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Select item 100728621.

Association of IFNAR1 and IFNAR2 with COVID-19 severity

Melyssa Yaugel-Novoa, Thomas Bourlet, Stéphanie Longet, Elisabeth Botelho-Nevers, Stéphane Paul

Lancet Microbe. 2023 Apr 4 doi: 10.1016/S2666-5247(23)00095-2 [Epub ahead of print]

Correction in:: Lancet Microbe. 2023 Apr 15; 4(6): e394.

PMCID:: PMC10072862

Article PDF–110K

Select item 100186382.

Polymorphism in interferon alpha/beta receptor contributes to glucocorticoid response and outcome of ARDS and COVID-19

Juho Jalkanen, Sofia Khan, Kati Elima, Teppo Huttunen, Ning Wang, Maija Hollmén, Laura L. Elo, Sirpa Jalkanen

Crit Care. 2023; 27: 112. Published online 2023 Mar 16. doi: 10.1186/s13054-023-04388-8

PMCID:: PMC10018638

Abstract Article PDF–4.6M

Select item 98582523.

Polymorphisms in ACE1, TMPRSS2, IFIH1, IFNAR2, and TYK2 Genes Are Associated with Worse Clinical Outcomes in COVID-19

Cristine Dieter, Leticia de Almeida Brondani, Natália Emerim Lemos, Ariell Freires Schaeffer, Caroline Zanotto, Denise Taurino Ramos, Eliandra Girardi, Felipe Mateus Pellenz, Joiza Lins Camargo, Karla Suzana Moresco, Lucas Lima da Silva, Mariana Rauback Aubin, Mayara Souza de Oliveira, Tatiana Helena Rech, Luís Henrique Canani, Fernando Gerchman, Cristiane Bauermann Leitão, Daisy Crispim

Genes (Basel) 2023 Jan; 14(1): 29. Published online 2022 Dec 22. doi: 10.3390/genes14010029

PMCID:: PMC9858252

Abstract Article PDF–364K

Select item 96917784.

Type I interferon receptor (IFNAR2) deficiency reveals Zika virus cytopathicity in human macrophages and microglia

Aidan T. Hanrath, Catherine F. Hatton, Florian Gothe, Cathy Browne, Jane Vowles, Peter Leary, Simon J. Cockell, Sally A. Cowley, William S. James, Sophie Hambleton, Christopher J. A. Duncan

Front Immunol. 2022; 13: 1035532. Published online 2022 Nov 11. doi: 10.3389/fimmu.2022.1035532

PMCID:: PMC9691778

Abstract Article PDF–7.9M

Select item 93744605.

IFNAR2 relevance in the clinical outcome of individuals with severe COVID-19

Ingrid Fricke-Galindo, Alfonso Martínez-Morales, Leslie Chávez-Galán, Ranferi Ocaña-Guzmán, Ivette Buendía-Roldán, Gloria Pérez-Rubio, Rafael de Jesus Hernández-Zenteno, Abigail Verónica-Aguilar, Aimé Alarcón-Dionet, Hiram Aguilar-Duran, Ilse Adriana Gutiérrez-Pérez, Oscar Zaragoza-García, Jesús Alanis-Ponce, Angel Camarena, Brandon Bautista-Becerril, Karol J. Nava-Quiroz, Mayra Mejía, Iris Paola Guzmán-Guzmán, Ramcés Falfán-Valencia

Front Immunol. 2022; 13: 949413. Published online 2022 Jul 29. doi: 10.3389/fimmu.2022.949413

PMCID:: PMC9374460

Abstract Article PDF–598K

Select item 92594966.

