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Select item 98754681.

A novel mutation in the proteoglycan 4 gene causing CACP syndrome: two sisters report

İlknur Bağrul, Serdar Ceylaner, Yasemin Tasci Yildiz, Serife Tuncez, Elif Arslanoglu Aydin, Esra Bağlan, Semanur Ozdel, Mehmet Bülbül

Pediatr Rheumatol Online J. 2023; 21: 8. Published online 2023 Jan 24. doi: 10.1186/s12969-023-00793-z

PMCID:: PMC9875468

Abstract Article PDF–1.1M

Select item 96578362.

Recombinant Human Proteoglycan 4 (rhPRG4) Downregulates TNFα-Stimulated NFκB Activity and FAT10 Expression in Human Corneal Epithelial Cells

Nikhil G. Menon, Yasir Suhail, Ruchi Goyal, Wenqiang Du, Adam P. Tanguay, Gregory D. Jay, Mallika Ghosh, Kshitiz, Tannin A. Schmidt

Int J Mol Sci. 2022 Nov; 23(21): 12711. Published online 2022 Oct 22. doi: 10.3390/ijms232112711

PMCID:: PMC9657836

Abstract Article PDF–2.1M

Select item 91050273.

Regulatory Mechanisms of Prg4 and Gdf5 Expression in Articular Cartilage and Functions in Osteoarthritis

Yoshifumi Takahata, Hiromasa Hagino, Ayaka Kimura, Mitsuki Urushizaki, Shiori Yamamoto, Kanta Wakamori, Tomohiko Murakami, Kenji Hata, Riko Nishimura

Int J Mol Sci. 2022 May; 23(9): 4672. Published online 2022 Apr 23. doi: 10.3390/ijms23094672

PMCID:: PMC9105027

Abstract Article PDF–1.6M

Select item 87250494.

Recombinant Human Proteoglycan 4 Regulates Phagocytic Activation of Monocytes and Reduces IL-1β Secretion by Urate Crystal Stimulated Gout PBMCs

Sandy ElSayed, Gregory D. Jay, Ralph Cabezas, Marwa Qadri, Tannin A. Schmidt, Khaled A. Elsaid

Front Immunol. 2021; 12: 771677. Published online 2021 Dec 21. doi: 10.3389/fimmu.2021.771677

PMCID:: PMC8725049

Abstract Article PDF–5.1M

Select item 84911695.

Proteoglycan 4 (PRG4) expression and function in dry eye associated inflammation

Nikhil G. Menon, Ruchi Goyal, Carolina Lema, Paige S. Woods, Adam P. Tanguay, Alyssa A. Morin, Nabangshu Das, Gregory D. Jay, Roman J. Krawetz, Antoine Dufour, Linda H. Shapiro, Rachel L. Redfern, Mallika Ghosh, Tannin A. Schmidt

Exp Eye Res. Author manuscript; available in PMC 2022 Jul 1.

Published in final edited form as: Exp Eye Res. 2021 Jul; 208: 108628. Published online 2021 May 25. doi: 10.1016/j.exer.2021.108628

PMCID:: PMC8491169

Abstract Article PDF–1.6M

Select item 83641816.

Protein interaction landscapes revealed by advanced in vivo cross-linking–mass spectrometry

Andrew Wheat, Clinton Yu, Xiaorong Wang, Anthony M. Burke, Ilan E. Chemmama, Robyn M. Kaake, Peter Baker, Scott D. Rychnovsky, Jing Yang, Lan Huang

Proc Natl Acad Sci U S A. 2021 Aug 10; 118(32): e2023360118. Published online 2021 Aug 4. doi: 10.1073/pnas.2023360118

PMCID:: PMC8364181

Abstract Article PDF–3.0M

Select item 82240647.

Proteoglycan 4 Modulates Osteogenic Smooth Muscle Cell Differentiation during Vascular Remodeling and Intimal Calcification

Till Seime, Asim Cengiz Akbulut, Moritz Lindquist Liljeqvist, Antti Siika, Hong Jin, Greg Winski, Rick H. van Gorp, Eva Karlöf, Mariette Lengquist, Andrew J. Buckler, Malin Kronqvist, Olivia J. Waring, Jan H. N. Lindeman, Erik A. L. Biessen, Lars Maegdefessel, Anton Razuvaev, Leon J. Schurgers, Ulf Hedin, Ljubica Matic

Cells. 2021 Jun; 10(6): 1276. Published online 2021 May 21. doi: 10.3390/cells10061276

PMCID:: PMC8224064

Abstract Article PDF–8.8M

Select item 79953008.

