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Select item 111583531.

Nek2 as a novel molecular target for the treatment of breast carcinoma

Nobuyuki Tsunoda, Toshio Kokuryo, Koji Oda, Takeshi Senga, Yukihiro Yokoyama, Masato Nagino, Yuji Nimura, Michinari Hamaguchi

Cancer Sci. 2009 Jan; 100(1): 111–116. Published online 2008 Nov 27. doi: 10.1111/j.1349-7006.2008.01007.x

PMCID:: PMC11158353

Abstract Article PDF–369K

Select item 111279042.

NEK2 promotes the development of ovarian endometriosis and impairs decidualization by phosphorylating FOXO1

Mengxue Wang, Fangyuan Sun, Shucai Zhang, Xiaohui Zhang, Yujun Sun, Ting Yu, Yuanyuan Li, Aifang Jiang, Pengyun Qiao, Chune Ren, Tingting Yang

Cell Mol Life Sci. 2024 Dec; 81(1): 237. Published online 2024 May 25. doi: 10.1007/s00018-024-05270-8

PMCID:: PMC11127904

Abstract Article PDF–17M

Select item 110798853.

Abnormal methylation mediated upregulation of LINC00857 boosts malignant progression of lung adenocarcinoma by modulating the miR‐486‐5p/NEK2 axis

Haoyu Fu, Mingming Zhang, Xiaohui Liu, Yiming Yang, Ying Xing

Clin Respir J. 2024 May; 18(5): e13765. Published online 2024 May 9. doi: 10.1111/crj.13765

PMCID:: PMC11079885

Abstract Article PDF–3.8M

Select item 109445104.

Nek2A prevents centrosome clustering and induces cell death in cancer cells via KIF2C interaction

Batuhan Mert Kalkan, Selahattin Can Ozcan, Enes Cicek, Mehmet Gonen, Ceyda Acilan

Cell Death Dis. 2024 Mar; 15(3): 222. Published online 2024 Mar 16. doi: 10.1038/s41419-024-06601-0

PMCID:: PMC10944510

Abstract Article PDF–4.9M

Select item 109305165.

NEK2通过抵抗肝癌细胞衰老促进肝癌进展

雷倩, 夏机良, 冯湘玲, 郭姣姣, 李官成, 周文

Zhong Nan Da Xue Xue Bao Yi Xue Ban. 2022 Feb 28; 47(2): 153–164. Chinese. doi: 10.11817/j.issn.1672-7347.2022.210058

PMCID:: PMC10930516

Abstract Article PDF–2.9M

Select item 108731976.

Inhibition of the YAP-MMB interaction and targeting NEK2 as potential therapeutic strategies for YAP-driven cancers

Marco Jessen, Dörthe Gertzmann, Franziska Liss, Franziska Zenk, Laura Bähner, Victoria Schöffler, Clemens Schulte, Hans Michael Maric, Carsten P. Ade, Björn von Eyss, Stefan Gaubatz

Oncogene. 2024; 43(8): 578–593. Published online 2024 Jan 5. doi: 10.1038/s41388-023-02926-w

PMCID:: PMC10873197

Abstract Article PDF–2.7M

Select item 108508187.

Cancer‐associated FBXW7 loss is synthetic lethal with pharmacological targeting of CDC7

Joseph S. Baxter, Rachel Brough, Dragomir B. Krastev, Feifei Song, Sandhya Sridhar, Aditi Gulati, John Alexander, Theodoros I. Roumeliotis, Zuza Kozik, Jyoti S. Choudhary, Syed Haider, Stephen J. Pettitt, Andrew N. J. Tutt, Christopher J. Lord

Mol Oncol. 2024 Feb; 18(2): 369–385. Published online 2023 Oct 22. doi: 10.1002/1878-0261.13537

PMCID:: PMC10850818

Abstract Article PDF–2.7M

Select item 100729068.

Multiplexed kinase interactome profiling quantifies cellular network activity and plasticity

Martin Golkowski, Andrea Lius, Tanmay Sapre, Ho-Tak Lau, Taylor Moreno, Dustin J. Maly, Shao-En Ong

Mol Cell. Author manuscript; available in PMC 2023 Apr 4.

Published in final edited form as: Mol Cell. 2023 Mar 2; 83(5): 803–818.e8. Published online 2023 Feb 2. doi: 10.1016/j.molcel.2023.01.015

PMCID:: PMC10072906

Abstract Article PDF–4.2M

Select item 91991379.

NEK2 promotes the migration and proliferation of ESCC via stabilization of YAP1 by phosphorylation at Thr-143

Wei Su, Hao Hu, Qiurong Ding, Min Wang, Yan Zhu, Zhaochao Zhang, Zihan Geng, Shengli Lin, Pinghong Zhou

Cell Commun Signal. 2022; 20: 87. Published online 2022 Jun 15. doi: 10.1186/s12964-022-00898-0

PMCID:: PMC9199137

Abstract Article PDF–4.0M

Select item 911973610.

