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Items: 1 to 20 of 28

1.
BRSK2 in pancreatic β cells promotes hyperinsulinemia-coupled insulin resistance and its genetic variants are associated with human type 2 diabetes
Rufeng Xu, Kaiyuan Wang, Zhengjian Yao, Yan Zhang, Li Jin, Jing Pang, Yuncai Zhou, Kai Wang, Dechen Liu, Yaqin Zhang, Peng Sun, Fuqiang Wang, Xiaoai Chang, Tengli Liu, Shusen Wang, Yalin Zhang, Shuyong Lin, Cheng Hu, Yunxia Zhu, Xiao Han
J Mol Cell Biol. 2023 May; 15(5): mjad033. Published online 2023 May 15. doi: 10.1093/jmcb/mjad033
PMCID:
PMC10782904
AbstractArticlePDF–2.6M
2.
Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity
Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong
Mol Cell. Author manuscript; available in PMC 2023 Apr 4.
Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015
PMCID:
PMC10072906
AbstractArticlePDF–4.2M
3.
Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome
Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi
Cell. Author manuscript; available in PMC 2022 May 27.
Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011
PMCID:
PMC8165030
AbstractArticlePDF–2.2M
4.
STK39 is a novel kinase contributing to the progression of hepatocellular carcinoma by the PLK1/ERK signaling pathway
Chengfei Zhang, Xiaoming Wang, Dan Fang, Ping Xu, Xiao Mo, Chao Hu, Alaa Abdelatty, Mei Wang, Haojun Xu, Qi Sun, Guoren Zhou, Junjun She, Jinglin Xia, Kam Man Hui, Hongping Xia
Theranostics. 2021; 11(5): 2108–2122. Published online 2021 Jan 1. doi: 10.7150/thno.48112
PMCID:
PMC7797677
AbstractArticlePDF–3.5M
5.
BCAR1 promotes proliferation and cell growth in lung adenocarcinoma via upregulation of POLR2A
Chun‐guo Mao, Sha‐sha Jiang, Cheng Shen, Tan Long, Hua Jin, Qun‐You Tan, Bo Deng
Thorac Cancer. 2020 Nov; 11(11): 3326–3336. Published online 2020 Oct 1. doi: 10.1111/1759-7714.13676
PMCID:
PMC7606008
AbstractArticlePDF–2.5M
6.
Kinase Interaction Network Expands Functional and Disease Roles of Human Kinases
Marija Buljan, Rodolfo Ciuffa, Audrey van Drogen, Anton Vichalkovski, Martin Mehnert, George Rosenberger, Sohyon Lee, Markku Varjosalo, Lucia Espona Pernas, Vincent Spegg, Berend Snijder, Ruedi Aebersold, Matthias Gstaiger
Mol Cell. 2020 Aug 6; 79(3): 504–520.e9. doi: 10.1016/j.molcel.2020.07.001
PMCID:
PMC7427327
AbstractArticle
7.
RIG-I regulates myeloid differentiation by promoting TRIM25-mediated ISGylation
Song-Fang Wu, Li Xia, Xiao-Dong Shi, Yu-Jun Dai, Wei-Na Zhang, Jun-Mei Zhao, Wu Zhang, Xiang-Qin Weng, Jing Lu, Huang-Ying Le, Sheng-ce Tao, Jiang Zhu, Zhu Chen, Yue-Ying Wang, Saijuan Chen
Proc Natl Acad Sci U S A. 2020 Jun 23; 117(25): 14395–14404. Published online 2020 Jun 8. doi: 10.1073/pnas.1918596117
PMCID:
PMC7322067
AbstractArticlePDF–2.7M
8.
A reference map of the human binary protein interactome
Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood
Nature. Author manuscript; available in PMC 2020 Oct 8.
Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x
PMCID:
PMC7169983
AbstractArticlePDF–5.4M
9.
Deleterious Variation in BRSK2 Associates with a Neurodevelopmental Disorder
Susan M. Hiatt, Michelle L. Thompson, Jeremy W. Prokop, James M.J. Lawlor, David E. Gray, E. Martina Bebin, Tuula Rinne, Marlies Kempers, Rolph Pfundt, Bregje W. van Bon, Cyril Mignot, Caroline Nava, Christel Depienne, Louisa Kalsner, Anita Rauch, Pascal Joset, Ruxandra Bachmann-Gagescu, Ingrid M. Wentzensen, Kirsty McWalter, Gregory M. Cooper
Am J Hum Genet. 2019 Apr 4; 104(4): 701–708. Published online 2019 Mar 14. doi: 10.1016/j.ajhg.2019.02.002
PMCID:
PMC6451696
AbstractArticlePDF–1.2M
10.
RNA-binding activity of TRIM25 is mediated by its PRY/SPRY domain and is required for ubiquitination
Nila Roy Choudhury, Gregory Heikel, Maryia Trubitsyna, Peter Kubik, Jakub Stanislaw Nowak, Shaun Webb, Sander Granneman, Christos Spanos, Juri Rappsilber, Alfredo Castello, Gracjan Michlewski
BMC Biol. 2017; 15: 105. Published online 2017 Nov 8. doi: 10.1186/s12915-017-0444-9
PMCID:
PMC5678581
AbstractArticlePDF–3.2M
11.