Interrelationship of MMP-9, Proteoglycan-4, and Inflammation in Osteoarthritis Patients Undergoing Total Hip Arthroplasty

Hannah Slovacek, Rajan Khanna, Pavel Poredos, Peter Poredos, Mateja Jezovnik, Debra Hoppensteadt, Jawed Fareed, William Hopkinson

Clin Appl Thromb Hemost. 2021 Jan-Dec; 27: 1076029621995569. Published online 2021 Mar 23. doi: 10.1177/1076029621995569

PMCID:: PMC7995300

Abstract Article PDF–437K

Select item 76810069.

Decrease of core 2 O-glycans on synovial lubricin in osteoarthritis reduces galectin-3 mediated crosslinking

Sarah A. Flowers, Kristina A. Thomsson, Liaqat Ali, Shan Huang, Yolanda Mthembu, Suresh C. Regmi, Jan Holgersson, Tannin A. Schmidt, Ola Rolfson, Lena I. Björkman, Martina Sundqvist, Anna Karlsson-Bengtsson, Gregory D. Jay, Thomas Eisler, Roman Krawetz, Niclas G. Karlsson

J Biol Chem. 2020 Nov 20; 295(47): 16023–16036. Published online 2020 Sep 14. doi: 10.1074/jbc.RA120.012882

PMCID:: PMC7681006

Abstract Article PDF–1.5M

Select item 677813710.

The midbody interactome reveals unexpected roles for PP1 phosphatases in cytokinesis

Luisa Capalbo, Zuni I. Bassi, Marco Geymonat, Sofia Todesca, Liviu Copoiu, Anton J. Enright, Giuliano Callaini, Maria Giovanna Riparbelli, Lu Yu, Jyoti S. Choudhary, Enrico Ferrero, Sally Wheatley, Max E. Douglas, Masanori Mishima, Pier Paolo D’Avino

Nat Commun. 2019; 10: 4513. Published online 2019 Oct 4. doi: 10.1038/s41467-019-12507-9

PMCID:: PMC6778137

Abstract Article PDF–7.8M

Select item 671472011.

Inflammatory Biomarker Profiling in Total Joint Arthroplasty and Its Relevance to Circulating Levels of Lubricin, a Novel Proteoglycan

Kevin Galicia, Chase Thorson, Andrew Banos, Matthew Rondina, William Hopkinson, Debra Hoppensteadt, Jawed Fareed

Clin Appl Thromb Hemost. 2018 Sep; 24(6): 950–959. Published online 2018 Apr 22. doi: 10.1177/1076029618765090

PMCID:: PMC6714720

Abstract Article PDF–428K

Select item 620421412.

FoxO transcription factors influence cartilage maturation, homeostasis and osteoarthritis pathogenesis by modulating autophagy and proteoglycan 4

Tokio Matsuzaki, Oscar Alvarez-Garcia, Sho Mokuda, Keita Nagira, Merissa Olmer, Ramya Gamini, Kohei Miyata, Yukio Akasaki, Andrew I. Su, Hiroshi Asahara, Martin K. Lotz

Sci Transl Med. Author manuscript; available in PMC 2019 Feb 14.

Published in final edited form as: Sci Transl Med. 2018 Feb 14; 10(428): eaan0746. doi: 10.1126/scitranslmed.aan0746

PMCID:: PMC6204214

Abstract Article PDF–1.2M

Select item 617103813.

cAMP attenuates TGF-β’s profibrotic responses in osteoarthritic synoviocytes: involvement of hyaluronan and PRG4

Marwa M. Qadri, Gregory D. Jay, Rennolds S. Ostrom, Ling X. Zhang, Khaled A. Elsaid

Am J Physiol Cell Physiol. 2018 Sep 1; 315(3): C432–C443. Published online 2018 Jun 13. doi: 10.1152/ajpcell.00041.2018

PMCID:: PMC6171038

Abstract Article

Select item 616668214.

