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Select item 108767251.

Club cell protein (CC16) in serum as an effect marker for small airway epithelial damage caused by diesel exhaust and blasting fumes in potash mining

Savo Neumann, Swaantje Casjens, Frank Hoffmeyer, Katrin Rühle, Lisa Gamrad-Streubel, Lisa-Marie Haase, Katharina K. Rudolph, Jörg Giesen, Volker Neumann, Dirk Taeger, Dirk Pallapies, Thomas Birk, Thomas Brüning, Jürgen Bünger

Int Arch Occup Environ Health. 2024; 97(2): 121–132. Published online 2023 Dec 18. doi: 10.1007/s00420-023-02035-x

PMCID:: PMC10876725

Abstract Article PDF–807K

Select item 106942442.

CC16 drives VLA-2-dependent SPLUNC1 expression

Natalie Iannuzo, Holly Welfley, Nicholas C. Li, Michael D. L. Johnson, Joselyn Rojas-Quintero, Francesca Polverino, Stefano Guerra, Xingnan Li, Darren A. Cusanovich, Paul R. Langlais, Julie G. Ledford

Front Immunol. 2023; 14: 1277582. Published online 2023 Nov 20. doi: 10.3389/fimmu.2023.1277582

PMCID:: PMC10694244

Abstract Article PDF–4.1M

Select item 99401453.

Low CC16 mRNA Expression Levels in Bronchial Epithelial Cells Are Associated with Asthma Severity

Xingnan Li, Stefano Guerra, Julie G. Ledford, Monica Kraft, Huashi Li, Annette T. Hastie, Mario Castro, Loren C. Denlinger, Serpil C. Erzurum, John V. Fahy, Benjamin Gaston, Elliot Israel, Nizar N. Jarjour, Bruce D. Levy, David T. Mauger, Wendy C. Moore, Joe Zein, Naftali Kaminski, Sally E. Wenzel, Prescott G. Woodruff, Deborah A. Meyers, Eugene R. Bleecker

Am J Respir Crit Care Med. 2023 Feb 15; 207(4): 438–451. Published online 2022 Sep 6. doi: 10.1164/rccm.202206-1230OC

PMCID:: PMC9940145

Abstract Article PDF–868K

Select item 96445144.

CC16 polymorphisms in asthma, asthma subtypes, and asthma control in adults from the Agricultural Lung Health Study

KC Gribben, AB Wyss, JA Poole, PA Farazi, C Wichman, M Richards-Barber, LE Beane Freeman, PK Henneberger, DM Umbach, SJ London, TD LeVan, Kelli C. Gribben

Respir Res. 2022; 23: 305. Published online 2022 Nov 9. doi: 10.1186/s12931-022-02211-6

Correction in:: Respir Res. 2022; 23: 350.

PMCID:: PMC9644514

Abstract Article PDF–1.2M

Select item 96131105.

Brief Research Report: Serum clara cell 16 kDa protein levels are increased in patients hospitalized for severe SARS-CoV-2 or sepsis infection

Nathalie Rohmann, Paula Stürmer, Corinna Geisler, Kristina Schlicht, Katharina Hartmann, Kathrin Türk, Tim Hollstein, Florian Tran, Philip Rosenstiel, Andre Franke, Jan Heyckendorf, Stefan Schreiber, Dominik M. Schulte, Matthias Laudes

Front Immunol. 2022; 13: 1037115. Published online 2022 Oct 13. doi: 10.3389/fimmu.2022.1037115

PMCID:: PMC9613110

Abstract Article PDF–538K

Select item 86487256.

A rapid point of care CC16 kit for screening of occupational silica dust exposed workers for early detection of silicosis/silico-tuberculosis

Shyam Sundar Nandi, Upendra P. Lambe, Kamalesh Sarkar, Sonali Sawant, Jagadish Deshpande

Sci Rep. 2021; 11: 23485. Published online 2021 Dec 6. doi: 10.1038/s41598-021-02392-y

PMCID:: PMC8648725

Abstract Article PDF–1.7M

Select item 85259307.

Roles of Clara cell 10-kD protein and type 2 innate lymphoid cells in allergic rhinitis

Xiaobo Long, Nan Wang, Xinhao Zhang

Cell Cycle. 2021; 20(18): 1923–1934. Published online 2021 Aug 26. doi: 10.1080/15384101.2021.1966961

PMCID:: PMC8525930

Abstract Article PDF–3.4M

Select item 81650308.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 78635389.

