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Select item 93720631.

Structural insights into inhibitory mechanism of human excitatory amino acid transporter EAAT2

Takafumi Kato, Tsukasa Kusakizako, Chunhuan Jin, Xinyu Zhou, Ryuichi Ohgaki, LiLi Quan, Minhui Xu, Suguru Okuda, Kan Kobayashi, Keitaro Yamashita, Tomohiro Nishizawa, Yoshikatsu Kanai, Osamu Nureki

Nat Commun. 2022; 13: 4714. Published online 2022 Aug 11. doi: 10.1038/s41467-022-32442-6

PMCID:: PMC9372063

Abstract Article PDF–2.2M

Select item 89409272.

PKCα phosphorylation of GLT-1 at Ser562/563 induces glutamate excitotoxicity in ischemia in mice

Yuqing Wang, Jun Du, Shanshan Lu, Xia Li, Yifei Chen, Chao Yuan, Sheng-Tao Hou, Yizheng Wang

Signal Transduct Target Ther. 2022; 7: 82. Published online 2022 Mar 23. doi: 10.1038/s41392-022-00897-0

PMCID:: PMC8940927

Article PDF–2.0M

Select item 89036233.

Polymorphism of rs12294045 in EAAT2 gene is potentially associated with schizophrenia in Chinese Han population

Lina Wang, Tantan Ma, Dongdong Qiao, Kaiyan Cui, Xiaojiao Bi, Chao Han, Limin Yang, Mengmeng Sun, Lanfen Liu

BMC Psychiatry. 2022; 22: 171. Published online 2022 Mar 8. doi: 10.1186/s12888-022-03799-1

PMCID:: PMC8903623

Abstract Article PDF–1.0M

Select item 86297854.

Identification by proximity labeling of novel lipidic and proteinaceous potential partners of the dopamine transporter

Dolores Piniella, Elena Martínez-Blanco, David Bartolomé-Martín, Ana B. Sanz-Martos, Francisco Zafra

Cell Mol Life Sci. 2021 Dec; 78(23): 7733–7756. Published online 2021 Oct 28. doi: 10.1007/s00018-021-03998-1

PMCID:: PMC8629785

Abstract Article PDF–10M

Select item 86265895.

Astrocytic transcription factor REST upregulates glutamate transporter EAAT2, protecting dopaminergic neurons from manganese-induced excitotoxicity

Edward Pajarillo, Alexis Digman, Ivan Nyarko-Danquah, Deok-Soo Son, Karam F.A. Soliman, Michael Aschner, Eunsook Lee

J Biol Chem. 2021 Dec; 297(6): 101372. Published online 2021 Oct 29. doi: 10.1016/j.jbc.2021.101372

PMCID:: PMC8626589

Abstract Article PDF–3.4M

Select item 86034236.

The Glutamate Transporter EAAT2 Is Transiently Expressed in Developing Human Cerebral White Matter

TARA M. DESILVA, HANNAH C. KINNEY, NATALIA S. BORENSTEIN, FELICIA L. TRACHTENBERG, NINA IRWIN, JOSEPH J. VOLPE, PAUL A. ROSENBERG

J Comp Neurol. Author manuscript; available in PMC 2021 Nov 19.

Published in final edited form as: J Comp Neurol. 2007 Apr 20; 501(6): 879–890. doi: 10.1002/cne.21289

PMCID:: PMC8603423

Abstract Article PDF–2.3M

Select item 84969587.

Downregulation of the Glial GLT1 Glutamate Transporter and Purkinje Cell Dysfunction in a Mouse Model of Myotonic Dystrophy

Géraldine Sicot, Laurent Servais, Diana M. Dinca, Axelle Leroy, Cynthia Prigogine, Fadia Medja, Sandra O. Braz, Aline Huguet-Lachon, Cerina Chhuon, Annie Nicole, Noëmy Gueriba, Ruan Oliveira, Bernard Dan, Denis Furling, Maurice S. Swanson, Ida Chiara Guerrera, Guy Cheron, Geneviève Gourdon, Mário Gomes-Pereira

Cell Rep. Author manuscript; available in PMC 2021 Oct 7.

