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Select item 111481841.

Genome-wide CRISPR screens identify novel regulators of wild-type and mutant p53 stability

YiQing Lü, Tiffany Cho, Saptaparna Mukherjee, Carmen Florencia Suarez, Nicolas S Gonzalez-Foutel, Ahmad Malik, Sebastien Martinez, Dzana Dervovic, Robin Hyunseo Oh, Ellen Langille, Khalid N Al-Zahrani, Lisa Hoeg, Zhen Yuan Lin, Ricky Tsai, Geraldine Mbamalu, Varda Rotter, Patricia Ashton-Prolla, Jason Moffat, Lucia Beatriz Chemes, Anne-Claude Gingras, Moshe Oren, Daniel Durocher, Daniel Schramek

Mol Syst Biol. 2024 Jun; 20(6): 719–740. Published online 2024 Apr 5. doi: 10.1038/s44320-024-00032-x

PMCID:: PMC11148184

Abstract Article PDF–8.1M

Select item 111094832.

K48- and K63-linked ubiquitin chain interactome reveals branch- and length-specific ubiquitin interactors

Anita Waltho, Oliver Popp, Christopher Lenz, Lukas Pluska, Mahil Lambert, Volker Dötsch, Philipp Mertins, Thomas Sommer

Life Sci Alliance. 2024 Aug; 7(8): e202402740. Published online 2024 May 21. doi: 10.26508/lsa.202402740

PMCID:: PMC11109483

Abstract Article PDF–2.9M

Select item 111055863.

Pathogenic mutation in the ALS/FTD gene, CCNF, causes elevated Lys48-linked ubiquitylation and defective autophagy

Albert Lee, Stephanie L. Rayner, Serene S. L. Gwee, Alana De Luca, Hamideh Shahheydari, Vinod Sundaramoorthy, Audrey Ragagnin, Marco Morsch, Rowan Radford, Jasmin Galper, Sarah Freckleton, Bingyang Shi, Adam K. Walker, Emily K. Don, Nicholas J. Cole, Shu Yang, Kelly L. Williams, Justin J. Yerbury, Ian P. Blair, Julie D. Atkin, Mark P. Molloy, Roger S. Chung

Cell Mol Life Sci. 2018 Jan; 75(2): 335–354. Published online 2017 Aug 29. doi: 10.1007/s00018-017-2632-8

PMCID:: PMC11105586

Abstract Article PDF–1.8M

Select item 110768084.

Vaccinia virus subverts xenophagy through phosphorylation and nuclear targeting of p62

Melanie Krause, Jerzy Samolej, Artur Yakimovich, Janos Kriston-Vizi, Moona Huttunen, Samuel Lara-Reyna, Eva-Maria Frickel, Jason Mercer

J Cell Biol. 2024 Jun 3; 223(6): e202104129. Published online 2024 May 6. doi: 10.1083/jcb.202104129

PMCID:: PMC11076808

Abstract Article PDF–5.0M

Select item 110219695.

Dual-specificity kinase DYRK3 phosphorylates p62 at the Thr-269 residue and promotes melanoma progression

Ye Hyung Lee, A-Rum Yoon, Chae-Ok Yun, Kwang Chul Chung

J Biol Chem. 2024 Apr; 300(4): 107206. Published online 2024 Mar 20. doi: 10.1016/j.jbc.2024.107206

PMCID:: PMC11021969

Abstract Article PDF–4.5M

Select item 109099446.

circRNA_SLC8A1 promotes the survival of mycobacterium tuberculosis in macrophages by upregulating expression of autophagy-related protein SQSTM1/p62 to activate the NF-κB pathway

Zhenyun Li, Yuan Gao, Bianfang Zhang, Wei Dong, Yuling Xi, Yan Li, Junwei Cui

Sci Rep. 2024; 14: 5233. Published online 2024 Mar 4. doi: 10.1038/s41598-024-55493-9

Correction in:: Sci Rep. 2024; 14: 8860.

PMCID:: PMC10909944

Abstract Article PDF–4.3M

Select item 108706647.

Endothelium-specific deletion of p62 causes organ fibrosis and cardiac dysfunction

Jing Feng, Yan Li, Yu Zhang, Shengnan Sun, Jian Sun, Quanlin Xu, Xingzhao Ji, Yi Liu, Qiang Wan

J Transl Med. 2024; 22: 161. Published online 2024 Feb 16. doi: 10.1186/s12967-024-04946-w

PMCID:: PMC10870664

Abstract Article PDF–8.1M

Select item 106758928.

Cancer-associated fibroblasts-derived CXCL12 enhances immune escape of bladder cancer through inhibiting P62-mediated autophagic degradation of PDL1

Zhao Zhang, Yongbo Yu, Zhilei Zhang, Dan Li, Zhijuan Liang, Liping Wang, Yuanbin Chen, Ye Liang, Haitao Niu

J Exp Clin Cancer Res. 2023; 42: 316. Published online 2023 Nov 25. doi: 10.1186/s13046-023-02900-0

PMCID:: PMC10675892

Abstract Article PDF–12M

Select item 106421589.

SQSTM1/p62 and Hepatic Mallory-Denk Body Formation in Alcohol-Associated Liver Disease

Hui Qian, Wen-Xing Ding

Am J Pathol. 2023 Oct; 193(10): 1415–1426. doi: 10.1016/j.ajpath.2023.02.015

PMCID:: PMC10642158

Abstract Article PDF–965K

Select item 1056587610.

