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Items: 1 to 20 of 22

1.
Inhibition of secretin/secretin receptor axis ameliorates non-alcoholic fatty liver disease phenotypes
Lixian Chen, Nan Wu, Lindsey Kennedy, Heather Francis, Ludovica Ceci, Tianhao Zhou, Niharika Samala, Konstantina Kyritsi, Chaodong Wu, Amelia Sybenga, Burcin Ekser, Wasim Dar, Constance Atkins, Vik Meadows, Shannon Glaser, Gianfranco Alpini
Hepatology. Author manuscript; available in PMC 2022 Oct 1.
Published in final edited form as: Hepatology. 2021 Oct; 74(4): 1845–1863. Published online 2021 Jul 29. doi: 10.1002/hep.31871
PMCID:
PMC8782246
AbstractArticlePDF–2.6M
2.
SCTR hypermethylation is a diagnostic biomarker in colorectal cancer
DaPeng Li, Lei Zhang, JinMing Fu, Hao Huang, SiMin Sun, Ding Zhang, LiYuan Zhao, Justina Ucheojor Onwuka, YaShuang Zhao, BinBin Cui
Cancer Sci. 2020 Dec; 111(12): 4558–4566. Published online 2020 Oct 8. doi: 10.1111/cas.14661
PMCID:
PMC7734158
AbstractArticlePDF–857K
3.
Structure and dynamics of the active Gs-coupled human secretin receptor
Maoqing Dong, Giuseppe Deganutti, Sarah J. Piper, Yi-Lynn Liang, Maryam Khoshouei, Matthew J. Belousoff, Kaleeckal G. Harikumar, Christopher A. Reynolds, Alisa Glukhova, Sebastian G. B. Furness, Arthur Christopoulos, Radostin Danev, Denise Wootten, Patrick M. Sexton, Laurence J. Miller
Nat Commun. 2020; 11: 4137. Published online 2020 Aug 18. doi: 10.1038/s41467-020-17791-4
PMCID:
PMC7435274
AbstractArticlePDF–4.5M
4.
Secretin/secretin receptor signaling mediates biliary damage and liver fibrosis in early-stage primary biliary cholangitis
Lindsey Kennedy, Heather Francis, Pietro Invernizzi, Julie Venter, Nan Wu, Marco Carbone, M. Eric Gershwin, Francesca Bernuzzi, Antonio Franchitto, Domenico Alvaro, Marco Marzioni, Paolo Onori, Eugenio Gaudio, Amelia Sybenga, Luca Fabris, Fanyin Meng, Shannon Glaser, Gianfranco Alpini
FASEB J. 2019 Sep; 33(9): 10269–10279. Published online 2019 Jun 28. doi: 10.1096/fj.201802606R
PMCID:
PMC6704456
AbstractArticle
5.
Structure and Function of Cross-class Complexes of G Protein-coupled Secretin and Angiotensin 1a Receptors
Kaleeckal G. Harikumar, Mary Lou Augustine, Leo T. O. Lee, Billy K. C. Chow, Laurence J. Miller
J Biol Chem. 2016 Aug 12; 291(33): 17332–17344. Published online 2016 Jun 21. doi: 10.1074/jbc.M116.730754
PMCID:
PMC5016131
AbstractArticlePDF–3.6M
6.
The secretin/secretin receptor axis modulates liver fibrosis through changes in TGF-β1 biliary secretion
Nan Wu, Fanyin Meng, Pietro Invernizzi, Francesca Bernuzzi, Julie Venter, Holly Standeford, Paolo Onori, Marco Marzioni, Domenico Alvaro, Antonio Franchitto, Eugenio Gaudio, Shannon Glaser, Gianfranco Alpini
Hepatology. Author manuscript; available in PMC 2017 Sep 1.
Published in final edited form as: Hepatology. 2016 Sep; 64(3): 865–879. Published online 2016 Jun 11. doi: 10.1002/hep.28622
PMCID:
PMC4992423
AbstractArticlePDF–3.6M
7.
Use of Cysteine Trapping to Map Spatial Approximations between Residues Contributing to the Helix N-capping Motif of Secretin and Distinct Residues within Each of the Extracellular Loops of Its Receptor
Maoqing Dong, Polo C.-H. Lam, Andrew Orry, Patrick M. Sexton, Arthur Christopoulos, Ruben Abagyan, Laurence J. Miller
J Biol Chem. 2016 Mar 4; 291(10): 5172–5184. Published online 2016 Jan 6. doi: 10.1074/jbc.M115.706010
PMCID:
PMC4777851
AbstractArticlePDF–4.2M
8.
