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Select item 102079511.

SPINK1 contributes to proliferation and clonal formation of HT29 cells through Beclin1 associated enhanced autophagy

NA HU, SHIQING ZHANG, AQUAN JIN, LIANYING GUO, ZHENYUN QU, JUN WANG

Oncol Res. 2022; 30(2): 89–97. Published online 2023 Jan 5. doi: 10.32604/or.2022.027058

PMCID:: PMC10207951

Abstract Article PDF–4.6M

Select item 97788212.

Pancreatic Secretory Trypsin Inhibitor (SPINK1) Gene Mutation in Patients with Acute Alcohol Pancreatitis (AAP) Compared to Healthy Controls and Heavy Alcohol Users without Pancreatitis

Anssi Nikkola, Kari Antero Mäkelä, Karl-Heinz Herzig, Shivaprakash Jagalur Mutt, Aishwarya Prasannan, Hanna Seppänen, Terho Lehtimäki, Mika Kähönen, Olli Raitakari, Ilkka Seppälä, Pihla Pakkanen, Isto Nordback, Juhani Sand, Johanna Laukkarinen

Int J Mol Sci. 2022 Dec; 23(24): 15726. Published online 2022 Dec 11. doi: 10.3390/ijms232415726

PMCID:: PMC9778821

Abstract Article PDF–413K

Select item 95150433.

Serine protease inhibitor Kazal type 1 (SPINK1) promotes proliferation, migration, invasion and radiation resistance in rectal cancer patients receiving concurrent chemoradiotherapy: a potential target for precision medicine

Yi-Ting Chen, Tzu-Ting Tseng, Hung-Pei Tsai, Shih-Hsun Kuo, Ming-Yii Huang, Jaw-Yuan Wang, Chee-Yin Chai

Hum Cell. 2022; 35(6): 1912–1927. Published online 2022 Sep 2. doi: 10.1007/s13577-022-00776-4

PMCID:: PMC9515043

Abstract Article PDF–8.1M

Select item 93414294.

Serine Protease Inhibitor Kazal Type 1, A Potential Biomarker for the Early Detection, Targeting, and Prediction of Response to Immune Checkpoint Blockade Therapies in Hepatocellular Carcinoma

Jianlong Jia, Latai Ga, Yang Liu, Zhiyi Yang, Yue Wang, Xuanze Guo, Ruichen Ma, Ruonan Liu, Tianyou Li, Zeyao Tang, Jun Wang

Front Immunol. 2022; 13: 923031. Published online 2022 Jul 18. doi: 10.3389/fimmu.2022.923031

PMCID:: PMC9341429

Abstract Article PDF–12M

Select item 89983365.

Structural and Biophysical Insights into SPINK1 Bound to Human Cationic Trypsin

Felix Nagel, Gottfried J. Palm, Norman Geist, Thomas C. R. McDonnell, Anne Susemihl, Britta Girbardt, Julia Mayerle, Markus M. Lerch, Michael Lammers, Mihaela Delcea

Int J Mol Sci. 2022 Apr; 23(7): 3468. Published online 2022 Mar 23. doi: 10.3390/ijms23073468

PMCID:: PMC8998336

Abstract Article PDF–2.1M

Select item 88765496.

Collision tumors revealed by prospectively assessing subtype-defining molecular alterations in 904 individual prostate cancer foci

Jacqueline Fontugne, Peter Y. Cai, Hussein Alnajar, Bhavneet Bhinder, Kyung Park, Huihui Ye, Shaham Beg, Verena Sailer, Javed Siddiqui, Mirjam Blattner-Johnson, Jaclyn A. Croyle, Zohal Noorzad, Carla Calagua, Theresa Y. MacDonald, Ulrika Axcrona, Mari Bogaard, Karol Axcrona, Douglas S. Scherr, Martin G. Sanda, Bjarne Johannessen, Arul M. Chinnaiyan, Olivier Elemento, Rolf I. Skotheim, Mark A. Rubin, Christopher E. Barbieri, Juan Miguel Mosquera

JCI Insight. 2022 Feb 22; 7(4): e155309. Published online 2022 Feb 22. doi: 10.1172/jci.insight.155309

PMCID:: PMC8876549

Abstract Article PDF–12M

Select item 88640217.

