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Select item 109076911.

Gasdermin E promotes translocation of p65 and c-jun into nucleus in keratinocytes for progression of psoriatic skin inflammation

Fangyuan Long, Xuecui Wei, Yujie Chen, Min Li, Ni Lian, Shanshan Yu, Sihan Chen, Yong Yang, Min Li, Heng Gu, Xu Chen

Cell Death Dis. 2024 Mar; 15(3): 180. Published online 2024 Mar 1. doi: 10.1038/s41419-024-06545-5

PMCID:: PMC10907691

Abstract Article PDF–9.3M

Select item 108055102.

Novel, pathogenic insertion variant of GSDME associates with autosomal dominant hearing loss in a large Chinese pedigree

Jingliang Cheng, Ting Li, Qi Tan, Jiewen Fu, Lianmei Zhang, Luquan Yang, Baixu Zhou, Lisha Yang, Shangyi Fu, Alora Grace Linehan, Junjiang Fu

J Cell Mol Med. 2024 Jan; 28(1): e18004. Published online 2023 Oct 20. doi: 10.1111/jcmm.18004

PMCID:: PMC10805510

Abstract Article PDF–3.9M

Select item 106415243.

Comparative proximity biotinylation implicates the small GTPase RAB18 in sterol mobilization and biosynthesis

Robert S. Kiss, Jarred Chicoine, Youssef Khalil, Robert Sladek, He Chen, Alessandro Pisaturo, Cyril Martin, Jessica D. Dale, Tegan A. Brudenell, Archith Kamath, Jeffrey Kyei-Boahen, Anouar Hafiane, Girija Daliah, Célia Alecki, Tayah S. Hopes, Martin Heier, Irene A. Aligianis, Jean-Jacques Lebrun, Julie Aspden, Emanuele Paci, Anja Kerksiek, Dieter Lütjohann, Peter Clayton, Jimi C. Wills, Alex von Kriegsheim, Tommy Nilsson, Eamonn Sheridan, Mark T. Handley

J Biol Chem. 2023 Nov; 299(11): 105295. Published online 2023 Sep 28. doi: 10.1016/j.jbc.2023.105295

PMCID:: PMC10641524

Abstract Article PDF–3.8M

Select item 104242964.

AMIGO2 attenuates innate cisplatin sensitivity by suppression of GSDME‐conferred pyroptosis in non‐small cell lung cancer

Lian‐kuai Chen, Shu‐ping Lin, Yong‐huan Xie, Xiang‐peng Tan, Ben‐han Xiong, Xiang‐feng Zeng, Cai‐rong Zhu, Shao‐yi Cao, Xiao‐yan Ye, Hong‐jiao Liu, Xiao‐ping Wu

J Cell Mol Med. 2023 Aug; 27(16): 2412–2423. Published online 2023 Jul 12. doi: 10.1111/jcmm.17827

PMCID:: PMC10424296

Abstract Article PDF–2.4M

Select item 102374225.

TRIM67 drives tumorigenesis in oligodendrogliomas through Rho GTPase-dependent membrane blebbing

Engin Demirdizen, Ruslan Al-Ali, Ashwin Narayanan, Xueyuan Sun, Julianna Patricia Varga, Bianca Steffl, Manuela Brom, Damir Krunic, Claudia Schmidt, Gabriele Schmidt, Felix Bestvater, Julian Taranda, Şevin Turcan

Neuro Oncol. 2023 Jun; 25(6): 1031–1043. Published online 2022 Nov 22. doi: 10.1093/neuonc/noac233

PMCID:: PMC10237422

Abstract Article PDF–23M

Select item 101201206.

Gasdermin E regulates the stability and activation of EGFR in human non-small cell lung cancer cells

Limei Xu, Feifei Shi, Yingdi Wu, Shun Yao, Yingying Wang, Xukai Jiang, Ling Su, Xiangguo Liu

Cell Commun Signal. 2023; 21: 83. Published online 2023 Apr 21. doi: 10.1186/s12964-023-01083-7

PMCID:: PMC10120120

Abstract Article PDF–7.4M

Select item 96776917.

OTUD4-mediated GSDME deubiquitination enhances radiosensitivity in nasopharyngeal carcinoma by inducing pyroptosis

Muping Di, Jingjing Miao, Qiuzhong Pan, Zonglong Wu, Boyu Chen, Muru Wang, Jingjing Zhao, Huageng Huang, Jiewen Bai, Qijing Wang, Yan Tang, Yongqiang Li, Jia He, Tong Xiang, Desheng Weng, Lin Wang, Jianchuan Xia, Chong Zhao

J Exp Clin Cancer Res. 2022; 41: 328. Published online 2022 Nov 21. doi: 10.1186/s13046-022-02533-9

PMCID:: PMC9677691

Abstract Article PDF–20M

Select item 95189928.

