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Select item 109076071.

Acid sphingomyelinase as a pathological and therapeutic target in neurological disorders: focus on Alzheimer’s disease

Byung Jo Choi, Min Hee Park, Hee Kyung Jin, Jae-sung Bae

Exp Mol Med. 2024 Feb; 56(2): 301–310. Published online 2024 Feb 9. doi: 10.1038/s12276-024-01176-4

PMCID:: PMC10907607

Abstract Article PDF–2.1M

Select item 103001642.

Acid sphingomyelinase expression is associated with survival in resectable pancreatic ductal adenocarcinoma

Gregory C. Wilson, Sameer H. Patel, Jiang Wang, Kui Xu, Kevin M. Turner, Katrin Anne Becker, Alexander Carpinteiro, Ildiko Szabo, Syed A. Ahmad, Erich Gulbins

J Mol Med (Berl) 2023; 101(7): 891–903. Published online 2023 May 29. doi: 10.1007/s00109-023-02331-6

PMCID:: PMC10300164

Abstract Article PDF–4.6M

Select item 102374223.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 100429794.

SMPD1 gene variants in patients with β-Thalassemia major

Fadime Ersoy Dursun, Filiz Özen

Mol Biol Rep. 2023; 50(4): 3355–3363. Published online 2023 Feb 1. doi: 10.1007/s11033-023-08275-x

PMCID:: PMC10042979

Abstract Article PDF–1.2M

Select item 100099355.

SMPD1 expression profile and mutation landscape help decipher genotype–phenotype association and precision diagnosis for acid sphingomyelinase deficiency

Ruisong Wang, Ziyi Qin, Long Huang, Huiling Luo, Han Peng, Xinyu Zhou, Zhixiang Zhao, Mingyao Liu, Pinhong Yang, Tieliu Shi

Hereditas. 2023; 160: 11. Published online 2023 Mar 13. doi: 10.1186/s41065-023-00272-1

PMCID:: PMC10009935

Abstract Article PDF–5.7M

Select item 92316236.

ESCPE-1 mediates retrograde endosomal sorting of the SARS-CoV-2 host factor Neuropilin-1

Boris Simonetti, James L. Daly, Lorena Simón-Gracia, Katja Klein, Saroja Weeratunga, Carlos Antón-Plágaro, Allan Tobi, Lorna Hodgson, Philip A. Lewis, Kate J. Heesom, Deborah K. Shoemark, Andrew D. Davidson, Brett M. Collins, Tambet Teesalu, Yohei Yamauchi, Peter J. Cullen

Proc Natl Acad Sci U S A. 2022 Jun 21; 119(25): e2201980119. Published online 2022 Jun 13. doi: 10.1073/pnas.2201980119

PMCID:: PMC9231623

Abstract Article PDF–6.0M

Select item 87211067.

Activation of Sphingomyelinase-Ceramide-Pathway in COVID-19 Purposes Its Inhibition for Therapeutic Strategies

Murad Abusukhun, Martin S. Winkler, Stefan Pöhlmann, Onnen Moerer, Konrad Meissner, Björn Tampe, Heike Hofmann-Winkler, Michael Bauer, Markus H. Gräler, Ralf A. Claus

Front Immunol. 2021; 12: 784989. Published online 2021 Dec 20. doi: 10.3389/fimmu.2021.784989

PMCID:: PMC8721106

Abstract Article PDF–2.5M

Select item 83966768.

Acid Sphingomyelinase, a Lysosomal and Secretory Phospholipase C, Is Key for Cellular Phospholipid Catabolism

Bernadette Breiden, Konrad Sandhoff

Int J Mol Sci. 2021 Aug; 22(16): 9001. Published online 2021 Aug 20. doi: 10.3390/ijms22169001

PMCID:: PMC8396676

Abstract Article PDF–1.8M

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 812360310.

In Silico Analysis of the Molecular-Level Impact of SMPD1 Variants on Niemann-Pick Disease Severity

François Ancien, Fabrizio Pucci, Marianne Rooman

Int J Mol Sci. 2021 May; 22(9): 4516. Published online 2021 Apr 26. doi: 10.3390/ijms22094516

PMCID:: PMC8123603

Abstract Article PDF–6.9M

Select item 806255011.

Inhibition of acid sphingomyelinase by ambroxol prevents SARS-CoV-2 entry into epithelial cells

Alexander Carpinteiro, Barbara Gripp, Markus Hoffmann, Stefan Pöhlmann, Nicolas Hoertel, Michael J. Edwards, Markus Kamler, Johannes Kornhuber, Katrin Anne Becker, Erich Gulbins

J Biol Chem. 2021 Jan-Jun; 296: 100701. Published online 2021 Apr 23. doi: 10.1016/j.jbc.2021.100701

PMCID:: PMC8062550

Abstract Article PDF–2.1M

Select item 769267212.

Sphingomyelinases and Liver Diseases

Naroa Insausti-Urkia, Estel Solsona-Vilarrasa, Carmen Garcia-Ruiz, Jose C. Fernandez-Checa

Biomolecules. 2020 Nov; 10(11): 1497. Published online 2020 Oct 30. doi: 10.3390/biom10111497

PMCID:: PMC7692672

Abstract Article PDF–1.4M

Select item 759853013.

