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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 107328692.

DJ-1: A Potential Biomarker Related to Prognosis, Chemoresistance, and Expression of Microenvironmental Chemokine in HR-Positive Breast Cancer

Yinghong Xie, Yuancheng Li, Mengzhu Yang

J Immunol Res. 2023; 2023: 5041223. Published online 2023 Dec 13. doi: 10.1155/2023/5041223

PMCID:: PMC10732869

Abstract Article PDF–5.7M

Select item 105201323.

TrkB inhibition of DJ-1 degradation promotes the growth and maintenance of cancer stem cell characteristics in hepatocellular carcinoma

Min Soo Kim, Won Sung Lee, Wook Jin

Cell Mol Life Sci. 2023 Oct; 80(10): 303. Published online 2023 Sep 25. doi: 10.1007/s00018-023-04960-z

PMCID:: PMC10520132

Abstract Article PDF–2.6M

Select item 102885064.

Disease-Modifying Effects of Vincamine Supplementation in Drosophila and Human Cell Models of Parkinson’s Disease Based on DJ-1 Deficiency

Francisco José Sanz, Cristina Solana-Manrique, Nuria Paricio

ACS Chem Neurosci. 2023 Jun 21; 14(12): 2294–2301. Published online 2023 Jun 8. doi: 10.1021/acschemneuro.3c00026

PMCID:: PMC10288506

Abstract Article PDF–2.7M

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101516156.

Cross-linking mass spectrometry discovers, evaluates, and corroborates structures and protein–protein interactions in the human cell

Tara K. Bartolec, Xabier Vázquez-Campos, Alexander Norman, Clement Luong, Marcus Johnson, Richard J. Payne, Marc R. Wilkins, Joel P. Mackay, Jason K. K. Low

Proc Natl Acad Sci U S A. 2023 Apr 25; 120(17): e2219418120. Published online 2023 Apr 18. doi: 10.1073/pnas.2219418120

PMCID:: PMC10151615

Abstract Article PDF–2.9M

Select item 101272647.

Kinetic evidence in favor of glyoxalase III and against deglycase activity of DJ‐1

Joonhyeok Choi, Sungho Tak, Hoe‐Myung Jung, Soyoung Cha, Eunha Hwang, Donghan Lee, Joon‐Hwa Lee, Kyoung‐Seok Ryu, Chankyu Park

Protein Sci. 2023 May; 32(5): e4641. Published online 2023 May 1. doi: 10.1002/pro.4641

PMCID:: PMC10127264

Abstract Article PDF–2.6M

Select item 101116858.

PARK7/DJ-1 in microglia: implications in Parkinson’s disease and relevance as a therapeutic target

Frida Lind-Holm Mogensen, Andrea Scafidi, Aurélie Poli, Alessandro Michelucci

J Neuroinflammation. 2023; 20: 95. Published online 2023 Apr 18. doi: 10.1186/s12974-023-02776-z

PMCID:: PMC10111685

Abstract Article PDF–1.9M

Select item 100350339.

Parkinsonism-Associated Protein DJ-1 Is an Antagonist, Not an Eraser, for Protein Glycation

Qingzeng Gao, Jeremiah W. Jacob-Dolan, Rebecca A. Scheck

Biochemistry. 2023 Mar 21; 62(6): 1181–1190. Published online 2023 Feb 23. doi: 10.1021/acs.biochem.3c00028

PMCID:: PMC10035033

Abstract Article PDF–10M

Select item 997863510.

Fibril treatment changes protein interactions of tau and α-synuclein in human neurons

Tagan A. Griffin, Paul D. Schnier, Elisa M. Cleveland, Robert W. Newberry, Julia Becker, George A. Carlson

J Biol Chem. 2023 Mar; 299(3): 102888. Published online 2023 Jan 10. doi: 10.1016/j.jbc.2023.102888

PMCID:: PMC9978635

Abstract Article PDF–10M

Select item 991592711.