Whole-genome sequencing reveals host factors underlying critical COVID-19

Athanasios Kousathanas, Erola Pairo-Castineira, Konrad Rawlik, Alex Stuckey, Christopher A. Odhams, Susan Walker, Clark D. Russell, Tomas Malinauskas, Yang Wu, Jonathan Millar, Xia Shen, Katherine S. Elliott, Fiona Griffiths, Wilna Oosthuyzen, Kirstie Morrice, Sean Keating, Bo Wang, Daniel Rhodes, Lucija Klaric, Marie Zechner, Nick Parkinson, Afshan Siddiq, Peter Goddard, Sally Donovan, David Maslove, Alistair Nichol, Malcolm G. Semple, Tala Zainy, Fiona Maleady-Crowe, Linda Todd, Shahla Salehi, Julian Knight, Greg Elgar, Georgia Chan, Prabhu Arumugam, Christine Patch, Augusto Rendon, David Bentley, Clare Kingsley, Jack A. Kosmicki, Julie E. Horowitz, Aris Baras, Goncalo R. Abecasis, Manuel A. R. Ferreira, Anne Justice, Tooraj Mirshahi, Matthew Oetjens, Daniel J. Rader, Marylyn D. Ritchie, Anurag Verma, Tom A. Fowler, Manu Shankar-Hari, Charlotte Summers, Charles Hinds, Peter Horby, Lowell Ling, Danny McAuley, Hugh Montgomery, Peter J. M. Openshaw, Paul Elliott, Timothy Walsh, Albert Tenesa, GenOMICC investigators, 23andMe investigators, COVID-19 Human Genetics Initiative, Angie Fawkes, Lee Murphy, Kathy Rowan, Chris P. Ponting, Veronique Vitart, James F. Wilson, Jian Yang, Andrew D. Bretherick, Richard H. Scott, Sara Clohisey Hendry, Loukas Moutsianas, Andy Law, Mark J. Caulfield, J. Kenneth Baillie

Nature. 2022; 607(7917): 97–103. Published online 2022 Mar 7. doi: 10.1038/s41586-022-04576-6

PMCID:: PMC9259496

Abstract Article PDF–8.1M

Select item 90262497.

Life-threatening viral disease in a novel form of autosomal recessive IFNAR2 deficiency in the Arctic

Christopher J.A. Duncan, Morten K. Skouboe, Sophie Howarth, Anne K. Hollensen, Rui Chen, Malene L. Børresen, Benjamin J. Thompson, Jarmila Stremenova Spegarova, Catherine F. Hatton, Frederik F. Stæger, Mette K. Andersen, John Whittaker, Søren R. Paludan, Sofie E. Jørgensen, Martin K. Thomsen, Jacob G. Mikkelsen, Carsten Heilmann, Daniela Buhas, Nina F. Øbro, Jakob T. Bay, Hanne V. Marquart, M. Teresa de la Morena, Joseph A. Klejka, Matthew Hirschfeld, Line Borgwardt, Isabel Forss, Tania Masmas, Anja Poulsen, Francisco Noya, Guy Rouleau, Torben Hansen, Sirui Zhou, Anders Albrechtsen, Reza Alizadehfar, Eric J. Allenspach, Sophie Hambleton, Trine H. Mogensen

J Exp Med. 2022 Jun 6; 219(6): e20212427. Published online 2022 Apr 20. doi: 10.1084/jem.20212427

PMCID:: PMC9026249

Abstract Article PDF–5.5M

Select item 89741508.

Long non-coding RNA prostate cancer-associated transcript 6 inhibited gefitinib sensitivity of non-small cell lung cancer by serving as a competing endogenous RNA of miR-326 to up-regulate interferon-alpha receptor 2

Yu Zheng, Ziyi Guo, Ying Li

Bioengineered. 2022; 13(2): 3785–3796. Published online 2022 Jan 26. doi: 10.1080/21655979.2022.2031416

PMCID:: PMC8974150

Abstract Article PDF–3.7M

Select item 89087909.

A partial form of inherited human USP18 deficiency underlies infection and inflammation

Marta Martin-Fernandez, Sofija Buta, Tom Le Voyer, Zhi Li, Lasse Toftdal Dynesen, Françoise Vuillier, Lina Franklin, Fatima Ailal, Alice Muglia Amancio, Louise Malle, Conor Gruber, Ibtihal Benhsaien, Jennie Altman, Justin Taft, Caroline Deswarte, Manon Roynard, Alejandro Nieto-Patlan, Kunihiko Moriya, Jérémie Rosain, Nathalie Boddaert, Aziz Bousfiha, Yanick J. Crow, Dragana Jankovic, Alan Sher, Jean-Laurent Casanova, Sandra Pellegrini, Jacinta Bustamante, Dusan Bogunovic

J Exp Med. 2022 Apr 4; 219(4): e20211273. Published online 2022 Mar 8. doi: 10.1084/jem.20211273

PMCID:: PMC8908790

Abstract Article PDF–6.1M

Select item 871637310.

