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Select item 109702591.

Peripheral Upregulation of Parkinson’s Disease-Associated Genes Encoding α-Synuclein, β-Glucocerebrosidase, and Ceramide Glucosyltransferase in Major Depression

Razvan-Marius Brazdis, Claudia von Zimmermann, Bernd Lenz, Johannes Kornhuber, Christiane Mühle

Int J Mol Sci. 2024 Mar; 25(6): 3219. Published online 2024 Mar 12. doi: 10.3390/ijms25063219

PMCID:: PMC10970259

Abstract Article PDF–1.5M

Select item 109488372.

Targeting glucosylceramide synthase induces antiproliferative and proapoptotic effects in osimertinib-resistant NSCLC cell models

Silvia La Monica, Federica Vacondio, Kamal Eltayeb, Alessio Lodola, Francesco Volta, Martina Viglioli, Francesca Ferlenghi, Francesca Galvani, Maricla Galetti, Mara Bonelli, Claudia Fumarola, Andrea Cavazzoni, Lisa Flammini, Michela Verzè, Roberta Minari, Pier Giorgio Petronini, Marcello Tiseo, Marco Mor, Roberta Alfieri

Sci Rep. 2024; 14: 6491. Published online 2024 Mar 18. doi: 10.1038/s41598-024-57028-8

PMCID:: PMC10948837

Abstract Article PDF–1.7M

Select item 109168663.

Cooperative polarization of MCAM/CD146 and ERM family proteins in melanoma

Suzannah G. Miller, Maria Hoh, Christopher C. Ebmeier, Jian Wei Tay, Natalie G. Ahn

Mol Biol Cell. 2024 Mar 1; 35(3): ar31. Published online 2024 Jan 29. doi: 10.1091/mbc.E23-06-0255

PMCID:: PMC10916866

Abstract Article PDF–4.7M

Select item 82181214.

HCV NS5A and NS5B enhance expression of human ceramide glucosyltransferase gene

Jia Guo, Ran Yan, Guo-dong Xu, Cong-yi Zheng

Virol Sin. 2012 Feb; 27(1): 38–47. Published online 2012 Jan 22. doi: 10.1007/s12250-012-3226-0

PMCID:: PMC8218121

Abstract Article PDF–637K

Select item 81650305.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 79392636.

β-Sitosterol 3-O-D-glucoside increases ceramide levels in the stratum corneum via the up-regulated expression of ceramide synthase-3 and glucosylceramide synthase in a reconstructed human epidermal keratinization model

Shogo Takeda, Shuko Terazawa, Hiroshi Shimoda, Genji Imokawa

PLoS One. 2021; 16(3): e0248150. Published online 2021 Mar 8. doi: 10.1371/journal.pone.0248150

PMCID:: PMC7939263

Abstract Article PDF–2.5M

Select item 72349957.

UGCG overexpression leads to increased glycolysis and increased oxidative phosphorylation of breast cancer cells

Nina Schömel, Lisa Gruber, Stephanie J. Alexopoulos, Sandra Trautmann, Ellen M. Olzomer, Frances L. Byrne, Kyle L. Hoehn, Robert Gurke, Dominique Thomas, Nerea Ferreirós, Gerd Geisslinger, Marthe-Susanna Wegner

Sci Rep. 2020; 10: 8182. Published online 2020 May 18. doi: 10.1038/s41598-020-65182-y

PMCID:: PMC7234995

Abstract Article PDF–2.6M

Select item 68218928.

UGCG influences glutamine metabolism of breast cancer cells

Nina Schömel, Sarah E. Hancock, Lisa Gruber, Ellen M. Olzomer, Frances L. Byrne, Divya Shah, Kyle L. Hoehn, Nigel Turner, Sabine Grösch, Gerd Geisslinger, Marthe-Susanna Wegner

Sci Rep. 2019; 9: 15665. Published online 2019 Oct 30. doi: 10.1038/s41598-019-52169-7

PMCID:: PMC6821892

Abstract Article PDF–1.8M

Select item 62311409.

Complex formation of sphingomyelin synthase 1 with glucosylceramide synthase increases sphingomyelin and decreases glucosylceramide levels

Yasuhiro Hayashi, Yoko Nemoto-Sasaki, Naoki Matsumoto, Kotaro Hama, Takashi Tanikawa, Saori Oka, Tadaaki Saeki, Tatsuya Kumasaka, Takanori Koizumi, Seisuke Arai, Ikuo Wada, Kazuaki Yokoyama, Takayuki Sugiura, Atsushi Yamashita

J Biol Chem. 2018 Nov 9; 293(45): 17505–17522. Published online 2018 Sep 21. doi: 10.1074/jbc.RA118.002048

PMCID:: PMC6231140

Abstract Article PDF–3.6M

Select item 614077710.

Glucosylceramide synthase inhibition with lucerastat lowers globotriaosylceramide and lysosome staining in cultured fibroblasts from Fabry patients with different mutation types

R W D Welford, A Mühlemann, M Garzotti, V Rickert, P M A Groenen, O Morand, N Üçeyler, M R Probst

Hum Mol Genet. 2018 Oct 1; 27(19): 3392–3403. Published online 2018 Aug 8. doi: 10.1093/hmg/ddy248

PMCID:: PMC6140777

Abstract Article PDF–18M

Select item 584108611.