Searching for Biomarkers in the Blood of Patients at Risk of Developing Parkinson’s Disease at the Prodromal Stage

Elena A. Katunina, Victor Blokhin, Marina R. Nodel, Ekaterina N. Pavlova, Alexander L. Kalinkin, Valerian G. Kucheryanu, Leyla Alekperova, Marianna V. Selikhova, Mikhail Yu. Martynov, Michael V. Ugrumov

Int J Mol Sci. 2023 Feb; 24(3): 1842. Published online 2023 Jan 17. doi: 10.3390/ijms24031842

PMCID:: PMC9915927

Abstract Article PDF–5.3M

Select item 976295012.

DJ-1 is an essential downstream mediator in PINK1/parkin-dependent mitophagy

Dorien Imberechts, Inge Kinnart, Fieke Wauters, Joanne Terbeek, Liselot Manders, Keimpe Wierda, Kristel Eggermont, Rodrigo Furtado Madeiro, Carolyn Sue, Catherine Verfaillie, Wim Vandenberghe

Brain. 2022 Dec; 145(12): 4368–4384. Published online 2022 Aug 30. doi: 10.1093/brain/awac313

PMCID:: PMC9762950

Abstract Article PDF–2.0M

Select item 952399713.

MBD5 and MBD6 stabilize the BAP1 complex and promote BAP1-dependent cancer

Natsumi Tsuboyama, Aileen Patricia Szczepanski, Zibo Zhao, Lu Wang

Genome Biol. 2022; 23: 206. Published online 2022 Sep 30. doi: 10.1186/s13059-022-02776-x

PMCID:: PMC9523997

Abstract Article PDF–6.9M

Select item 949923814.

SIRT5 is a proviral factor that interacts with SARS-CoV-2 Nsp14 protein

Marius Walter, Irene P. Chen, Albert Vallejo-Gracia, Ik-Jung Kim, Olga Bielska, Victor L. Lam, Jennifer M. Hayashi, Andrew Cruz, Samah Shah, Frank W. Soveg, John D. Gross, Nevan J. Krogan, Keith R. Jerome, Birgit Schilling, Melanie Ott, Eric Verdin

PLoS Pathog. 2022 Sep; 18(9): e1010811. Published online 2022 Sep 12. doi: 10.1371/journal.ppat.1010811

PMCID:: PMC9499238

Abstract Article PDF–3.7M

Select item 948193315.

ALS-linked loss of Cyclin-F function affects HSP90

Alexander Siebert, Vanessa Gattringer, Jochen H Weishaupt, Christian Behrends

Life Sci Alliance. 2022 Dec; 5(12): e202101359. Published online 2022 Sep 16. doi: 10.26508/lsa.202101359

PMCID:: PMC9481933

Abstract Article PDF–3.5M

Select item 944065316.

Suppression of ACE2 SUMOylation protects against SARS-CoV-2 infection through TOLLIP-mediated selective autophagy

Shouheng Jin, Xing He, Ling Ma, Zhen Zhuang, Yiliang Wang, Meng Lin, Sihui Cai, Lu Wei, Zheyu Wang, Zhiyao Zhao, Yaoxing Wu, Lin Sun, Chunwei Li, Weihong Xie, Yong Zhao, Zhou Songyang, Ke Peng, Jincun Zhao, Jun Cui

Nat Commun. 2022; 13: 5204. Published online 2022 Sep 3. doi: 10.1038/s41467-022-32957-y

PMCID:: PMC9440653

Abstract Article PDF–2.9M

Select item 943756317.

SMYD3 Impedes Small Cell Lung Cancer Sensitivity to Alkylation Damage through RNF113A Methylation–Phosphorylation Cross-talk

Valentina Lukinović, Simone Hausmann, Gael S. Roth, Clement Oyeniran, Tanveer Ahmad, Ning Tsao, Joshua R. Brickner, Alexandre G. Casanova, Florent Chuffart, Ana Morales Benitez, Jessica Vayr, Rebecca Rodell, Marianne Tardif, Pascal W.T.C. Jansen, Yohann Couté, Michiel Vermeulen, Pierre Hainaut, Pawel K. Mazur, Nima Mosammaparast, Nicolas Reynoird

Cancer Discov. 2022 Sep 2; 12(9): 2158–2179. Published online 2022 Jul 12. doi: 10.1158/2159-8290.CD-21-0205