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Select item 86000291.

KCND2 variants associated with global developmental delay differentially impair Kv4.2 channel gating

Yongqiang Zhang, Georgios Tachtsidis, Claudia Schob, Mahmoud Koko, Ulrike B S Hedrich, Holger Lerche, Johannes R Lemke, Arie van Haeringen, Claudia Ruivenkamp, Trine Prescott, Kristian Tveten, Thorsten Gerstner, Brianna Pruniski, Stephanie DiTroia, Grace E VanNoy, Heidi L Rehm, Heather McLaughlin, Hanno J Bolz, Ulrich Zechner, Emily Bryant, Tiffani McDonough, Stefan Kindler, Robert Bähring

Hum Mol Genet. 2021 Dec 1; 30(23): 2300–2314. Published online 2021 Jul 10. doi: 10.1093/hmg/ddab192

PMCID:: PMC8600029

Abstract Article PDF–1.4M

Select item 85662402.

Structural basis of gating modulation of Kv4 channel complexes

Yoshiaki Kise, Go Kasuya, Hiroyuki H. Okamoto, Daichi Yamanouchi, Kan Kobayashi, Tsukasa Kusakizako, Tomohiro Nishizawa, Koichi Nakajo, Osamu Nureki

Nature. 2021; 599(7883): 158–164. Published online 2021 Sep 22. doi: 10.1038/s41586-021-03935-z

PMCID:: PMC8566240

Abstract Article PDF–38M

Select item 81650303.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 74435054.

Modulation of Kv4.2/KChIP3 interaction by the ceroid lipofuscinosis neuronal 3 protein CLN3

Carolin Seifert, Stephan Storch, Robert Bähring

J Biol Chem. 2020 Aug 21; 295(34): 12099–12110. Published online 2020 Jul 7. doi: 10.1074/jbc.RA120.013828

PMCID:: PMC7443505

Abstract Article PDF–1.4M

Select item 67824505.

Neuronal Interleukin-16 (NIL-16): A Dual Function PDZ Domain Protein

Cornelia Kurschner, Michisuke Yuzaki

J Neurosci. 1999 Sep 15; 19(18): 7770–7780. doi: 10.1523/JNEUROSCI.19-18-07770.1999

PMCID:: PMC6782450

Abstract Article PDF–604K

Select item 67730476.

Localization and Enhanced Current Density of the Kv4.2 Potassium Channel by Interaction with the Actin-Binding Protein Filamin

Kevin Petrecca, David M. Miller, Alvin Shrier

J Neurosci. 2000 Dec 1; 20(23): 8736–8744. doi: 10.1523/JNEUROSCI.20-23-08736.2000

PMCID:: PMC6773047

Abstract Article PDF–675K

Select item 67587377.

PKA Modulation of Kv4.2-Encoded A-Type Potassium Channels Requires Formation of a Supramolecular Complex

Laura A. Schrader, Anne E. Anderson, Amber Mayne, Paul J. Pfaffinger, John David Sweatt

J Neurosci. 2002 Dec 1; 22(23): 10123–10133. doi: 10.1523/JNEUROSCI.22-23-10123.2002

PMCID:: PMC6758737

Abstract Article PDF–503K

Select item 58994408.

Kv4.2 autism and epilepsy mutation enhances inactivation of closed channels but impairs access to inactivated state after opening

Meng-chin A. Lin, Stephen C. Cannon, Diane M. Papazian

Proc Natl Acad Sci U S A. 2018 Apr 10; 115(15): E3559–E3568. Published online 2018 Mar 26. doi: 10.1073/pnas.1717082115

PMCID:: PMC5899440

Abstract Article PDF–1.3M

Select item 57920069.

Somatodendritic surface expression of epitope-tagged and KChIP binding-deficient Kv4.2 channels in hippocampal neurons

Helena Prechtel, Sven Hartmann, Daniel Minge, Robert Bähring

PLoS One. 2018; 13(1): e0191911. Published online 2018 Jan 31. doi: 10.1371/journal.pone.0191911

PMCID:: PMC5792006

Abstract Article PDF–15M

Select item 553161110.

Architecture of the human interactome defines protein communities and disease networks

Edward L. Huttlin, Raphael J. Bruckner, Joao A. Paulo, Joe R. Cannon, Lily Ting, Kurt Baltier, Greg Colby, Fana Gebreab, Melanie P. Gygi, Hannah Parzen, John Szpyt, Stanley Tam, Gabriela Zarraga, Laura Pontano-Vaites, Sharan Swarup, Anne E. White, Devin K. Schweppe, Ramin Rad, Brian K. Erickson, Robert A. Obar, K.G. Guruharsha, Kejie Li, Spyros Artavanis-Tsakonas, Steven P. Gygi, J. Wade Harper

Nature. Author manuscript; available in PMC 2017 Nov 17.

Published in final edited form as: Nature. 2017 May 25; 545(7655): 505–509. Published online 2017 May 17. doi: 10.1038/nature22366

PMCID:: PMC5531611

Abstract Article PDF–2.7M

Select item 501613411.