Pulse-SILAC and Interactomics Reveal Distinct DDB1-CUL4–Associated Factors, Cellular Functions, and Protein Substrates

Jennifer Raisch, Marie-Line Dubois, Marika Groleau, Dominique Lévesque, Thomas Burger, Carla-Marie Jurkovic, Romain Brailly, Gwendoline Marbach, Alyson McKenna, Catherine Barrette, Pierre-Étienne Jacques, François-Michel Boisvert

Mol Cell Proteomics. 2023 Oct; 22(10): 100644. Published online 2023 Sep 7. doi: 10.1016/j.mcpro.2023.100644

PMCID:: PMC10565876

Abstract Article PDF–3.7M

Select item 1055264811.

S-acylation of p62 promotes p62 droplet recruitment into autophagosomes in mammalian autophagy

Xue Huang, Jia Yao, Lu Liu, Jing Chen, Ligang Mei, Jingjing Huangfu, Dong Luo, Xinyi Wang, Changhai Lin, Xiaorong Chen, Yi Yang, Sheng Ouyang, Fujing Wei, Zhuolin Wang, Shaolin Zhang, Tingxiu Xiang, Dante Neculai, Qiming Sun, Eryan Kong, Edward W. Tate, Aimin Yang

Mol Cell. 2023 Oct 5; 83(19): 3485–3501.e11. doi: 10.1016/j.molcel.2023.09.004

PMCID:: PMC10552648

Abstract Article PDF–6.9M

Select item 1047415612.

The transcription factor NRF1 (NFE2L1) activates aggrephagy by inducing p62 and GABARAPL1 after proteasome inhibition to maintain proteostasis

Atsushi Hatanaka, Sota Nakada, Gen Matsumoto, Katsuya Satoh, Iori Aketa, Akira Watanabe, Tomoaki Hirakawa, Tadayuki Tsujita, Tsuyoshi Waku, Akira Kobayashi

Sci Rep. 2023; 13: 14405. Published online 2023 Sep 1. doi: 10.1038/s41598-023-41492-9

PMCID:: PMC10474156

Abstract Article PDF–2.8M

Select item 1041544613.

The E3 Ubiquitin Ligase SCF Cyclin F Promotes Sequestosome-1/p62 Insolubility and Foci Formation and is Dysregulated in ALS and FTD Pathogenesis

Jennilee M. Davidson, Sharlynn S. L. Wu, Stephanie L. Rayner, Flora Cheng, Kimberley Duncan, Carlo Russo, Michelle Newbery, Kunjie Ding, Natalie M. Scherer, Rachelle Balez, Alberto García-Redondo, Alberto Rábano, Livia Rosa-Fernandes, Lezanne Ooi, Kelly L. Williams, Marco Morsch, Ian P. Blair, Antonio Di Ieva, Shu Yang, Roger S. Chung, Albert Lee

Mol Neurobiol. 2023; 60(9): 5034–5054. Published online 2023 May 27. doi: 10.1007/s12035-023-03355-2

PMCID:: PMC10415446

Abstract Article PDF–4.2M

Select item 1036634214.

The selective autophagy adaptor p62/SQSTM1 forms phase condensates regulated by HSP27 that facilitate the clearance of damaged lysosomes via lysophagy

Elizabeth R. Gallagher, Erika L.F. Holzbaur

Cell Rep. Author manuscript; available in PMC 2023 Oct 23.

Published in final edited form as: Cell Rep. 2023 Feb 28; 42(2): 112037. Published online 2023 Jan 25. doi: 10.1016/j.celrep.2023.112037

PMCID:: PMC10366342

Abstract Article PDF–3.6M

Select item 1035147215.

HSPB8 frameshift mutant aggregates weaken chaperone-assisted selective autophagy in neuromyopathies

Barbara Tedesco, Leen Vendredy, Elias Adriaenssens, Marta Cozzi, Bob Asselbergh, Valeria Crippa, Riccardo Cristofani, Paola Rusmini, Veronica Ferrari, Elena Casarotto, Marta Chierichetti, Francesco Mina, Paola Pramaggiore, Mariarita Galbiati, Margherita Piccolella, Jonathan Baets, Femke Baeke, Riet De Rycke, Vincent Mouly, Tommaso Laurenzi, Ivano Eberini, Anna Vihola, Bjarne Udd, Lan Weiss, Virginia Kimonis, Vincent Timmerman, Angelo Poletti

Autophagy. 2023; 19(8): 2217–2239. Published online 2023 Feb 28. doi: 10.1080/15548627.2023.2179780

PMCID:: PMC10351472

Abstract Article PDF–5.9M

Select item 1035083316.

Phosphorylation of phase‐separated p62 bodies by ULK1 activates a redox‐independent stress response

Ryo Ikeda, Daisuke Noshiro, Hideaki Morishita, Shuhei Takada, Shun Kageyama, Yuko Fujioka, Tomoko Funakoshi, Satoko Komatsu‐Hirota, Ritsuko Arai, Elena Ryzhii, Manabu Abe, Tomoaki Koga, Hozumi Motohashi, Mitsuyoshi Nakao, Kenji Sakimura, Arata Horii, Satoshi Waguri, Yoshinobu Ichimura, Nobuo N Noda, Masaaki Komatsu

EMBO J. 2023 Jul; 42(14): e113349. Published online 2023 Jun 12. doi: 10.15252/embj.2022113349