BRSK2 induced by nutrient deprivation promotes Akt activity in pancreatic cancer via downregulation of mTOR activity
Hexige Saiyin, Ning Na, Xu Han, Yuan Fang, Yanhua Wu, Wenhui Lou, Xianmei Yang
Oncotarget. 2017 Jul 4; 8(27): 44669–44681. Published online 2017 May 18. doi: 10.18632/oncotarget.17965
PMCID:
PMC5546509
AbstractArticlePDF–6.7M
12.
Roles of tau protein in health and disease
Tong Guo, Wendy Noble, Diane P. Hanger
Acta Neuropathol. 2017; 133(5): 665–704. Published online 2017 Apr 6. doi: 10.1007/s00401-017-1707-9
PMCID:
PMC5390006
AbstractArticlePDF–1.4M
13.
Skp2-dependent Ubiquitination and Activation of LKB1 Is Essential for Cancer Cell Survival under Energy Stress
Szu-Wei Lee, Chien-Feng Li, Guoxiang Jin, Zhen Cai, Fei Han, Chia-Hsin Chan, Wei-Lei Yang, Bin-Kui Li, Abdol Hossein Rezaeian, Hong-Yu Li, Hsuan-Ying Huang, Hui-Kuan Lin
Mol Cell. Author manuscript; available in PMC 2017 Mar 4.
Published in final edited form as: Mol Cell. 2015 Mar 19; 57(6): 1022–1033. Published online 2015 Feb 26. doi: 10.1016/j.molcel.2015.01.015
PMCID:
PMC5337120
AbstractArticlePDF–3.2M
14.
SAD-A and AMPK kinases: The “yin and yang” regulators of mTORC1 signaling in pancreatic β cells
Jia Nie, Xiao Han, Yuguang Shi
Cell Cycle. 2013 Nov 1; 12(21): 3366–3369. Published online 2013 Sep 18. doi: 10.4161/cc.26496
PMCID:
PMC3895425
AbstractArticlePDF–253K
15.
Genetic variants associated with idiopathic pulmonary fibrosis susceptibility and mortality: a genome-wide association study
Imre Noth, Yingze Zhang, Shwu-Fan Ma, Carlos Flores, Mathew Barber, Yong Huang, Steven M Broderick, Michael S Wade, Pirro Hysi, Joseph Scuirba, Thomas J Richards, Brenda M Juan-Guardela, Rekha Vij, MeiLan K Han, Fernando J Martinez, Karl Kossen, Scott D Seiwert, Jason D Christie, Dan Nicolae, Naftali Kaminski, Joe G N Garcia
Lancet Respir Med. Author manuscript; available in PMC 2014 Jun 1.
Published in final edited form as: Lancet Respir Med. 2013 Jun; 1(4): 309–317. Published online 2013 Apr 17. doi: 10.1016/S2213-2600(13)70045-6
PMCID:
PMC3894577
AbstractArticlePDF–400K
16.
APC/CCdh1 Targets Brain-Specific Kinase 2 (BRSK2) for Degradation via the Ubiquitin-Proteasome Pathway
Ruwei Li, Bo Wan, Jun Zhou, Yingli Wang, Ting Luo, Xiuting Gu, Fang Chen, Long Yu
PLoS One. 2012; 7(9): e45932. Published online 2012 Sep 21. doi: 10.1371/journal.pone.0045932
PMCID:
PMC3448725
AbstractArticlePDF–663K
17.
Brain-selective Kinase 2 (BRSK2) Phosphorylation on PCTAIRE1 Negatively Regulates Glucose-stimulated Insulin Secretion in Pancreatic β-Cells
Xin-Ya Chen, Xiu-Ting Gu, Hexige Saiyin, Bo Wan, Yu-Jing Zhang, Jing Li, Ying-Li Wang, Rui Gao, Yu-Fan Wang, Wei-Ping Dong, Sonia M. Najjar, Chen-Yu Zhang, Han-Fei Ding, Jun O. Liu, Long Yu
J Biol Chem. 2012 Aug 31; 287(36): 30368–30375. Published online 2012 Jul 13. doi: 10.1074/jbc.M112.375618
PMCID:
PMC3436288
AbstractArticlePDF–1.3M
18.
Synapses of Amphids Defective (SAD-A) Kinase Promotes Glucose-stimulated Insulin Secretion through Activation of p21-activated Kinase (PAK1) in Pancreatic β-Cells
Jia Nie, Chao Sun, Omar Faruque, Guangming Ye, Jia Li, Qiangrong Liang, Zhijie Chang, Wannian Yang, Xiao Han, Yuguang Shi
J Biol Chem. 2012 Jul 27; 287(31): 26435–26444. Published online 2012 Jun 5. doi: 10.1074/jbc.M112.378372
PMCID:
PMC3406726
AbstractArticlePDF–3.2M
19.
Investigating the Regulation of Brain-specific Kinases 1 and 2 by Phosphorylation
Nicola J. Bright, David Carling, Claire Thornton
J Biol Chem. 2008 May 30; 283(22): 14946–14954. doi: 10.1074/jbc.M710381200
PMCID:
PMC3258900
AbstractArticlePDF–312K
20.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M

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