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Select item 112251641.

METTL1/FOXM1 promotes lung adenocarcinoma progression and gefitinib resistance by inhibiting PTPN13 expression

Wei Peng, Jia Fu, Lijun Zhou, Huaxin Duan

Cancer Med. 2024 Jul; 13(13): e7420. Published online 2024 Jul 5. doi: 10.1002/cam4.7420

PMCID:: PMC11225164

Abstract Article PDF–9.8M

Select item 111791472.

Structural basis of regulated m⁷G tRNA modification by METTL1-WDR4

Jiazhi Li, Longfei Wang, Quentin Hahn, Radosław P. Nowak, Thibault Viennet, Esteban Orellana, Shourya S. Roy Burman, Hong Yue, Moritz Hunkeler, Pietro Fontana, Hao Wu, Haribabu Arthanari, Eric Fischer, Richard I. Gregory

Nature. Author manuscript; available in PMC 2024 Jun 15.

Published in final edited form as: Nature. 2023 Jan; 613(7943): 391–397. Published online 2023 Jan 4. doi: 10.1038/s41586-022-05566-4

PMCID:: PMC11179147

Abstract Article PDF–5.7M

Select item 111408663.

METTL1-mediated tRNA m⁷G methylation and translational dysfunction restricts breast cancer tumorigenesis by fueling cell cycle blockade

Dan Du, Mingxia Zhou, Chenxi Ju, Jie Yin, Chang Wang, Xinyu Xu, Yunqing Yang, Yun Li, Le Cui, Zhengyang Wang, Yuqing Lei, Hongle Li, Fucheng He, Jing He

J Exp Clin Cancer Res. 2024; 43: 154. Published online 2024 May 31. doi: 10.1186/s13046-024-03076-x

PMCID:: PMC11140866

Abstract Article PDF–17M

Select item 105274834.

QKI shuttles internal m⁷G-modified transcripts into stress granules and modulates mRNA metabolism

Zhicong Zhao, Ying Qing, Lei Dong, Li Han, Dong Wu, Yangchan Li, Wei Li, Jianhuang Xue, Keren Zhou, Miao Sun, Brandon Tan, Zhenhua Chen, Chao Shen, Lei Gao, Andrew Small, Kitty Wang, Keith Leung, Zheng Zhang, Xi Qin, Xiaolan Deng, Qiang Xia, Rui Su, Jianjun Chen

Cell. Author manuscript; available in PMC 2024 Jul 20.

Published in final edited form as: Cell. 2023 Jul 20; 186(15): 3208–3226.e27. Published online 2023 Jun 27. doi: 10.1016/j.cell.2023.05.047

PMCID:: PMC10527483

Abstract Article PDF–4.0M

Select item 104409165.

P300/SP1 complex mediating elevated METTL1 regulates CDK14 mRNA stability via internal m7G modification in CRPC

Mingpeng Zhang, Duo Kan, Boya Zhang, Xueqiao Chen, Chun Wang, Songmao Chen, Wenlong Gao, Zhao Yang, Yang Li, Yutong Chen, Shimiao Zhu, Simeng Wen, Yuanjie Niu, Zhiqun Shang

J Exp Clin Cancer Res. 2023; 42: 215. Published online 2023 Aug 21. doi: 10.1186/s13046-023-02777-z

PMCID:: PMC10440916

Abstract Article PDF–4.3M

Select item 103881136.

The role of vitamin D-synthesizing enzyme CYP27B1 in systemic lupus erythematosus

Man LUO, Jing LIU, Yeshuang YUAN, Yong CHEN, Guohua YUAN

Turk J Med Sci. 2022; 52(4): 984–989. Published online 2022 Mar 26. doi: 10.55730/1300-0144.5399

PMCID:: PMC10388113

Abstract Article PDF–253K

Select item 103445497.

METTL1 gene polymorphisms and Wilms tumor susceptibility in Chinese children: A five-center case-control study

Linqing Deng, Ruixi Hua, Zhengtao Zhang, Jinhong Zhu, Jiao Zhang, Jiwen Cheng, Suhong Li, Haixia Zhou, Guochang Liu, Jing He, Wen Fu

Chin Med J (Engl) 2023 Jul 20; 136(14): 1750–1752. Published online 2023 May 26. doi: 10.1097/CM9.0000000000002739

PMCID:: PMC10344549

Article PDF–199K

Select item 103000028.

Structural insight into how WDR4 promotes the tRNA N7-methylguanosine methyltransferase activity of METTL1

Xiaohuan Jin, Zeyuan Guan, Na Hu, Chunjie He, Ping Yin, Zhou Gong, Delin Zhang

Cell Discov. 2023; 9: 65. Published online 2023 Jun 27. doi: 10.1038/s41421-023-00562-y

PMCID:: PMC10300002

Article PDF–974K

Select item 102374229.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 993064110.

Structures and Mechanisms of tRNA Methylation by METTL1-WDR4

Victor M. Ruiz-Arroyo, Rishi Raj, Kesavan Babu, Otgonbileg Onolbaatar, Paul H. Roberts, Yunsun Nam

Nature. Author manuscript; available in PMC 2023 Jul 4.

Published in final edited form as: Nature. 2023 Jan; 613(7943): 383–390. Published online 2023 Jan 4. doi: 10.1038/s41586-022-05565-5

PMCID:: PMC9930641

Abstract Article PDF–3.4M

Select item 988914211.