Clara cell 16 KDa protein mitigates house dust mite-induced airway inflammation and damage via regulating airway epithelial cell apoptosis in a manner dependent on HMGB1-mediated signaling inhibition

Meixuan Liu, Jingjing Lu, Qian Zhang, Yunxuan Zhang, Zhongliang Guo

Mol Med. 2021; 27: 11. Published online 2021 Feb 4. doi: 10.1186/s10020-021-00277-4

PMCID:: PMC7863538

Abstract Article PDF–8.9M

Select item 765439410.

Gender‐dependent association between exhaled nitric oxide and the CC16 38AA genotype in young school children

Sarah J. D. Nauwelaerts, Nancy H. C. Roosens, Koen De Cremer, Alfred Bernard, Sigrid C. J. De Keersmaecker

Immun Inflamm Dis. 2020 Dec; 8(4): 497–505. Published online 2020 Aug 6. doi: 10.1002/iid3.332

PMCID:: PMC7654394

Abstract Article PDF–577K

Select item 742246511.

Renal dysfunction reduces the diagnostic and prognostic value of serum CC16 for acute respiratory distress syndrome in intensive care patients

Jinle Lin, Wuyuan Tao, Jian Wei, Jian Wu, Wenwu Zhang, Jianbing Ye, Xuan Fu, Shiyong Zeng, Qingli Dou, Lijun Wang, Fang Tian

BMC Pulm Med. 2020; 20: 212. Published online 2020 Aug 12. doi: 10.1186/s12890-020-01245-0

Correction in:: BMC Pulm Med. 2021; 21: 54.

PMCID:: PMC7422465

Abstract Article PDF–1.3M

Select item 737106612.

Club cell protein 16 as a biomarker for early detection of silicosis

Nibedita Naha, Jaseer C.J. Muhamed, Avinash Pagdhune, Bidisa Sarkar, Kamalesh Sarkar

Indian J Med Res. 2020 Apr; 151(4): 319–325. doi: 10.4103/ijmr.IJMR_1799_18

PMCID:: PMC7371066

Abstract Article PDF–617K

Select item 716998313.

A reference map of the human binary protein interactome

Katja Luck, Dae-Kyum Kim, Luke Lambourne, Kerstin Spirohn, Bridget E. Begg, Wenting Bian, Ruth Brignall, Tiziana Cafarelli, Francisco J. Campos-Laborie, Benoit Charloteaux, Dongsic Choi, Atina G. Coté, Meaghan Daley, Steven Deimling, Alice Desbuleux, Amélie Dricot, Marinella Gebbia, Madeleine F. Hardy, Nishka Kishore, Jennifer J. Knapp, István A. Kovács, Irma Lemmens, Miles W. Mee, Joseph C. Mellor, Carl Pollis, Carles Pons, Aaron D. Richardson, Sadie Schlabach, Bridget Teeking, Anupama Yadav, Mariana Babor, Dawit Balcha, Omer Basha, Christian Bowman-Colin, Suet-Feung Chin, Soon Gang Choi, Claudia Colabella, Georges Coppin, Cassandra D’Amata, David De Ridder, Steffi De Rouck, Miquel Duran-Frigola, Hanane Ennajdaoui, Florian Goebels, Liana Goehring, Anjali Gopal, Ghazal Haddad, Elodie Hatchi, Mohamed Helmy, Yves Jacob, Yoseph Kassa, Serena Landini, Roujia Li, Natascha van Lieshout, Andrew MacWilliams, Dylan Markey, Joseph N. Paulson, Sudharshan Rangarajan, John Rasla, Ashyad Rayhan, Thomas Rolland, Adriana San-Miguel, Yun Shen, Dayag Sheykhkarimli, Gloria M. Sheynkman, Eyal Simonovsky, Murat Taşan, Alexander Tejeda, Vincent Tropepe, Jean-Claude Twizere, Yang Wang, Robert J. Weatheritt, Jochen Weile, Yu Xia, Xinping Yang, Esti Yeger-Lotem, Quan Zhong, Patrick Aloy, Gary D. Bader, Javier De Las Rivas, Suzanne Gaudet, Tong Hao, Janusz Rak, Jan Tavernier, David E. Hill, Marc Vidal, Frederick P. Roth, Michael A. Calderwood

Nature. Author manuscript; available in PMC 2020 Oct 8.