Gene expression accurately distinguishes liver metastases of small bowel and pancreas neuroendocrine tumors
Scott K. Sherman, Jessica E. Maxwell, Jennifer C. Carr, Donghong Wang, Andrew M. Bellizzi, M. Sue O’Dorisio, Thomas M. O’Dorisio, James R. Howe
Clin Exp Metastasis. Author manuscript; available in PMC 2015 Dec 1.
Published in final edited form as: Clin Exp Metastasis. 2014 Dec; 31(8): 935–944. Published online 2014 Sep 21. doi: 10.1007/s10585-014-9681-2
PMCID:
PMC4263419
AbstractArticlePDF–580K
9.
Pattern of Intra-Family Hetero-Oligomerization Involving the G-Protein-Coupled Secretin Receptor
Kaleeckal G. Harikumar, Maria M. Morfis, Patrick M. Sexton, Laurence J. Miller
J Mol Neurosci. Author manuscript; available in PMC 2014 Jan 3.
Published in final edited form as: J Mol Neurosci. 2008 Nov; 36(0): 10.1007/s12031-008-9060-z. Published online 2008 Apr 10. doi: 10.1007/s12031-008-9060-z
PMCID:
PMC3880023
AbstractArticlePDF–1.1M
10.
MTR120/KIAA1383, a novel microtubule-associated protein, promotes microtubule stability and ensures cytokinesis
Ka-wing Fong, Justin Wai-chung Leung, Yujing Li, Wenqi Wang, Lin Feng, Wenbin Ma, Dan Liu, Zhou Songyang, Junjie Chen
J Cell Sci. 2013 Feb 1; 126(3): 825–837. doi: 10.1242/jcs.116137
PMCID:
PMC3619811
AbstractArticle
11.
Mapping spatial approximations between the amino terminus of secretin and each of the extracellular loops of its receptor using cysteine trapping
Maoqing Dong, Xiequn Xu, Alicja M. Ball, Joshua A. Makhoul, Polo C.-H. Lam, Delia I. Pinon, Andrew Orry, Patrick M. Sexton, Ruben Abagyan, Laurence J. Miller
FASEB J. 2012 Dec; 26(12): 5092–5105. doi: 10.1096/fj.12-212399
PMCID:
PMC3509059
AbstractArticle
12.
Toward an understanding of the protein interaction network of the human liver
Jian Wang, Keke Huo, Lixin Ma, Liujun Tang, Dong Li, Xiaobi Huang, Yanzhi Yuan, Chunhua Li, Wei Wang, Wei Guan, Hui Chen, Chaozhi Jin, Junchen Wei, Wanqiao Zhang, Yongsheng Yang, Qiongming Liu, Ying Zhou, Cuili Zhang, Zhihao Wu, Wangxiang Xu, Ying Zhang, Tao Liu, Donghui Yu, Yaping Zhang, Liang Chen, Dewu Zhu, Xing Zhong, Lixin Kang, Xiang Gan, Xiaolan Yu, Qi Ma, Jing Yan, Li Zhou, Zhongyang Liu, Yunping Zhu, Tao Zhou, Fuchu He, Xiaoming Yang
Mol Syst Biol. 2011; 7: 536. Published online 2011 Oct 11. doi: 10.1038/msb.2011.67
Correction in:
Mol Syst Biol. 2017 Dec; 13(12): 965.
PMCID:
PMC3261708
AbstractArticlePDF–2.0M
13.
Phylogenetic-based propagation of functional annotations within the Gene Ontology consortium
Pascale Gaudet, Michael S. Livstone, Suzanna E. Lewis, Paul D. Thomas
Brief Bioinform. 2011 Sep; 12(5): 449–462. Published online 2011 Aug 27. doi: 10.1093/bib/bbr042
PMCID:
PMC3178059
AbstractArticlePDF–1.0M
14.
Lactam Constraints Provide Insights into the Receptor-Bound Conformation of Secretin and Stabilize a Receptor Antagonist
Maoqing Dong, Jerez A. Te, Xiequn Xu, Jinhui Wang, Delia I. Pinon, Laura Storjohann, Andrew J. Bordner, Laurence J. Miller
Biochemistry. Author manuscript; available in PMC 2012 Sep 27.