Pharmacological Inhibition of Acid Sphingomyelinase Prevents Uptake of SARS-CoV-2 by Epithelial Cells

Alexander Carpinteiro, Michael J. Edwards, Markus Hoffmann, Georg Kochs, Barbara Gripp, Sebastian Weigang, Constantin Adams, Elisa Carpinteiro, Anne Gulbins, Simone Keitsch, Carolin Sehl, Matthias Soddemann, Barbara Wilker, Markus Kamler, Thomas Bertsch, Karl S. Lang, Sameer Patel, Gregory C. Wilson, Silke Walter, Hartmut Hengel, Stefan Pöhlmann, Philipp A. Lang, Johannes Kornhuber, Katrin Anne Becker, Syed A. Ahmad, Klaus Fassbender, Erich Gulbins

Cell Rep Med. 2020 Nov 17; 1(8): 100142. Published online 2020 Oct 29. doi: 10.1016/j.xcrm.2020.100142

PMCID:: PMC7598530

Abstract Article PDF–2.3M

Select item 759827714.

Sphingolipid Metabolism in Glioblastoma and Metastatic Brain Tumors: A Review of Sphingomyelinases and Sphingosine-1-Phosphate

Cyntanna C. Hawkins, Tomader Ali, Sasanka Ramanadham, Anita B. Hjelmeland

Biomolecules. 2020 Oct; 10(10): 1357. Published online 2020 Sep 23. doi: 10.3390/biom10101357

PMCID:: PMC7598277

Abstract Article PDF–1.7M

Select item 756688115.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 720385216.

Niemann-Pick disease type-B: a unique case report with compound heterozygosity and complicated lipid management

L. Ordieres-Ortega, F. Galeano-Valle, M. Mallén-Pérez, C. Muñoz-Delgado, J. E. Apaza-Chavez, F. J. Menárguez-Palanca, L. A. Alvarez-Sala Walther, P. Demelo-Rodríguez

BMC Med Genet. 2020; 21: 94. Published online 2020 May 6. doi: 10.1186/s12881-020-01027-9

PMCID:: PMC7203852

Abstract Article PDF–1.0M

Select item 714585017.

Comparative lipidomics of 5-Fluorouracil–sensitive and –resistant colorectal cancer cells reveals altered sphingomyelin and ceramide controlled by acid sphingomyelinase (SMPD1)

Jae Hun Jung, Kohei Taniguchi, Hyeong Min Lee, Min Young Lee, Raju Bandu, Kazumasa Komura, Kil Yeon Lee, Yukihiro Akao, Kwang Pyo Kim

Sci Rep. 2020; 10: 6124. Published online 2020 Apr 9. doi: 10.1038/s41598-020-62823-0

PMCID:: PMC7145850

Abstract Article PDF–3.0M

Select item 692901018.

Decreased Activity of Blood Acid Sphingomyelinase in the Course of Multiple Myeloma

Marzena Wątek, Ewelina Piktel, Joanna Barankiewicz, Ewa Sierlecka, Sylwia Kościołek-Zgódka, Anna Chabowska, Łukasz Suprewicz, Przemysław Wolak, Bonita Durnaś, Robert Bucki, Ewa Lech-Marańda

Int J Mol Sci. 2019 Dec; 20(23): 6048. Published online 2019 Nov 30. doi: 10.3390/ijms20236048

PMCID:: PMC6929010

Abstract Article PDF–2.8M

Select item 646964319.

SMPD1 mutations, activity and α-synuclein accumulation in Parkinson’s disease

Roy N. Alcalay, Victoria Mallett, Benoît Vanderperre, Omid Tavassoly, Yves Dauvilliers, Richard Y.J. Wu, Jennifer A. Ruskey, Claire S. Leblond, Amirthagowri Ambalavanan, Sandra B. Laurent, Dan Spiegelman, Alexandre Dionne-Laporte, Christopher Liong, Oren A. Levy, Stanley Fahn, Cheryl Waters, Sheng-Han Kuo, Wendy K. Chung, Blair Ford, Karen S. Marder, Un Jung Kang, Sharon Hassin-Baer, Lior Greenbaum, Jean-Francois Trempe, Pavlina Wolf, Petra Oliva, Xiaokui Kate Zhang, Lorraine N. Clark, Melanie Langlois, Patrick A. Dion, Edward A. Fon, Nicolas Dupre, Guy A. Rouleau, Ziv Gan-Or

Mov Disord. Author manuscript; available in PMC 2020 Apr 1.

Published in final edited form as: Mov Disord. 2019 Apr; 34(4): 526–535. Published online 2019 Feb 20. doi: 10.1002/mds.27642

PMCID:: PMC6469643

Abstract Article PDF–867K

Select item 598770620.

Nitric Oxide Generated by Tumor-Associated Macrophages Is Responsible for Cancer Resistance to Cisplatin and Correlated With Syntaxin 4 and Acid Sphingomyelinase Inhibition

Cristiana Perrotta, Davide Cervia, Ilaria Di Renzo, Claudia Moscheni, Maria Teresa Bassi, Lara Campana, Cristina Martelli, Elisabetta Catalani, Matteo Giovarelli, Silvia Zecchini, Marco Coazzoli, Annalisa Capobianco, Luisa Ottobrini, Giovanni Lucignani, Patrizia Rosa, Patrizia Rovere-Querini, Clara De Palma, Emilio Clementi

Front Immunol. 2018; 9: 1186. Published online 2018 May 29. doi: 10.3389/fimmu.2018.01186

PMCID:: PMC5987706

Abstract Article PDF–12M

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