DFNA5 inhibits colorectal cancer proliferation by suppressing the mTORC1/2 signaling pathways via upregulation of DEPTOR

Jing Guo, Junhui Yu, Mingchao Mu, Zilu Chen, Zhengshui Xu, Chenye Zhao, Kui Yang, Jianbao Zheng, Xiao Qin, Wei Zhao, Xuejun Sun

Cell Cycle. 2022; 21(20): 2165–2178. Published online 2022 Aug 3. doi: 10.1080/15384101.2022.2088570

PMCID:: PMC9518992

Abstract Article PDF–3.8M

Select item 94754539.

The N⁶-methyladenosine-mediated lncRNA WEE2-AS1 promotes glioblastoma progression by stabilizing RPN2

Boyan Li, Rongrong Zhao, Wei Qiu, Ziwen Pan, Shulin Zhao, Yanhua Qi, Jiawei Qiu, Shouji Zhang, Qindong Guo, Yang Fan, Hao Xu, Ming Li, Gang Li, Hao Xue

Theranostics. 2022; 12(14): 6363–6379. Published online 2022 Aug 29. doi: 10.7150/thno.74600

PMCID:: PMC9475453

Abstract Article PDF–4.4M

Select item 945851010.

Expression levels of caspase‐3 and gasdermin E and their involvement in the occurrence and prognosis of lung cancer

Yuan‐Li Huang, Guang‐Hui Zhang, Qing Zhu, Xia Wu, Li‐Gao Wu

Cancer Rep (Hoboken) 2022 Sep; 5(9): e1561. Published online 2021 Sep 23. doi: 10.1002/cnr2.1561

PMCID:: PMC9458510

Abstract Article PDF–1.7M

Select item 938104111.

Zika virus causes placental pyroptosis and associated adverse fetal outcomes by activating GSDME

Zikai Zhao, Qi Li, Usama Ashraf, Mengjie Yang, Wenjing Zhu, Jun Gu, Zheng Chen, Changqin Gu, Youhui Si, Shengbo Cao, Jing Ye

eLife. 2022; 11: e73792. Published online 2022 Aug 16. doi: 10.7554/eLife.73792

PMCID:: PMC9381041

Abstract Article PDF–8.7M

Select item 930521212.

Attenuation of Rheumatoid Arthritis Through the Inhibition of Tumor Necrosis Factor–Induced Caspase 3/Gasdermin E–Mediated Pyroptosis

Zeqing Zhai, Fangyuan Yang, Wenchao Xu, Jiaochan Han, Guihu Luo, Yehao Li, Jian Zhuang, Hongyu Jie, Xing Li, Xingliang Shi, Xinai Han, Xiaoqing Luo, Rui Song, Yonghong Chen, Jianheng Liang, Shufan Wu, Yi He, Erwei Sun

Arthritis Rheumatol. 2022 Mar; 74(3): 427–440. Published online 2022 Jan 18. doi: 10.1002/art.41963

PMCID:: PMC9305212

Abstract Article PDF–7.8M

Select item 910810013.

Human NLRP1 is a sensor of pathogenic coronavirus 3CL proteases in lung epithelial cells

Rémi Planès, Miriam Pinilla, Karin Santoni, Audrey Hessel, Charlotte Passemar, Kenneth Lay, Perrine Paillette, Ana-Luiza Chaves Valadão, Kim Samirah Robinson, Paul Bastard, Nathaniel Lam, Ricardo Fadrique, Ida Rossi, David Pericat, Salimata Bagayoko, Stephen Adonai Leon-Icaza, Yoann Rombouts, Eric Perouzel, Michèle Tiraby, COVID Human Genetic Effort, Qian Zhang, Pietro Cicuta, Emmanuelle Jouanguy, Olivier Neyrolles, Clare E. Bryant, Andres R. Floto, Caroline Goujon, Franklin Zhong Lei, Guillaume Martin-Blondel, Stein Silva, Jean-Laurent Casanova, Céline Cougoule, Bruno Reversade, Julien Marcoux, Emmanuel Ravet, Etienne Meunier

Mol Cell. 2022 Jul 7; 82(13): 2385–2400.e9. Published online 2022 May 16. doi: 10.1016/j.molcel.2022.04.033

PMCID:: PMC9108100

Abstract Article PDF–4.3M

Select item 903572314.

