päivi Saavalainen, Kimmo Kontula, Martti Färkkilä, Dermot P. B. McGovern, Andre Franke, Kari Stefansson, John D. Rioux, Ramnik J. Xavier, Mark J. Daly, J. Barrett, K. de Lane, C. Edwards, A. Hart, C. Hawkey, L. Jostins, N. Kennedy, C. Lamb, J. Lee, C. Lees, J. Mansfield, C. Mathew, C. Mowatt, B. Newman, E. Nimmo, M. Parkes, M. Pollard, N. Prescott, J. Randall, D. Rice, J. Satsangi, A. Simmons, M. Tremelling, H. Uhlig, D. Wilson, C. Abraham, J. P. Achkar, A. Bitton, G. Boucher, K. Croitoru, P. Fleshner, J. Glas, S. Kugathasan, J. V. Limbergen, R. Milgrom, D. Proctor, M. Regueiro, P. L. Schumm, Y. Sharma, J. M. Stempak, S. R. Targan, M. H. Wang

Nat Commun. 2016; 7: 12342. Published online 2016 Aug 9. doi: 10.1038/ncomms12342

Correction in:: Nat Commun. 2016; 7: 12869.

PMCID:: PMC4980482

Abstract Article PDF–409K

Select item 37720579.

Deep Resequencing of GWAS Loci Identifies Rare Variants in CARD9, IL23R and RNF186 That Are Associated with Ulcerative Colitis

Mélissa Beaudoin, Philippe Goyette, Gabrielle Boucher, Ken Sin Lo, Manuel A. Rivas, Christine Stevens, Azadeh Alikashani, Martin Ladouceur, David Ellinghaus, Leif Törkvist, Gautam Goel, Caroline Lagacé, Vito Annese, Alain Bitton, Jakob Begun, Steve R. Brant, Francesca Bresso, Judy H. Cho, Richard H. Duerr, Jonas Halfvarson, Dermot P. B. McGovern, Graham Radford-Smith, Stefan Schreiber, Philip L. Schumm, Yashoda Sharma, Mark S. Silverberg, Rinse K. Weersma, Quebec IBD Genetics Consortium, NIDDK IBD Genetics Consortium, International IBD Genetics Consortium, Mauro D'Amato, Severine Vermeire, Andre Franke, Guillaume Lettre, Ramnik J. Xavier, Mark J. Daly, John D. Rioux

PLoS Genet. 2013 Sep; 9(9): e1003723. Published online 2013 Sep 12. doi: 10.1371/journal.pgen.1003723

PMCID:: PMC3772057

Abstract Article PDF–359K

Select item 317805910.

Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium

Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas

Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042

PMCID:: PMC3178059

Abstract Article PDF–1.0M

Select item 308760011.

Genome-wide association identifies multiple ulcerative colitis susceptibility loci

Dermot P.B. McGovern, Agnès Gardet, Leif Törkvist, Philippe Goyette, Jonah Essers, Kent D. Taylor, Benjamin M. Neale, Rick T.H. Ong, Caroline Lagacé, Chun Li, Todd Green, Christine R. Stevens, Claudine Beauchamp, Phillip R. Fleshner, Marie Carlson, Mauro D'Amato, Jonas Halfvarson, Martin L. Hibberd, Mikael Lördal, Leonid Padyukov, Angelo Andriulli, Elisabetta Colombo, Anna Latiano, Orazio Palmieri, Edmond-Jean Bernard, Colette Deslandres, Daan W. Hommes, Dirk J de Jong, Pieter C. Stokkers, Rinse K. Weersma, The NIDDK IBDGC, Yashoda Sharma, Mark Silverberg, Judy H. Cho, Jing Wu, Kathryn Roeder, Steven R. Brant, L. Phillip Schumm, Richard H. Duerr, Marla C. Dubinsky, Nicole L. Glazer, Talin Haritunians, Andy Ippoliti, Gil Y. Melmed, David S. Siscovick, Eric A. Vasiliauskas, Stephan R. Targan, Vito Annese, Cisca Wijmenga, Sven Pettersson, Jerome I. Rotter, Ramnik J. Xavier, Mark J. Daly, John D. Rioux, Mark Seielstad

Nat Genet. Author manuscript; available in PMC 2011 May 4.

Published in final edited form as: Nat Genet. 2010 Apr; 42(4): 332–337. Published online 2010 Mar 14. doi: 10.1038/ng.549

Correction in:: volume 43 on page 388

PMCID:: PMC3087600

Abstract Article PDF–505K

Select item 273665212.

A comprehensive framework of E2–RING E3 interactions of the human ubiquitin–proteasome system

Sjoerd J L van Wijk, Sjoerd J de Vries, Patrick Kemmeren, Anding Huang, Rolf Boelens, Alexandre M J J Bonvin, H Th Marc Timmers

Mol Syst Biol. 2009; 5: 295. Published online 2009 Aug 18. doi: 10.1038/msb.2009.55

Correction in:: Mol Syst Biol. 2009; 5: 317.

PMCID:: PMC2736652

Abstract Article PDF–5.6M

Select item 265283713.

Ulcerative colitis loci on chromosomes 1p36 and 12q15 identified by genome-wide association study

Mark S. Silverberg, Judy H. Cho, John D. Rioux, Dermot P.B. McGovern, Jing Wu, Vito Annese, Jean-Paul Achkar, Philippe Goyette, Regan Scott, Wei Xu, M. Michael Barmada, Lambertus Klei, Mark J. Daly, Clara Abraham, Theodore M. Bayless, Fabrizio Bossa, Anne M. Griffiths, Andrew F. Ippoliti, Raymond G. Lahaie, Anna Latiano, Pierre Paré, Deborah D. Proctor, Miguel D. Regueiro, A. Hillary Steinhart, Stephan R. Targan, L. Philip Schumm, Emily O. Kistner, Annette T. Lee, Peter K. Gregersen, Jerome I. Rotter, Steven R. Brant, Kent D. Taylor, Kathryn Roeder, Richard H. Duerr

Nat Genet. Author manuscript; available in PMC 2009 Aug 1.

Published in final edited form as: Nat Genet. 2009 Feb; 41(2): 216–220. Published online 2009 Jan 4. doi: 10.1038/ng.275

Correction in:: volume 41 on page 762

PMCID:: PMC2652837

Abstract Article PDF–571K

Select item 52892814.

The Status, Quality, and Expansion of the NIH Full-Length cDNA Project: The Mammalian Gene Collection (MGC)

Genome Res. 2004 Oct; 14(10b): 2121–2127. doi: 10.1101/gr.2596504

Correction in:: Genome Res. 2006 Jun; 16(6): 804.

PMCID:: PMC528928

Abstract Article PDF–140K

Select item 13924115.

Generation and initial analysis of more than 15,000 full-length human and mouse cDNA sequences

Mammalian Gene Collection (MGC) Program Team

Proc Natl Acad Sci U S A. 2002 Dec 24; 99(26): 16899–16903. Published online 2002 Dec 11. doi: 10.1073/pnas.242603899

PMCID:: PMC139241

Abstract Article PDF–118K

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