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Select item 111548371.

MST1 knockdown inhibits osteoarthritis progression through Parkin‐mediated mitophagy and Nrf2/NF‐κB signalling pathway

Hantao Ye, Tingwen Cai, Yang Shen, Lin Zhao, Haojie Zhang, Jianxin Yang, Feida Li, Jiaoxiang Chen, Xiaolong Shui

J Cell Mol Med. 2024 Jun; 28(11): e18476. Published online 2024 Jun 6. doi: 10.1111/jcmm.18476

PMCID:: PMC11154837

Abstract Article PDF–31M

Select item 111481842.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 109145843.

Inhibition of MST1 ameliorates neuronal apoptosis via GSK3β/β-TrCP/NRF2 pathway in spinal cord injury accompanied by diabetes

Weijun Huang, Depeng Wu, Chaoyang Cai, Hui Yao, Zhenming Tian, Yang Yang, Mao Pang, Limin Rong, Bin Liu

Redox Biol. 2024 May; 71: 103104. Published online 2024 Feb 28. doi: 10.1016/j.redox.2024.103104

Correction in:: Redox Biol. 2024 Aug; 74: 103198.

PMCID:: PMC10914584

Abstract Article PDF–17M

Select item 106964034.

Smurf1 polyubiquitinates on K285/K282 of the kinases Mst1/2 to attenuate their tumor-suppressor functions

Yana Xu, Meiyu Qu, Yangxun He, Qiangqiang He, Tingyu Shen, Jiahao Luo, Dan Tan, Hangyang Bao, Chengyun Xu, Xing Ji, Xinhua Hu, Muhammad Qasim Barkat, Ling-Hui Zeng, Ximei Wu

J Biol Chem. 2023 Dec; 299(12): 105395. Published online 2023 Oct 27. doi: 10.1016/j.jbc.2023.105395

PMCID:: PMC10696403

Abstract Article PDF–5.4M

Select item 98412295.

Mst1-mediated phosphorylation of Nur77 improves the endometrial receptivity in human and mice

Xinyu Cai, Yue Jiang, Zhiwen Cao, Mei Zhang, Na Kong, Lina Yu, Yedong Tang, Shuangbo Kong, Wenbo Deng, Haibin Wang, Jianxin Sun, Lijun Ding, Ruiwei Jiang, Haixiang Sun, Guijun Yan

eBioMedicine. 2023 Feb; 88: 104433. Published online 2023 Jan 7. doi: 10.1016/j.ebiom.2022.104433

PMCID:: PMC9841229

Abstract Article PDF–3.2M

Select item 95756736.

Deficiency of MST1 in endometriosis related peritoneal macrophages promoted the autophagy of ectopic endometrial stromal cells by IL-10

Yufei Huang, Shumin Yan, Xiaoyu Dong, Xue Jiao, Shuang Wang, Dong Li, Guoyun Wang

Front Immunol. 2022; 13: 993788. Published online 2022 Oct 3. doi: 10.3389/fimmu.2022.993788

PMCID:: PMC9575673

Abstract Article PDF–10M

Select item 95404347.

Regulation of MST complexes and activity via SARAH domain modifications

Sofiia Karchugina, Dorothy Benton, Jonathan Chernoff

Biochem Soc Trans. Author manuscript; available in PMC 2022 Oct 7.

Published in final edited form as: Biochem Soc Trans. 2021 Apr 30; 49(2): 675–683. doi: 10.1042/BST20200559

PMCID:: PMC9540434

Abstract Article PDF–485K

Select item 87756448.

Apoptosis in Type 2 Diabetes: Can It Be Prevented? Hippo Pathway Prospects

Agnieszka Kilanowska, Agnieszka Ziółkowska

Int J Mol Sci. 2022 Jan; 23(2): 636. Published online 2022 Jan 7. doi: 10.3390/ijms23020636

PMCID:: PMC8775644

Abstract Article PDF–834K

Select item 81650309.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 798603710.

MST1 inhibits the progression of breast cancer by regulating the Hippo signaling pathway and may serve as a prognostic biomarker

Xiang Jin, Lihua Zhu, Sheng Xiao, Zhuhong Cui, Jing Tang, Jiangyong Yu, Mingjun Xie

Mol Med Rep. 2021 May; 23(5): 383. Published online 2021 Mar 18. doi: 10.3892/mmr.2021.12022

PMCID:: PMC7986037

Abstract Article PDF–4.4M

Select item 759048811.

circCRAMP1L is a novel biomarker of preeclampsia risk and may play a role in preeclampsia pathogenesis via regulation of the MSP/RON axis in trophoblasts

Yonggang Zhang, Hongling Yang, Yipeng Zhang, Junzhu Shi, Ronggui Chen

BMC Pregnancy Childbirth. 2020; 20: 652. Published online 2020 Oct 27. doi: 10.1186/s12884-020-03345-5

PMCID:: PMC7590488

Abstract Article PDF–4.1M

Select item 756688112.