Published in final edited form as: Nature. 2020 Apr; 580(7803): 402–408. Published online 2020 Apr 8. doi: 10.1038/s41586-020-2188-x

PMCID:: PMC7169983

Abstract Article PDF–5.4M

Select item 706008114.

Reduced Serum Concentration of CC16 Is Associated with Severity of Chronic Obstructive Pulmonary Disease and Contributes to the Diagnosis and Assessment of the Disease

Biaoxue Rong, Tian Fu, Wenlong Gao, Min Li, Congxue Rong, Wen Liu, Hua Liu

Int J Chron Obstruct Pulmon Dis. 2020; 15: 461–470. Published online 2020 Mar 2. doi: 10.2147/COPD.S230323

PMCID:: PMC7060081

Abstract Article PDF–7.8M

Select item 682241715.

Club cell protein 16 in sera from trauma patients modulates neutrophil migration and functionality via CXCR1 and CXCR2

Baolin Xu, Andrea Janicova, Jan Tilmann Vollrath, Philipp Störmann, Lukas Martin, Ingo Marzi, Sebastian Wutzler, Frank Hildebrand, Sabrina Ehnert, Borna Relja

Mol Med. 2019; 25: 45. Published online 2019 Oct 30. doi: 10.1186/s10020-019-0115-0

PMCID:: PMC6822417

Abstract Article PDF–2.1M

Select item 681721516.

Serum Clara cell protein and atopic phenotype in children up to 2 years of age

Nevenka Ilic, Natasa Mihailovic

J Clin Lab Anal. 2017 Nov; 31(6): e22151. Published online 2017 Feb 1. doi: 10.1002/jcla.22151

PMCID:: PMC6817215

Abstract Article PDF–528K

Select item 674264617.

Extensive disruption of protein interactions by genetic variants across the allele frequency spectrum in human populations

Robert Fragoza, Jishnu Das, Shayne D. Wierbowski, Jin Liang, Tina N. Tran, Siqi Liang, Juan F. Beltran, Christen A. Rivera-Erick, Kaixiong Ye, Ting-Yi Wang, Li Yao, Matthew Mort, Peter D. Stenson, David N. Cooper, Xiaomu Wei, Alon Keinan, John C. Schimenti, Andrew G. Clark, Haiyuan Yu

Nat Commun. 2019; 10: 4141. Published online 2019 Sep 12. doi: 10.1038/s41467-019-11959-3

PMCID:: PMC6742646

Abstract Article PDF–1.2M

Select item 654374918.

The Club Cell Marker SCGB1A1 Downstream of FOXA2 is Reduced in Asthma

Lingxiang Zhu, Lingling An, Di Ran, Rosa Lizarraga, Cheryl Bondy, Xu Zhou, Richart W. Harper, Shu-Yi Liao, Yin Chen

Am J Respir Cell Mol Biol. 2019 Jun; 60(6): 695–704. doi: 10.1165/rcmb.2018-0199OC

PMCID:: PMC6543749

Abstract Article PDF–1.0M

Select item 636397119.

Club Cell Secretory Protein Deficiency Leads to Altered Lung Function

Jing Zhai, Michael Insel, Kenneth J. Addison, Debra A. Stern, William Pederson, Alane Dy, Joselyn Rojas-Quintero, Caroline A. Owen, Duane L. Sherrill, Wayne Morgan, Anne L. Wright, Marilyn Halonen, Fernando D. Martinez, Monica Kraft, Stefano Guerra, Julie G. Ledford

Am J Respir Crit Care Med. 2019 Feb 1; 199(3): 302–312. Published online 2019 Feb 1. doi: 10.1164/rccm.201807-1345OC

PMCID:: PMC6363971

Abstract Article PDF–1.1M

Select item 635868920.

ABL kinase inhibition promotes lung regeneration through expansion of an SCGB1A1+ SPC+ cell population following bacterial pneumonia

Aaditya Khatri, Bryan D. Kraft, Purushothama Rao Tata, Scott H. Randell, Claude A. Piantadosi, Ann Marie Pendergast

Proc Natl Acad Sci U S A. 2019 Jan 29; 116(5): 1603–1612. Published online 2019 Jan 17. doi: 10.1073/pnas.1816030116

PMCID:: PMC6358689

Abstract Article PDF–2.7M

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