Association of RNA m⁷G Modification Gene Polymorphisms with Pediatric Glioma Risk

Jinhong Zhu, Xiaoping Liu, Wei Chen, Yuxiang Liao, Jiabin Liu, Li Yuan, Jichen Ruan, Jing He

Biomed Res Int. 2023; 2023: 3678327. Published online 2023 Jan 24. doi: 10.1155/2023/3678327

PMCID:: PMC9889142

Abstract Article PDF–385K

Select item 927928512.

Scalable multiplex co-fractionation/mass spectrometry platform for accelerated protein interactome discovery

Pierre C. Havugimana, Raghuveera Kumar Goel, Sadhna Phanse, Ahmed Youssef, Dzmitry Padhorny, Sergei Kotelnikov, Dima Kozakov, Andrew Emili

Nat Commun. 2022; 13: 4043. Published online 2022 Jul 13. doi: 10.1038/s41467-022-31809-z

PMCID:: PMC9279285

Abstract Article PDF–2.5M

Select item 911973613.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 898145114.

Astrocytes expressing Vitamin D‐activating enzyme identify Parkinson’s disease

Samanta Mazzetti, Michela Barichella, Federica Giampietro, Angelica Giana, Alessandra M Calogero, Alida Amadeo, Nicola Palazzi, Alessandro Comincini, Giorgio Giaccone, Manuela Bramerio, Serena Caronni, Viviana Cereda, Emanuele Cereda, Graziella Cappelletti, Chiara Rolando, Gianni Pezzoli

CNS Neurosci Ther. 2022 May; 28(5): 703–713. Published online 2022 Feb 15. doi: 10.1111/cns.13801

PMCID:: PMC8981451

Abstract Article PDF–4.0M

Select item 871830315.

Polymorphisms CYP2R1 rs10766197 and CYP27B1 rs10877012 in Multiple Sclerosis: A Case-Control Study

A. Martinez-Hernandez, E. E. Perez-Guerrero, M. A. Macias-Islas, C. A. Nava-Valdivia, A. Villagomez-Vega, B. Contreras-Haro, Y. E. Garcia-Ortega, Y. Esparza-Guerrero, S. G. Gallardo-Moya, J. I. Gamez-Nava, L. Gonzalez-Lopez, E. Oliva-Flores, N. A. Rodriguez-Jimenez, F. Cortes-Enriquez, A. M. Saldaña-Cruz

J Immunol Res. 2021; 2021: 7523997. Published online 2021 Dec 23. doi: 10.1155/2021/7523997

PMCID:: PMC8718303

Abstract Article PDF–508K

Select item 866658416.

METTL1 promotes hepatocarcinogenesis via m⁷G tRNA modification‐dependent translation control

Zhihang Chen, Wanjie Zhu, Shenghua Zhu, Kaiyu Sun, Junbin Liao, Haining Liu, Zihao Dai, Hui Han, Xuxin Ren, Qingxia Yang, Siyi Zheng, Baogang Peng, Sui Peng, Ming Kuang, Shuibin Lin

Clin Transl Med. 2021 Dec; 11(12): e661. Published online 2021 Dec 12. doi: 10.1002/ctm2.661

PMCID:: PMC8666584

Abstract Article PDF–15M

Select item 863616917.

METTL1/WDR4-mediated m⁷G tRNA modifications and m⁷G codon usage promote mRNA translation and lung cancer progression

Jieyi Ma, Hui Han, Ying Huang, Chunlong Yang, Siyi Zheng, Tiancai Cai, Jiong Bi, Xiaohui Huang, Ruiming Liu, Libin Huang, Yifeng Luo, Wen Li, Shuibin Lin

Mol Ther. 2021 Dec 1; 29(12): 3422–3435. Published online 2021 Aug 8. doi: 10.1016/j.ymthe.2021.08.005

PMCID:: PMC8636169

Abstract Article PDF–4.3M

Select item 838073018.

METTL1-mediated m⁷G modification of Arg-TCT tRNA drives oncogenic transformation

Esteban A. Orellana, Qi Liu, Eliza Yankova, Mehdi Pirouz, Etienne De Braekeleer, Wencai Zhang, Jihoon Lim, Demetrios Aspris, Erdem Sendinc, Dimitrios A. Garyfallos, Muxin Gu, Raja Ali, Alejandro Gutierrez, Sigitas Mikutis, Gonçalo J. L. Bernardes, Eric S. Fischer, Allan Bradley, George S. Vassiliou, Frank J. Slack, Konstantinos Tzelepis, Richard I. Gregory

Mol Cell. Author manuscript; available in PMC 2022 Aug 19.

Published in final edited form as: Mol Cell. 2021 Aug 19; 81(16): 3323–3338.e14. Published online 2021 Aug 4. doi: 10.1016/j.molcel.2021.06.031

PMCID:: PMC8380730

Abstract Article PDF–2.1M

Select item 836418119.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 827089820.

Reciprocal interaction between SIRT6 and APC/C regulates genomic stability

Helin Wang, Kangze Feng, Qingtao Wang, Haiteng Deng

Sci Rep. 2021; 11: 14253. Published online 2021 Jul 9. doi: 10.1038/s41598-021-93684-w

PMCID:: PMC8270898

Abstract Article PDF–2.6M

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