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Select item 112270351.

Constitutive internalisation of EP2 differentially regulates G protein signalling

Abigail R Walker, Holly A Parkin, Sung Hye Kim, Vasso Terzidou, David F Woodward, Phillip R Bennett, Aylin C Hanyaloglu

J Mol Endocrinol. 2024 Jul 1; 73(1): e230153. Prepublished online 2024 Apr 19. Published online 2024 May 15. doi: 10.1530/JME-23-0153

PMCID:: PMC11227035

Abstract Article PDF–2.9M

Select item 111139332.

Intracellular EP2 prostanoid receptor promotes cancer-related phenotypes in PC3 cells

Ana Belén Fernández-Martínez, Javier Lucio-Cazaña

Cell Mol Life Sci. 2015 Sep; 72(17): 3355–3373. Published online 2015 Apr 1. doi: 10.1007/s00018-015-1891-5

PMCID:: PMC11113933

Abstract Article PDF–5.8M

Select item 110983453.

Impact of Bone Morphogenetic Protein 7 and Prostaglandin receptors on osteoblast healing and organization of collagen

Mohammad Ali Salama, Asmaa Anwar Ismail, Md Sofiqul Islam, Aghila Rani K. G., Sausan Al Kawas, A. R. Samsudin, Smriti Aryal A. C.

PLoS One. 2024; 19(5): e0303202. Published online 2024 May 16. doi: 10.1371/journal.pone.0303202

PMCID:: PMC11098345

Abstract Article PDF–3.9M

Select item 95422244.

Increased COX‐2 after ureter obstruction attenuates fibrosis and is associated with EP₂ receptor upregulation in mouse and human kidney

Signe S. Tofteng, Line Nilsson, Amalie K. Mogensen, Rikke Nørregaard, Rolf Nüsing, Mikhail Diatchikhine, Lars Lund, Claus Bistrup, Boye L. Jensen, Kirsten Madsen

Acta Physiol (Oxf) 2022 Aug; 235(4): e13828. Published online 2022 May 20. doi: 10.1111/apha.13828

PMCID:: PMC9542224

Abstract Article PDF–53M

Select item 86560355.

Identification of ACOT13 and PTGER2 as novel candidate genes of autosomal dominant polycystic kidney disease through whole exome sequencing

Na Du, Dan Dong, Luyao Sun, Lihe Che, Xiaohua Li, Yong Liu, Bin Wang

Eur J Med Res. 2021; 26: 142. Published online 2021 Dec 9. doi: 10.1186/s40001-021-00613-8

PMCID:: PMC8656035

Abstract Article PDF–1.2M

Select item 85718796.

Alpha-Synuclein, cyclooxygenase-2 and prostaglandins-EP2 receptors as neuroinflammatory biomarkers of autism spectrum disorders: Use of combined ROC curves to increase their diagnostic values

Afaf El-Ansary, Manan Alhakbany, Abeer Aldbass, Hanan Qasem, Sarah Al-Mazidi, Ramesa Shafi Bhat, Laila Al-Ayadhi

Lipids Health Dis. 2021; 20: 155. Published online 2021 Nov 6. doi: 10.1186/s12944-021-01578-7

Correction in:: Lipids Health Dis. 2021; 20: 172.

PMCID:: PMC8571879

Abstract Article PDF–1.4M

Select item 85611117.

Prostaglandin E₂ directly inhibits the conversion of inducible regulatory T cells through EP2 and EP4 receptors via antagonizing TGF‐β signalling

Marie Goepp, Siobhan Crittenden, You Zhou, Adriano G Rossi, Shuh Narumiya, Chengcan Yao

Immunology. 2021 Dec; 164(4): 777–791. Published online 2021 Oct 1. doi: 10.1111/imm.13417

PMCID:: PMC8561111

Abstract Article PDF–1.4M

Select item 77239368.