Raised SPINK1 levels play a role in angiogenesis and the transendothelial migration of ALL cells

Dong Luo, Dongqiang Liu, Chunbao Rao, Shanshan Shi, Xiaomei Zeng, Sha Liu, Hua Jiang, Lishi Liu, Zhenhong Zhang, Xiaomei Lu

Sci Rep. 2022; 12: 2999. Published online 2022 Feb 22. doi: 10.1038/s41598-022-06946-6

PMCID:: PMC8864021

Abstract Article PDF–6.9M

Select item 86635518.

SPINK1 as a plasma marker for tumor hypoxia and a therapeutic target for radiosensitization

Tatsuya Suwa, Minoru Kobayashi, Yukari Shirai, Jin-Min Nam, Yoshiaki Tabuchi, Norihiko Takeda, Shusuke Akamatsu, Osamu Ogawa, Takashi Mizowaki, Ester M. Hammond, Hiroshi Harada

JCI Insight. 2021 Nov 8; 6(21): e148135. Published online 2021 Nov 8. doi: 10.1172/jci.insight.148135

PMCID:: PMC8663551

Abstract Article PDF–7.9M

Select item 86192309.

Chronic Pancreatitis: The True Pathogenic Culprit within the SPINK1 N34S-Containing Haplotype Is No Longer at Large

Na Pu, Emmanuelle Masson, David N. Cooper, Emmanuelle Génin, Claude Férec, Jian-Min Chen

Genes (Basel) 2021 Nov; 12(11): 1683. Published online 2021 Oct 23. doi: 10.3390/genes12111683

PMCID:: PMC8619230

Abstract Article PDF–667K

Select item 860514910.

Performance of SPINK1 and SPINK1‐based diagnostic model in detection of hepatocellular carcinoma

Fang Wang, Hui Liu, Youxi Bai, Hui Li, Zhonglin Wang, Xin Xu

J Clin Lab Anal. 2021 Nov; 35(11): e24025. Published online 2021 Sep 27. doi: 10.1002/jcla.24025

PMCID:: PMC8605149

Abstract Article PDF–756K

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 794913012.

Defective binding of SPINK1 variants is an uncommon mechanism for impaired trypsin inhibition in chronic pancreatitis

András Szabó, Vanda Toldi, Lívia Diána Gazda, Alexandra Demcsák, József Tőzsér, Miklós Sahin-Tóth

J Biol Chem. 2021 Jan-Jun; 296: 100343. Published online 2021 Jan 28. doi: 10.1016/j.jbc.2021.100343

PMCID:: PMC7949130

Abstract Article PDF–2.2M

Select item 770466113.

The Histopathology of SPINK1-associated Chronic Pancreatitis

Terrell E. Jones, Melena D. Bellin, Dhiraj Yadav, Martin L. Freeman, Sarah J. Schwarzenberg, Adam Slivka, Jennifer S. Chennat, Gregory J. Beilman, Srinath Chinnakotla, Timothy L. Pruett, Varvara Kirchner, Abhinav Humar, Martin Wijkstrom, Amer H. Zureikat, Marina N. Nikiforova, Abigail I. Wald, David C. Whitcomb, Aatur D. Singhi

Pancreatology. Author manuscript; available in PMC 2021 Dec 1.

Published in final edited form as: Pancreatology. 2020 Dec; 20(8): 1648–1655. Published online 2020 Oct 16. doi: 10.1016/j.pan.2020.10.030

PMCID:: PMC7704661

Abstract Article PDF–2.0M

Select item 768596714.