Published in final edited form as: Biochemistry. 2011 Sep 27; 50(38): 8181–8192. Published online 2011 Aug 30. doi: 10.1021/bi2008036
PMCID:
PMC3177990
AbstractArticlePDF–2.2M
15.
THE MOLECULAR BASIS OF ASSOCIATION OF RECEPTOR ACTIVITY-MODIFYING PROTEIN 3 WITH THE FAMILY B G PROTEIN-COUPLED SECRETIN RECEPTOR
Kaleeckal G. Harikumar, John Simms, George Christopoulos, Patrick M. Sexton, Laurence J. Miller
Biochemistry. Author manuscript; available in PMC 2010 Dec 15.
Published in final edited form as: Biochemistry. 2009 Dec 15; 48(49): 11773–11785. doi: 10.1021/bi901326k
PMCID:
PMC2790544
AbstractArticlePDF–1.6M
16.
Dimerization in the Absence of Higher Order Oligomerization of the G Protein-Coupled Secretin Receptor
Kaleeckal G. Harikumar, Renee M. Happs, Laurence J. Miller
Biochim Biophys Acta. Author manuscript; available in PMC 2009 Nov 1.
Published in final edited form as: Biochim Biophys Acta. 2008 Nov; 1778(11): 2555–2563. Published online 2008 Jul 17. doi: 10.1016/j.bbamem.2008.07.008
PMCID:
PMC2676241
AbstractArticlePDF–675K
17.
Secretin Receptor Oligomers Form Intracellularly during Maturation through Receptor Core Domains
Cayle S. Lisenbee, Laurence J. Miller
Biochemistry. Author manuscript; available in PMC 2008 Aug 11.
Published in final edited form as: Biochemistry. 2006 Jul 11; 45(27): 8216–8226. doi: 10.1021/bi060494y
PMCID:
PMC2505178
AbstractArticlePDF–756K
18.
Secretin-receptor and secretin-receptor-variant expression in gastrinomas: Correlation with clinical and tumoral features and secretin and calcium provocative test results.
Scott H. Long, Marc J. Berna, Michelle Thill, Andrea Pace, Tapas K. Pradhan, K. Martin Hoffmann, Jose Serrano, Robert T. Jensen
J Clin Endocrinol Metab. Author manuscript; available in PMC 2008 Jul 14.
Published in final edited form as: J Clin Endocrinol Metab. 2007 Nov; 92(11): 4394–4402. Published online 2007 Aug 21. doi: 10.1210/jc.2007-0986
PMCID:
PMC2464459
AbstractArticlePDF–1.9M
19.
Secretin Receptors in Normal and Diseased Human Pancreas : Marked Reduction of Receptor Binding in Ductal Neoplasia
Meike Körner, Gregory M. Hayes, Ruth Rehmann, Arthur Zimmermann, Helmut Friess, Laurence J. Miller, Jean Claude Reubi
Am J Pathol. 2005 Oct; 167(4): 959–968. doi: 10.1016/S0002-9440(10)61186-8
PMCID:
PMC1603664
AbstractArticlePDF–2.8M
20.
Diversification of transcriptional modulation: Large-scale identification and characterization of putative alternative promoters of human genes
Kouichi Kimura, Ai Wakamatsu, Yutaka Suzuki, Toshio Ota, Tetsuo Nishikawa, Riu Yamashita, Jun-ichi Yamamoto, Mitsuo Sekine, Katsuki Tsuritani, Hiroyuki Wakaguri, Shizuko Ishii, Tomoyasu Sugiyama, Kaoru Saito, Yuko Isono, Ryotaro Irie, Norihiro Kushida, Takahiro Yoneyama, Rie Otsuka, Katsuhiro Kanda, Takahide Yokoi, Hiroshi Kondo, Masako Wagatsuma, Katsuji Murakawa, Shinichi Ishida, Tadashi Ishibashi, Asako Takahashi-Fujii, Tomoo Tanase, Keiichi Nagai, Hisashi Kikuchi, Kenta Nakai, Takao Isogai, Sumio Sugano
Genome Res. 2006 Jan; 16(1): 55–65. doi: 10.1101/gr.4039406
PMCID:
PMC1356129
AbstractArticlePDF–438K

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