The role of EP-2 receptor expression in cervical intraepithelial neoplasia

Elisa Schmoeckel, Patricia Fraungruber, Christina Kuhn, Udo Jeschke, Sven Mahner, Theresa Maria Kolben, Thomas Kolben, Theresa Vilsmaier, Anna Hester, Helene Hildegard Heidegger

Histochem Cell Biol. 2020; 154(6): 655–662. Published online 2020 Aug 26. doi: 10.1007/s00418-020-01909-2

PMCID:: PMC7723936

Abstract Article PDF–1.4M

Select item 74922119.

Syntenin-1 promotes colorectal cancer stem cell expansion and chemoresistance by regulating prostaglandin E2 receptor

Kazuya Iwamoto, Hidekazu Takahashi, Daisuke Okuzaki, Hideo Osawa, Takayuki Ogino, Norikatsu Miyoshi, Mamoru Uemura, Chu Matsuda, Hirofumi Yamamoto, Tsunekazu Mizushima, Masaki Mori, Yuichiro Doki, Hidetoshi Eguchi

Br J Cancer. 2020 Sep 15; 123(6): 955–964. Published online 2020 Jun 29. doi: 10.1038/s41416-020-0965-9

PMCID:: PMC7492211

Abstract Article PDF–1.6M

Select item 729066710.

Concerted EP2 and EP4 Receptor Signaling Stimulates Autocrine Prostaglandin E₂ Activation in Human Podocytes

Eva Mangelsen, Michael Rothe, Angela Schulz, Aikaterini Kourpa, Daniela Panáková, Reinhold Kreutz, Juliane Bolbrinker

Cells. 2020 May; 9(5): 1256. Published online 2020 May 19. doi: 10.3390/cells9051256

PMCID:: PMC7290667

Abstract Article PDF–2.1M

Select item 717116511.

Prostaglandin EP2 receptor downstream of Notch signaling inhibits differentiation of human skeletal muscle progenitors in differentiation conditions

Fusako Sakai-Takemura, Ken’ichiro Nogami, Ahmed Elhussieny, Kota Kawabata, Yusuke Maruyama, Naohiro Hashimoto, Shin’ichi Takeda, Yuko Miyagoe-Suzuki

Commun Biol. 2020; 3: 182. Published online 2020 Apr 20. doi: 10.1038/s42003-020-0904-6

PMCID:: PMC7171165

Abstract Article PDF–3.6M

Select item 698123112.

The prostaglandin receptor EP2 determines prognosis in EP3-negative and galectin-3-high cervical cancer cases

Sebastian Dietlmeier, Yao Ye, Christina Kuhn, Aurelia Vattai, Theresa Vilsmaier, Lennard Schröder, Bernd P. Kost, Julia Gallwas, Udo Jeschke, Sven Mahner, Helene Hildegard Heidegger

Sci Rep. 2020; 10: 1154. Published online 2020 Jan 24. doi: 10.1038/s41598-020-58095-3

PMCID:: PMC6981231

Abstract Article PDF–1.7M

Select item 672580313.

Deletion of the Prostaglandin E₂ EP2 Receptor Reduces Oxidative Damage and Amyloid Burden in a Model of Alzheimer's Disease

Xibin Liang, Qian Wang, Tracey Hand, Liejun Wu, Richard M. Breyer, Thomas J. Montine, Katrin Andreasson

J Neurosci. 2005 Nov 2; 25(44): 10180–10187. doi: 10.1523/JNEUROSCI.3591-05.2005

PMCID:: PMC6725803

Abstract Article PDF–335K

Select item 642556314.

Altered PGE2-EP2 is associated with an excessive immune response in HBV-related acute-on-chronic liver failure

Yunyun Wang, Chao Chen, Jinjin Qi, Fengtian Wu, Jun Guan, Zhi Chen, Haihong Zhu

J Transl Med. 2019; 17: 93. Published online 2019 Mar 19. doi: 10.1186/s12967-019-1844-0

PMCID:: PMC6425563

Abstract Article PDF–1.8M

Select item 612144515.