Gasdermin E is required for induction of pyroptosis and severe disease during enterovirus 71 infection

Siwen Dong, Yujin Shi, Xiaojing Dong, Xia Xiao, Jianli Qi, Lili Ren, Zichun Xiang, Zhuo Zhou, Jianwei Wang, Xiaobo Lei

J Biol Chem. 2022 May; 298(5): 101850. Published online 2022 Mar 23. doi: 10.1016/j.jbc.2022.101850

PMCID:: PMC9035723

Abstract Article PDF–3.0M

Select item 892400015.

Gasdermin E mediates resistance of pancreatic adenocarcinoma to enzymatic digestion through a YBX1–mucin pathway

Jiadi Lv, Yuying Liu, Siqi Mo, Yabo Zhou, Fengye Chen, Feiran Cheng, Cong Li, Dilizhatai Saimi, Mengyu Liu, Huafeng Zhang, Ke Tang, Jingwei Ma, Zhenfeng Wang, Qiangqiang Zhu, Wei-Min Tong, Bo Huang

Nat Cell Biol. 2022; 24(3): 364–372. Published online 2022 Mar 15. doi: 10.1038/s41556-022-00857-4

PMCID:: PMC8924000

Abstract Article PDF–17M

Select item 884216516.

CFTR interactome mapping using the mammalian membrane two‐hybrid high‐throughput screening system

Sang Hyun Lim, Jamie Snider, Liron Birimberg‐Schwartz, Wan Ip, Joana C Serralha, Hugo M Botelho, Miquéias Lopes‐Pacheco, Madalena C Pinto, Mohamed Taha Moutaoufik, Mara Zilocchi, Onofrio Laselva, Mohsen Esmaeili, Max Kotlyar, Anna Lyakisheva, Priscilla Tang, Lucía López Vázquez, Indira Akula, Farzaneh Aboualizadeh, Victoria Wong, Ingrid Grozavu, Teuta Opacak‐Bernardi, Zhong Yao, Meg Mendoza, Mohan Babu, Igor Jurisica, Tanja Gonska, Christine E Bear, Margarida D Amaral, Igor Stagljar

Mol Syst Biol. 2022 Feb; 18(2): e10629. Published online 2022 Feb 14. doi: 10.15252/msb.202110629

PMCID:: PMC8842165

Abstract Article PDF–3.0M

Select item 874184617.

Apoptin induces pyroptosis of colorectal cancer cells via the GSDME-dependent pathway

Zirui Liu, Yiquan Li, Yilong Zhu, Nan Li, Wenjie Li, Chao Shang, Gaojie Song, Shanzhi Li, Jianan Cong, Tingyu Li, Zhiru Xiu, Jing Lu, Chenchen Ge, Xia Yang, Yaru Li, Lili Sun, Xiao Li, Ningyi Jin

Int J Biol Sci. 2022; 18(2): 717–730. Published online 2022 Jan 1. doi: 10.7150/ijbs.64350

PMCID:: PMC8741846

Abstract Article PDF–3.0M

Select item 859474318.

Virus-mediated inactivation of anti-apoptotic Bcl-2 family members promotes Gasdermin E-dependent pyroptosis in barrier epithelial cells

Megan H. Orzalli, Aleksandra Prochera, Laurellee Payne, Avi Smith, Jonathan A. Garlick, Jonathan C. Kagan

Immunity. Author manuscript; available in PMC 2022 Jul 13.

Published in final edited form as: Immunity. 2021 Jul 13; 54(7): 1447–1462.e5. Published online 2021 May 11. doi: 10.1016/j.immuni.2021.04.012

PMCID:: PMC8594743

Abstract Article PDF–2.5M

Select item 844854219.

Long non-coding RNA nuclear paraspeckle assembly transcript 1 regulates ionizing radiation-induced pyroptosis via microRNA-448/gasdermin E in colorectal cancer cells

Fei Su, Junzhao Duan, Jie Zhu, Hanjiang Fu, Xiaofei Zheng, Changhui Ge

Int J Oncol. 2021 Oct; 59(4): 79. Published online 2021 Sep 1. doi: 10.3892/ijo.2021.5259

PMCID:: PMC8448542

Abstract Article PDF–2.8M

Select item 841917420.

Caspase‐3‐mediated GSDME induced Pyroptosis in breast cancer cells through the ROS/JNK signalling pathway

Ziwen Zhang, Han Zhang, Dongbo Li, Xiaoping Zhou, Qi Qin, Qingyuan Zhang

J Cell Mol Med. 2021 Sep; 25(17): 8159–8168. Published online 2021 Aug 8. doi: 10.1111/jcmm.16574

PMCID:: PMC8419174

Abstract Article PDF–1.3M

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