Soluble Receptor Isoform of IFN-Beta (sIFNAR2) in Multiple Sclerosis Patients and Their Association With the Clinical Response to IFN-Beta Treatment

Pablo Aliaga-Gaspar, Isaac Hurtado-Guerrero, Nicolas Lundahl Ciano-Petersen, Patricia Urbaneja, Isabel Brichette-Mieg, Virginia Reyes, Jose Luis Rodriguez-Bada, Roberto Alvarez-Lafuente, Rafael Arroyo, Ester Quintana, Lluis Ramió-Torrentà, Ana Alonso, Laura Leyva, Oscar Fernández, Begoña Oliver-Martos

Front Immunol. 2021; 12: 778204. Published online 2021 Dec 16. doi: 10.3389/fimmu.2021.778204

PMCID:: PMC8716373

Abstract Article PDF–1.2M

Select item 816503011.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 813600312.

Integrative genomics analysis reveals a 21q22.11 locus contributing risk to COVID-19

Yunlong Ma, Yukuan Huang, Sen Zhao, Yinghao Yao, Yaru Zhang, Jia Qu, Nan Wu, Jianzhong Su

Hum Mol Genet. 2021 Jul 1; 30(13): 1247–1258. Published online 2021 May 5. doi: 10.1093/hmg/ddab125

PMCID:: PMC8136003

Abstract Article PDF–926K

Select item 785570713.

Interferon Receptor Trafficking and Signaling: Journey to the Cross Roads

Natacha Zanin, Christine Viaris de Lesegno, Christophe Lamaze, Cedric M. Blouin

Front Immunol. 2020; 11: 615603. Published online 2021 Jan 20. doi: 10.3389/fimmu.2020.615603

PMCID:: PMC7855707

Abstract Article PDF–2.0M

Select item 723052714.

Antiviral, Immunomodulatory and Antiproliferative Activities of Recombinant Soluble IFNAR2 without IFN-ß Mediation

Isaac Hurtado-Guerrero, Bruno Hernáez, María J. Pinto-Medel, Esther Calonge, José L. Rodriguez-Bada, Patricia Urbaneja, Ana Alonso, Natalia Mena-Vázquez, Pablo Aliaga, Shohreh Issazadeh-Navikas, José Pavia, Laura Leyva, José Alcamí, Antonio Alcamí, Óscar Fernández, Begoña Oliver-Martos

J Clin Med. 2020 Apr; 9(4): 959. Published online 2020 Mar 31. doi: 10.3390/jcm9040959

PMCID:: PMC7230527

Abstract Article PDF–3.9M

Select item 720192015.

Homozygous STAT2 gain-of-function mutation by loss of USP18 activity in a patient with type I interferonopathy

Conor Gruber, Marta Martin-Fernandez, Fatima Ailal, Xueer Qiu, Justin Taft, Jennie Altman, Jérémie Rosain, Sofija Buta, Aziz Bousfiha, Jean-Laurent Casanova, Jacinta Bustamante, Dusan Bogunovic

J Exp Med. 2020 May 4; 217(5): e20192319. Published online 2020 Feb 24. doi: 10.1084/jem.20192319

PMCID:: PMC7201920

Abstract Article PDF–3.0M

Select item 705213516.

Regulation of the linear ubiquitination of STAT1 controls antiviral interferon signaling

Yibo Zuo, Qian Feng, Lincong Jin, Fan Huang, Ying Miao, Jin Liu, Ying Xu, Xiangjie Chen, Hongguang Zhang, Tingting Guo, Yukang Yuan, Liting Zhang, Jun Wang, Hui Zheng

Nat Commun. 2020; 11: 1146. Published online 2020 Mar 2. doi: 10.1038/s41467-020-14948-z