Neuritin Up-regulates Kv4.2 α-Subunit of Potassium Channel Expression and Affects Neuronal Excitability by Regulating the Calcium-Calcineurin-NFATc4 Signaling Pathway

Jin-jing Yao, Qian-Ru Zhao, Dong-Dong Liu, Chi-Wing Chow, Yan-Ai Mei

J Biol Chem. 2016 Aug 12; 291(33): 17369–17381. Published online 2016 Jun 15. doi: 10.1074/jbc.M115.708883

PMCID:: PMC5016134

Abstract Article PDF–2.9M

Select item 480586912.

Intra- and Intersubunit Dynamic Binding in Kv4.2 Channel Closed-State Inactivation

Jessica Wollberg, Robert Bähring

Biophys J. 2016 Jan 5; 110(1): 157–175. Published online 2016 Jan 5. doi: 10.1016/j.bpj.2015.10.046

PMCID:: PMC4805869

Abstract Article PDF–3.5M

Select item 456624413.

Kv4.2 and Accessory Dipeptidyl Peptidase-like Protein 10 (DPP10) Subunit Preferentially Form a 4:2 (Kv4.2:DPP10) Channel Complex

Masahiro Kitazawa, Yoshihiro Kubo, Koichi Nakajo

J Biol Chem. 2015 Sep 11; 290(37): 22724–22733. Published online 2015 Jul 24. doi: 10.1074/jbc.M115.646794

PMCID:: PMC4566244

Abstract Article PDF–2.0M

Select item 449261414.

Hydrogen Sulfide Targets the Cys320/Cys529 Motif in Kv4.2 to Inhibit the I_to Potassium Channels in Cardiomyocytes and Regularizes Fatal Arrhythmia in Myocardial Infarction

Shan-Feng Ma, Yan Luo, Ying-Jiong Ding, Ying Chen, Shi-Xin Pu, Hang-Jing Wu, Zhong-Feng Wang, Bei-Bei Tao, Wen-Wei Wang, Yi-Chun Zhu

Antioxid Redox Signal. 2015 Jul 10; 23(2): 129–147. doi: 10.1089/ars.2014.6094

PMCID:: PMC4492614

Abstract Article PDF–1.7M

Select item 417058515.

Genome-Wide Analysis of Polymorphisms Associated with Cytokine Responses in Smallpox Vaccine Recipients

Richard B. Kennedy, Inna G. Ovsyannikova, V. Shane Pankratz, Iana H. Haralambieva, Robert A. Vierkant, Gregory A. Poland

Hum Genet. Author manuscript; available in PMC 2014 Sep 22.

Published in final edited form as: Hum Genet. 2012 Sep; 131(9): 1403–1421. Published online 2012 May 19. doi: 10.1007/s00439-012-1174-2

PMCID:: PMC4170585

Abstract Article PDF–594K

Select item 406719516.

The Stoichiometry and Biophysical Properties of the Kv4 Potassium Channel Complex with K⁺ Channel-interacting Protein (KChIP) Subunits Are Variable, Depending on the Relative Expression Level

Masahiro Kitazawa, Yoshihiro Kubo, Koichi Nakajo

J Biol Chem. 2014 Jun 20; 289(25): 17597–17609. Published online 2014 May 8. doi: 10.1074/jbc.M114.563452

PMCID:: PMC4067195

Abstract Article PDF–3.2M

Select item 404930617.

Exome sequencing identifies de novo gain of function missense mutation in KCND2 in identical twins with autism and seizures that slows potassium channel inactivation

Hane Lee, Meng-chin A. Lin, Harley I. Kornblum, Diane M. Papazian, Stanley F. Nelson

Hum Mol Genet. 2014 Jul 1; 23(13): 3481–3489. Published online 2014 Feb 5. doi: 10.1093/hmg/ddu056

PMCID:: PMC4049306

Abstract Article PDF–443K

Select item 396817618.

S-Glutathionylation of an Auxiliary Subunit Confers Redox Sensitivity to Kv4 Channel Inactivation

Henry H. Jerng, Paul J. Pfaffinger

PLoS One. 2014; 9(3): e93315. Published online 2014 Mar 27. doi: 10.1371/journal.pone.0093315

PMCID:: PMC3968176

Abstract Article PDF–1.6M

Select item 392327619.

Identification of Genes Promoting Skin Youthfulness by Genome-Wide Association Study

Anne L.S. Chang, Gil Atzmon, Aviv Bergman, Samantha Brugmann, Scott X Atwood, Howard Y Chang, Nir Barzilai

J Invest Dermatol. 2014 Mar; 134(3): 651–657. Prepublished online 2013 Sep 13. Published online 2013 Oct 17. doi: 10.1038/jid.2013.381

PMCID:: PMC3923276

Abstract Article PDF–2.3M

Select item 387357720.

The Prion Protein Modulates A-type K⁺ Currents Mediated by Kv4.2 Complexes through Dipeptidyl Aminopeptidase-like Protein 6

Robert C. C. Mercer, Li Ma, Joel C. Watts, Robert Strome, Serene Wohlgemuth, Jing Yang, Neil R. Cashman, Michael B. Coulthart, Gerold Schmitt-Ulms, Jack H. Jhamandas, David Westaway

J Biol Chem. 2013 Dec 27; 288(52): 37241–37255. Published online 2013 Nov 13. doi: 10.1074/jbc.M113.488650

PMCID:: PMC3873577

Abstract Article PDF–2.4M

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Postmortem temporal cortex from Medical Research Council Cognitive Function and Ageing Study (MRC-CFAS) cohort: astrocytes
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