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Select item 113065241.

TACE inhibition: a promising therapeutic intervention against AATF‐mediated steatohepatitis to hepatocarcinogenesis

Akshatha N. Srinivas, Diwakar Suresh, Prashant M. Vishwanath, Suchitha Satish, Prasanna K. Santhekadur, Saisudha Koka, Divya P. Kumar

Mol Oncol. 2024 Aug; 18(8): 1940–1957. Published online 2024 Apr 1. doi: 10.1002/1878-0261.13646

PMCID:: PMC11306524

Abstract Article PDF–12M

Select item 113010742.

Ectodomain shedding of PLA2R1 is mediated by the metalloproteases ADAM10 and ADAM17

Guillaume Dolla, Sarah Nicolas, Ligia Ramos dos Santos, Alexandre Bourgeois, Raphaëlle Pardossi-Piquard, Franck Bihl, Christelle Zaghrini, Joana Justino, Christine Payré, Pascal Mansuelle, Christoph Garbers, Pierre Ronco, Frédéric Checler, Gérard Lambeau, Agnès Petit-Paitel

J Biol Chem. 2024 Jul; 300(7): 107480. Published online 2024 Jun 17. doi: 10.1016/j.jbc.2024.107480

PMCID:: PMC11301074

Abstract Article PDF–4.9M

Select item 112489963.

Cryo-EM reveals that iRhom2 restrains ADAM17 protease activity to control the release of growth factor and inflammatory signals

Fangfang Lu, Hongtu Zhao, Yaxin Dai, Yingdi Wang, Chia-Hsueh Lee, Matthew Freeman

Mol Cell. 2024 Jun 6; 84(11): 2152–2165.e5. doi: 10.1016/j.molcel.2024.04.025

PMCID:: PMC11248996

Abstract Article PDF–6.6M

Select item 111677764.

Downregulation of the metalloproteinases ADAM10 or ADAM17 promotes osteoclast differentiation

Aaron Babendreyer, Julia Kieselhorst, Cindy Rinkens, Anastasia M. Lyashenko, Stefan Düsterhöft, Holger Jahr, Rogerio B. Craveiro, Michael Wolf, Andreas Ludwig

Cell Commun Signal. 2024; 22: 322. Published online 2024 Jun 11. doi: 10.1186/s12964-024-01690-y

PMCID:: PMC11167776

Abstract Article PDF–11M

Select item 111588385.

Up‐regulated expression of ADAM17 in gastrointestinal stromal tumors: coexpression with EGFR and EGFR ligands

Motomichi Nakagawa, Kazuki Nabeshima, Shigeyuki Asano, Makoto Hamasaki, Noriko Uesugi, Hiroki Tani, Yuichi Yamashita, Hiroshi Iwasaki

Cancer Sci. 2009 Apr; 100(4): 654–662. Published online 2009 Mar 1. doi: 10.1111/j.1349-7006.2009.01089.x

PMCID:: PMC11158838

Abstract Article PDF–2.1M

Select item 111151186.

The sheddase activity of ADAM17/TACE is regulated by the tetraspanin CD9

Maria Dolores Gutiérrez-López, Alvaro Gilsanz, María Yáñez-Mó, Susana Ovalle, Esther M. Lafuente, Carmen Domínguez, Peter N. Monk, Isidoro González-Alvaro, Francisco Sánchez-Madrid, Carlos Cabañas

Cell Mol Life Sci. 2011 Oct; 68(19): 3275–3292. Published online 2011 Mar 2. doi: 10.1007/s00018-011-0639-0

PMCID:: PMC11115118

Abstract Article PDF–1.0M

Select item 111050097.

Degradome of soluble ADAM10 and ADAM17 metalloproteases

Franka Scharfenberg, Andreas Helbig, Martin Sammel, Julia Benzel, Uwe Schlomann, Florian Peters, Rielana Wichert, Maximilian Bettendorff, Dirk Schmidt-Arras, Stefan Rose-John, Catherine Moali, Stefan F. Lichtenthaler, Claus U. Pietrzik, Jörg W. Bartsch, Andreas Tholey, Christoph Becker-Pauly

Cell Mol Life Sci. 2020 Jan; 77(2): 331–350. Published online 2019 Jun 17. doi: 10.1007/s00018-019-03184-4

PMCID:: PMC11105009

Abstract Article PDF–2.2M

Select item 110501088.

Regulation of Mertk Surface Expression via ADAM17 and γ-Secretase Proteolytic Processing

Kevin C. Lahey, Christopher Varsanyi, Ziren Wang, Ahmed Aquib, Varsha Gadiyar, Alcina A. Rodrigues, Rachael Pulica, Samuel Desind, Viralkumar Davra, David C. Calianese, Dongfang Liu, Jong-Hyun Cho, Sergei V. Kotenko, Mariana S. De Lorenzo, Raymond B. Birge

Int J Mol Sci. 2024 Apr; 25(8): 4404. Published online 2024 Apr 17. doi: 10.3390/ijms25084404

PMCID:: PMC11050108

Abstract Article PDF–5.9M

Select item 109772549.