Prostanoid EP₂ Receptors Are Up-Regulated in Human Pulmonary Arterial Hypertension: A Key Anti-Proliferative Target for Treprostinil in Smooth Muscle Cells

Jigisha A. Patel, Lei Shen, Susan M. Hall, Chabha Benyahia, Xavier Norel, Robin J. McAnulty, Shahin Moledina, Adam M. Silverstein, Brendan J. Whittle, Lucie H. Clapp

Int J Mol Sci. 2018 Aug; 19(8): 2372. Published online 2018 Aug 12. doi: 10.3390/ijms19082372

PMCID:: PMC6121445

Abstract Article PDF–3.2M

Select item 583050616.

Stromal C-type lectin receptor COLEC12 integrates H. pylori, PGE2-EP2/4 axis and innate immunity in gastric diseases

Lin-Li Chang, Wen-Hung Hsu, Mou-Chieh Kao, Chih-Chung Chou, Chung-Cheng Lin, Chung-Jung Liu, Bi-Chuang Weng, Fu-Chen Kuo, Chao-Hung Kuo, Ming-Hong Lin, Chun-Jen Wang, Chun-Hung Lin, Deng-Chyang Wu, Shau-Ku Huang

Sci Rep. 2018; 8: 3821. Published online 2018 Feb 28. doi: 10.1038/s41598-018-20957-2

PMCID:: PMC5830506

Abstract Article PDF–1.4M

Select item 541918817.

Selective Inhibition of Prostaglandin E2 Receptors EP2 and EP4 Induces Apoptosis of Human Endometriotic Cells through Suppression of ERK1/2, AKT, NFκB, and β-Catenin Pathways and Activation of Intrinsic Apoptotic Mechanisms

Sakhila K. Banu, JeHoon Lee, V. O. Speights, Jr., Anna Starzinski-Powitz, Joe A. Arosh

Mol Endocrinol. August 1, 2009; 23(8): 1291–1305. doi: 10.1210/me.2009-0017

PMCID:: PMC5419188

Abstract Article

Select item 536963918.

Prostaglandin E₂ Mediates Immunosuppression in Acutely Decompensated Cirrhosis

Alastair J. O’Brien, James N. Fullerton, Karen A. Massey, Grace Auld, Gavin Sewell, Sarah James, Justine Newson, Effie Karra, Alison Winstanley, William Alazawi, Rita Garcia-Marquez, Juan Cordoba, Anna Nicolaou, Derek W. Gilroy

Nat Med. Author manuscript; available in PMC 2017 Mar 28.

Published in final edited form as: Nat Med. 2014 May; 20(5): 518–523. Published online 2014 Apr 13. doi: 10.1038/nm.3516

PMCID:: PMC5369639

Abstract Article PDF–1.4M

Select item 507455719.

Prostaglandin E₂ Differentially Modulates Proinflammatory/Prodestructive Effects of TNF-α on Synovial Fibroblasts via Specific E Prostanoid Receptors/cAMP

Elke Kunisch, Anne Jansen, Fumiaki Kojima, Ivonne Löffler, Mohit Kapoor, Shinichi Kawai, Ignacio Rubio, Leslie J. Crofford, Raimund W. Kinne

J Immunol. Author manuscript; available in PMC 2016 Oct 21.

Published in final edited form as: J Immunol. 2009 Jul 15; 183(2): 1328–1336. Published online 2009 Jun 19. doi: 10.4049/jimmunol.0900801

PMCID:: PMC5074557

Abstract Article PDF–690K

Select item 488248620.

PGE₂ maintains self-renewal of human adult stem cells via EP2-mediated autocrine signaling and its production is regulated by cell-to-cell contact

Byung-Chul Lee, Hyung-Sik Kim, Tae-Hoon Shin, Insung Kang, Jin Young Lee, Jae-Jun Kim, Hyun Kyoung Kang, Yoojin Seo, Seunghee Lee, Kyung-Rok Yu, Soon Won Choi, Kyung-Sun Kang

Sci Rep. 2016; 6: 26298. Published online 2016 May 27. doi: 10.1038/srep26298