Systematic mapping of genetic interactions for de novo fatty acid synthesis identifies C12orf49 as a regulator of lipid metabolism

Michael Aregger, Keith A. Lawson, Maximillian Billmann, Michael Costanzo, Amy H. Y. Tong, Katherine Chan, Mahfuzur Rahman, Kevin R. Brown, Catherine Ross, Matej Usaj, Lucy Nedyalkova, Olga Sizova, Andrea Habsid, Judy Pawling, Zhen-Yuan Lin, Hala Abdouni, Cassandra J. Wong, Alexander Weiss, Patricia Mero, James W. Dennis, Anne-Claude Gingras, Chad L. Myers, Brenda J. Andrews, Charles Boone, Jason Moffat

Nat Metab. Author manuscript; available in PMC 2020 Dec 1.

Published in final edited form as: Nat Metab. 2020 Jun; 2(6): 499–513. Published online 2020 Jun 1. doi: 10.1038/s42255-020-0211-z

PMCID:: PMC7566881

Abstract Article PDF–4.8M

Select item 748573113.

Mst1 promotes mitochondrial dysfunction and apoptosis in oxidative stress-induced rheumatoid arthritis synoviocytes

Yingjie Wang, Qi Yang, Songpo Shen, Linjie Zhang, Yongbo Xiang, Xisheng Weng

Aging (Albany NY) 2020 Aug 31; 12(16): 16211–16223. Published online 2020 Jul 21. doi: 10.18632/aging.103643

PMCID:: PMC7485731

Abstract Article PDF–2.3M

Select item 734339314.

The Legionella effector kinase LegK7 hijacks the host Hippo pathway to promote infection

Pei-Chung Lee, Matthias P. Machner

Cell Host Microbe. Author manuscript; available in PMC 2020 Jul 8.

Published in final edited form as: Cell Host Microbe. 2018 Sep 12; 24(3): 429–438.e6. doi: 10.1016/j.chom.2018.08.004

PMCID:: PMC7343393

Abstract Article PDF–1.5M

Select item 732628215.

MicroRNA-18a targeting of the STK4/MST1 tumour suppressor is necessary for transformation in HPV positive cervical cancer

Ethan L. Morgan, Molly R. Patterson, Emma L. Ryder, Siu Yi Lee, Christopher W. Wasson, Katherine L. Harper, Yigen Li, Stephen Griffin, G. Eric Blair, Adrian Whitehouse, Andrew Macdonald

PLoS Pathog. 2020 Jun; 16(6): e1008624. Published online 2020 Jun 18. doi: 10.1371/journal.ppat.1008624

PMCID:: PMC7326282

Abstract Article PDF–3.5M

Select item 722438416.

FGFR4 phosphorylates MST1 to confer breast cancer cells resistance to MST1/2-dependent apoptosis

S. Pauliina Turunen, Pernilla von Nandelstadh, Tiina Öhman, Erika Gucciardo, Brinton Seashore-Ludlow, Beatriz Martins, Ville Rantanen, Huini Li, Katrin Höpfner, Päivi Östling, Markku Varjosalo, Kaisa Lehti

Cell Death Differ. 2019 Dec; 26(12): 2577–2593. Published online 2019 Mar 22. doi: 10.1038/s41418-019-0321-x

PMCID:: PMC7224384

Abstract Article PDF–3.7M

Select item 716998317.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 640767718.

POPX2 is a novel LATS phosphatase that regulates the Hippo pathway

Muhammad Bakhait Rahmat, Songjing Zhang, Cheng-Gee Koh

Oncotarget. 2019 Feb 19; 10(15): 1525–1538. Published online 2019 Feb 19. doi: 10.18632/oncotarget.26689

Correction in:: Oncotarget. 2019 Oct 8; 10(56): 5890–5891.

PMCID:: PMC6407677

Abstract Article PDF–3.3M

Select item 620541519.

Mst1 deletion attenuates renal ischaemia-reperfusion injury: The role of microtubule cytoskeleton dynamics, mitochondrial fission and the GSK3β-p53 signalling pathway

Hongyan Li, Jianxun Feng, Yunfang Zhang, Junxia Feng, Qi Wang, Shili Zhao, Ping Meng, Jingchun Li

Redox Biol. 2019 Jan; 20: 261–274. Published online 2018 Oct 19. doi: 10.1016/j.redox.2018.10.012

PMCID:: PMC6205415

Abstract Article PDF–6.9M

Select item 586706820.

A novel susceptibility locus in MST1 and gene‐gene interaction network for Crohn's disease in the Chinese population

William K.K. Wu, Rui Sun, Tao Zuo, Yuanyuan Tian, Zhirong Zeng, Jeffery Ho, Justin C.Y. Wu, Francis K.L. Chan, Matthew T.V. Chan, Jun Yu, Joseph J.Y. Sung, Sunny H. Wong, Maggie H. Wang, Siew C. Ng

J Cell Mol Med. 2018 Apr; 22(4): 2368–2377. Published online 2018 Feb 14. doi: 10.1111/jcmm.13530

PMCID:: PMC5867068

Abstract Article PDF–816K

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