Liver Cancer–Specific Serine Protease Inhibitor Kazal Is a Potentially Novel Biomarker for the Early Detection of Hepatocellular Carcinoma

Felix Lu, Pir Ahmad Shah, Abhishek Rao, Cynthia Gifford-Hollingsworth, Anne Chen, Gary Trey, Mina Soryal, Arslan Talat, Aysha Aslam, Bilal Nasir, Saad Choudhry, Rizwan Ishtiaq, Hanna Sanoff, Lanla F. Conteh, Anne Noonan, Ke-Qin Hu, Carl Schmidt, Min Fu, Jesse Civan, Gary Xiao, Daryl T.-Y. Lau, Xuanyong Lu

Clin Transl Gastroenterol. 2020 Dec; 11(12): e00271. Published online 2020 Nov 23. doi: 10.14309/ctg.0000000000000271

PMCID:: PMC7685967

Abstract Article PDF–632K

Select item 757271215.

Targeting an autocrine IL-6 – SPINK1 signaling axis to suppress metastatic spread in ovarian clear cell carcinoma

Christine Mehner, Erin Miller, Alexandra Hockla, Mathew Coban, S. John Weroha, Derek C. Radisky, Evette S. Radisky

Oncogene. Author manuscript; available in PMC 2021 Mar 14.

Published in final edited form as: Oncogene. 2020 Oct; 39(42): 6606–6618. Published online 2020 Sep 14. doi: 10.1038/s41388-020-01451-4

PMCID:: PMC7572712

Abstract Article PDF–1.3M

Select item 725744016.

Differential expression of Annexin 2, SPINK1, and Hsp60 predict progression of prostate cancer through bifurcated WHO Gleason score categories in African American men

Desta A. Beyene, Tammey J. Naab, Norma F. Kanarek, Victor Apprey, Ashwini Esnakula, Farahan A. Khan, Marc R. Blackman, Collis A. Brown, Tamaro S. Hudson

Prostate. Author manuscript; available in PMC 2020 May 29.

Published in final edited form as: Prostate. 2018 Aug; 78(11): 801–811. Published online 2018 Apr 22. doi: 10.1002/pros.23537

PMCID:: PMC7257440

Abstract Article PDF–895K

Select item 716998317.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 699664318.

Meta‐analysis and field synopsis of genetic variants associated with the risk and severity of acute pancreatitis

F. F. van den Berg, M. A. Kempeneers, H. C. van Santvoort, A. H. Zwinderman, Y. Issa, M. A. Boermeester

BJS Open. 2020 Feb; 4(1): 3–15. Published online 2019 Dec 3. doi: 10.1002/bjs5.50231

PMCID:: PMC6996643

Abstract Article PDF–540K

Select item 697108419.

Androgen deprivation upregulates SPINK1 expression and potentiates cellular plasticity in prostate cancer

Ritika Tiwari, Nishat Manzar, Vipul Bhatia, Anjali Yadav, Mushtaq A. Nengroo, Dipak Datta, Shannon Carskadon, Nilesh Gupta, Michael Sigouros, Francesca Khani, Matti Poutanen, Amina Zoubeidi, Himisha Beltran, Nallasivam Palanisamy, Bushra Ateeq

Nat Commun. 2020; 11: 384. Published online 2020 Jan 20. doi: 10.1038/s41467-019-14184-0

PMCID:: PMC6971084

Abstract Article PDF–4.7M

Select item 693870520.

PRSS contributes to cetuximab resistance in colorectal cancer

Zhaoli Tan, Lihua Gao, Yan Wang, Huihui Yin, Yongyi Xi, Xiaojie Wu, Yong Shao, Weiyi Qiu, Peng Du, Wenlong Shen, Ling Fu, Ru Jia, Chuanhua Zhao, Yun Zhang, Zhihu Zhao, Zhiwei Sun, Hongxing Chen, Xianwen Hu, Jianming Xu, Youliang Wang

Sci Adv. 2020 Jan; 6(1): eaax5576. Published online 2020 Jan 1. doi: 10.1126/sciadv.aax5576

PMCID:: PMC6938705

Abstract Article PDF–5.3M

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