Published in final edited form as: Cell Rep. 2017 Jun 27; 19(13): 2718–2729. doi: 10.1016/j.celrep.2017.06.006

PMCID:: PMC8496958

Abstract Article PDF–2.5M

Select item 84450788.

Endocytosis of the glutamate transporter 1 is regulated by Laforin and Malin: implications in Lafora Disease.

Eva Perez-Jimenez, Rosa Viana, Carmen Muñoz-Ballester, Carlos Vendrell-Tornero, Raquel Moll-Diaz, Maria Adelaida Garcia-Gimeno, Pascual Sanz

Glia. Author manuscript; available in PMC 2021 Sep 16.

Published in final edited form as: Glia. 2021 May; 69(5): 1170–1183. Published online 2020 Dec 23. doi: 10.1002/glia.23956

PMCID:: PMC8445078

Abstract Article PDF–1.7M

Select item 80959789.

Excitatory Amino Acid Transporter EAAT‐2 in Tangle‐bearing Neurons in Alzheimer's Disease

Dietmar Rudolf Thal

Brain Pathol. 2002 Oct; 12(4): 405–411. Published online 2006 Apr 5. doi: 10.1111/j.1750-3639.2002.tb00457.x

PMCID:: PMC8095978

Summary PDF–277K

Select item 760667010.

An amino-terminal point mutation increases EAAT2 anion currents without affecting glutamate transport rates

Bettina Kolen, Daniel Kortzak, Arne Franzen, Christoph Fahlke

J Biol Chem. 2020 Oct 30; 295(44): 14936–14947. Published online 2020 Aug 20. doi: 10.1074/jbc.RA120.013704

PMCID:: PMC7606670

Abstract Article PDF–3.2M

Select item 710530611.

A computational approach yields selective inhibitors of human excitatory amino acid transporter 2 (EAAT2)

Kelly L. Damm-Ganamet, Marie-Laure Rives, Alan D. Wickenden, Heather M. McAllister, Taraneh Mirzadegan

J Biol Chem. 2020 Mar 27; 295(13): 4359–4366. Published online 2020 Feb 20. doi: 10.1074/jbc.AC119.011190

PMCID:: PMC7105306

Abstract Article PDF–1.2M

Select item 708043112.

Assessment of three essential tremor genetic loci in sporadic Parkinson's disease in Eastern China

Ting Gao, Jiong Wu, Ran Zheng, Yi Fang, Chong‐Yao Jin, Yang Ruan, Jin Cao, Jun Tian, Jia‐Li Pu, Bao‐Rong Zhang

CNS Neurosci Ther. 2020 Apr; 26(4): 448–452. Published online 2019 Nov 21. doi: 10.1111/cns.13272

PMCID:: PMC7080431

Abstract Article PDF–467K

Select item 681516913.

Divergent roles of astrocytic versus neuronal EAAT2 deficiency on cognition and overlap with aging and Alzheimer’s molecular signatures

Abhijeet Sharma, Syed Faraz Kazim, Chloe S. Larson, Aarthi Ramakrishnan, Jason D. Gray, Bruce S. McEwen, Paul A. Rosenberg, Li Shen, Ana C. Pereira

Proc Natl Acad Sci U S A. 2019 Oct 22; 116(43): 21800–21811. Published online 2019 Oct 7. doi: 10.1073/pnas.1903566116

PMCID:: PMC6815169

Abstract Article PDF–2.8M

Select item 680021014.

Recurrent SLC1A2 variants cause epilepsy via a dominant negative mechanism

Andrew B. Stergachis, Jonai Pujol-Giménez, Gergely Gyimesi, Daniel Fuster, Giusppe Albano, Marina Troxler, Jonathan Picker, Paul A. Rosenberg, Ann Bergin, Jurriaan Peters, Christelle Moufawad El Achkar, Chellamani Harini, Shannon Manzi, Alexander Rotenberg, Matthias A. Hediger, Lance H. Rodan

Ann Neurol. Author manuscript; available in PMC 2019 Dec 1.