Histone Interaction Landscapes Visualized by Crosslinking Mass Spectrometry in Intact Cell Nuclei

Domenico Fasci, Hugo van Ingen, Richard A. Scheltema, Albert J. R. Heck

Mol Cell Proteomics. 2018 Oct; 17(10): 2018–2033. Published online 2018 Jul 18. doi: 10.1074/mcp.RA118.000924

PMCID:: PMC6166682

Abstract Article PDF–3.8M

Select item 572549415.

Cell cycle-dependent phosphorylation regulates RECQL4 pathway choice and ubiquitination in DNA double-strand break repair

Huiming Lu, Raghavendra A. Shamanna, Jessica K. de Freitas, Mustafa Okur, Prabhat Khadka, Tomasz Kulikowicz, Priscella P. Holland, Jane Tian, Deborah L. Croteau, Anthony J. Davis, Vilhelm A. Bohr

Nat Commun. 2017; 8: 2039. Published online 2017 Dec 11. doi: 10.1038/s41467-017-02146-3

PMCID:: PMC5725494

Abstract Article PDF–4.0M

Select item 571039316.

Genotype-Phenotype Associations of IL6 and PRG4 With Conjunctival Fibrosis After Glaucoma Surgery

Cynthia Yu-Wai-Man, Aristides D. Tagalakis, Jinhong Meng, Yann Bouremel, Richard M. H. Lee, Alex Virasami, Stephen L. Hart, Peng T. Khaw

JAMA Ophthalmol. 2017 Nov; 135(11): 1147–1155. Prepublished online 2017 Sep 21. Published online 2017 Nov 9. doi: 10.1001/jamaophthalmol.2017.3407

PMCID:: PMC5710393

Abstract Article

Select item 548607517.

Friction-Induced Mitochondrial Dysregulation Contributes to Joint Deterioration in Prg4 Knockout Mice

Kimberly A. Waller, Ling X. Zhang, Gregory D. Jay

Int J Mol Sci. 2017 Jun; 18(6): 1252. Published online 2017 Jun 11. doi: 10.3390/ijms18061252

PMCID:: PMC5486075

Abstract Article PDF–3.8M

Select item 542302518.

The autocrine role of proteoglycan-4 (PRG4) in modulating osteoarthritic synoviocyte proliferation and expression of matrix degrading enzymes

Ali Alquraini, Maha Jamal, Ling Zhang, Tannin Schmidt, Gregory D. Jay, Khaled A. Elsaid

Arthritis Res Ther. 2017; 19: 89. Published online 2017 May 8. doi: 10.1186/s13075-017-1301-5

PMCID:: PMC5423025

Abstract Article PDF–2.2M

Select item 508109619.

Glycoproteomics Reveals Decorin Peptides with Anti-Myostatin Activity in Human Atrial Fibrillation

Javier Barallobre-Barreiro, Shashi K. Gupta, Anna Zoccarato, Rika Kitazume-Taneike, Marika Fava, Xiaoke Yin, Tessa Werner, Marc N Hirt, Anna Zampetaki, Alessandro Viviano, Mei Chong, Marshall Bern, Antonios Kourliouros, Nieves Domenech, Peter Willeit, Ajay M Shah, Marjan Jahangiri, Liliana Schaefer, Jens W. Fischer, Renato V. Iozzo, Rosa Viner, Thomas Thum, Joerg Heineke, Antoine Kichler, Kinya Otsu, Manuel Mayr

Circulation. Author manuscript; available in PMC 2017 Mar 13.

Published in final edited form as: Circulation. 2016 Sep 13; 134(11): 817–832. Published online 2016 Aug 24. doi: 10.1161/CIRCULATIONAHA.115.016423

PMCID:: PMC5081096

Abstract Article PDF–2.5M

Select item 475096320.

Cartilage Derived from Bone Marrow Mesenchymal Stem Cells Expresses Lubricin In Vitro and In Vivo

Yusuke Nakagawa, Takeshi Muneta, Koji Otabe, Nobutake Ozeki, Mitsuru Mizuno, Mio Udo, Ryusuke Saito, Katsuaki Yanagisawa, Shizuko Ichinose, Hideyuki Koga, Kunikazu Tsuji, Ichiro Sekiya

PLoS One. 2016; 11(2): e0148777. Published online 2016 Feb 11. doi: 10.1371/journal.pone.0148777

PMCID:: PMC4750963

Abstract Article PDF–17M

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