OpenCell: proteome-scale endogenous tagging enables the cartography of human cellular organization

Nathan H. Cho, Keith C. Cheveralls, Andreas-David Brunner, Kibeom Kim, André C. Michaelis, Preethi Raghavan, Hirofumi Kobayashi, Laura Savy, Jason Y. Li, Hera Canaj, James Y.S. Kim, Edna M. Stewart, Christian Gnann, Frank McCarthy, Joana P. Cabrera, Rachel M. Brunetti, Bryant B. Chhun, Greg Dingle, Marco Y. Hein, Bo Huang, Shalin B. Mehta, Jonathan S. Weissman, Rafael Gómez-Sjöberg, Daniel N. Itzhak, Loic A. Royer, Matthias Mann, Manuel D. Leonetti

Science. Author manuscript; available in PMC 2022 Sep 11.

Published in final edited form as: Science. 2022 Mar 11; 375(6585): eabi6983. Published online 2022 Mar 11. doi: 10.1126/science.abi6983

PMCID:: PMC9119736

Abstract Article PDF–3.3M

Select item 894865911.

Genetic Aberrations and Interaction of NEK2 and TP53 Accelerate Aggressiveness of Multiple Myeloma

Xiangling Feng, Jiaojiao Guo, Gang An, Yangbowen Wu, Zhenhao Liu, Bin Meng, Nihan He, Xinying Zhao, Shilian Chen, Yinghong Zhu, Jiliang Xia, Xin Li, Zhiyong Yu, Ruixuan Li, Guofeng Ren, Jihua Chen, Minghua Wu, Yanjuan He, Lugui Qiu, Jiaxi Zhou, Wen Zhou

Adv Sci (Weinh) 2022 Mar; 9(9): 2104491. Published online 2022 Jan 27. doi: 10.1002/advs.202104491

PMCID:: PMC8948659

Abstract Article PDF–6.5M

Select item 876030512.

NEK2 enhances malignancies of glioblastoma via NIK/NF-κB pathway

Jianyang Xiang, Wahafu Alafate, Wei Wu, Yichang Wang, Xiaodong Li, Wanfu Xie, Xiaobin Bai, Ruichun Li, Maode Wang, Jia Wang

Cell Death Dis. 2022 Jan; 13(1): 58. Published online 2022 Jan 14. doi: 10.1038/s41419-022-04512-6

PMCID:: PMC8760305

Abstract Article PDF–5.5M

Select item 872664413.

ETV4 mediated lncRNA C2CD4D-AS1 overexpression contributes to the malignant phenotype of lung adenocarcinoma cells via miR-3681-3p/NEK2 axis

Binliang Wang, Yuanyuan Cai, Xiaobo Li, Yiming Kong, Haiwei Fu, Jianying Zhou

Cell Cycle. 2021; 20(24): 2607–2618. Published online 2021 Dec 1. doi: 10.1080/15384101.2021.2005273

PMCID:: PMC8726644

Abstract Article PDF–3.6M

Select item 831646914.

NEK2 inhibition triggers anti-pancreatic cancer immunity by targeting PD-L1

Xiaozhen Zhang, Xing Huang, Jian Xu, Enliang Li, Mengyi Lao, Tianyu Tang, Gang Zhang, Chengxiang Guo, Xiaoyu Zhang, Wen Chen, Dipesh Kumar Yadav, Xueli Bai, Tingbo Liang

Nat Commun. 2021; 12: 4536. Published online 2021 Jul 27. doi: 10.1038/s41467-021-24769-3

PMCID:: PMC8316469

Abstract Article PDF–11M

Select item 816503015.

Dual Proteome-scale Networks Reveal Cell-specific Remodeling of the Human Interactome

Edward L. Huttlin, Raphael J. Bruckner, Jose Navarrete-Perea, Joe R. Cannon, Kurt Baltier, Fana Gebreab, Melanie P. Gygi, Alexandra Thornock, Gabriela Zarraga, Stanley Tam, John Szpyt, Brandon M. Gassaway, Alexandra Panov, Hannah Parzen, Sipei Fu, Arvene Golbazi, Eila Maenpaa, Keegan Stricker, Sanjukta Guha Thakurta, Tian Zhang, Ramin Rad, Joshua Pan, David P. Nusinow, Joao A. Paulo, Devin K. Schweppe, Laura Pontano Vaites, J. Wade Harper, Steven P. Gygi

Cell. Author manuscript; available in PMC 2022 May 27.

Published in final edited form as: Cell. 2021 May 27; 184(11): 3022–3040.e28. Published online 2021 May 6. doi: 10.1016/j.cell.2021.04.011

PMCID:: PMC8165030

Abstract Article PDF–2.2M

Select item 807971116.

The Nek2 centrosome-mitotic kinase contributes to the mesenchymal state, cell invasion, and migration of triple-negative breast cancer cells

Yainyrette Rivera-Rivera, Mihaela Marina, Shirley Jusino, Miyoung Lee, Jaleisha Vélez Velázquez, Camille Chardón-Colón, Geraldine Vargas, Jaya Padmanabhan, Srikumar P. Chellappan, Harold I. Saavedra

Sci Rep. 2021; 11: 9016. Published online 2021 Apr 27. doi: 10.1038/s41598-021-88512-0