Published in final edited form as: Ann Neurol. 2019 Jun; 85(6): 921–926. Published online 2019 Apr 26. doi: 10.1002/ana.25477

PMCID:: PMC6800210

Abstract Article PDF–1.2M

Select item 673116915.

The role of astrocytic glutamate transporters GLT-1 and GLAST in neurological disorders: potential targets for neurotherapeutics

Edward Pajarillo, Asha Rizor, Jayden Lee, Michael Aschner, Eunsook Leea

Neuropharmacology. Author manuscript; available in PMC 2020 Dec 15.

Published in final edited form as: Neuropharmacology. 2019 Dec 15; 161: 107559. Published online 2019 Mar 6. doi: 10.1016/j.neuropharm.2019.03.002

PMCID:: PMC6731169

Abstract Article PDF–792K

Select item 661658416.

Reprogramming of Amino Acid Transporters to Support Aspartate and Glutamate Dependency Sustains Endocrine Resistance in Breast Cancer

Marina Bacci, Nicla Lorito, Luigi Ippolito, Matteo Ramazzotti, Simone Luti, Simone Romagnoli, Matteo Parri, Francesca Bianchini, Federica Cappellesso, Federico Virga, Qiong Gao, Bruno M. Simões, Elisabetta Marangoni, Lesley-Ann Martin, Giuseppina Comito, Manuela Ferracin, Elisa Giannoni, Massimiliano Mazzone, Paola Chiarugi, Andrea Morandi

Cell Rep. 2019 Jul 2; 28(1): 104–118.e8. Published online 2019 Jul 2. doi: 10.1016/j.celrep.2019.06.010

PMCID:: PMC6616584

Abstract Article

Select item 657710217.

Functional comparisons of three glutamate transporter subtypes cloned from human motor cortex

JL Arriza, WA Fairman, JI Wadiche, GH Murdoch, MP Kavanaugh, SG Amara

J Neurosci. 1994 Sep 1; 14(9): 5559–5569. doi: 10.1523/JNEUROSCI.14-09-05559.1994

PMCID:: PMC6577102

Abstract PDF–1.6M

Select item 653328218.

Genetic variant in SLC1A2 is associated with elevated anterior cingulate cortex glutamate and lifetime history of rapid cycling

Marin Veldic, Vincent Millischer, John D. Port, Ada Man-Choi Ho, Yun-Fang Jia, Jennifer R. Geske, Joanna M. Biernacka, Lena Backlund, Susan L. McElroy, David J. Bond, J. Carlos Villaescusa, Michelle Skime, Doo-Sup Choi, Catharina Lavebratt, Martin Schalling, Mark A. Frye

Transl Psychiatry. 2019; 9: 149. Published online 2019 May 23. doi: 10.1038/s41398-019-0483-9

PMCID:: PMC6533282

Abstract Article PDF–1.3M

Select item 633509919.

Blood-Brain Barrier: From Physiology to Disease and Back

Melanie D. Sweeney, Zhen Zhao, Axel Montagne, Amy R. Nelson, Berislav V. Zlokovic

Physiol Rev. 2019 Jan 1; 99(1): 21–78. Published online 2018 Oct 3. doi: 10.1152/physrev.00050.2017

PMCID:: PMC6335099

Abstract Article

Select item 599216820.

Novel interaction between Alzheimer’s disease-related protein presenilin 1 and glutamate transporter 1

Katarzyna Marta Zoltowska, Masato Maesako, Joshua Meier, Oksana Berezovska

Sci Rep. 2018; 8: 8718. Published online 2018 Jun 7. doi: 10.1038/s41598-018-26888-2

PMCID:: PMC5992168

Abstract Article PDF–2.0M

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