High-content genome-wide RNAi screens identify regulators of parkin upstream of mitophagy

Samuel A. Hasson, Lesley A. Kane, Koji Yamano, Chiu-Hui Huang, Danielle A. Sliter, Eugen Buehler, Chunxin Wang, Sabrina M. Heman-Ackah, Tara Hessa, Rajarshi Guha, Scott E. Martin, Richard J. Youle

Nature. Author manuscript; available in PMC 2018 Mar 7.

Published in final edited form as: Nature. 2013 Dec 12; 504(7479): 291–295. Published online 2013 Nov 24. doi: 10.1038/nature12748

PMCID:: PMC5841086

Abstract Article PDF–5.3M

Select item 580167912.

The UDP-glucose ceramide glycosyltransferase (UGCG) and the link to multidrug resistance protein 1 (MDR1)

Marthe-Susanna Wegner, Lisa Gruber, Peter Mattjus, Gerd Geisslinger, Sabine Grösch

BMC Cancer. 2018; 18: 153. Published online 2018 Feb 6. doi: 10.1186/s12885-018-4084-4

PMCID:: PMC5801679

Abstract Article PDF–1.3M

Select item 567858113.

RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination

Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski

BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9

PMCID:: PMC5678581

Abstract Article PDF–3.2M

Select item 553161114.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 539349715.

Dysregulated Sphingolipid Metabolism in Endometriosis

Yie Hou Lee, Chin Wen Tan, Abhishek Venkatratnam, Chuen Seng Tan, Liang Cui, Seong Feei Loh, Linda Griffith, Steven R. Tannenbaum, Jerry Kok Yen Chan

J Clin Endocrinol Metab. 2014 Oct; 99(10): E1913–E1921. Published online 2014 Jun 24. doi: 10.1210/jc.2014-1340

PMCID:: PMC5393497

Abstract Article

Select item 509503716.

Altered methylation of glucosylceramide synthase promoter regulates its expression and associates with acquired multidrug resistance in invasive ductal breast cancer

Jiannan Liu, Xiaofang Zhang, Aina Liu, Daoping Zhang, Yi Su, Ying Liu, Dong You, Leilei Yuan, Xiangshuo Kong, Xiaodan Wang, Ping Sun

Oncotarget. 2016 Jun 14; 7(24): 36755–36766. Published online 2016 May 13. doi: 10.18632/oncotarget.9337

PMCID:: PMC5095037

Abstract Article PDF–5.5M

Select item 488499017.

Targeting glucosylceramide synthase upregulation reverts sorafenib resistance in experimental hepatocellular carcinoma

Milica Stefanovic, Anna Tutusaus, Guillermo A. Martinez-Nieto, Cristina Bárcena, Estefania de Gregorio, Catia Moutinho, Elisabet Barbero-Camps, Alberto Villanueva, Anna Colell, Montserrat Marí, Carmen García-Ruiz, Jose C. Fernandez-Checa, Albert Morales

Oncotarget. 2016 Feb 16; 7(7): 8253–8267. Published online 2016 Jan 22. doi: 10.18632/oncotarget.6982

PMCID:: PMC4884990

Abstract Article PDF–9.7M

Select item 461721118.

The BioPlex Network: A Systematic Exploration of the Human Interactome

Edward L. Huttlin, Lily Ting, Raphael J. Bruckner, Fana Gebreab, Melanie P. Gygi, John Szpyt, Stanley Tam, Gabriela Zarraga, Greg Colby, Kurt Baltier, Rui Dong, Virginia Guarani, Laura Pontano Vaites, Alban Ordureau, Ramin Rad, Brian K. Erickson, Martin Wühr, Joel Chick, Bo Zhai, Deepak Kolippakkam, Julian Mintseris, Robert A. Obar, Tim Harris, Spyros Artavanis-Tsakonas, Mathew E. Sowa, Pietro DeCamilli, Joao A. Paulo, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2016 Jul 16.

Published in final edited form as: Cell. 2015 Jul 16; 162(2): 425–440. doi: 10.1016/j.cell.2015.06.043

PMCID:: PMC4617211

Abstract Article PDF–2.2M

Select item 403786319.

Glucosylceramide synthase, a factor in modulating drug resistance, is overexpressed in metastatic breast carcinoma

YONG-YU LIU, GAURI A. PATWARDHAN, PING XIE, XIN GU, ARMANDO E. GIULIANO, MYLES C. CABOT

Int J Oncol. Author manuscript; available in PMC 2014 May 29.

Published in final edited form as: Int J Oncol. 2011 Aug; 39(2): 425–431. Published online 2011 May 23. doi: 10.3892/ijo.2011.1052

PMCID:: PMC4037863

Abstract Article PDF–969K

Select item 397610020.

Expression of glucosylceramide synthase in invasive ductal breast cancer may be correlated with high estrogen receptor status and low HER-2 status

Jiannan Liu, Ping Sun, Yuan Sun, Aina Liu, Dong You, Fenge Jiang, Yuping Sun

Diagn Pathol. 2014; 9: 22. Published online 2014 Jan 23. doi: 10.1186/1746-1596-9-22

PMCID:: PMC3976100

Abstract Article PDF–676K

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