The Important Role of Phosphatidylserine, ADAM17, TNF-Alpha, and Soluble MER on Efferocytosis Activity in Central Obesity

Chandra Agung Purnama, Anna Meiliana, Melisa Intan Barliana, Keri Lestari, Andi Wijaya

J Obes. 2024; 2024: 1424404. Published online 2024 Mar 20. doi: 10.1155/2024/1424404

PMCID:: PMC10977254

Abstract Article PDF–782K

Select item 1089812310.

Tumor-derived exosomal ADAM17 promotes pre-metastatic niche formation by enhancing vascular permeability in colorectal cancer

Keyu Li, Wenhua Xue, Zhihua Lu, Suo Wang, Jiayao Zheng, Kuangyi Lu, Ming Li, Yang Zong, Feng Xu, Jiamin Dai, Yang Yang, Jinbing Sun

J Exp Clin Cancer Res. 2024; 43: 59. Published online 2024 Feb 27. doi: 10.1186/s13046-024-02991-3

PMCID:: PMC10898123

Abstract Article PDF–16M

Select item 1086094711.

Expression of ADAM17 and its clinical value for patients with pernicious placenta previa: A retrospective study of 148 PPP patients underwent cesarean section

Xiutao Huang, Xingxing Wang, Xiang Xiao, Jin Li, Hang Yuan, Li Hou

Medicine (Baltimore) 2024 Feb 9; 103(6): e32848. Published online 2024 Feb 9. doi: 10.1097/MD.0000000000032848

PMCID:: PMC10860947

Abstract Article PDF–532K

Select item 1073466612.

m⁶A-modified HOXC10 promotes HNSCC progression via co-activation of ADAM17/EGFR and Wnt/β-catenin signaling

Yujuan Zhou, Qiang Huang, Chunping Wu, Ye Xu, Yang Guo, Xiaohui Yuan, Chengzhi Xu, Liang Zhou

Int J Oncol. 2024 Feb; 64(2): 10. Published online 2023 Dec 6. doi: 10.3892/ijo.2023.5598

PMCID:: PMC10734666

Abstract Article PDF–13M

Select item 1070740613.

Predictive Roles of ADAM17 in Patient Survival and Immune Cell Infiltration in Hepatocellular Carcinoma

Tianlong Ding, Yang Yu, Lei Gao, Lin Xiang, Bo Xu, Baohong Gu, Hao Chen

Int J Mol Sci. 2023 Dec; 24(23): 17069. Published online 2023 Dec 2. doi: 10.3390/ijms242317069

PMCID:: PMC10707406

Abstract Article PDF–22M

Select item 1064746114.

Genetic Predisposition to Elevated Levels of Circulating ADAM17 Is Associated with the Risk of Severe COVID-19

Mengyu Pan, Isabel Goncalves, Andreas Edsfeldt, Jiangming Sun, Per Swärd

Int J Mol Sci. 2023 Nov; 24(21): 15879. Published online 2023 Nov 1. doi: 10.3390/ijms242115879

PMCID:: PMC10647461

Abstract Article PDF–763K

Select item 1043837815.

ADAM17 targeting by human cytomegalovirus remodels the cell surface proteome to simultaneously regulate multiple immune pathways

Anzelika Rubina, Mihil Patel, Katie Nightingale, Martin Potts, Ceri A. Fielding, Simon Kollnberger, Betty Lau, Kristin Ladell, Kelly L. Miners, Jenna Nichols, Luis Nobre, Dawn Roberts, Terrence M. Trinca, Jason P. Twohig, Virginia-Maria Vlahava, Andrew J. Davison, David A. Price, Peter Tomasec, Gavin W. G. Wilkinson, Michael P. Weekes, Richard J. Stanton, Eddie C. Y. Wang

Proc Natl Acad Sci U S A. 2023 Aug 15; 120(33): e2303155120. Published online 2023 Aug 10. doi: 10.1073/pnas.2303155120

PMCID:: PMC10438378

Abstract Article PDF–1.5M

Select item 1041714916.

Ectodomain Shedding by ADAM17 Increases the Release of Soluble CD40 from Human Endothelial Cells under Pro-Inflammatory Conditions

Anton Klersy, Sören Meyer, Florian Leuschner, Thorsten Kessler, Markus Hecker, Andreas H. Wagner

Cells. 2023 Aug; 12(15): 1926. Published online 2023 Jul 25. doi: 10.3390/cells12151926

PMCID:: PMC10417149

Abstract Article PDF–2.0M

Select item 1030263717.

Investigation of CD56, ADAM17 and FGF21 Expressions in the Placentas of Preeclampsia Cases

Irem Darka Aslan, Gorker Sel, Figen Barut, Rabia Baser Acikgoz, Sibel Balci, Ulku Ozmen, Aykut Barut, Muge Harma, Mehmet Ibrahim Harma

Medicina (Kaunas) 2023 Jun; 59(6): 1145. Published online 2023 Jun 14. doi: 10.3390/medicina59061145

PMCID:: PMC10302637

Abstract Article PDF–3.3M

Select item 1023742218.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233